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Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety

RSC Med. Chem., 2024, 15,3837-3852
DOI: 10.1039/D4MD00426D, Research Article
Abdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. Bednarski
Structure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safety
The content of this RSS Feed (c) The Royal Society of Chemistry




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Lanthanum-doped nickel-based composite metal oxide catalyst for hydrogenation of isophthalonitrile to produce meta-xylenediamine

Catal. Sci. Technol., 2024, Advance Article
DOI: 10.1039/D4CY00802B, Paper
Heng Shao, Jing Guo, Rulong Li, Dekun Ji, Long Huang, Haibin Chu
Lanthanum-doped nickel-based composite metal oxide catalysts exhibited excellent activity in IPN hydrogenation reactions with remarkable stability in fixed-bed reactors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Mid-day updates: Markets deepen losses as metals, auto stocks drag; Sensex down nearly 500 points 

The broader market reflected selling pressure, particularly in metal and automotive sectors, with Hindalco leading the decline at 3.67 per cent




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Google and Meta Accused of Teen Ad Targeting

Google staff have been accused of exploiting a loophole to target ads at children. The workaround reportedly broke company policy but not any existing laws. According to the Financial Times, the workaround was done in partnership with Meta, which wanted a way to advertise Instagram on YouTube and target 13 to 17 year olds. (Source: ft.com ) Normally that would be impossible under Google's rules for targeting, which don't let advertisers specify ages under 18 when selecting who does and doesn't see an ad. Known Unknowns However, the Financial Times claims Google staff not only knew Meta wanted ... (view more)




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Microbial metabolic redundancy is a key mechanism in a sulfur-rich glacial ecosystem

Trivedi, C B; Stamps, B W; Lau, G E; Grasby, S E; Templeton, A S; Spear, J R. mSystems vol. 5, issue 4, e00504-20, 2020 p. 1-16, https://doi.org/10.1128/mSystems.00504-20
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200388.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200388.jpg" title="mSystems vol. 5, issue 4, e00504-20, 2020 p. 1-16, https://doi.org/10.1128/mSystems.00504-20" height="150" border="1" /></a>




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40Ar/39Ar hornblende and biotite cooling ages for metaplutonic rocks of the central Thelon Tectonic Zone, Nunavut

Camacho, A; Berman, R G; Sanborn-Barrie, M. Geological Survey of Canada, Open File 8625, 2020, 77 pages, https://doi.org/10.4095/315135
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of8625.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of8625.jpg" title="Geological Survey of Canada, Open File 8625, 2020, 77 pages, https://doi.org/10.4095/315135" height="150" border="1" /></a>




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Geological and uranium metallogenic comparisons of the Thelon and Athabasca basins

Jefferson, C W; Potter, E G; Rainbird, R H; Davis, W; Card, C; Bosman, S; Ramaekers, P. GAC-MAC 2021; Geological Association of Canada-Mineralogical Association of Canada, Joint Annual Meeting, Abstracts Volume vol. 44, 2021 p. 151
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210215.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210215.jpg" title="GAC-MAC 2021; Geological Association of Canada-Mineralogical Association of Canada, Joint Annual Meeting, Abstracts Volume vol. 44, 2021 p. 151" height="150" border="1" /></a>




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Geophysical contributions to a synthesis of western Churchill geology and metallogeny

Re-release; Tschirhart, V; Pehrsson, S; Wodicka, N; Percival, J A; Jefferson, C W; Peterson, T; Berman, R G. Geological Survey of Canada, Preprint 3, 2022, 47 pages, https://doi.org/10.4095/330639
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_330639.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_330639.jpg" title="Geological Survey of Canada, Preprint 3, 2022, 47 pages, https://doi.org/10.4095/330639" height="150" border="1" /></a>




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150 Myr of episodic metamorphism recorded in the Yukon-Tanana Terrane, Northern Canadian Cordillera: evidence from monazite and xenotime petrochronology

Soucy La Roche, R; Dyer, S C; Zagorevski, A; Cottle, J M; Gaidies, F. Lithos 7708357, 2022, 1-29 pages, https://doi.org/10.2113/2022/7708357
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210423.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210423.jpg" title="Lithos 7708357, 2022, 1-29 pages, https://doi.org/10.2113/2022/7708357" height="150" border="1" /></a>




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The Paleoproterozoic Amer supergroup, Amer Fold Belt, Nunavut: stratigraphy, structure, correlations and uranium metallogeny

Jefferson, C W; Rainbird, R H; Young, G M; White, J C; Tschirhart, V L; Creaser, R A. Canadian Journal of Earth Sciences vol. 60, 2023 p. 1005-1039, https://doi.org/10.1139/cjes-2022-0077
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220600.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220600.jpg" title="Canadian Journal of Earth Sciences vol. 60, 2023 p. 1005-1039, https://doi.org/10.1139/cjes-2022-0077" height="150" border="1" /></a>




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Geophysical contributions to a synthesis of western Churchill geology and metallogeny, Northwest Territories, Nunavut, and Saskatchewan

Tschirhart, V; Pehrsson, S; Wodicka, N; Percival, J; Jefferson, C; Peterson, T; Berman, R. Canada's northern Shield: new perspectives from the Geoscience for Energy and Minerals Program; Geological Survey of Canada, Bulletin 612, 2024 p. 295-325, https://doi.org/10.4095/332502
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_332502.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_332502.jpg" title="Canada's northern Shield: new perspectives from the Geoscience for Energy and Minerals Program; Geological Survey of Canada, Bulletin 612, 2024 p. 295-325, https://doi.org/10.4095/332502" height="150" border="1" /></a>




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Geology and metallogeny of the northeast Thelon Basin region, Nunavut, and comparison with the Athabasca Basin, Saskatchewan

Jefferson, C W; Pehrsson, S; Tschirhart, V; Peterson, T; Chorlton, L; Bethune, K; White, J C; Davis, W; McNicoll, V; Paulen, R C; Rayner, N. Canada's northern Shield: new perspectives from the Geoscience for Energy and Minerals Program; Geological Survey of Canada, Bulletin 612, 2024 p. 163-281, https://doi.org/10.4095/332499
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_332499.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_332499.jpg" title="Canada's northern Shield: new perspectives from the Geoscience for Energy and Minerals Program; Geological Survey of Canada, Bulletin 612, 2024 p. 163-281, https://doi.org/10.4095/332499" height="150" border="1" /></a>




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Tuning the Catalytic Behavior of Metal Oxides

The behavior of catalysts that promote chemical reactions is not always straightforward. Using a combination of experiments and computer simulations, scientists now understand how oxygen affects the way the catalyst copper oxide reacts with hydrogen versus carbon monoxide gases and how to control and enhance related chemical reactions.





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God uses metal

Logos Hope crew member Tom Critchley spent three months in Finland. He shares about contemporary Christian music in Finland, focusing on the metal band Terapia.




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Predicting paediatric asthma exacerbations with machine learning: a systematic review with meta-analysis

Background

Asthma exacerbations in children pose a significant burden on healthcare systems and families. While traditional risk assessment tools exist, artificial intelligence (AI) offers the potential for enhanced prediction models.

Objective

This study aims to systematically evaluate and quantify the performance of machine learning (ML) algorithms in predicting the risk of hospitalisation and emergency department (ED) admission for acute asthma exacerbations in children.

Methods

We performed a systematic review with meta-analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The risk of bias and applicability for eligible studies was assessed according to the prediction model study risk of bias assessment tool (PROBAST). The protocol of our systematic review was registered in the International Prospective Register of Systematic Reviews.

Results

Our meta-analysis included seven articles encompassing a total of 17 ML-based prediction models. We found a pooled area under the curve (AUC) of 0.67 (95% CI 0.61–0.73; I2=99%; p<0.0001 for heterogeneity) for models predicting ED admission, indicating moderate accuracy. Notably, models predicting child hospitalisation demonstrated a higher pooled AUC of 0.79 (95% CI 0.76–0.82; I2=95%; p<0.0001 for heterogeneity), suggesting good discriminatory power.

Conclusion

This study provides the most comprehensive assessment of AI-based algorithms in predicting paediatric asthma exacerbations to date. While these models show promise and ML-based hospitalisation prediction models, in particular, demonstrate good accuracy, further external validation is needed before these models can be reliably implemented in real-life clinical practice.




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Association between second-hand smoke exposure and lung cancer risk in never-smokers: a systematic review and meta-analysis

Background

Lung cancer ranks as the leading cause of cancer-related deaths worldwide. There is evidence that second-hand smoke (SHS) exposure is a risk factor for the development of lung cancer in never-smokers. This systematic review and meta-analysis aims to provide the most accurate quantification of the association between SHS exposure and lung cancer risk in never-smokers.

Materials and methods

Through the use of an innovative method to identify original publications, we conducted a systematic review of the literature, with corresponding meta-analysis, of all epidemiological studies evaluating the association between SHS exposure and lung cancer risk among never-smokers, published up to May 2023. Pooled relative risks were obtained using random-effects models. Dose–response relationships were derived using log-linear functions or cubic splines.

Results

Out of 126 identified eligible studies, 97 original articles were included in the meta-analysis. The pooled relative risk for lung cancer for overall exposure to SHS was 1.24 (95% CI 1.16–1.32, number of articles, n=82). Setting-specific relative risks were 1.20 (95% CI 1.12–1.28, n=67) for SHS exposure at home, 1.38 (95% CI 1.28–1.62, n=30) at a workplace, 1.37 (95% CI 1.22–1.53, n=28) at home or a workplace and 1.27 (95% CI 1.11–1.44, n=24) in nonspecified settings. The risk of lung cancer significantly increased with the duration, intensity and pack-years of SHS exposure.

Conclusions

This meta-analysis shows that exposure to SHS increases by more than 20% the risk of lung cancer among never-smokers, providing definitive evidence of the association between SHS exposure and lung cancer risk.




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Transition-Metal Free Approaches to Access N-Heterocycles and Valuable Intermediates from Aryldiazonium Salts

Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01776E, Review Article
Mani Ramanathan, Ziad Moussa
Efforts for the discovery of novel and efficient synthetic methods to achieve valuable N-fused heterocycles is an important research theme of organic chemistry for several decades. Owing to the importance...
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Johannes Gutenberg - His early training was in goldsmithing - Gutenberg had the idea of utilizing techniques of metalworking, such as casting, punch-cutting, and stamping, for the mass production of books. European books at this time were hand written by

Johannes Gutenberg was born into a noble family of the city of Mainz, Germany. His early training was in goldsmithing. In 1428, he moved to Strasbourg for political reasons, where he remained for over 20 years. It was in Strasbourg that he probably made his first experiments with moveable type. -- Gutenberg had the idea of utilizing techniques of metalworking, such as casting, punch-cutting, and stamping, for the mass production of books. European books at this time were hand written by scribes in a gothic script with many flourishes and ligatures (interconnected letter pairs). To reproduce this "look" Gutenberg fashioned a font of over 300 characters, far larger than the fonts of today. To make this possible, he invented the variable-width mold, and perfected the blend of lead, antimony, and tin used by type foundries up to the present century. -- Many years of Gutenberg's life are lost to history, but by 1450 he was back in Mainz at work on a printing press. Between 1450 and 1455, while preparing to produce a large folio Latin Bible, Gutenberg is thought to have printed a number of smaller books, a calendar, and a papal Letter of Indulgence. The Bible of 42 lines, the oldest surviving printed book in the western world, was completed by August 15, 1456, and while it is now credited to Gutenberg, he appears to have been relieved of his supervisory position, and his press, before the time of its publication. In fact, no printed material was ever credited to Gutenberg during his lifetime. -- Gutenberg is also believed to have worked on the Catholicon of Johannes de Janua, an enormous encyclopedia: 748 pages in two columns of 66 lines each. In later years, he received a position as a courtier to the archbishop of Mainz, and was buried in the town's Franciscan church.



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire

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GT Medical Technologies Announces Data Demonstrating Positive Local Control and Safety Outcomes with GammaTile Therapy for Large Brain Metastases




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New Webinar Added: Assessment of Treatment Response to Established and Novel Therapies in Glioblastoma Patients using Metabolic and Physiologic MR Imaging Techniques




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Rising up to the cloud: SNP publishes meta study on S/4HANA migrations

SNP SE, a leading provider of software for digital transformation, automated data migration and data management in the SAP environment, has published a meta study examining the current state of SAP S/4HANA migrations.




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How effective can the Metatime's MetaChain Blockchain Platform be in Turkey's CBDC movement?

MetaChain, a high-performance blockchain platform, could be the key to revolutionizing the Turkish Central Bank Digital Currency (CBDC).




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Metal Organic Frameworks Market worth $1.70 billion by 2030

(EMAILWIRE.COM, October 23, 2024 ) The report "Metal Organic Frameworks Market by Type (Zinc-based, Copper-based, Iron-based, Aluminium-based, Chromium-based), Synthesis Method (Solvothermal/Hydrothermal, Microwave-assisted, Mechanochemical), and Region - Global forecast to 2030 " The global Metal...




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Metamaterials Market Set to Reach $1.38 Billion by 2029 at a CAGR of 44.8%

(EMAILWIRE.COM, November 12, 2024 ) The metamaterial market is projected to reach USD 1.38 billion by 2029 from USD 0.22 billion in 2024 at a CAGR of 44.8% during the forecast period. Increasing use of metalens cameras in applications such as smartphones, laptops, and automotive and rising demand...




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***** Product Portfolio - Primetake (rank 16)

Primetake is the world leader in non-lethal bird scaring and wildlife management solutions. View Range Public Order Primetake offers a number of public order products for use in both law enforcement operations and in training. View Range Counter Drone Primetake’s Kinetic Effector 'DB-5' is a rapidly deployable, cost-effective counter-drone device.




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Herencia inaugura una nueva pista de pádel de metacrilato con mejoras de seguridad y tecnología

Herencia estrena desde hoy una nueva y modernizada pista de pádel que promete elevar la experiencia de juego y seguridad de los usuarios. Esta nueva instalación se suma a las tres pistas ya existentes en el complejo deportivo local y está diseñada para satisfacer la creciente demanda de los aficionados a esta disciplina. Las obras […]

Artículo publicado en : Herencia inaugura una nueva pista de pádel de metacrilato con mejoras de seguridad y tecnología




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Prescott oversees Britain's silent metamorphosis

Mr Prescott is pushing through his plans to see 1,400,000 new homes built in the next 20 years...




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"Embracing the Metaverse: A Survey of Virtual Reality and Augmented Reality Practices at the United States’ Top One Hundred University Libraries"

The purpose of this study is to learn more about virtual reality (VR) and augmented reality (AR) practices at the United States’ top one hundred university libraries, as well as how they are engaging with the metaverse. We conducted qualitative and descriptive analysis on the websites of the top one hundred university libraries in the … Continue reading ""Embracing the Metaverse: A Survey of Virtual Reality and Augmented Reality Practices at the United States’ Top One Hundred University Libraries""




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Metal Slug Tactics : le jeu est enfin dispo, voici son trailer de lancement et du gameplay de la Ikari Warriors

En attendant que SNK veuille bien nous annoncer son reboot de Metal Slug, ce sont les Français de DotEmu qui se sont chargés de ressuciter cette licence si chère des adorateur...




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Meta is testing face recognition to battle scams impersonating celebs

Celebrity impersonation became one of the more serious threats on social media to users Meta, the parent company of Facebook and Instagram, is testing out facial recognition tools to combat a rising problem: fake ads featuring celebrities. These are popularly referred to as “celeb-bait” scams, where scammers use images of popular public figures to dupe […]




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Controlling Web crawlers (search engine spiders) with robots.txt and meta tags

How to instruct Web crawlers (search engine spiders) what to do when they visit your site. You can specify that some parts of your site should be private and non-searchable. You can control how Web crawlers index your site at different levels - the entire site, specific directories, and individual pages.




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Metallica Worldwired UK Leg

No further details available.




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Gaming platforms FlickPlay, The Sandbox take steps toward metaverse

FlickPlay and The Sandbox is partnering to allow players the opportunity to use blockchain assets on both platforms.




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Meta cuts Facebook, Instagram prices, offers new low-ads option to comply with EU rules

(Telecompaper) Meta announced it's cutting the price of its paid subscriptions for Facebook and Instagram in Europe...




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Vorige week in telecom: DT neemt het op tegen Meta in 'fair share' debat, Google vecht tegen Microsoft en Docsis 4.0 op komst

Een drukke week voor Meta, met nieuwe AR/VR-producten op het Connect-evenement en een nieuwe escalatie van het 'fair share'-debat met de telecomwereld...




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Intel Denies RMA Request For Core i9-14900K CPU Witnessing Instability Issues Due To Use of Liquid-Metal Thermal Paste



  • HardForum Tech News

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Meta Quest 3



  • VR & Head-Mounted Displays

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Meta taps US, UK universities to test VR in education, creates digital twin 'metaversities' in Europe

Paul Sawers, TechCrunch, Nov 13, 2024

According to this article, "Meta has launched a new partnership with a slew of universities in the U.S. and U.K., as it looks to ingrain VR across the education system." I guess it's a big deal (per Mixed, Upload, Social Media Today, Technopedia, ReadWrite, etc etc) but it's hard for me to stifle a yawn. It's not simply that I was here for the Second Life hype, it's that their product is a "digital twin" of the university - "environments that directly replicate their real-world campus counterparts" - the least imaginative use of any media ever. I think there's a lot of room for VR in education, but this announcement isn't it.

Web: [Direct Link] [This Post]




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OCLC Research Will Harvest DSpace Metadata

Craig Neilson and Ray Matthews recently returned from North Carolina to learn about using DSpace, ePrints, and LOCKSS-Docs for providing permanent public access to state publications. OCLC has announced it is teaming with Google and MIT to harvest DSpace OAI-PMH metadata to turn it into a format which can be indexed and searched by Google. This will enable information about publications stored by governments and universities using this open source institutional archiving system to be readily retrievable.







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My Metaverse diary: what it’s like to live, work and shop inside the Internet




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New: Google Search Supports C2PA Metadata For About This Image Feature

A couple of months ago, we reported how Google Search will label if an image was AI-generated, edited by photo editing software or taken with a camera by working with Coalition for Content Provenance and Authenticity (C2PA) as a technical standard. Well, now Google officially supports C2PA metadata in the about this image feature.

Google wrote this morning, Google Search now supports this [C2PA] metadata in the "About this image" feature."

Google updated its image meta data documentation to add a new section for "How C2PA metadata can appear in Google Search results."

The new section reads:

If an image contains C2PA metadata, Google can extract those details and may show information in the "About this image" feature, such as how the image was created or if it was edited with AI tools. This metadata comes from a signer, which is usually an app, device, or service (for example, photo editing software, the camera itself, or other services that modify or create images) that meets the following conditions:

  • The app, device, or service has adopted C2PA version 2.1 or later.
  • The image's manifest must be signed by a certificate from a Certification Authority on the C2PA Trust List.

It does seem like Adobe products, like Photoshop, Illustrated, and others, do support this metadata.

I just wonder how it handles the image above, which I generate using Midjourney AI and then edit later in Photoshop.

Forum discussion at X.




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Kenotic Metanoia

Fr Joseph interviews rockers Lacey and Josh Sturm. They talk about the struggles and joys of Orthodoxy, song writing, iconography, and the new album "Kenotic Metanoia" (available now).




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Metania - Things I Wish I Knew About Orthodoxy

In this episode of The Wilderness Journal Angela continues her conversation with Summer Kinard, Jamey Bennett and Geoff Thompson about things we wish we had known about Orthodoxy before entering into the faith, including talk of Spiritual Fathers and people made of cheese.




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Scientists Uncover New Metabolic Compound That Controls Appetite and Weight




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Friday Nov 9 - St. Symeon Metaphrastes




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St Nikon Metanoite (“Repent!”) (~1000)

He was born about 930 to a pious and wealthy family near Trebizond. Once, making an inspection of the family's estates, he was so affected by the wretched conditions of the poor fieldworkers that he despaired of happiness in this world and determined to live a monastic life.   After years spent in a monastery, where he shone in obedience, prayer and self-denial, the Saint was given leave to travel in the ministry of the Gospel of Christ. For three years he wandered the East, without home or possessions, crying to everyone he met, "Repent!" and proclaiming with tears the message of salvation in Christ. He then spent seven years in Crete, then went to Greece, walking barefoot from place to place, preaching repentance and becoming so well known that he acquired the nickname "Metanoite," meaning "Repent!"   After driving a great plague from Sparta through his prayers, he settled near that city, building a great church dedicated to Christ the Savior, and living in the church for the remainder of his life. In time, a monastery was attached to the church for his disciples. His last counsel to his disciples was: "Flee pride, cleave to humility; do not despise the poor; keep clear of all evil, of all envy and of the remembrance of wrongs; forgive your brethren. Go regularly to church and confess your sins often to the priests and spiritual fathers. If you keep to these counsels, I will never abandon you." He then gave his soul back to God.   Saint Nikon was immediately venerated as a saint by the people of Sparta, and is regarded as the protector of the city, where his relics are venerated to this day.