Readers offer a variety of reasons Donald Trump defeated Kamala Harris -- gender bias, the presentation of Harris' policies and Democrats' track record under Joe Biden.
Arrangement of digits, letters and symbols on telephones and other devices that can be used for gaining access to a telephone network
Today, we hear from a group helping neighbors prepare for future wildfires. Then, a new anthology of love letters to San Francisco. And, ArtSpan's Open Studios celebrates 50 years.
Dear Readers: On Sept. 23, I published two letters from older adults struggling to find a connection (“Still Grieving” and “Wants a Connection”). I asked those of you who have successfully found friendship and romantic partnership at a later stage in life to write in.
"The city has been investing in housing, albeit on a much more modest scale, for decades using limited local funds and a variety of federal funds it receives since the 1990s." -- Charles Kreiman, Denver
"Please, Mr. Kroenke. You have your 124,000 playground ranch and billions in cash. Can't we have some space? How much money do you need?"
"As a descendant of Lebanese heritage, I find it insulting and remiss that Friednash can't seem to acknowledge the toll this conflict is exacting upon innocent Lebanese civilians caught in the middle of this conflict. By his logic, failing to mention the collateral damage to the Lebanese people is actually anti-Lebanese." -- Peter Murr, Denver
"We shouldn’t accept an election system where most of us don’t have a voice." -- Nick Troiano, Denver
"Along with Colorado's increased property taxes and inflated grocery, utilities, and gas prices, I'm not sure how we will make our 2025 monthly budget work, but I know I’m voting for change, I’m voting for Gabe Evans." -- Susan Walker, Greeley
"Instead of taxing law-abiding gun owners who purchase ammunition for recreational shooting and hunting, or defense, why don't we just reallocate part of the $40 billion Colorado annual budget?" -- Richard D VanOrsdale, Broomfield
"It will be so disappointing if the good people of District 4 can’t see through her and instead elect her to replace the honorable and decent Congressman Ken Buck. Talk about trading a diamond for a clod of dirt!" -- Kristina Woods, Durango
"Donald Trump is not a politician who guards his words carefully to avoid offending anyone. But we don't need a politician now." -- Angie Many, Eckert
Stop your self-centered whining, and let’s get on with the job of building more badly needed housing. And thank the Kroenkes’ for investing in Denver’s housing stock.
"With the re-election of Trump I’m convinced that our generation’s time – I’m in my 80s -- has passed. The values I admire, the qualities of character I respect, seem to be relegated to some kind of antique standards shop. We’re decidedly outta style." -- Harry Puncec, Lakewood
The Bermuda Underwater Exploration Institute [BUEI] is set to feature the 2023 comedy/mystery ‘Wicked Little Letters,’ directed by Thea Sharrock, as part of its ongoing ‘Films at BUEI’ series. A spokesperson said, “‘Films at BUEI’ continues at the Bermuda Underwater Exploration Institute [BUEI] with the screening of the 2023 Comedy/Mystery, ‘Wicked Little Letters’ on Saturday, […]
In their comment (1) on our publication (2), the authors make two points: (i) they raise concerns about the possible effect of residual NONOate in our study, and (ii) they promote nitrosylcobalamin (NOCbl) supplied by their own company. Both points lack merit for the following reasons. The authors make the astonishing claim that the spectra of nitric oxide (NO•) and cobalamins overlap. Unlike NO•, cobalamin absorbs in the visible region, permitting unequivocal spectral assignment of NOCbl as reported (3). We demonstrated that whereas NOCbl is highly unstable in solution, it is stabilized by the B12 trafficking protein CblC. So even if present, residual NONOate (which is unstable at neutral pH and is removed during the work-up (3)) could not account for the observed difference.The authors then misrepresent our synthetic method, claiming that anaerobic conditions were used to generate nitrocobalamin (NO2Cbl), which results in the transient formation of NOCbl. We synthesized NO2Cbl aerobically using nitrite as described (4); NOCbl is not an intermediate in this ligand exchange reaction. The aerobic instability of NOCbl has been rigorously described by inorganic chemists (3, 5) and raises obvious questions about its purported biological effects as exemplified by the authors' own 2003 JBC publication, which was later withdrawn.As to promoting NOCbl from their company, the authors refer to a synthetic route from a mixture of NO• gas and aquocobalamin. The authors' method (6) has been described as “dubious” by chemists (5). Whereas DEAE NONOate used in our method is widely known as an NO• donor,...
After a thorough read of this paper (1), we wish to clarify that the authors' anaerobic method of synthesis for the production of nitrocobalamin results in the transient formation of nitrosylcobalamin, an unstable intermediate upon exposure to air. We concur that the authors' method results in the production of nitrocobalamin based on the UV-visible data as shown. The authors' adapted anaerobic method consists of mixing hydroxocobalamin hydrochloride with diethylamine NONOate diethylammonium salt in aqueous solution. Of concern, the UV spectrum of nitric oxide overlaps that of all cobalamin species under anaerobic conditions, making any assignments of the binding of nitric oxide to hydroxocobalamin suspect (2). Additionally, the use of acetone to precipitate the authors' product causes precipitation of diethylamine NONOate, resulting in an impure product. As a result, its utility for drawing experimental conclusions is faulty.The product from the authors' anaerobic synthetic method has not been assessed for purity, and the synthetic method itself has not been validated using a stability-indicating method as required by the International Conference on Harmonization (ICH) (ICH Q2B, Validation of Analytical Procedures) methodology, which is a hallmark for analytical characterization. Our nitrosylcobalamin synthesis involves reacting nitric oxide gas with hydroxocobalamin acetate as a heterogeneous mixture in a non-electron-donating solvent followed by rotary evaporation. Our nitrosylcobalamin product is stable in air, releases nitric oxide gas in situ (3), and meets ICH stability guidelines (4). Additionally, our nitrosylcobalamin product demonstrates biological activity, which has not been observed for nitrocobalamin (3, 5).
A Missouri thrift store is unraveling the mystery of a cache of World War II love letters found in a donation bin.
When it comes to education, the 49th state faces its own challenges, some of which are unique to Alaska and some that it shares with other rural states. This series explores how cultural and geographic barriers, teacher shortages, historical developments, and more have shaped schooling in Alaska.
Two British artists travel to Pittsburgh for their second installment of their "Mysterious Letters" art project.
The New Collective Quantified Goal – a post-2025 climate finance target – is set to be a defining agenda item at COP29, aiming for a more ambitious and equitable financial commitment for developing countries, says Punki Modise.
The Division of Unemployment Insurance (UI) recently mailed 2024 UI tax rate letters that contained incorrect information. We apologize for the error. We are working to correct the issue and will mail new letters with the correct rate as quickly as possible. All employers will receive updated letters even if their rate does not change. […]
The Division of Unemployment Insurance has corrected the issue related to the 2024 UI tax rate letters mailed in January. Corrected letters have been mailed to employers the week of February 5, 2024. The corrected letters have a date of February 1, 2024. The Division of Unemployment would like to thank all employers for their […]
The Delaware Division of Revenue is warning the public of a new tax scam that’s happening in Delaware. Victims receive a letter from the “Tax Processing Unit” that threatens property seizure and wage garnishment unless the victim calls a toll-free number to “avoid enforcement.”
Title: Warning Letters Target Illegal Online Sales of Opioid Meds: FDA
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/29/2018 12:00:00 AM
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