Donald Trumps’s representativessaid he also expressed an interest in further conversations to discuss “the resolution of Ukraine’s war soon.”

Often panned for not realising the minefield of talent that he is, Samson became the first Indian batter to hit back-to-back centuries in T20 Internationals as his 50-ball-107 with as many as 10 monstrous sixes took India to 202 for 8 in 20 overs.

Some experts and central bankers point to regulation as the way forward. And supervising stablecoins and crypto exchanges would be a much easier affair than exercising controls over individual financial crypto products.

Understanding the reasons for people failing to respond is important, particularly to our mental health

Time limit for MFs to invest NFO funds not a good idea

The belief that walls and roofs should be solid for long lasting strength is a myth.

New surface chemistry method answers mechanistic questions that have eluded chemists for 40 years

Students’ association points to RTI data, says only 2 seats filled by SC and 4 by OBC candidates against sanctioned strength of 18 and 34 respectively

A Competition Commission probe has found that food delivery platforms Zomato and Swiggy indulged in unfair business practices, including alleged preferential treatment to some restaurant partners, according to sources. The detailed investigation was ordered by the Competition Commission of India (CCI) in April 2022 and the probe report was submitted to the regulator earlier this year. Under the norms, CCI director general's report has been shared with the parties concerned and later, they will be called for hearings by the watchdog.

Like man buns on scooters and ukulele busking, Covid-19 has now spread to the north from London – inspiring a coronavirus soapcom from our self-isolating comedy-writer

Up here in the north-west, we’re used to living in the slipstream of London’s sleek urban shenanigans. Whatever the cultural breakthrough – man buns on scooters, cashless ukulele busking, emotional support bees – it takes a while to reach the Lancaster and Morecambe Non-Metropolitan Area. If it ever does.

A Street Stranger Watch leads to a death and the appearance at midnight of the street’s original Victorian inhabitants

Marketers fear ‘racist’ Trump supporters, says head of Hispanic advertising group

Elections test region’s democratic mettle; markets test its finances

Lewis Library - ML3917.L27 C85 2018

Latinos have been hit especially hard by the coronavirus. A medical group in northern Virginia is stepping up testing for the Latino community.

Members of the Joint Operational Committee in Tshwane is in self-isolation after one member tested positive for Covid-19, spokesperson Brigadier Vishnu Naidoo has told News24.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

OM workers explain, their home has become a mix of Latin American and Middle Eastern cultures.

Doulos had a transforming impact on Latin America and its church. To this day, it is remembered as the initiator of the mission movement in Latin America.

Santa Marta, Colombia :: Logos Hope is welcomed to a new region of the world, where the ship's community is adjusting to a new language.