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Fire chiefs hail £30m investment in ‘whole new level’ 999 emergency system

The technology will deliver enhanced day-to-day and major incident response capability




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RPG Cast – Episode 582: “Are Those Cat Butthole Coasters?”

Chris gets review bombed outta existence, after Pascal gleefully mocks the list of games that Chris still didn't play. Anna Marie insists genital monsters yes, f-bombs no. Kelley thinks Anna Marie should get out of the pocket of Big Farming. We're all pretty tired from vaccine side effects, please bear with us.

The post RPG Cast – Episode 582: “Are Those Cat Butthole Coasters?” appeared first on RPGamer.




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RPG Cast – Episode 584: “A Crater Sized Hole Filled with Funko Pops!”

Anna Marie wonders why we can't be friends. Jonathan becomes a Marbula One fan. Kelley engages "pants off, games on" mode. And Chris learns that the only person he's cheating is himself...and his dire gryphon.

The post RPG Cast – Episode 584: “A Crater Sized Hole Filled with Funko Pops!” appeared first on RPGamer.




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In strategy game Sintopia you harvest a whole civilisation's souls for your own custom-built hell

One of my favourite satires is the Screwtape Letters, an epistolary novel by Narnia scribe C.S. Lewis. It consists of messages from an oily elder demon to his nephew about how to correctly groom the soul of an unsuspecting human being. It's a claustrophobic send-up of managerial politics and nepotism, with World War 1 unfolding in the background. A real pick-me-up. Sintopia is the Two Point incarnation of that premise - in other words, brighter and breezier and definitely more slapstick than Christian. It puts you in charge of a world divided between Earth and hell, and challenges you to ensure a steady movement of optimally sinful souls between one and the other. Say your prayers and watch the trailer.

Read more




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Foxhole is getting planes next summer and an infantry combat overhaul later this month

Foxhole is one of my favourite games to read about, even if I don't play it. It's a massively multiplayer World War 2 game, viewed from above, where battlefield logistics matters as much as aiming and flanking. Its developers have just announced a major new update coming next summer, Foxhole: Airborne, which adds planes to the game for the first time.

Planes, in a topdown MMO? It makes a little more sense if you watch the trailer.

Read more




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A black hole devouring a giant star gives clues to a cosmic mystery

In the centre of a distant galaxy, a supermassive black hole has swallowed up a star 9 times the sun’s mass in the biggest and brightest such cosmic meal we’ve ever seen




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Our galaxy may host strange black holes born just after the big bang

The Milky Way may be home to strange black holes from the first moments of the universe, and the best candidates are the three closest black holes to Earth




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Dark matter may allow giant black holes to form in the early universe

The long-standing mystery of how supermassive black holes grew so huge so quickly could be solved by decaying dark matter




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Black hole’s jets are so huge that they may shake up cosmology

Spanning 23 million light years, or 220 Milky Way galaxies, a set of giant, newly discovered black hole jets known as Porphyrion may change our understanding of black holes and the structure of the universe




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The astrophysicist unravelling the origins of supermassive black holes

How did the supermassive black holes we’re now seeing in the early universe get so big so fast? Astrophysicist Sophie Koudmani is using sophisticated galaxy simulations to figure it out




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What does it mean to “look” at a black hole?

General relativity teaches us that observing a black hole is all a question of perspective – and technique, says Chanda Prescod-Weinstein




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The Wholesome Competition

In order to promote the flow of soothing energies, starting October 1st all TIGS folk are wholly encouraged to consider taking part in The Wholesome Competition. Less of a bloody-toothed competition between gladiatorial rivals and more of a friendly environment to tinker away merrily on a small project with pals. A call to jolly cooperation, […]




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Available for Preorder: The 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors

On October 8, 2024, Drug Channels Institute will release our 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors. This report—our fifteenth edition—remains the most comprehensive, fact-based tool for understanding and analyzing the large and growing U.S. pharmaceutical distribution industry.

9 chapters, 350+ pages, 178 exhibits, 750+ endnotes: There is nothing else available that comes close to this valuable resource.

We are providing you with the opportunity to preorder this thoroughly updated, revised, and expanded 2024-25 edition at special discounted prices. This means that you can be among the first to access our new report. Those who preorder will receive a download link before October 8.
You can pay online with all major credit cards (Visa, MasterCard, American Express, and Discover) or via PayPal. Click here to contact us if you would like to pay by corporate check or ACH.

Special preorder and launch pricing discounts will be valid through October 23, 2024.

Read on for more details.
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NOW AVAILABLE: 2024–25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors

I am pleased to announce Drug Channels Institute's new 2024–25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors, available for purchase and immediate download.
We’re offering special discounted pricing if you order before October 23, 2024.

2024–25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors—our 15th edition--remains the most comprehensive, fact-based tool for understanding and analyzing the large and growing U.S. pharmaceutical distribution industry. This 2024-25 edition includes substantial new material—outlined on page vii of the report overview.

9 chapters, 380+ pages, 178 exhibits, more than 750 endnotes: There is nothing else available that comes close to this valuable resource.

You can pay online with all major credit cards (Visa, MasterCard, American Express, and Discover) or via PayPal. Click here to contact us if you would like to pay by corporate check or ACH.

Email Paula Fein (paula@drugchannels.net) if you’d like to bundle your report purchase with access to DCI’s video webinars.

If you preordered the report, you should have already received an email with download instructions last week. Please contact us if you did not receive your email.

Read on for some additional details.
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Five Crucial Trends Facing U.S. Drug Wholesalers in 2024 and Beyond

As regular readers of Drug Channels know, U.S. distribution and dispensing channels for prescription drugs are undergoing significant evolution and consolidation as the changing economics of pharmaceuticals challenge conventional business models.

During this period of volatility, the core business model of the Big Three public pharmaceutical distribution companies—Cardinal Health, Cencora, and McKesson—remains intact. Put simply: Buy low, sell high, collect early, and pay late.

But as I explain below, wholesalers continue to position themselves as essential intermediaries by expanding their industry position and strengthening their economic fundamentals.

Read on for five key pricing, pharmacy, provider, and manufacturer trends that are driving the U.S. drug wholesaling industry.

For even more, check out DCI's new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors, the fifteenth edition of our deep dive into wholesale distribution channels.Click here to download a free report overview (including key industry trends, the table of contents, and a list of exhibits)
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BJ's Wholesale Club Introduces New Pick Up & Pay Service - BJ�s Wholesale Club New Pick Up & Pay Service

BJ's Wholesale Club Members now have the option to �pick up and pay� at all of its 213 club locations along the east coast.




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Whole You Celebrates The Senses And Encourages People To Live A Life Without Limitations - Video of legally-blind photographer living his Whole Day

Video of legally-blind photographer living his Whole Day, as he captures a celebration of senses and movement




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We Have To Stop Letting Assholes Ruin Everything.

We have to do better. If you feel attacked, it's about you.




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Make Horror Wholesome

With everything going on these days, sometimes it's good to give ourselves a break from the usual late night creepshow classics. Join the SA Forum photoshop goons in their quest to make horror wholesome!




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A Black Hole At The Center Of The Galaxy

The Smile “The Slip” It’s unfortunate that The Smile records have to carry the weight of questions like “wait, is there never going to be another Radiohead album?” and “hold on, so is this basically Radiohead from now on?” But what can you do? Those are big questions for anyone who’d want to listen to […]




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A Wholesome Helping Of Cool Cats Who Call The Shots In Their Respective Households

Hey there, cat lovers. We would like to make a statement. Cats are the coolest species to ever exist in the history of the world. A dramatic statement, yes, but an accurate one, definitely. We think it has to do largely with the feline inclination to dominate, but in a cute way. Our cats run our households, and they weigh around 12 pounds each. It seems absurd when you think about it, but that's the reality that we cat appreciators live in. 

Being cool is about not giving a hoot and marching to the beat of your own drum, that's why we think cats take the cool cake. Also, can we talk about how they can dictate the entire lives of us humans, swindle us into financing their suspicious pyramid schemes, and feed them half of our rations every time we open a tuna can? There needs to be some discussion around this topic. In the meantime, enjoy a silly series of cool cats being their goofy selves. 




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22 Coo-Coo Cat Memes Madly Meowing For a Feline Filled Full Wholesome Weekend

There's something special about spending an absurd amount of time goofing around with your cat. It can be a simple playtime toy that your cat loves so much, making them wiggle wiggle before they pounce to hunt it, or it can be a full playtime of hide and seek between your cat and you - but there's definitely something special about this time. It's the ultimate coo-coo cat time, full of cat craziness and cuteness. And since now it's still the weekend - you can have as much of a coo-coo cat time as you want. Or as much as your cat wants, obviously, but they usually like it so much that they just want to continue playing.

If you want to feel the cat coo-cooness and get inspired for a fully-fledged feline friendly playtime, we have here a very coo-coo-inspiring cat meme list. It can definitely get you, and your cat, in the right crazy cat mindset.




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23 Funny Fluffy Feline Memes Making Their Way This Meownday to Make a Whimsy Wholesome Week

Hello cat pawrents and enthusiasts, is this Meownday treating you alright until now? Starting another workweek can be rough, making any Monday morning a leading candidate in the "Worst Morning of the Week" list. This is especially difficult for cat pawrents, who need to leave for work after they've had a full weekend of cat time. It's rough to leave your cat at home after a two-day-long cuddle session with them, and a wholesome hang-out time.

This is why trying to surround yourself with cats as much as you can, while you're away from your cute cat, can be beneficial. It sort of acts as a solution for the cat-yearning soul of a cat pawrent on a Meownday morning. And the easiest way to surround yourself with cats, and just general cat wholesomeness, is by scrolling through a bunch of cat memes - especially the wholesome kind, which are made for a whimsy week.





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24 Wholesome Happy Cats Healing Even Your Worst Workday With Purr Joy for the Soul

There is some sort of smear campaign going on against cats, and we're here to dispel it. Cats are not emeowtionless creatures, they are full of love, joy, and funny facial expressions! Our cats have been more connected to us than most hoomans (although the bar is not set very high for hoomans, unfortunately), and if we're being purrfectly honest, our cats do a lot more things that make us smile than our fellow sapiens. Fur example, just watching them smile makes us smile, as simple as that.

It also makes us smile when they fall asleep in a silly pawsition, when they do a biiiiiiiiiiiiiiiiiiiiiig stretch after waking up for a nap, or when they run to greet us when we come home from work. Cats are so full of love and pawsitivity that they have the power to heal even our worst workday. No matter what may have happened at the office, as soon as we see their purrfect little faces, we furget everything bad that happened and we can only think of one thing: how much we love our awwdorable little fur babies.




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Stepsisters hide 18-year-old's passport so she would miss the family vacation and take care of the kids, father retaliates by cancelling the whole trip: 'I was livid'

There is a lot of irresponsible parenting in this story. First, let's start with the stepsisters in question. This is a pair of 25 and 28-year-old single moms who were so reliant on the Redditor's 18-year-old daughter to babysit their kids that they couldn't possibly get a real babysitter to take care of them. So when it came time for a family vacation, the stepsisters tried to convince the Redditor's daughter to stay behind, despite the fact that she wanted to partake in some much-deserved time off as well.

Then, there's the Redditor's wife, who tried to defend her fully-grown daughters for trying to sabotage the 18-year-old's ability to join the family on the trip. These ladies stole her passport, leaving the 18-year-old and her father scrambling just hours before their flight departure. Tension was so high between all the members of the family that the Redditor decided to cancel the entire trip. Looks like his stepdaughters would have to take care of their own kids for a change.

Keep scrolling below for the full story and for the best reactions from folks in the comments section. For more, check out this post about a Thanksgiving meltdown.




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Is there a £22bn ‘black hole’ in the UK’s public finances?

Economists say the state of public finances should not have come as a complete surprise to the new government.




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Say Goodbye to Liver Cancer with a Non-Statin Cholesterol-Lowering Drug

Primary medlinkliver cancer/medlink is a malignant tumor that starts in the liver. It is the sixth most commonly occurring cancer worldwide and the




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Bharat Biotech Unveils Oral Vaccine to Tackle Global Cholera Threat

Bharat Biotech announced the release of an medlinkoral cholera vaccine/medlink (OCV), a significant public health issue in regions with inadequate sanitation (!--ref1--).




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Why One Egg a Day Won't Raise Your Cholesterol?

Eating an egg a day is both heart-friendly and safe, with no risk of increasing blood cholesterol.




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Is High-Density Lipoprotein Cholesterol Really Good?

Cholesterol are of two types namely high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL). HDL or good cholesterol




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High And Low Levels Of 'Good' Cholesterol Linked To Premature Death

Commonly touted as bgood cholesterol/b for helping to reduce risk of stroke and heart attack, both high and low levels of high-density lipoprotein




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LipidSeq Effective in Diagnosing Genetically Based High Cholesterol

Using next-generation sequencing (NGS) technology, researchers were able to pinpoint specific areas of a person's DNA to more effectively diagnose genetic




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Moderate Alcohol Intake Has Least Impact on Good Cholesterol's Decline

Moderate drinking was associated with slower declines in high-density lipoprotein (HDL), or good cholesterol, over time in Chinese, according to a preliminary




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New Analysis Examines How Low Cholesterol Can Safely Go

Very aggressive reduction of LDL-cholesterol to ultra-low levels was associated with progressively fewer cardiovascular events and appears to pose no




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Cholesterol Lowering Medications are Used to Treat Danes

More than 600,000 Danes are being treated with cholesterol lowering medicine. 98 per cent of them are treated with statins, which curb the body's own




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No Need To Fast Before A Cholesterol Test With A New Method

A newer method of calculating so-called "bad cholesterol" levels in the blood is more accurate than the older method in people who did not fast before blood was drawn.




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Gene Target To Reduce Triglyceride, Cholesterol Levels by 50%

Using a variation of CRISPR gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to lower cholesterol levels and heart disease risks.




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Less than 40 Percent Get Treated for High Cholesterol

Most people with severe elevations in cholesterol are not treated with appropriate drugs. Less than 40 percent receive treatment, despite many screening and awareness programs.




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Genome Editing reduces Cholesterol in Large Animal Model

Study conducted by researchers from the Perelman School of Medicine at the University of Pennsylvania on genome editing in non-human primates highlights




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Good Cholesterol may Increase Heart Disease Risk in Postmenopausal Women

University of Pittsburgh Graduate School of Public Health researchers have found that postmenopausal factors may have an impact on the heart-protective




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Blood Donation Programs Help Reveal Life Threatening Genetic Cholesterol Condition

Blood donation programs were found to help identify donors with the often undiagnosed genetic disorder familial hypercholesterolemia, which results in




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Link Between Early-onset Alzheimer's and High LDL Cholesterol Levels Discovered

A new association between early-onset Alzheimer's disease and increased LDL cholesterol levels has been identified by Atlanta Veterans Affairs Medical Center and Emory University researchers.




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Fasting Before Cholesterol Test Found Unnecessary

Nonfasting lipid levels were same as fasting lipid levels in the same individuals, which helps to predict the risk of cardiovascular diseases, according




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Chicken as Bad as Red Meats for Cholesterol

Red and white meat such as poultry were found to be equally bad for blood cholesterol, said study published today in the American Journal of Clinical Nutrition.




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Eggs in Cholesterol Linked to Heart Disease and Death

The number of eggs people consume is linked to increased risk of heart disease and death, stated UMass Lowell nutrition expert who has studied the issue.




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Cholesterol Levels Dropping in Western Nations, but Rising in Asia: Study

A new study of global cholesterol levels has revealed that cholesterol levels are declining sharply in Western nations, but rising in low- and middle-income nations - particularly in Asia.




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'Good Cholesterol' to Gauge Heart Attack and Stroke Risk

Analysis of HDL-P, which tally how many particles of HDL are circulating in the blood, is a better predictor of heart attack and stroke compared to the




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Autism is Linked to Cholesterol: Study

Autism subtype arising from a cluster of genes that regulate cholesterol metabolism and brain development has been identified by researchers at Harvard




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High Cholesterol Levels In Young Age Can Lead To Heart Problems by Middle Age

Teenagers with high cholesterol levels have an increased risk of heart attack, stroke or other cardiovascular events during middle age, according to a