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DevLog Spotlight: Leilani’s Island

I started work on it around a year ago on a whim because I was reading a lot of game design articles and couldn’t resist the idea of a small platform game. It’s really expanded a lot beyond that though! I’d like to start showing it to and discussing it with more people as I […]




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Archaeologists unearth 13,000-year-old mastodon skull in Iowa

Iowa archaeologists have unearthed a 13,600-year-old mastodon skull in pristine condition during a nearly two-week excavation at an eroding creek bank in Wayne County.



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NASA reconnects with interstellar Voyager 1 spacecraft using technology not used in decades

NASA reconnected with Voyager 1, which is located nearly 15 billion miles away from Earth, after a brief pause that triggered the spacecraft's fault protection system.



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Lion Cavern in Eswatini is World’s Oldest Ochre Mine, Archaeologists Say

Archaeologists say they have discovered the oldest known evidence for intensive ochre mining worldwide, at least 48,000 years ago, in Lion Cavern at Ngwenya in Eswatini, a landlocked country in southern Africa.

The post Lion Cavern in Eswatini is World’s Oldest Ochre Mine, Archaeologists Say appeared first on Sci.News: Breaking Science News.




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Paleontologists Discover New Species of Ankylosaurid Dinosaur

A new genus and species of ankylosaur has been identified from an articulated and partial skeleton found in 1986 in southern China.

The post Paleontologists Discover New Species of Ankylosaurid Dinosaur appeared first on Sci.News: Breaking Science News.




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Next-generation technology is a critical mid-step in dementia care

New technologies will radically change the experience of living with and caring for someone with Alzheimer's, says Professor Fiona Carragher, chief policy and research officer at Alzheimer's Society, UK




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Over 500 Amazon workers decry “non-data-driven” logic for 5-day RTO policy

“I used to be proud of my work and excited about my future here. I don't feel that anymore."




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Even as A.I. Technology Races Ahead, the Prehistoric Science of Wildlife Tracking Is Making a Comeback

Humans perfected how to identify wild animals over millennia, and now biologists are rediscovering the exceptional worth of the tracks and marks left behind






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Winnipeg hospital apologizes after patient says wrong leg amputated

A 48-year-old man in Winnipeg who says his right leg was to be amputated due to an infection came out of the medical procedure to find out his left leg was amputated instead. Jason Kennedy knew he may eventually lose both legs to the infection but he still has questions about what happened.



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Ottawa principal apologizes for playing Arabic song during Remembrance Day ceremony

An Ottawa high school principal has apologized for playing an Arabic song about peace during a Remembrance Day ceremony after facing swift backlash from critics calling it inappropriate and hurtful to members of the Jewish community.



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From Taiwan to technology, China ponders what's to come under Trump 2.0

Chinese business people may be able to find creative ways to avoid U.S. tariffs, but for Beijing, its concerns for the incoming Trump presidency go beyond trade.




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$250 Analogue 3D will play all your N64 cartridges in 4K early next year

FPGA-powered hardware will capture CRT glow with "bespoke, purpose-built upscaler"




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New ‘Star Wars’ trilogy in the works at Lucasfilm from ‘Rebels’ creator Simon Kinberg

While initial rumors suggested that Kinberg’s trilogy might continue the iconic Skywalker Saga, insiders have clarified that the upcoming series will chart new territory within the ‘Star Wars’ universe




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Mr Beast, KSI and Logan Paul are all set for India launch event in Mumbai

The launch event will see the YouTubers partnering with Ajey Nagar, known as CarryMinati, for a special fan interaction in Mumbai




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‘BTS’ movie review: A moving anthology about ordinary people with celluloid dreams

The five-film Kannada anthology is a realistic exploration of people on the margins of the film industry






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Steam Deck Weekly: Visions of Mana and More Reviews, Reynatis Preview, Age of Mythology Retold Steam Deck Impressions, News, and More

Welcome to this week’s edition of the Steam Deck Weekly. If you missed my Gundam Breaker 4 Steam Deck review, …




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New Zealand formally apologizes to victims of abuse in state care

An inquiry found abuse, torture and neglect of some 200,000 people in state care over 70 years. People with disabilities or from Maori and Pacific Islander communities were especially vulnerable.




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Mattel apologizes for mistakenly printing porn website on Wicked toy doll packaging

Toy giant Mattel says it "deeply" regrets an error on the packaging of its Wicked movie-themed dolls, which mistakenly links toy buyers to a pornographic website.




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Pies board accepts McGuire apology

UPDATE: EDDIE McGuire has the backing of the Collingwood board to remain president after accepting his apology for his explosive radio comments about Caroline Wilson.




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National online certificate course for pathologists on cervical cancer screening to begin from November 25

The Indian Council of Medical Research─National Institute of Cancer Prevention and Research (ICMR─NICPR) is set to launch its first─ever DHR─funded National NICPR─ECHO online certificate course on cervical




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WITTMANN BATTENFELD presents latest technology at Compamed

WITTMANN BATTENFELD will present the latest solutions for time and cost optimisation in the production of parts with nano structures at Compamed, booth No. F03-1 in hall 8b.




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Astrology Was an Important Science for Medieval People

In medieval times, astrology was considered a serious science, a branch of astronomy. Curator Larisa Grollemond of the Getty Museum, walks us through the medieval zodiac and how someone’s sign decided their day-to-day life.




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Misinformation Really Does Spread like a Virus, Epidemiology Shows

“Going viral” appears to be more than just a catchphrase when it comes to the rampant spread of misinformation




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The Pivotal Role of Technology in Delivering Effective Patient Services

Today’s guest post comes from George Moore, Chief Information Technology Officer at CareMetx.

As George explains using novel survey data, manufacturers view new technologies  as crucial for patient services. He then explains how digital technology, artificial intelligence (AI), and machine learning (ML) can be used to improve patient adherence and increase hub efficiencies.

To learn more, download CareMetx’s new 2024 Patient Services ReportRevealing Manufacturer Priorities: Patients Naturally Take Center Stage.

Read on for George’s insights.
Read more »
       




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Cardiology Research: Business As Usual During the Pandemic

At this moment in time the pre-pandemic cardiology research agenda needs to be completely reprioritized. There are two broad areas that now take precedence over all existing research concerns. On the one hand, researchers need to achieve a better understanding of the staggering incidence of deferred or delayed treatment of cardiovascular events and conditions as...

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Regulatory update for post-registration of biological products in Brazil

<p>On 3<sup>&nbsp;</sup>June 2024,&nbsp;Resolution&nbsp;RDC No. 876 was published in Brazil in the Official Journal of the Union (DOU)[1],&nbsp;modifying the current regulations regarding the post-registration of biological products (RDC 413/2020).</p>




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Top nine biological drugs by sales in 2023

<p>The global biologicals market surged to an impressive US$419.07 billion in 2023. Blood and blood products led the market, commanding a dominant 66% share. Oncology stood out as the leading application segment, accounting for 36% of the market. North America held the largest revenue share, at 46%, while the Asia-Pacific region emerged as a rising star, poised to be the fastest-growing region over the next decade.</p>




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Transforming healthcare: CinnaGen’s leadership in follow-on biologicals/ biosimilars development and market expansion

<p> <b>Abstract</b><br />CinnaGen, the largest biopharmaceutical company in the MENA region, is a leader in developing follow-on biologicals/biosimilars. Dr&nbsp;Haleh Hamedifar, Chairperson of CinnaGen, spoke to GaBI<i>&nbsp;</i>(Generics and Biosimilars Initiative) about the company’s strategic focus, which includes expanding its product portfolio, entering highly regulated global markets, and advancing affordable treatments for conditions such as multiple sclerosis and&nbsp;immunological diseases—transforming healthcare in underserved regions.</p><p><b>Keywords</b>: Biosimilars, clinical development, commercialization, MENA</p>




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Pharmacology: The Anchor for Nearly Every Diligence

By Haojing Rong and Aimee Raleigh, as part of the From The Trenches feature of LifeSciVC This blog post is the second in a series on key diligence concepts and questions. If you missed the intro blog post yesterday, click

The post Pharmacology: The Anchor for Nearly Every Diligence appeared first on LifeSciVC.




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Mariana Oncology’s Radiopharm Platform Acquired By Novartis

Novartis recently announced the acquisition of Mariana Oncology, an emerging biotech focused on advancing a radioligand therapeutics platform, for up to $1.75 billion in upfronts and future milestones. The capstone of its three short years of operations, this acquisition represents

The post Mariana Oncology’s Radiopharm Platform Acquired By Novartis appeared first on LifeSciVC.




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Has Spring Sprouted New Growth in Immuno-Oncology?

By Jonathan Montagu, CEO of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC As Boston’s weather has started its turn from the frigid darkness that is a northeast winter to the longer days and lighter conditions

The post Has Spring Sprouted New Growth in Immuno-Oncology? appeared first on LifeSciVC.




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Neuro-Immunology: The Promise Of A Differentiated Approach To Neurodegenerative Disease

By Ivana Magovčević-Liebisch, CEO of Vigil Neuroscience, as part of the From The Trenches feature of LifeSciVC In the last decade, our industry has made great strides in combating cancer by harnessing the body’s own immune system. As it was

The post Neuro-Immunology: The Promise Of A Differentiated Approach To Neurodegenerative Disease appeared first on LifeSciVC.





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Brave New Biopharm Blogging

Although a few articles on this site are older, I really only began blogging in earnest about 15 months ago. However, I suppose that's long enough that I can count myself as at least somewhat established, and take a moment to welcome and encourage some interesting newcomers to the scene.
 
Bloggers in dank basements their natural habitat.
There are 3 relative newcomers that I've found really interesting, all with very different perspectives on drug development and clinical research:


The Big Pharma insider.
With the exception of John LaMattina (the former Pfizer exec who regularly provides seriously thought provoking ideas over on Forbes), I don’t know of anyone from the ranks of Big Pharma who writes both consistently and well. Which is a shame, given how many major past, current, and future therapies pass through those halls.

Enter Frank David, the Director of Strategy at AstraZeneca's Oncology Innovative Medicines unit. Frank started his Pharmagellan blog this April, and has been putting out a couple thoughtful perspective pieces a month since then.

Frank also gets my vote for most under-followed Twitter account in the industry, as he’s putting out a steady stream of interesting material.


Getting trials done.
Clinical operations – the actual execution of the clinical trials we all talk about – is seriously underrepresented in the blogosphere. There are a number of industry blogs, but none that aren’t trying first and foremost to sell you something.

I met Nadia Bracken on my last trip out to the San Francisco bay area. To say Nadia is driven is to make a rather silly understatement. Nadia is driven. She thinks fast and she talks fast. ClinOps Toolkit is a blog (or resource? or community?) that is still very much in development, but I think it holds a tremendous amount of potential. People working in ClinOps should be embracing her, and those of us who depend on operations teams getting the job done should keep a close eye on the website.


Watching the money.
I am not a stock trader. I am a data person, and data says trust big sample sizes. And, honestly, I just don't have the time.

But that doesn't stop me from realizing that a lot of great insight about drug development – especially when it concerns small biotechs – is coming from the investment community. So I tend to follow a number of financial writers, as I've found that they do a much better job of digging through the hype than can ever be expected of the mainstream media.

One stock writer who I've been following for a while is Andrew Goodwin, who maintains the Biotech Due Diligence website and blog. Andrew clearly has a great grasp on a number of topics, so when he described a new blog as a “must-have addition” to one's reading list, I had to take a look.

And the brand-new-this-month blog, by David Sable at Special Situations Fund, does seem like a great read. David looks both at the corporate dynamics and scientific stories of biotechs with a firmly skeptical view. I know most blogs this new will not be around 6 months from now (and David admits as much in his opening post), but I’m hoping this one lasts.

. . . . .

So, I encourage you to take a look at the above 3 blogs. I'm happy to see more and diverse perspectives on the drug development process starting to emerge, and hope that all 3 of these authors stick around for quite a while – we need their ideas.



[Bloggerhole photo courtesy of Flikr user second_mouse.]




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Private Equity Is Picking Up Biologics CDMO Avid Bioservices in $1.1B Acquisition

CDMO Avid Bioservices is being acquired by the private equity firms GHO Capital Partners and Ampersand Capital Partners. Avid specializes in manufacturing biologic products for companies at all stages of development.

The post Private Equity Is Picking Up Biologics CDMO Avid Bioservices in $1.1B Acquisition appeared first on MedCity News.




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Standard Technology Presents Opportunities for Medical Record Data Extraction

Technology has revolutionized the way people live their lives. Individuals can use smartphones to access their bank account, shop from almost any store, and connect with friends and family around the globe. In fact, these personal devices have tethered communities together during the coronavirus pandemic, allowing many people to maintain much of their lives remotely.




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Blog | CATO SMS




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SAS and Hadoop Technology: The Overview

Currently, more than 20 SAS products, solutions, and technology packages interact with Hadoop. Read this book to understand how to maximize your big data assets.




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236981: U.S. Tauscher engages Rao in strategic security dialogue

While each side adhered to familiar positions, the chemistry between the principals was good and the dialogue was cordial and frank.




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Dynamics of Nuclear and Radiological Terrorism Threats to Post-Soviet Russia

Simon Saradzhyan was invited to publicly brief the National Academy of Sciences (NAS) committee addressing the adequacy of strategies to prevent, counter, and respond to nuclear terrorism, and identify technical, policy, and resource gaps. The consensus study is a congressionally mandated analysis included in the 2021 National Defense Authorization Act (Section 1299I) sponsored by the Office of the Secretary of Defense (Policy).  Nearly 60 stakeholders concerned about this topic from the Department of Defense, US Department of Energy, National Nuclear Security Administration, State Department, National Security Council, US Congress, the National Labs, and many non-governmental organizations were in attendance. The briefings are available at the NAS event website. Video of the presentation can be found here.




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Pest-resistant Maize Variety Opens Way for Technological Advancement

"It is estimated that the spotted stem borer and the African stem borer reduce Kenya's maize crop by 13 per cent or 400,000 tonnes annually. Controlling the pest using biotechnology will not only reduce Kenya's food imports, it will also equip the country with new techniques that can be redeployed for other sectors such as drug and vaccine development."




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Rebooting African Economies: The Place of Science and Technology in Society

"African countries are already at the forefront of harnessing these technologies. For example, Rwanda has set itself the ambitious goal of building the first drone airport in the world. An increasing number of African countries are leveraging drone technology to address a variety of resource mapping, delivery and agricultural services. It is through such efforts that salient basic research challenges are likely to emerge."




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Rebooting African Development: Science, Technology and Innovation Strategy for Africa

As the African Union develops its long-term agenda 2063 for the continent, science, technology and innovation will play a bigger part in development goal setting, especially in the context of social and economic growth.




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From the Frontlines to the Future: Assessing Emerging Technology in Russia's Invasion Strategy and NATO's Next Moves

This piece is a series in the Defense, Emerging Technology, and Strategy (DETS) Program’s analysis on the war in Ukraine, including a corresponding policy brief on Ukraine’s Battlefield Technologies and Lessons for the U.S. published in July 2023. 




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Unraveling the Political Dynamics Shaping the U.S. Strategy for Technology Leadership

Although there is broad agreement between the two major parties on the desirability of technology leadership, significant sources of tension—and confusion—persist. By examining the political dynamics that led to the enactment of the CHIPS and Science Act, Constanza M. Vidal Bustamante and Douglass Vijay Calidas probe these tensions and seek to assess their likely impact on the federal technology strategy in the coming years.




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Space Technology Advances: Catalysts for Conflict or Pathways for Human Progress?

Ensuring that space remains a domain for peaceful exploration and mutual benefit rather than a new frontier for conflict will significantly depend on the global community's ability to navigate the complex interplay of technological advancements, regulatory frameworks, economic opportunities, and geopolitical challenges. 

This paper was written for the final assignment of IGA-250, a Harvard Kennedy School course on emerging technology: security, strategy, and risk.