Andrey Avendaño, vocero de la comisión de paz de la disidencia del Estado Mayor Central de las FARC, mencionó en Caracol Radio que esperan que los colombianos participen en la construcción de la paz. 

Medellín es la primera ciudad de Latinoamérica en estar en el Metaverso

Rafaela Cortés reveló en 6AM que las disidencias de Iván Mordisco se estarían fortaleciendo en el departamento por cuenta de extorsiones y estarían atentando contra bases militares del Ejército

En 6am hoy por hoy, estuvo Rafaela Cortés, gobernadora del Meta, quien hablo sobre cómo está la situación de orden público en el meta. 

Rob Grabowski and Tom Antonson caught Metallica, Pantera and Mammoth WVH In The Act during the Chicago stop of the M72 Tour at Soldiers Field on August 9th. Check out Rob's photos and Tom's review!

De tijd dringt: de Meta Pixel – jarenlang een essentiële tool voor het volgen van conversies en gebruikersgedrag – wordt begin 2025 uitgefaseerd, zo meldt mijn contactpersoon bij Meta Support. Voor marketeers betekent dit een cruciale overgang naar de Conversions API (CAPI). Een oplossing die niet alleen inspeelt op de toenemende focus op privacy, maar […]

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Победители будут объявлены на церемонии награждения в отеле Beverly Hilton в Лос-Анджелесе 19 февраля 2025 года. Среди знаменитостей, которые в прошлом были ведущими церемонии и участвовали в ней, - Dave Chappelle, Dave Grohl, Sir Elton John, Don Henley, Sebastian Maniscalco, Lars Ulrich и другие.

В номинации "Rock Tour Of The Year" на награду претендуют:

Blink-182’s “The More Time Tour”
Bruce Springsteen And The E Street Band’s “2024 World Tour”
Coldplay’s “Music Of The Spheres World Tour”
Foo Fighters’ “Everything Or Nothing At All Tour”
Green Day’s “The Saviors Tour”
Metallica’s “M72 World Tour”

В категории "Residency Of The Year" на награду претендуют:

Adele at The Colosseum at Caesars Palace/Neue Messe München
Billy Joel at Madison Square Garden
Dead & Company at The Sphere
Eagles at The Sphere
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U2 at The Sphere
#Metallica #ModernRock #Modern_Rock #AvantgardeRock #Avantgarde_Rock #HeavyMetal #Heavy_Metal #ProgressiveMetal #Progressive_Metal #SymphonicMetal #Symphonic_Metal #ThrashMetal #Thrash_Metal #AvantgardeMetal #Avantgarde_Metal

I first arrived in Silicon Valley in 1977 — 45 years ago. I was 24 years old and had accepted a Stanford fellowship paying $2,575 for the academic year. My on-campus apartment rent was $175 per month and a year later I’d buy my first Palo Alto house for $57,000 (sold 21 years later for $990,000). It was an exciting time to be living and working in Silicon Valley. And it still is. We’re right now in a period of economic confusion and reflection when many of the loudest voices have little to no sense of history. Well my old brain is crammed with history and I’m here to tell you that the current situation — despite the news coverage — is no big deal. […]

Are you just getting started?  GO HERE!

Before one approaches seriously the study of metaphysics, magick, the occult, or mysticism, it is appropriate that one prepares oneself on all levels: mentally, emotionally, physically and spiritually.

It is of vital importance that the student be psychologically prepared for the reception of Cosmic truths; for without adequate preparation, without the required purity, the right attitude and the right motive, one simply deludes or sidetracks oneself from all that which is essential in occult study to those phenomena and teachings that are unessential, delusive, and misleading; to phenomena that simply strengthen one's hold in a world of illusion, glamour, pride and ego; aside from this, should one attempt occult work without due preparation one exposes oneself to certain dangers which are far-reaching. Without adequate preparation the student would abuse and misuse occult, spiritual teachings and powers.

The karmic consequences of this abuse may stall or cause stagnation in one's
spiritual evolution for countless incarnations. Basically, religion without the theological dogmas, is an appropriate basis for the study of metaphysics. Students of metaphysics are advised to deepen their religious activities by engaging in personal study of their scriptures or holy book without relying on the usual channels or interpreters for clarification. This is to preserve one's bicameral mind from
external influence and dependency on "authority figures" that may be damaging to the psyche in the long run.

Purity, sincerity, humility, and a selfless motive which seeks to serve one's fellow men are qualities to possess or develop when requesting from, or studying the teachings of a spiritual/ metaphysical teacher, or even when embarking on our own by studying books on the occult. These qualities or virtues are our safeguard. They protect us from negative forces which affect our mental and emotional stability.

One of the keys to preparation is to eliminate the false ego from our thinking and centeredness. Think from the Christ level. Think the thoughts of Jesus, Muhammad-the Prophet, Krishna, Lao Tze, or Buddha. What do you think these avatars and prophets of God think constantly of? They think of God, Truth, Beauty, and Goodness. Therefore we advise each student to do likewise. Thinking abstract thoughts, divine thoughts, spiritual thoughts, and holy thoughts raises the vibrations of the physical, etheric, astral and mental bodies. This facilitates metaphysical and spiritual development so needed by the human race. It improves the quality of humanity.

One of the problems which poses as an obstacle to occult and metaphysical study is that of the crystallized mind. As a preparation, the first step that has to be undertaken by the student of metaphysics and the occult is to temporary put away all previous concepts and beliefs regarding them. There are many false beliefs and superstition concerning the occult perpetuated by ignorant individuals, by psychics of a low caliber, by secular education, and even by religion, that we have to cast all of those beliefs aside and prepare our minds to really think and use our reason and intuition.

Even if we had learnt metaphysics or branches of it previously from genuine teachers, it is still required of us to shelve them aside when we begin our apprenticeship under a new tutor.  Our minds should be open and receptive to the teachings of the higher worlds, but if our minds are closed and crystallized, we fail to register the truths concealed in occult and metaphysical teachings regarding the laws of the cosmos, the higher worlds, the principles of mind and one's psychic nature.

If the teachings of any metaphysical system or teacher (including this writer) contradict your personal notions and feelings and you have trouble accepting them, simply shelve them aside for the time being and consider them again at a later date when you have acquired more experiences and knowledge. Realize, however, that most of the time opinions and beliefs do not reflect Truth. We teach what we personally know or what others personally know. We do not proselytize or impose our words upon others against their will. We are happy to give to others the teachings of the Spiritual Masters should they be receptive and just as happy not to give should they be non-receptive. We can lead a horse to a drinking trough but we are unable to make it drink.

Granted, that information concerning the occult the tyro or neophyte often has to regard as hypothesis, or working theories, but in time the student is given methods for investigating and proving to himself the verities of metaphysical truths and the realities of the higher worlds. We seek knowledge, wisdom, and experience--not mere beliefs. For the student of Nature's mysteries, beliefs will not do. Beliefs are blatant expressions of one's ignorance, for if one knows, why is there a need for beliefs? If one should say that one believes in the existence of something, one
implies in that statement that one does not really know if that something exists.

Belief and knowledge are poles apart. In spiritual and occult training one invokes intense energies, powers and forces emanating from the spiritual worlds. These energies flow into the whole microcosm even down to the physical level. Should the physical body and its force-field vibrate at a very low level because of the presence of
impurities, toxins, and negative forces, the nervous and energy systems of the physical and etheric bodies would explode and rupture during the influx of those higher energies. This is one reason why one embarks upon the Path of Purification prior to engaging in advance occult work.

The Master's Advice
In days gone by, when a student approached a spiritual or occult master for instructions, the master would say "empty your cup." The master illustrates the purpose of this by pouring fresh tea into a cup already filled to the brim with the liquid. The tea would naturally overflow. "Likewise," the master would say, "will the teachings I fill your mind be rejected by all of your previous thoughts and false
beliefs. Therefore, empty your cup." Which means, in other words, "empty your mind of previous ideas and conceptions." Most people are disinclined to accepting new ideas. They dislike change, and yet we must change towards a positive direction if we are to progress. There is a senseless fear and laziness in most people in operating their brain faculties such as using their mind to reason. Our
minds must be open and flexible, yet putting all new ideas to the test where possible before accepting them. We must strive to see the logic and rationality in concepts, if any, that are new to us. In other words, we must think! It would not hurt to be critical in a positive and constructive sense of novel ideas or even religious ideas if we believe that our criticism is valid. Although the mind is limited, it
has its purpose and we should not shirk from using it.

It is an important requirement for the occult student not to form any false ideas concerning himself and lower his self-esteem. He should not limit his mind and divine expression by saying "I can't do this," "I can't do that." One never knows what one can do until one tries. This applies to all branches of learning and study. Often we hear people say "nobody's perfect," and they use this as an excuse not to improve their morality, their character, their minds or even their social standing. If one approaches the study of metaphysics and the occult in this manner, one is bound to fail. Metaphysics is hard work, and those who are not interested in work should leave metaphysics alone. Metaphysical truths awaken a person from self-complacency and the slumber of mortal errors. The student of metaphysics
should be prepared for this and not rebel when it occurs. When you come to the point where you can think of nothing but metaphysics in your everyday activities, you shall succeed in being a metaphysician. Metaphysics has to be incorporated into one's life 24 hours a day.

Studying the occult and metaphysics requires great perseverance, endurance, patience, and fortitude. It even requires a certain degree of intelligence. Note that we do not say education or intellect, for the educated mind and intellect at times can be more of a hindrance than an asset. Unless our mind is receptive and open to modify previous findings or concepts expounded by science or religion which
from the point of view of metaphysics are erroneous, one would simply fail in metaphysical study and the probing of Nature's higher laws. The intellect, as the result of education is simply the building blocks that we accumulate, whereas intelligence is the conscious directive power that builds an edifice out of those blocks. Being educated implies gathering data and information that may or may
not be true or even relevant to one's life. We should seek the sort of knowledge that is applicable to our everyday lives with its countless challenges and problems.

Overcoming human problems is mastership. Intelligence is a necessary attribute to comprehending metaphysical principles. You need not be concerned of any lack of intelligence, however, for metaphysical practices itself raises one's I.Q., E.Q., and S.Q. Some occultists, metaphysicians, and mystics have declared that it is much easier acquiring an academic degree than getting fruitful results from occult study. This is indeed true, for occult study requires unfolding the inner senses to register higher vibrations and the various phenomena of the higher dimensions, and this takes much time and energy for practice and training. The purpose of metaphysical study is to make each and every one torchbearers of Truth. Work for Truth, live in
Truth, promote Truth and it is guaranteed that you will evolve into God's Light.

However, seek no reward. Metaphysical development requires time, patience, perseverance and great concentration--the type of concentration not normally possessed by the average person. This training of psychic and metaphysical faculties may take a whole life time for its perfect functioning and control. We should
not be daunted by this, however. The Master Jesus said, "In patience possess ye your soul," and this each student of metaphysics must be conscientious of. The student must have patience and possess his or her soul and not allow the Dark forces to possess it. In metaphysics we learn to direct our lower self, if we do not do this, negative beings will. It is expedient that the student remove religious and any form of prejudice from his mind and heart.

At times teachers of metaphysics may refer to the text of one religion in preference to another to illustrate or substantiate certain metaphysical concepts. This they do, not because of their personal background and not because of any animosity toward the other religions, but because of convenience sake. We know that the essence of all religions is Truth itself. Metaphysicians, therefore, teach and refer to the Truth in all religions whenever possible.

This brings up another subject to mind:
fanaticism. Fanaticism is not to be tolerated, not in metaphysics, not in religion, not in any human endeavor whatsoever. Fanaticism simply indicates a blind belief in principles and opinions, most of which may be dubious as to their validity. Fanaticism is separatism, narrow-minded and destructive, and should be avoided. It breaks up unity by creating divisions and schisms. It is the very antithesis
of the spiritual precept: "unity in diversity." The motto of the Dark forces will always be "divide and conquer."

Man is a microcosm of the macrocosm. In religious terms, man is a reflection of God, for he/she was made in God's image. Since God is perfect, man likewise, in a spiritual sense, is perfect. Man carries the seeds of perfection within him. He only needs to unfold this divine seed of perfection lying dormant within him. When this is done all things become possible to man. In order to nurture these divine seeds, one must overcome inertia and work with the evolutionary forces of Nature.

The Motive of Study
One of the first few things that a student of metaphysic has to do is to introspect and analyze as to the motive for approaching metaphysical study. Why does one want to study metaphysics, its branches, and its various arts such as magick, mysticism, esotericism, psychometry, dowsing, or telepathy? For what reason? For what motive? Is it simply to gain advantage over another, for power over others? Or
is it simply to acquire name and fame or the riches that it will produce? Approaching metaphysics with such motives would retard one's spiritual growth and is not condoned by any spiritual teacher of worth. A true and noble motive would be to serve God and humanity in spiritualizing this physical world, in manifesting Heaven on Earth, where Truth, Justice, Righteousness, Love, Peace and Goodwill between men prevails. Should your motive be negative, you are advised to transform it
now. Do not deceive yourself as to your motive. Another thing that we must not do, is to steal the secrets of heaven or gain entry into it by force, meaning that we should not force our occult growth by engaging in dubious exercises obtained through sources with no real integrity or authority to transmitting them and hoping for an instant development with their application. Should occult abilities be "instantly" procured, it would not be permanent and would result in adverse effects in most cases. We all know the low quality of plants cultivated in greenhouses as compared to the cultivation done underneath Nature's roof. It is the same with metaphysical growth. Heaven is not willing to release her secrets to the profane, and if by
chance any of us acquire her secrets and apply them without the proper motive and purity, we unknowingly curse ourselves. The scriptures say that God is not mocked. This is a symbolic way of saying that the Law of Karma is operative and no one is able to avoid its influence.

The student should be aware that there are false Gurus in the metaphysical field. Every student should be wary and cautious in accepting what they have to teach, for though what they teach be sweet to the mouth, their effects may be bitter to the stomach. These Gurus have no sense of responsibility, and they control and manipulate the minds of their followers for their own nefarious reasons. They create
a morbid dependency on the part of the student. Without the adequate and correct preparation through the Path of Purification, although one may unfold in a psychic manner, if accepted and trained by a "Guru," one would limit one's psychic
development and stagnate in one's spiritual evolution. The higher occult and mystical abilities requires that one be spiritually developed, and this cannot be attained without the necessary purification of the microcosm.

Spiritual Masters of the occult and metaphysics are wary and watchful of students with impure motives. It is not unusual for Spiritual Masters to reject applicants for study or to put them through certain tests, or to give them some advise and told to return at a later date, perhaps a week, or a year later. Just because a student is anxious to study the occult does not imply that he is ready for it or that he should be accepted by a Spiritual Master or Adept. Acceptance by a Spiritual Master and the
initiations that he has to offer requires sincerity of motive and more besides. The false Guru may perhaps accept such a student for personal reasons--for fame, name, glory or wealth. The true Guru, however, never consider these things as criteria for accepting students, although he may work in  strange ways that sometimes seem amoral or irrational in order to test candidates. An occult axiom
states that, "When the student is ready, the master appears." The advise here is to make oneself ready through proper preparation and not sit and wait and twiddle one's thumbs. The master in this axiom may refer to a spiritual being, one's personal spiritual guide or guardian, or even to a metaphysical school.

It should be known that the metaphysical path is a strenuous one requiring every minute of the day. One does not engage in metaphysics at certain spare moments available. One must make time for the study and practice of metaphysics. Reduce unnecessary socializing and reduce watching TV and movies to a bare minimum; preferable not at all wasting time on them. This may result in some conflict between your friends and relatives as you settle-in to your new metaphysical routine, but
consider this: what is more important, their egoistic and personal gratification and demands or your study of Truth with its eternal worth and its spiritual application in the affairs of men? It is up to you to decide; however, if results are not forthcoming from your practice because of your lack of application, you have no one to blame but yourself. One piece of advice: you may drop-out from metaphysical study but never drop-out from life, for it may be that your real metaphysical teacher and lesson is life itself. Accept whatever life brings and learn from it; otherwise, seek to change it using your God-given creative powers.

The Contemplation of Life and Death
Perhaps one of the things that a novice of metaphysics is told to do at the very outset by a true metaphysical or spiritual teacher is to contemplate the meaning of death and the opportunity that life offers. This dual theme is a healthy, sane, and balanced contemplation that when analyzed individually tends to produce an unhealthy pessimistic or overly hopeful attitude. How does one begin this contemplation? By reflecting on the following: first of all realize that we are all heading toward physical death, This might seem discouraging nevertheless is a true statement that cannot be contradicted. With every second, with every breath that we take we approach closer to our grave. Nature guarantees us nothing in life but our coming demise. This is her promise. We do not know when we will leave the physical body permanently. It may be the next hour, today or tomorrow, but leave it we shall. From these musings questions would arise: "What then is the meaning of life?" What is the purpose of life?" Shall we say as the materialists would say, "let us eat, drink, and be merry, for tomorrow we die"? What sort of a philosophy is that when our query remains unanswered? It would be preferable to say "let us study the purpose and meaning of life for we know not when we will pass away and God's purpose for us here may not be carried-out if we spend our time on frivolous matters." Contemplating further, we will realize one major thing, and that life here is an opportunity. Opportunity for what? An opportunity to grow, to become, and to be.

Heraclitus, the philosopher of ancient Greece said that everything is becoming. This is the Law of Change. From our metaphysical point of view, we understand that he was referring to the Law of Evolution. If we think about it we will realize that we are unable to take anything material with us to the higher worlds when we pass on. We are unable to take along with us our house, our money, our possessions, our titles, etc. What we do take along are things that are immaterial--our knowledge, our memories, our karma, our habits, our character, our spiritual and psychic development, our aspirations and desires. We can see from this that our purpose in this world, in this physical plane is in connection with those immaterial things mentioned above, and if--and metaphysics declare it to be so--evolution
is a law of Nature, a Cosmic law, then our true purpose is to evolve, to improve and to purify those immaterial things. Our greatest opportunity in this world is the correct use of time. Use this gift of God searching for Truth and not wasting it on non-essentials.

Perhaps after being a little pessimistic about reflecting death just awhile ago we may now be cheerful and be optimistic about life and to carry-out the main purpose of physical existence instead of wasting our precious time, energy and resources on immoderate and excessive entertainment: too much watching TV, too much sex, the taking of drugs, and indulgence in other material devices invented and designed by the Dark forces to sidetrack and make us forget our divine heritage, purpose of being and our mission here on Earth. This is the nature of evil: it diverts us from
experiencing our true soul-purpose and need. Anything that distracts us from improving our soul nature, our character, our morals, or acquiring metaphysical knowledge of Cosmic laws and truths, is to be considered as an evil mechanism and an intruder to our microcosmic system. These evil intruders sometimes work in such a subtle manner at times that even disciples of metaphysics are sometimes caught off-guard.

The Pure Life
A metaphysical life entails living a life of purity. Even before approaching a Master for
apprenticeship, a pure, spiritual, constructive life should be lived as best as one is able to. The degree of purity within us can be seen and felt by the Spiritual Masters and Adepts of metaphysics and the occult. They know our spiritual state and status by the colors and the luminosity of our aura, by our facial expression, by the quality of the emanations of our eyes, and by the way we think, speak and act.
By the above we do not imply that one has to be a saint in order to be a worthy student of the occult or metaphysics. What we are saying is that purity is a necessary quality to possess and to develop when one becomes a serious student of the occult. It is an indispensable quality for it prepares our psycho-biological system, our nervous systems to withstand intense energies that we invoke from the
higher worlds through our occult and metaphysical studies. We often hear of people going insane because of their involvement with the occult or metaphysics. This is because of their lack of purity. Their nervous systems were not able to sustain the spiritual vibrations coursing through them. When this occurs, as mentioned before, the nervous system ruptures, certain brain cells and nerve centers are destroyed, and the etheric webs protecting the student from overexposure to impressions of higher frequencies coming from the other dimensions, are shattered. One is then unable to shift focus from one reality to another but is opened to both. This causes too much strain. Insanity is the sad result. Spiritual energy invoked through mystical practices also evokes the undesirable elements lying within us. If these elements are not cleared by a process of purification, they would cause us trouble. This is not to say that metaphysics or the occult is an unsafe study. There is danger in  everything. One simply needs the right information and common sense, and take precautionary measures when delving into any study, especially metaphysics and the occult.

Purification is a multi-level process. It should occur on all levels of the microcosm. For instance, our physical body, our blood-stream, our energy-structures, our emotions, our minds, our aura, and chakras, all need to undergo purification. The Path of Purification is a basic step in any system of occult, metaphysical, and spiritual study. To neglect this essential step is to open-up ourselves to spiritual dangers. Any Guru neglecting the Path of Purification in his or her metaphysical system is a false teacher working against the evolutionary tide and spiritual current. It is not beyond the means of any average person to become pure and holy. The difficulty is that people do not see purity or holiness for what it is. They have many erroneous concepts regarding it. For instance, some of us believe that to be holy one has to seclude oneself from society, be celibate, or wear white robes or
even tattered clothing. They believe that to be holy one must dress oneself in some special way or wear a certain hairstyle or do strange things, or act a little mad. These are all fallacies. We should all  strive for holiness by being what we truly are, and not be what we think ourselves to be. In the name of Light, Life and Love, we appeal to all students to be pure and holy.

A Balanced Approach Towards Metaphysics
In metaphysics or in the occult, the student is requested to take a balanced approach. There are three factors that students have to consider:
1) Knowledge of metaphysical laws, principles, and cosmic truths.
2) Unfoldment of spiritual and psychic senses, faculties, and abilities.
3) Acceleration of one's spiritual development, of one's soul evolution.
The pursuit of these three together in a harmonious way is necessary in
developing a well-rounded attainment. When one is over-emphasized and the
others compromised as to their importance, then trouble results for the
metaphysical student. For instance, too much knowledge without spiritual
abilities and a spiritual development results in a poor instrument, one ineffective
in the service of men, and one filled with pride and vanity. Psychic abilities
without knowledge and a degree of spiritual advancement causes similar
symptoms as the above--pride and vanity, together with a poor understanding of
what one registers through the psychic centers. Though one be "spiritual,"
without metaphysical knowledge and understanding one is often deluded and
misled by psychic forces. One falls into the trap of glamour and illusion.
To be spiritually developed without adequate knowledge and psychic ability results in one's ineffectiveness in serving humanity. We can see from this that the problem facing the metaphysical
student is the correct pursuit and development of those three factors simultaneously. The unfoldment of these three factors causes that Divine Spark (Spirit), the Soul-Flame within us to grow in strength and magnitude. This Spark is threefold. There is a will-power aspect (blue), a love-wisdom aspect (pink) and an intelligence-understanding aspect (yellow). This divine flame, metaphysically, has its location within our physical heart and is about 2 cm in size. It is representative of the Higher Soul within the microcosm which is likewise threefold in nature. Esoteric students of Theosophy, for instance, call these components of the threefold Soul, atma, buddhi, and manas.

Too often metaphysical, occult, or so-called spiritual Gurus teach on the basis of a single approach. This does much harm to the student and to society in the long run, or in the very least, it does no lasting good. Advanced teachers, or true Spiritual Masters would synthesize the above three factors. Their approach as a synthesis of those triune factors, would be practical, instructive, and informative. Let us look again at those three factors. What do we mean by occult and metaphysical knowledge?

By such knowledge we mean of the following :
Knowledge concerning, the origin of Spirit-Man; the origin of human beings; the origin of the solar system; civilizations of unrecorded history; the real history of man; man's purpose of being; the progression and the transmission of the ageless teachings throughout the centuries; the origin of religion; the Mystery Schools; the occult anatomy of man; man's latent powers and faculties; the secret teachings and oral tradition of the prophets; the nature and laws governing the higher worlds and man; the application of Cosmic laws; the hidden laws of this three-dimensional world; the principles of counseling and healing; the nature of man, etc.
Now what do we mean by the unfoldment of psychic and spiritual abilities? What are they? Here are just a few: the ability to register spiritual impulses emanating from the Soul, the Spirit, the Spiritual Hierarchy, one's spiritual group, and Master; telepathy; the ability to direct the elements and forces of Nature; spiritual vision; etheric vision; the ability to function consciously in the higher worlds; the
ability to attune with the Divine Cosmic Mind; the ability to know the past, present and future; the ability to heal body, mind and soul; the power to create; etc.
And lastly, what do we mean by spiritual development? We means expanding one's consciousness; opening up the intuitive channels; the transcendence of the false ego; the expression of one's divinity; oneness with Nature, God and one's fellow men; the purification of one's thoughts, words, and actions; the realization and awareness of one's true identity, and the unfoldment of all spiritual virtues
and attitudes such as sacrifice, renunciation, detachment, steadfastness, endurance, strength, self-control, patience, magnanimity, purity, heroism, truthfulness, generosity, compassion, understanding, love, affection, serenity, faithfulness, altruism, tolerance, reason, devotion, adaptability, sincerity,
joy, discernment between the real and the unreal, service, balance, beauty, harmony, creativity, confidence, perception, reverence, sympathy, punctuality, love, tenderness, gratitude, gentleness, harmlessness, inclusiveness, desirelessness, forgiveness, trust, self-discipline, etc. 

So far we have used the words occult, metaphysics, and spirituality interchangeably. At this time this suits our purpose, but we have to realize that these terms are not synonymous and each have a specific definition of their own. To these terms we may include mysticism, magick, parapsychology, parapsychic science, and esotericism as each having a definite meaning and yet still connected with
metaphysics in general. In the course of one's metaphysical study one would gradually come to realize the fundamental difference. Humility and Fearlessness
So far, we have already dealt at some length with the qualities that the candidate of metaphysical studies has to possess, such as purity and an open mind. Other important qualities are those of humility and fearlessness.

Humility is the quality of acknowledging the greatness of God as expressing throughout Nature. It is the realization that no matter what one attains or what one becomes there is always room for further growth. Thus, one never view oneself as representing a final attainment such as being the smartest kid in school, for one knows that there are still others much more smarter than oneself. There is
always room for improvement. We should not just look down before us, look upwards as well and see that there are others far above us. Reaching one peak allows us to see a higher summit. There is pride in thinking of being wise or in being stupid. There is also pride in thinking of being rich or in being poor. The writer has often heard people lamenting on how poor they are, and they enjoy saying this and proving it. They would take quite a lot of trouble to prove that they are poor and
that none are in as much a need as themselves. This is pride expressing itself, for they fail to see that they possess many of God's precious gifts to them, such as their senses to register impressions, their minds to think, their will to act, and their hands and feet to carry-out their desire; in short, all that is required to manifesting prosperity. Such people are ungrateful beings. In this they show their lack of
humility.

When approaching an Occult Master in an egoistic manner, he would most certainly reprimand us verbally . . . or in silence. Such applicants for the teachings are quickly shown the exit. Demanding to be taught indicates one's unreadiness for occultism and metaphysics. Instead of requesting from the Guru the higher teachings, one should come to realize that one still requires the lower teachings and
disciplines from the many challenges that life has to offer and instruct us. All of these challenges are simply for the purpose of taming the human ego. The ego when unbridled, is an unfit vessel for metaphysical and spiritual teachings. Where the ego strives, there humility dies. Fear is one of the obstacles to metaphysical understanding and awareness. Approaching and advancing on the occult path entails facing many enemies and frightening phenomena, the worst of
these is our own lower self with its many subconscious projections which in occult circles is called the Dweller on the Threshold. If we wish to pursue occult studies, fearlessness is a paramount virtue to possess, for in truth nothing can hurt us unless we give it the power to do so. One of the maxims of the Great White Brotherhood is to know, to dare, to do, and to be silent. Make this maxim a part of
yourself.

In the maxim above the student is advised to be silent. It is disrespectful to the teacher and to the Cosmic to reveal secret and esoteric matters to those unprepared for it. Be ever watchful of your mouth, for as the Master Jesus said: "Do not cast pearls before swines." Silence is a protective quality. It protects the person who keeps silent on sacred matters as well as others who may be inclined to misuse the information. Assume silence when you should be silent and only speak when others are not courageous enough to defend Truth. Silence is golden at the right place and at the right time, and on sacred matters. Students will progress more rapidly should silence be a part of their being. Do not draw attention to yourself. Do not speak of your occult experiences to those unsympathetic to metaphysics, for this would simply provide them with offensive weapons.
In metaphysics too often than not, one may encounter contradictions. These contradictions may just be apparent and not real. Truth is like a cut diamond with its many facets. Keep in mind that what is relatively true is synonymous to being relatively false. However, in cases of contradictions, adopt that which seems more logical to you.

This is an important article and the student is advised to consider it wisely. It is hoped that the student be sincere and apply these teachings that he or she may acquire the virtues that we have referred to. In the days of Atlantis, men misused and abused occult and metaphysical teachings. This was one of the direct reasons why the continent submerged and leaving very few traces as to its geographical
location, its place in the memory of men, or in our history books. Many civilizations ended drastically because of the misuse and exploitation of knowledge for selfish ends. People mistakenly believe that the ends justify the means. This is false. The means determines the end. Let us not repeat our ancient mistakes, as it interrupts the evolutionary process and cause the holy ones to weep.

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What is metaphysics, and why should we bother studying it? What benefits does it have for humanity? What is its purpose? How will its teachings help advance society? How will it assist our civilization and culture to progress? How will our lives be re-created individually and collectively with the application of metaphysical principles?

Questions abound concerning metaphysics, for people intuitively feel that it may have something precious to offer in terms of facilitating personal growth and self-empowerment. Among those spiritually inclined, it has become a "prime directive" to understanding their lives in terms of metaphysical principles and concepts such as multi-dimensional realities, the Higher Self, love, karma, reincarnation, etheric
energies, psychicism, oneness with all, cosmic beings, the ascension, etc., and some of the causes of this higher thinking and awareness is the thinning of the cosmic veil between dimensions; the increased contact with invisible forces; the influence of intense electromagnetic cosmic energies bombarding upon our planet and solar system at this time; the influx of higher spiritual beings incarnating in the physical realm; the discoveries of many ancient secrets left hidden in monumental structures and time capsules; scientific developments in hyper-space technologies,
and shifts in its paradigms, etc. All of these are occurring on a global  scale, in every nation of this planet, and it is affecting every human being. So it would seem that  humanity is awakening from its long sleep of forgetfulness and ignorance.

The Tree of Life of immortality, enlightenment, and illumination will be found hidden in the seeds of the Tree of metaphysical knowledge--using the word "metaphysics" in its most spiritual, Gnostic sense.

For thousands of years we have sought for truth, and most of the time from  the wrong persons and in the wrong places--what we received were man-made opinions and beliefs which were forced upon our minds to be accepted as the "word of God," or the way that Nature had decreed, and that there is nothing that anyone can do to change it. While in our infancy, physically and spiritually speaking, we accepted everything told to us by organized religion, elders, and
pedagogues as gospel and truth and we based our philosophy of life on the indoctrination imposed upon us and which subsequently formed our false sense of "conscience," and a poor understanding of spiritual values. This caused us great soulful sufferings and torment in succeeding years in our everyday life--an intense sense of shame, guilt, fear, and sin whenever we "violated" any so-called law of God formulated by theology; and it never occurred to us to
question the systems, the mechanisms, and their origins that brought about our morbid condition. This naturally lowered our self-esteem. Conscience is not similar to the concept of the "still, small voice." The latter is the silent voice of the Spirit, whereas conscience in part, is simply the engrams or programs imprinted upon the subconscious mind. Conscience is also partially our memory of the negative consequences of our past actions impinging upon our conscious mind
whenever we are about to act in a negative way resembling that of the past.

But to return from our digression: in past centuries we were told lies by false prophets and the ministers of religions that mediators between God and men were necessary; that theirs was the only way to God; that their race or sect were the chosen one of God; that everything that God would reveal to humanity lies in a single book; that God punishes us for sinning and perhaps in the afterlife casts us into hell; that illness, old-age, and death were a natural part of life; that one no longer receives any new revelation from God, etc. We were told to fear God, to see
everything as separated from us, to believe that we were born in sin, that  the sexual act is shameful, that we were simply mortals subjected to the whims of God for the determination of our fate, that we were inherently bad--and even more--that the world was flat! While at the same time heinous crimes against the Holy Human Spirit were being committed by those very same representatives of religions such as the crimes of persecution, torture, and murder of innocent human beings who simply were more spiritually and psychically inclined or conceived the universe from a different viewpoint--and all these atrocious acts were carried-out in the name of
Religion, Love and God. The Crusades and the Inquisition are dark chapters in the history of man.

One of the points that we wish to put forth here is that since time began  the dark, retrogressive forces have infiltrated or have tried infiltrating every institution that have sought to improve the condition of the soul, and the expression of the human spirit in our mundane lives. They have always opposed and attacked the true representatives of God and steered seekers of truth away from them. Their purpose is to stall human evolution and progression indefinitely, that human beings cringe and cower under their manipulative control, that humans be made into slaves and
automatons answering to their every whim. They work openly and subtly, physically and psychically. They make us believe that we need them--their services and wares--and we are psychologically controlled to be dependent upon them and return to them again and again for their assistance--usually for a large fee or with some loss on our part.

We will not be too specific here, we simply caution our readers to "be wary, be very, very wary!"

Treading the spiritual metaphysical path will assist one to be more discerning as to the understanding of what is True and what is false, what is Real and what is illusory. Generally speaking, a portion of humanity is now more experienced in the ways of men and the world than in bygone days, and they seek for that which will release them from all their mortal limitations and errors, from that Gorgon we  call "the human ego," from concepts that bind one to personal illusions and glamour, and from that state of human mortality.

Many of us are beginning to realize the existence of different dimensions and multifold realities. We seek ways for improving the human condition, for perfecting human expression, and the generation of a new type of Homo sapiens whose intelligence and heart matches those of the immortal gods. Human beings are basically seekers. Some of us thirst for that which we know not what. The
"curiosity instinct" impels every one of us to learn everything we can of  our environment, of ourselves, of the universe, of Nature, and of God. What fascinates and intrigues us most are the phenomena caused by forces and powers that transcends the perceptual capacity of the physical senses and the apprehension of the human mind. Humanity is intensely interested in the Intelligence that shapes human destiny--whether this "Intelligence" be considered as a being, a force, a Universal Mind, an omnipresent energy, or a collective consciousness. People are
seeking explanations to their "inexplicable" experiences in the field of  psychicism and the paranormal. Such occurrences as coincidences or "synchronicity" also baffles the mind as it begs for enlightenment. Those of elderly years wonder what lies for them in the "after-life," as the youthful ones wonder of their place in this world. A questioning being is a thinking being and it denotes, whether consciously realized or not, as a desire to seek, to know, and to be aware of Truth. The curiosity instinct mentioned above could well be the primitive stirrings of the divine will of the highest aspect of Man seeking to be aware of Its essential nature. The teachings of the Ageless Wisdom as taught in metaphysical, esoteric, occult and arcane schools are filled with principles that would help us understand ourselves and our  omniverse.

Humanity as a whole, is jaded and sickened by the constant wars and conflicts; with the materialistic and hedonistic life that do not offer any permanent peace and happiness or solutions to the various problems facing us as we approach a new millenium with its tremendous supernal and mundane challenges. Many seek for a more profound meaning in life, for they see through their mundane activities as a brittle illusory facade presenting itself as reality. We often ask "why am I here?" "why do I exist?" "where will I go from here?" Our present systems of religion, philosophy, and science offer no real solution, consolation, solace or comfort to our hearts and
soul-search, instead they tend to mislead, confine, and circumscribe the soul and mind to a certain area of life; to a limited way of living and thinking; to a sense of separatism; to a dualistic judgmental attitude; to a sense of fear and helplessness; and to a state of external dependency-it especially confines man to a mortal sense of existence--and we say this not from a sense of judgment but from an  observational standpoint. Conversely, metaphysics as a repository of "New-Age" concepts, the Ageless Wisdom, divine energies, power-centers, and angelic and cosmic support, seek to liberate us from self-imposed limitations as it offers answers to questions that troubles the human soul. The soul loves freedom
for freedom is ingrained in the soul. God gave man the liberty to choose,  and this privilege should not be taken away from man by any being for it is a violation of the natural order of things. Freedom may be considered as an instinct for it is to be found in animals as well. No creature enjoys being confined in a cage. Every creature love to be free and to express the genetic joy programmed in its DNA. Nature has granted all creatures their freedom of expression but some
of us would impose our will upon Divine Will by creating cages of man-made laws and regulations that do not reflect the laws of Heaven. Man-made laws may easily be manipulated by the unscrupulous for their own heinous purposes. Crimes may be committed that are "lawful," that goes undisciplined in our courts of judgment. In the laws of our society, the innocents are often made to pay for the crimes of another. Where is the love (religion), and rationality (science), and justice (philosophy) in that?

We are writing intuitively here and our statements may be interpreted and applied in various ways. In fact, statements in our literary works may seem to lack any logical structure or sequence. They may appear to be non sequitur. Logic may appeal to the thinking mind, however it is more than conceptual reasoning that we have to develop. There are higher faculties of the soul that should be cultivated and made used of, such as intuition. The cliché "reading between the lines" may seem irrational to the scientific type and yet it is this particular mode of perception that has to be practiced as a spiritual stimulus to the Soul. There are many scholarly definitions of metaphysics and they are all valid; however, for our purpose, without explaining metaphysics in an overly-academic way, let us say that metaphysics
in its more modern connotation, deals with cosmic laws and principles, with unseen forces and powers influencing ourselves and the circumstances and conditions of our daily lives, and how we may take advantage of those laws and principles by re-directing them so as to improve our holistic lives for the better. Metaphysics teaches us how to harness and apply the cosmic power lying latent within us. In its most profound spiritual aspect metaphysics teaches us the nature of
Reality and how we and Nature relate to it. Metaphysics instructs us how to harmonize ourselves with the Divine Plan of God, and it reveals the true purpose of life.

Metaphysics, therefore, has a dual function: it helps us to improve our lives secularly now in this physical dimension, and it also prepares us for a glorious life in the higher cosmic realms. Actually, as seen from a spiritual perspective, life has no divisions: life is one, as it is continuous. There is no death only a constant change.

The application of certain metaphysical principles assists the acceleration of one's evolution and the quantum leap to a higher level of intelligence and spiritual awareness. We emphasize the word "application," for knowledge of principles or techniques alone is of no value. Knowledge of itself is not power, it is the application of knowledge that empowers one. Spiritually, it is not what we know or the psychic powers that we possess that counts, it is what we are. We know
many people possessing a little knowledge or power feel themselves highly superior to their fellow men. This is arrogance and carries the seeds of peril. The saying that "a little knowledge is a dangerous thing" is literally and evidently true; we can well understand how insufficient knowledge and a disregard for life may result in catastrophes. It was the cause of destruction of previous high-tech civilizations, historically unrecorded, as it is the cause of our present social, political, and ecological unrest.

To understand the above concept of incomplete knowledge, consider for instance the knowledge that we have to construct nuclear weapons--how much do we really know of the impact that it will have upon us and the universe should we choose to detonate one? We may presently believe that the effects of a nuclear blast be localized causing the exploded area to be radioactive for centuries to come. This is an obvious effect, but what about the not-so-obvious rippling, chain- reaction that it would cause in the physical and not-physical universes to the very end of our
galaxy? Basically, arrogance is an inferior attitude masking as superiority.  Inferiority or superiority complexes are both egoic expressions. The human ego often wishes the Self to appear what it is not. Even if we knew a lot, if we have read a thousand books, studied under countless Gurus, have permanent contact with a Cosmic Master, experienced a 1001 delights and terrors, meditate constantly, possess the world, or are powerful in some psychic way, it still does not give us a reason to egoically compare others with ourselves, or to judge them--by seeing others as inferior to us, by labeling them as bad, low, and vile. Many so-called spiritual teachers still do this. They criticize and condemn others without realizing that, spiritually speaking, there is no separation between others and themselves. What we see in others also lies below the conscious threshold within ourselves; what we do to others, we also do to ourselves, what we think of others, we also think of ourselves. What another is doing in the present we may well have done so ourselves in the past or perhaps will do so in the future. There is no need for judgment but a lot of need of mercy, understanding, and tolerance. Essentially, a spiritual being will not indulge in the judgment of dualistic concepts and the relativistic opposites such as good and bad, right and wrong, rich and poor, strong and weak, etc. These things are reconciled or transcended by the mage. St. Paul once said that if we owned the world and all powers and gifts of the spirit but lack
love we were nothing. This is felt by all true spiritual teachers and practitioners.
Metaphysics should not be confused with the paranormal nor with parapsychology. The paranormal and parapsychology are simply aspects of metaphysics--using the term in its broadest sense..In regards to metaphysical experiences we should keep in mind that metaphysics encompasses the two basic divisions of psychicism and mysticism, thaumaturgy and theurgy. Experiences in both fields may be  considered "metaphysical," however, a psychic experience is dissimilar to a
mystical one, and vice versa. One relates to the perception of events occurring in the lower planes or dimensions, the other to spiritual Self-awareness and the expansion of the consciousness encompassing the Whole.

As can be understood from the above, metaphysics has a transcendent value. It caters to both the physical and spiritual aspects of man. Metaphysics begins where traditional psychology leaves off, it goes where dogmatic religion is afraid to go, it extents further than mainstream science is able to reach with its laboratory equipment--although we must admit that many technological advances have been made in this direction, most of which have not yet been made available to
the general public for reasons of censure. The release of such technology would dethrone the powers that seek to enslave the world and the Dark forces are trying very hard to prevent humanity from being empowered.

One of the misconceptions regarding metaphysics is that it is unscientific and based upon superstitious ideas. This is not in our experience. Metaphysics is scientific, rational, empirical and pragmatic, or it could indeed well e "superstitious" depending on one's attitude, beliefs, and manner of approach, or how one would like it to be. This might seem as a paradox and yet it may be reconciled. We liberate our minds or impose limitations upon it by our beliefs and attitudes, and by those limitations we circumscribe our mental and spiritual growth.

Our beliefs and attitudes form our basic interpretation of Reality. If a thing is of value, because of prejudice we will not see it. We will see what we want to see, and refuse to see what we refuse to see. Metaphysics may be approached in various ways. If one has a background in mathematics, one's approach would be mathematical. If one has a psychological background one would naturally approach it from a psychological standpoint. And if one simply believes or disbelieves in
metaphysical principles then the result would be in accordance to that  mental condition. For instance, if we disbelieve that man may go to the moon we would not exert effort to putting him there. If we believe that we are doomed to failure we would never motivate ourselves to work for success. This concept relates to how we form our own personal experiences in life, our own personal reality. Intrinsically, however, personal opinions do not affect the natural laws operating in our universe. We may discount the reality of gravity, for instance, and yet the law still functions in our everyday experience. The same goes with the other natural laws like karma and
reincarnation. Belief or disbelief in them will not affect their existence and operation. Just because these laws are not mentioned by prophets and written about in Holy Scriptures do not nullify their activity. Come to think of it, many scientific natural laws are not mentioned in Holy Writ, does this prove their non-existence?

Though certain aspects of metaphysics may be considered to be speculative, as it deals with the Ultimate Reality, the First Cause, creation, and ontology or the nature of being--what interests us is the application of its principles and direction of Cosmic laws in everyday life. The worth of a science lies in its value, relevancy, and applicability in everyday living. If it is inefficient in aiding humanity to create abundance, peace, health, etc., then it is impractical and worthless. Some people have this kind of misconception concerning metaphysics, they believe that
metaphysics is impractical, too abstract, or that it violates natural law  and hence, religion; however, the opposite is true. Metaphysics and its principles work in  harmony with Cosmic laws and is extremely practical. Applied Metaphysics, as differentiated from Speculative Metaphysics, is wholly practical and essential to daily life. It empowers us with the tools and knowledge necessary to achieve a successful and fulfilled life. Though the art and science of metaphysics is still in its infancy compared to what lies ahead, there is enough teachings, techniques and systems to assist us live a fruitful, productive and creative life in accord with the Divine Will. The more we know and understand, the more wisdom we possess, the more motivated, focused and confident we are--the more chances we have of fulfilling our mission in life.

There is an on-going electromagnetic regeneration occurring in our solar system in our present "time-period." The present interaction and interfacing of energy fields in the part of our galaxy that our solar system is entering are causing the transformation of worlds and all beings connected to them in an evolutionary manner. Electromagnetic energies radiating from power centers in multi-dimensional universes are affecting and transforming everything in its path or
field of influence. These energies induce and impel all beings to rise in  their awareness level. They stimulate Man and Nature to form a new relationship based on trust and healthy cooperation. St Francis of Assisi was a pioneer and a model for us in this regard. This friar considered all beings--trees and animals, included--as his brothers and sisters. The transformations that are currently occurring politically and socially in the world are just a few of the physical effects of the cosmic bombardment of these energy rays. Changes will occur at every level lifting humanity to a new state of being, to a higher level of divine expression. The
transmutational process currently operating is represented by the Water Bearer-the sign of Aquarius, and the Aquarian Age. The water flowing from the vessel represents the energies flowing from the Mental, Buddhic and Atmic realms. These are just some of the higher dimensions operating above the personality level. Collectively, these three dimensions are represented by the pail held by the Water Bearer from whence these energies flow, and the Water Bearer as the Higher Christ Self within each individual.

The New Age or the Aquarian Age can be interpreted as the "second-coming" of Christ, for His sign (Aquarius) shall appear or is appearing in the sky in an astronomical sense; he "appears" in the clouds or energies of the New Age, and every eye shall "see" him—that is, feel his influence. How can we appreciate the value of metaphysics? It takes careful study and analysis with a non-prejudicial mind before a true evaluation can be made of any science or thing. Metaphysics is of
no exception. The problem is that too many people have preconceived the nature of metaphysics without having investigated the matter. Some consider it as the science of Lucifer or other such nonsense. All knowledge is essentially neutral in nature. Nothing is good or bad in itself. We attribute a thing as good or bad, right or wrong from the standpoint of our own moral standards or preference and this is constantly changing in consonance with the level of our spiritual awareness.
Metaphysical teachings help us in various ways. It teaches us the  existence of the many Cosmic laws operating in the universe and how these laws function in the world of beings. If understanding just a simple Cosmic law like karma helps one to correct misconceptions and alleviate our struggles, and relieve certain  psychological pain, can you imagine how the awareness and understanding of a dozen Cosmic laws would help improve the quality and value of one's life? It should be realized that if a person were to cry out in pain to God for an explanation to all of her problems and excruciating experiences, and that if she were confused and at a loss of knowing how to react or respond to certain situations, then it should be known that there are possible errors in that person's philosophy of life, in that person's understanding of the functions and laws of the universe, and the purpose of life, or of the person's personal mission. Since one's philosophy of life is associated with one's cultural and religious beliefs, then those beliefs should be looked into for possible false notions and dogmatic errors that do not reflect the workings of Nature.

True religion brings joy, bliss, understanding and wisdom to the heart, and is scientifically inclined. If it does not do so, and if it simply causes one to believe a thing without offering personal determination of its truth through experience,  knowledge and  understanding then it may be seen as a diversion from the true spiritual path. We state emphatically here that to be religious is not synonymous to being spiritual. A spiritual person may be religious, but a religious person  is not always spiritual. A spiritual person knows whereas a religious person simply possesses faith, which at times may be expressed blindly in the condition called fanaticism.

In metaphysics we develop power, intelligence and wisdom. Wisdom is a blend of knowledge, understanding, and experience directed by the buddhic principle of love--unconditional love. It is thinking with the heart and feeling with the mind. This distinguishes the higher metaphysical development of spirituality from the lower metaphysical unfoldment of psychicism. In a lower metaphysical development we may solely possess psychic ability or power but no wisdom and understanding to use it. We unfold in an unbalanced way. When power exceeds the wisdom to
apply it, the seeds of self-destruction is inherent and might be the  probable outcome. Advanced metaphysicians have all three aspects of divinity in full development or unfolding in a balanced and harmonious way, these three are: the aspects of love/wisdom, power/will, and intelligence/activity. The more Cosmic laws and truths we apprehend with our souls and apply in our every day lives, the more spiritual, divine, and powerful we become. The more we purify ourselves from all the
dross and toxins in our energy-structures, and the more we liberate ourselves from preconceived human mortal limitations, the more we are able to access divine energies and express our divinity, or our divine attributes. We are able to manifest our Christ Self. The term "Christ Self" should be understood as a component within the microcosm, or Man--both visible and invisible, and as the True Self functioning at a certain consciousness level beyond personality functions and expressions. In metaphysics Christ is not conceived as a historical person but rather understood from a mystical and mythical standpoint. Christ is often apprehended as a state of
awareness of man functioning at a spiritual level. This is real power: the  power derived from one's own spiritual knowing, awareness and being. Most of the so-called powers claimed by some psychics are borrowed from disembodied entities and are basically illusory and impermanent. Such temporal and borrowed powers in the end may seek to control and obsess the person using them. This is one reason that one should be aware of the dangers in psychicism before embarking upon its development. It is always safer to first develop true spirituality and
the taming of the false ego. The injunction is to first seek the kingdom  of God that all things shall be added unto us. In metaphysics we come to learn of many teachings of Cosmic laws and principles that aid us to deal with life, to master our lower self and express all that is divine in us. This is true mastery. The word Master does not mean being able to control Nature or others, it is the ability to effectively work in cooperation with Her and with our fellow man in creating harmony, peace,
and abundance in our world, in our shared reality, in our conjoined dream.  Real Masters are those who have mastered the animalistic and humanistic elements of their being and are now expressing their god-hood. Cosmic or Ascended Masters do not generally consider themselves as Masters for they realize that they themselves are in a state of learning.

Such is their humility.

Last week, I briefly mentioned the shaded metallic thread sets from Au Ver a Soie that I’m so happy to …

Best Buy

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Newegg

Asgard’s Wrath 2 free when you buy Meta Quest 3*

Also, get a 6-month trial of BBY’s VR subscription included when you purchase a 512GB headset**

Offer ends 1/27/24; terms apply.

**Eligibility and auto-renewal terms apply for trial subscription. See full terms.

 

I thought I'd just start a new topic since they changed from Oculus to Meta nearly two years ago.

At any rate, meta was kind enough to give us a few weekly deals.

Systematic review produced by the EPPI-Centre in 2015.This systematic review aimed to evaluate the effect of HAART and ARV monotherapy on liver disease progression and liver-related mortality in individuals co-infected with HIV and hepatitis C, including in patients with haemophilia.

This substack is brought to you by McAlvany Precious Metals

Meta has been fined 21.62 billion won ($15.67 million) by South Korea's data privacy watchdog for illegally collecting sensitive personal information from Facebook users, including data about their political views and sexual orientation, and sharing it with advertisers without their consent. The country's Personal Information Protection Commission (PIPC) said Meta gathered information such as

Companies have continued to cut jobs in 2024 after a wave of layoffs last year. Meta, Goldman Sachs, Google, and Tesla are among those shedding staff.

Meta is taking the European Union a little more seriously, as the EU has requested the US-based company to put… Continue reading Meta and the EU butt heads again amid changes to ads

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Minerals and Metals for a Low-Carbon Future: Implications for Developing Countries 30 October 2017 — 5:00PM TO 8:00PM Anonymous (not verified) 13 October 2017 Chatham House, London

This roundtable will explore two sides of minerals and metals for a low-carbon future - the growing demand for metals required for low-carbon technology and the technological and policy innovations that will be required to manage the carbon footprint of the mining sector and its wider energy and industrial linkages. Based around a presentation and scenarios developed by the World Bank, this roundtable discussion will assess which strategic metals will likely rise in demand in order to deliver a low-carbon future, before exploring the possible implications for resource-rich developing countries. In particular, what does a growing demand of minerals for a clean energy future mean for governments and industry, and how might developing countries benefit from this trend? What impact might growth of the mining sector have on a sustainable and climate-smart development? Can renewable energy and other clean tech innovations in the mining industry help reduce the carbon footprint of the sector and related industries, and under what circumstances? And how fit-for-purpose are current donor approaches to the mining sector in an increasingly carbon-constrained world?

Attendance at this event is by invitation only.

Mining and the Circular Economy: Implications for the Minerals and Metals Industries 6 November 2017 — 4:00PM TO 5:30PM Anonymous (not verified) 31 October 2017 Chatham House, London

Visualizing the Data: The Evolution of Trade Tensions in Metals and Minerals Markets 18 January 2018 — 4:30PM TO 6:00PM Anonymous (not verified) 19 December 2017 Chatham House, London

Over the past decade, producer countries such as South Africa, Zambia, Indonesia, the DRC and, most recently, Tanzania have restricted exports of unprocessed precious metals, copper, nickel, cobalt and other minerals in an attempt to support, or create, downstream processing industries and jobs or increase revenues. These moves have invariably created tensions with trading partners. Research suggests that export restrictions are not the best way to achieve such policy objectives and can instead harm the producer country’s economy and undermine the functioning of international metals and minerals.

Drawing on OECD and Chatham House research on resource trade, the speaker will present analysis and data visualizations exploring the drivers of past export restrictions and their political and economic impacts. They will also consider how the drivers of ‘resource nationalist measures’ are changing, whether and where export restrictions might present strategic and economic risks in the current context, and the extent to which producer and consumer governments and international governance mechanisms are prepared to address them.

Attendance at this event is by invitation only.

A New Era for China: Implications for the Global Mining and Metals Industries 18 June 2018 — 9:00AM TO 10:30AM Anonymous (not verified) 8 June 2018 Chatham House, London

Since the turn of the century, China’s demand for resources has dominated global headlines. It’s rapid demand growth through the early 2000s sparked the beginning of the commodities ‘super cycle’, and encouraged a growing Chinese presence in international mining, and in global metals and minerals markets. More recently, its transition toward the ‘new normal’ of slower but higher quality growth has underpinned the sudden slowdown in global commodities demand.

Drawing on China’s domestic ambitions, as set out in the 19th party congress, and on its wider strategic ambitions through the Belt and Road Initiative, the speaker will set out his thoughts on China’s next era of growth, and its likely implications for international mining investment and global metals and minerals markets.

Mining, Minerals and Metals Expert Roundtable: Forest-Smart Mining Report Launch 10 May 2019 — 5:30PM TO 6:30PM Anonymous (not verified) 12 April 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE

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Cation diffusion facilitator (CDF) proteins are a conserved family of divalent transition metal cation transporters. CDF proteins are usually composed of two domains: the transmembrane domain, in which the metal cations are transported through, and a regulatory cytoplasmic C-terminal domain (CTD). Each CDF protein transports either one specific metal or multiple metals from the cytoplasm, and it is not known whether the CTD takes an active regulatory role in metal recognition and discrimination during cation transport. Here, the model CDF protein MamM, an iron transporter from magnetotactic bacteria, was used to probe the role of the CTD in metal recognition and selectivity. Using a combination of biophysical and structural approaches, the binding of different metals to MamM CTD was characterized. Results reveal that different metals bind distinctively to MamM CTD in terms of their binding sites, thermodynamics, and binding-dependent conformations, both in crystal form and in solution, which suggests a varying level of functional discrimination between CDF domains. Furthermore, these results provide the first direct evidence that CDF CTDs play a role in metal selectivity. We demonstrate that MamM's CTD can discriminate against Mn2+, supporting its postulated role in preventing magnetite formation poisoning in magnetotactic bacteria via Mn2+ incorporation.

Viral infection is one environmental factor that may contribute to the initiation of pancreatic β-cell destruction during the development of autoimmune diabetes. Picornaviruses, such as encephalomyocarditis virus (EMCV), induce a pro-inflammatory response in islets leading to local production of cytokines, such as IL-1, by resident islet leukocytes. Furthermore, IL-1 is known to stimulate β-cell expression of iNOS and production of the free radical nitric oxide. The purpose of this study was to determine whether nitric oxide contributes to the β-cell response to viral infection. We show that nitric oxide protects β-cells against virally mediated lysis by limiting EMCV replication. This protection requires low micromolar, or iNOS-derived, levels of nitric oxide. At these concentrations nitric oxide inhibits the Krebs enzyme aconitase and complex IV of the electron transport chain. Like nitric oxide, pharmacological inhibition of mitochondrial oxidative metabolism attenuates EMCV-mediated β-cell lysis by inhibiting viral replication. These findings provide novel evidence that cytokine signaling in β-cells functions to limit viral replication and subsequent β-cell lysis by attenuating mitochondrial oxidative metabolism in a nitric oxide–dependent manner.

In addition to their well-known role in the control of cellular proliferation and cancer, cell cycle regulators are increasingly identified as important metabolic modulators. Several GWAS have identified SNPs near CDKN2A, the locus encoding for p16INK4a (p16), associated with elevated risk for cardiovascular diseases and type-2 diabetes development, two pathologies associated with impaired hepatic lipid metabolism. Although p16 was recently shown to control hepatic glucose homeostasis, it is unknown whether p16 also controls hepatic lipid metabolism. Using a combination of in vivo and in vitro approaches, we found that p16 modulates fasting-induced hepatic fatty acid oxidation (FAO) and lipid droplet accumulation. In primary hepatocytes, p16-deficiency was associated with elevated expression of genes involved in fatty acid catabolism. These transcriptional changes led to increased FAO and were associated with enhanced activation of PPARα through a mechanism requiring the catalytic AMPKα2 subunit and SIRT1, two known activators of PPARα. By contrast, p16 overexpression was associated with triglyceride accumulation and increased lipid droplet numbers in vitro, and decreased ketogenesis and hepatic mitochondrial activity in vivo. Finally, gene expression analysis of liver samples from obese patients revealed a negative correlation between CDKN2A expression and PPARA and its target genes. Our findings demonstrate that p16 represses hepatic lipid catabolism during fasting and may thus participate in the preservation of metabolic flexibility.

Cellular energy demands are met by uptake and metabolism of nutrients like glucose. The principal transcriptional regulator for adapting glycolytic flux and downstream pathways like de novo lipogenesis to glucose availability in many cell types is carbohydrate response element–binding protein (ChREBP). ChREBP is activated by glucose metabolites and post-translational modifications, inducing nuclear accumulation and regulation of target genes. Here we report that ChREBP is modified by proline hydroxylation at several residues. Proline hydroxylation targets both ectopically expressed ChREBP in cells and endogenous ChREBP in mouse liver. Functionally, we found that specific hydroxylated prolines were dispensable for protein stability but required for the adequate activation of ChREBP upon exposure to high glucose. Accordingly, ChREBP target gene expression was rescued by re-expressing WT but not ChREBP that lacks hydroxylated prolines in ChREBP-deleted hepatocytes. Thus, proline hydroxylation of ChREBP is a novel post-translational modification that may allow for therapeutic interference in metabolic diseases.

Cancer cachexia is characterized by reductions in peripheral lean muscle mass. Prior studies have primarily focused on increased protein breakdown as the driver of cancer-associated muscle wasting. Therapeutic interventions targeting catabolic pathways have, however, largely failed to preserve muscle mass in cachexia, suggesting that other mechanisms might be involved. In pursuit of novel pathways, we used untargeted metabolomics to search for metabolite signatures that may be linked with muscle atrophy. We injected 7-week–old C57/BL6 mice with LLC1 tumor cells or vehicle. After 21 days, tumor-bearing mice exhibited reduced body and muscle mass and impaired grip strength compared with controls, which was accompanied by lower synthesis rates of mixed muscle protein and the myofibrillar and sarcoplasmic muscle fractions. Reductions in protein synthesis were accompanied by mitochondrial enlargement and reduced coupling efficiency in tumor-bearing mice. To generate mechanistic insights into impaired protein synthesis, we performed untargeted metabolomic analyses of plasma and muscle and found increased concentrations of two methylarginines, asymmetric dimethylarginine (ADMA) and NG-monomethyl-l-arginine, in tumor-bearing mice compared with control mice. Compared with healthy controls, human cancer patients were also found to have higher levels of ADMA in the skeletal muscle. Treatment of C2C12 myotubes with ADMA impaired protein synthesis and reduced mitochondrial protein quality. These results suggest that increased levels of ADMA and mitochondrial changes may contribute to impaired muscle protein synthesis in cancer cachexia and could point to novel therapeutic targets by which to mitigate cancer cachexia.

Pectins are a major dietary nutrient source for the human gut microbiota. The prominent gut microbe Bacteroides thetaiotaomicron was recently shown to encode the founding member (BT1017) of a new family of pectin methylesterases essential for the metabolism of the complex pectin rhamnogalacturonan-II (RG-II). However, biochemical and structural knowledge of this family is lacking. Here, we showed that BT1017 is critical for the metabolism of an RG-II–derived oligosaccharide ΔBT1017oligoB generated by a BT1017 deletion mutant (ΔBT1017) during growth on carbohydrate extract from apple juice. Structural analyses of ΔBT1017oligoB using a combination of enzymatic, mass spectrometric, and NMR approaches revealed that it is a bimethylated nonaoligosaccharide (GlcA-β1,4-(2-O-Me-Xyl-α1,3)-Fuc-α1,4-(GalA-β1,3)-Rha-α1,3-Api-β1,2-(Araf-α1,3)-(GalA-α1,4)-GalA) containing components of the RG-II backbone and its side chains. We showed that the catalytic module of BT1017 adopts an α/β-hydrolase fold, consisting of a central twisted 10-stranded β-sheet sandwiched by several α-helices. This constitutes a new fold for pectin methylesterases, which are predominantly right-handed β-helical proteins. Bioinformatic analyses revealed that the family is dominated by sequences from prominent genera of the human gut microbiota, including Bacteroides and Prevotella. Our re-sults not only highlight the critical role played by this family of enzymes in pectin metabolism but also provide new insights into the molecular basis of the adaptation of B. thetaiotaomicron to the human gut.

Methionine, through S-adenosylmethionine, activates a multifaceted growth program in which ribosome biogenesis, carbon metabolism, and amino acid and nucleotide biosynthesis are induced. This growth program requires the activity of the Gcn4 transcription factor (called ATF4 in mammals), which facilitates the supply of metabolic precursors that are essential for anabolism. However, how Gcn4 itself is regulated in the presence of methionine is unknown. Here, we discover that Gcn4 protein levels are increased by methionine, despite conditions of high cell growth and translation (in which the roles of Gcn4 are not well-studied). We demonstrate that this mechanism of Gcn4 induction is independent of transcription, as well as the conventional Gcn2/eIF2α-mediated increased translation of Gcn4. Instead, when methionine is abundant, Gcn4 phosphorylation is decreased, which reduces its ubiquitination and therefore degradation. Gcn4 is dephosphorylated by the protein phosphatase 2A (PP2A); our data show that when methionine is abundant, the conserved methyltransferase Ppm1 methylates and alters the activity of the catalytic subunit of PP2A, shifting the balance of Gcn4 toward a dephosphorylated, stable state. The absence of Ppm1 or the loss of the PP2A methylation destabilizes Gcn4 even when methionine is abundant, leading to collapse of the Gcn4-dependent anabolic program. These findings reveal a novel, methionine-dependent signaling and regulatory axis. Here methionine directs the conserved methyltransferase Ppm1 via its target phosphatase PP2A to selectively stabilize Gcn4. Through this, cells conditionally modify a major phosphatase to stabilize a metabolic master regulator and drive anabolism.

Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-regulating the proline cycle and proline biosynthesis, and knockdowns of PYCR1 lead to decreased cell proliferation. Thus, evidence is growing for PYCR1 as a potential cancer therapy target. Inhibitors of cancer targets are useful as chemical probes for studying cancer mechanisms and starting compounds for drug discovery; however, there is a notable lack of validated inhibitors for PYCR1. To fill this gap, we performed a small-scale focused screen of proline analogs using X-ray crystallography. Five inhibitors of human PYCR1 were discovered: l-tetrahydro-2-furoic acid, cyclopentanecarboxylate, l-thiazolidine-4-carboxylate, l-thiazolidine-2-carboxylate, and N-formyl l-proline (NFLP). The most potent inhibitor was NFLP, which had a competitive (with P5C) inhibition constant of 100 μm. The structure of PYCR1 complexed with NFLP shows that inhibitor binding is accompanied by conformational changes in the active site, including the translation of an α-helix by 1 Å. These changes are unique to NFLP and enable additional hydrogen bonds with the enzyme. NFLP was also shown to phenocopy the PYCR1 knockdown in MCF10A H-RASV12 breast cancer cells by inhibiting de novo proline biosynthesis and impairing spheroidal growth. In summary, we generated the first validated chemical probe of PYCR1 and demonstrated proof-of-concept for screening proline analogs to discover inhibitors of the proline cycle.