Herencia estrena desde hoy una nueva y modernizada pista de pádel que promete elevar la experiencia de juego y seguridad de los usuarios. Esta nueva instalación se suma a las tres pistas ya existentes en el complejo deportivo local y está diseñada para satisfacer la creciente demanda de los aficionados a esta disciplina. Las obras […]

Artículo publicado en : Herencia inaugura una nueva pista de pádel de metacrilato con mejoras de seguridad y tecnología

A combination of images shows pistachios and a vision chart through an prescription glasses. — Pexels/Unsplash

Carrots are often hailed as a superfood for eye health, but not everyone enjoys eating them. Fortunately, scientists have identified a nutty alternative for sharper vision:...

Pistachios have emerged not only as a profitable option for growers in the U.S., but also as a favorite snack among consumers.

The newest addition to the snack nut line combines a touch of heat and tangy citrus flavor.

The sweet, spicy nuts are hitting shelves ahead of the fall and winter holidays.

IFPA Global attendees will get to experience the variety before its release in February 2025.

The European frozen bakery company created the new product in response to customer requests and flavor trends.

The snack featuring the Mexican seasoning now comes in bolder packaging and a new size.

Welcome to my October 2021 Favorites! Hi there! I hope you are all doing well and staying on top of the daily clutter that requires constant maintenance. It’s a lot sometimes. But don’t you worry, I’ve got so many resources on my site to help you. And with the holidays coming up, I’ve got the ... Read More about Catching Up with Org Junkie #19 ~ October 2021 Favorites: Pistachios, Maid & Countdown to Christmas

The post Catching Up with Org Junkie #19 ~ October 2021 Favorites: Pistachios, Maid & Countdown to Christmas appeared first on I'm an Organizing Junkie.

The updated In-Shell packaging design showcases the Wonderful Pistachios brand logo more prominently, while the addition of a new “Protein Power” logo reinforces the health benefits of pistachios. 

Dos de los más veteranos periodistas de sucesos de Madrid presentan esta tarde un libro sobre el caso de Marta del Castillo

Miguel y su mujer, Vilma, en busca y captura, montaron una tapadera (casi) perfecta para introducir droga desde Sudamérica, una empresa importadora de frutas tropicales que hasta patrocinaba eventos deportivos y tenían a sueldo, supuestamente, al jefe de Blanqueo de la Policía en Madrid, detenido con 21 millones en su casa Leer

El británico, que ganó seis medallas de oro en los Juegos de 2004, 2008 y 2012, afirma que pese a su enfermedad "se siente afortunado" Leer

El senador y exjefe negociador de paz se pronunció frente a la carta emitida por el secretario de la Organización de Estados Americanos (OEA) en las que advierte “amenazas de interrupción” al mandato de Gustavo Petro 

Carlos Fernando Galán, alcalde de Bogotá, hizo hincapié en cuáles son las principales causas de las inundaciones en la Autopista Norte 

Rodrigo Negrete, director de la ANLA, aseguró que una vez subsanen los problemas actuales, esta organización tomará una nueva decisión dentro de tres meses

En 6AM de Caracol Radio estuvo Juan Manuel Mariño, Gerente general de la Concesión Ruta Bogotá Norte, quien habló sobre la ampliación de la Autopista norte de Bogotá.

The new Trump administration is bad news for American civil and human rights and brings uncertainty for the rest of the world

Scientists have recreated the scent of the embalming fluid used to preserve a noblewoman more than 3,500 years ago — and they say it's quite lovely, indeed.

From one of the world's top pistachio-producing regions, comes a not-too-entirely nutty idea: Burning waste shells to heat buildings.

Vodka infused with pistachio shells adds nutty savoriness to the kick of a classic mule.

Ferrari's 488 Pista, which replaces the 458 Speciale, is driven by the most powerful V8 engine Ferrari has ever put in a road car.

ABSTRACT

Intracellular bacterial pathogens remodel cellular functions during their infectious cycle via the coordinated actions of effector molecules delivered through dedicated secretion systems. While the function of many individual effectors is known, how they interact to promote pathogenesis is rarely understood. The zoonotic bacterium Brucella abortus, the causative agent of brucellosis, delivers effector proteins via its VirB type IV secretion system (T4SS) which mediate biogenesis of the endoplasmic reticulum (ER)-derived replicative Brucella-containing vacuole (rBCV). Here, we show that T4SS effectors BspB and RicA display epistatic interactions in Brucella replication. Defects in rBCV biogenesis and Brucella replication caused by deletion of bspB were dependent on the host GTPase Rab2a and suppressed by the deletion of ricA, indicating a role of Rab2-binding effector RicA in these phenotypic defects. Rab2a requirements for rBCV biogenesis and Brucella intracellular replication were abolished upon deletion of both bspB and ricA, demonstrating that the functional interaction of these effectors engages Rab2-dependent transport in the Brucella intracellular cycle. Expression of RicA impaired host secretion and caused Golgi fragmentation. While BspB-mediated changes in ER-to-Golgi transport were independent of RicA and Rab2a, BspB-driven alterations in Golgi vesicular traffic also involved RicA and Rab2a, defining BspB and RicA’s functional interplay at the Golgi interface. Altogether, these findings support a model where RicA modulation of Rab2a functions impairs Brucella replication but is compensated by BspB-mediated remodeling of Golgi apparatus-associated vesicular transport, revealing an epistatic interaction between these T4SS effectors.

IMPORTANCE Bacterial pathogens with an intracellular lifestyle modulate many host cellular processes to promote their infectious cycle. They do so by delivering effector proteins into host cells via dedicated secretion systems that target specific host functions. While the roles of many individual effectors are known, how their modes of action are coordinated is rarely understood. Here, we show that the zoonotic bacterium Brucella abortus delivers the BspB effector that mitigates the negative effect on bacterial replication that the RicA effector exerts via modulation of the host small GTPase Rab2. These findings provide an example of functional integration between bacterial effectors that promotes proliferation of pathogens.

La stratégie déployée vendredi dans la grande région de Montréal nécessitera plus de personnel en santé.

A new "eco-city" being planned for Turkey will use waste pistachio shells for heating public and private buildings.

Squash and sweet potato work beautifully with earthy, aromatic Moroccan spices and saffron

If you like pistachio ice cream, you'll love this. It is worthwhile trying to find pistachio extract, but if you can't almond extract is fine

Ising model could account for nut production of pistachio orchards