Cruciferous vegetables have been of special interest due to the rich presence of bioactive compounds such as sulforaphane which show promising potential on cancer prevention and therapy as an epigenetic dietary strategy. Abnormal epigenetic alteration as one of the primary contributors to tumor development is closely related to breast cancer initiation and progression. In the present study, we investigated the effect of dietary broccoli sprouts (BSp), a common cruciferous vegetable, on prevention of estrogen receptor (ER)-negative mammary tumors at three different temporal exposure windows using a spontaneous breast cancer mouse model. Our findings indicate that maternal BSp treatment exhibited profound inhibitory and preventive effects on mammary cancer formation in the nontreated mouse offspring. The BSp diet administered to adult mice also showed suppressive effects on mammary cancer but was not as profound as the maternal BSp preventive effects. Moreover, such protective effects were linked with differentially expressed tumor- and epigenetic-related genes, as well as altered global histone acetylation, DNA methylation, and DNA hydroxymethylation levels. We also found that the expression changes of tumor-related genes were associated with the levels of histone methylation of H3K4 and H3K9 in the gene promoter regions. In addition, BSp-enriched sulforaphane was shown to increase protein expression of tumor suppressor genes such as p16 and p53 and inhibit the protein levels of Bmi1, DNA methyltransferases, and histone deacetylases in ERα-negative breast cancer cell lines. Collectively, these results suggest that maternal exposure to key phytochemicals may contribute to ER-negative mammary tumor prevention in their offspring through epigenetic regulations.

BACKGROUND AND PURPOSE:

Diffuse intrinsic pontine glioma is a lethal childhood brain cancer with dismal prognosis and MR imaging is the primary methodology used for diagnosis and monitoring. Our aim was to determine whether advanced diffusion, perfusion, and permeability MR imaging metrics predict survival and pseudoprogression in children with newly diagnosed diffuse intrinsic pontine glioma.

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Every day on Pluto, nitrogen puffs out the icy world’s heart-shaped plain into the atmosphere, and every night it refreezes, creating winds unlike any we’ve seen before

The Rosetta spacecraft’s measurements of comet 67P have revealed a hidden source of nitrogen that may help us learn how giant planets – and even life – formed

Your weekly selection of awesome robot videos

Blue Frog Robotics CEO Rodolphe Hasselvander on the future of Buddy

After finding common ground, Jen and Judy split up to spend time with new friends who could end up being something more.

बीते बुधवार को सरकार ने फीचर फोन और लैंडलाइन यूजर्स के लिए आईवीआरएस सेवा लॉन्च की थी। वहीं, अब सरकार जियोफोन यूजर्स के लिए अलग से आरोग्य सेतु मोबाइल एप को पेश करने की तैयारी कर रही है।

A team of researchers at the Massachusetts Institute of Technology (MIT) has demonstrated that single-celled microorganisms such as Escherichia coli and Saccharomyces cerevisiae that normally do not inhabit hydrogen-rich environments can survive and grow in a 100% hydrogen atmosphere. “There’s a diversity of habitable worlds out there, and we have confirmed that Earth-based life can [...]

An international team of paleontologists from the University of Plymouth, the University of Kansas and the Forge Fossils has found a specimen of the squid-like cephalopod Clarkeiteuthis montefiorei preserved with the herring-like fish Dorsetichthys bechei in its two arms; the bones in the head of the fish are broken in a manner that suggests a [...]

Hockey India said the recommendations are based on the premise of the a few principles.

ROGER FEDERER has explained why he gets injured less than rivals Rafael Nadal and Novak Djokovic..

Joe Biden's campaign is gaining the support of key progressive groups to unite the party's factions.

Brookfield, known for its contrarian bets on malls, will take minority stakes in struggling retailers

Announcement comes as new report from Statistics Canada shows almost two million more Canadians have lost their jobs

Investment mandate of the Clean Energy Financing Corporation will be changed, but no guarantee hydrogen will be produced from renewables

The Morrison government will change the investment mandate of the Clean Energy Finance Corporation, directing it to make up to $300m available for a new Advancing Hydrogen Fund as part of the national hydrogen strategy.

The Coalition’s move to create a dedicated hydrogen financing fund will be confirmed on Monday, and comes ahead of other changes the government intends to make to the CEFC’s investment program, including requiring it to support new investments in grid reliability.

Hydrogen is a possible next generation energy solution, and it can be produced from sunlight and water using photocatalysts. A research group has now developed a strategy that greatly increases the amount of hydrogen produced using hematite photocatalysts. In addition to boosting the high efficiency of what is thought to be the world's highest performing photoanode, this strategy will be applied to artificial photosynthesis and solar water-splitting technologies via university-industry collaborations.

Rookie phenom Connor Bedard is the headliner of a workmanlike forward group that's looking to come of age with the Regina Pats.

The Australian government on Monday set aside A$300 million ($191 million) to jumpstart hydrogen projects with the help of low-cost financing as the country aims to build the industry by 2030, the country's energy minister said on Monday.

BP Plc has won Australian government backing for a feasibility study into producing hydrogen using wind and solar power to split water and converting the hydrogen to ammonia in Western Australia.

Hydrogen has long been touted as a clean alternative to fossil fuels. Now, as major economies prepare green investments to kickstart growth, advocates spy a golden chance to drag the niche energy into the mainstream of a post-pandemic world.

The U.S. government's $660 billion program to rescue small businesses hit by the coronavirus pandemic thwarts the intention of Congress by making it hard for some borrowers to convert loans to grants and failing to prioritize the right businesses, a government watchdog said on Friday.

Follow our live Covid-19 updates HERE Coronavirus: The symptoms

Dozens of climate activists have been referred to the Home Office's anti-terror Prevent programme amid fears they may become radicalised, it has emerged.

A homeowner was conned out of more than £100,000 by rogue builders who overcharged for roof repairs — before posing as police and trading standards officers to swindle him again.

A solar-driven hydrogen-producing machine that makes more copies of itself.

NASA has selected teams led by Blue Origin, Dynetics and SpaceX to develop lunar landing systems capable of putting astronauts on the moon by as early as 2024. "We want to be able to go to the moon, but we want to be a customer," NASA Administrator Jim Bridenstine told reporters today during a teleconference. "We want to drive down the costs, we want to increase the access, we want to have our partners have customers that are not just us, so they compete on cost and innovation, and just bring capabilities that we've never had before." Fixed-price contracts totaling… Read More

A hard Brexit is more likely due to the coronavirus crisis because Britain and the European Union have made so little progress in talks, Germany's foreign minister has said. Heiko Maas said that negotiations between Britain and the EU so far on the future trade relationship had yielded few gains with the UK disregarding the political declaration, which he said was "simply not on". Britain left the EU in January, and talks with the bloc are now focused on setting new trading terms from 2021, when London's status-quo transition period ends. However, the talks quickly hit an impasse when negotiations resumed last month, according to diplomats and officials. "It's worrying that Britain is moving further away from our jointly agreed political declaration on key issues in the negotiations," Mr Maas told the Augsburger Allgemeine newspaper. "It's simply not on, because the negotiations are a complete package as it's laid out in the political declaration." Mr Maas said there was currently neither common ground on how to shape a comprehensive trade deal or on whether to extend the negotiation period beyond the end of the year. "The British government is still refusing to extend the deadline," Mr Maas said. "If it stays that way, we will have to deal with Brexit in addition to the coronavirus at the turn of the year." Simon Coveney, Ireland's foreign minister, said on Friday that the coronavirus pandemic had made an already difficult timeline for a British-European Union trade deal "virtually impossible" and that it would make sense to seek more time.

Since its launch on April 2 this year, over 96 million people have registered with the Aarogya Setu health care application, which has become the fastest mobile app to reach 50 million users globally . The Aarogya Setu has helped the government with its twin objective -- "whom to test" and "where to test more" in its battle against COVID-19.

'I am a fan of ETFs, well certainly they have grown a whole lot'

By Allan Eastman The photographs of water bombers fighting the horrendous Ft. McMurray conflagration of 2016 invoked a sudden wash of memories having to do with two of the great Canadian cultural institutions that I had the good fortune to be involved with and a bizarre set of circumstances that led from a burned out […]

It is "too early" to begin easing any lockdown measures "in any meaningful way", Nicola Sturgeon has said.

France's minister of education, Jean-Michel Blanquer, talked with NPR about the gradual reopening of schools, which will be voluntary. Still, many parents and administrators are against the plan.

Starting Monday, “park ambassadors” will be stationed at Ottawa’s busiest parks to provide information about what's permitted under pandemic rules.

During Jimmy Kimmel Live! filmed at their respective houses

Surreal reality series will unveil remaining celebrities in a matter of weeks

Australian National Audit Office evidence to Senate appears to contradict Morrison’s claim that he provided no authorisation

The prime minister’s office asked Bridget McKenzie to seek Scott Morrison’s “authority” for intended recipients of $100m of sports grants and coordinate the announcement with Coalition campaign headquarters, according to new evidence to the sports rorts inquiry.

The evidence from the Australian National Audit Office to the Senate inquiry contradicts Morrison’s claims that McKenzie, the former sports minister, was the ultimate decision-maker for the grant program, and that changes were not made after parliament was dissolved.

Parents are getting a helping hand from some famous faces

It's the BBC's 'biggest push on education in its history' and kicks off Monday, April 20

The new scheme wants to ensure diverse founders are still standing once things are back to normal

This year's digital-only festival has dropped nearly 600 events, but it will be completely free

Chess-based, card-based, roguelike dungeon crawler. And you might as well throw puzzler on top of it too. That’s quite a …

Continue reading "‘Pawnbarian’ is a Chess-Based, Card-Based, Roguelike Dungeon Crawler Coming to Mobile and Desktop"

Marko Grujic has conceded that he may need to move on from Liverpool this summer if he is to fulfil his potential.

New Chelsea signing Hakim Ziyech says he wants to hit the same heights as Didier Drogba when he completes his move from Ajax.

L.A. Mayor Eric Garcetti announced Friday evening that producer Steve Tisch and the Jonas Brothers each donated $500,000 — $1 million total — to the Mayor’s Fund for Los Angeles and to the Angelino Card program. Garcetti called Tisch “a friend who moved here to Los Angeles…to make a life for himself, found great success […]

ASUS has been pushing laptops with second screens for a couple of years now, but it's still searching for a winning formula. Last year's ZenBook Pro Duo pushed the keyboard down to the edge of the laptop's body, with the rest of the surface housing a second screen. The problem with that configuration was an awkwardly placed trackpad. But, you know who cares less about trackpad placement? Gamers. Hence, almost a year later, the company's Republic Of Gamers (ROG) division has its own spin on the concept: the ROG Zephyrus Duo 15.

What at first seemed like a potential April Fool's joke has turned out to be real: almost seven years after the original came out, Cellar Door Games has confirmed it's working on a Rogue Legacy sequel. The indie studio didn't share a release date for Rogue Legacy 2, nor did it say anything about potential platforms. In fact, besides some screenshots showing off a lovely new art style, the only significant tidbit of information we got is that Judson Cowan and A Shell in the Pit will return to score the game's soundtrack.

The ATP, WTA, ITF and four Grand Slam events have created a program to support players affected by the sport's coronavirus-related shutdown.