The man shares that by reducing personal choices, he experiences a lighter mental load, enabling effective decision-making at work.

The title compound, C16H17N3O3, is racemic as it crystallizes in a centrosymmetric space group (Poverline{1}), although the trans disposition of substituents about the central C—C bond is established. The five- and six-membered rings are oriented at a dihedral angle of 75.88 (8)°. In the crystal, N—H⋯N hydrogen bonds form chains of mol­ecules extending along the c-axis direction that are connected by inversion-related pairs of O—H⋯N into ribbons. The ribbons are linked by C—H⋯π(ring) inter­actions, forming layers parallel to the ab plane. A Hirshfeld surface analysis indicates that the most important contributions for the crystal packing are from H⋯H (45.9%), H⋯N/N⋯H (23.3%), H⋯C/C⋯H (16.2%) and H⋯O/O⋯H (12.3%) inter­actions. Hydrogen bonding and van der Waals inter­actions are the dominant inter­actions in the crystal packing. The volume of the crystal voids and the percentage of free space were calculated to be 100.94 Å3 and 13.20%, showing that there is no large cavity in the crystal packing. Evaluation of the electrostatic, dispersion and total energy frameworks indicates that the stabilization is dominated by the electrostatic energy contributions in the title compound. Moreover, the DFT-optimized structure at the B3LYP/6–311 G(d,p) level is compared with the experimentally determined mol­ecular structure in the solid state. The HOMO–LUMO behaviour was elucidated to determine the energy gap.

The in­do­line portion of the title mol­ecule, C16H13NO2, is planar. In the crystal, a layer structure is generated by C—H⋯O hydrogen bonds and C—H⋯π(ring), π-stacking and C=O⋯π(ring) inter­actions. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (43.0%), H⋯C/C⋯H (25.0%) and H⋯O/O⋯H (22.8%) inter­actions. Hydrogen bonding and van der Waals inter­actions are the dominant inter­actions in the crystal packing. The volume of the crystal voids and the percentage of free space were calculated to be 120.52 Å3 and 9.64%, respectively, showing that there is no large cavity in the crystal packing. Evaluation of the electrostatic, dispersion and total energy frameworks indicate that the stabilization is dominated by the dispersion energy contributions in the title compound. Moreover, the DFT-optimized structure at the B3LYP/6-311G(d,p) level is compared with the experimentally determined mol­ecular structure in the solid state.

In the title mol­ecule, C21H23N3O3, the imidazolidine ring slightly deviates from planarity and the morpholine ring exhibits the chair conformation. In the crystal, N—H⋯O and C—H⋯O hydrogen bonds form helical chains of mol­ecules extending parallel to the c axis that are connected by C—H⋯π(ring) inter­actions. A Hirshfeld surface analysis reveals that the most important contributions for the crystal packing are from H⋯H (55.2%), H⋯C/C⋯H (22.6%) and H⋯O/O⋯H (20.5%) inter­actions. The volume of the crystal voids and the percentage of free space were calculated to be 236.78 Å3 and 12.71%, respectively. Evaluation of the electrostatic, dispersion and total energy frameworks indicates that the stabilization is dominated by the nearly equal electrostatic and dispersion energy contributions. The DFT-optimized mol­ecular structure at the B3LYP/6-311 G(d,p) level is compared with the experimentally determined mol­ecular structure in the solid state. Moreover, the HOMO–LUMO behaviour was elucidated to determine the energy gap.

The pyrazolo­pyrimidine moiety in the title mol­ecule, C13H12N4S, is planar with the methyl­sulfanyl substituent lying essentially in the same plane. The benzyl group is rotated well out of this plane by 73.64 (6)°, giving the mol­ecule an approximate L shape. In the crystal, C—H⋯π(ring) inter­actions and C—H⋯S hydrogen bonds form tubes extending along the a axis. Furthermore, there are π–π inter­actions between parallel phenyl rings with centroid-to-centroid distances of 3.8418 (12) Å. A Hirshfeld surface analysis of the crystal structure indicates that the most important contributions to the crystal packing are from H⋯H (47.0%), H⋯N/N⋯H (17.6%) and H⋯C/C⋯H (17.0%) inter­actions. The volume of the crystal voids and the percentage of free space were calculated to be 76.45 Å3 and 6.39%, showing that there is no large cavity in the crystal packing. Evaluation of the electrostatic, dispersion and total energy frameworks indicate that the cohesion of the crystal structure is dominated by the dispersion energy contributions.

The title mol­ecule, C25H23BrN2O2, adopts a cup shaped conformation with the distinctly ruffled imidazolidine ring as the base. In the crystal, weak C—H⋯O hydrogen bonds and C—H⋯π(ring) inter­actions form helical chains of mol­ecules extending along the b-axis direction that are linked by additional weak C—H⋯π(ring) inter­actions across inversion centres. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (51.0%), C⋯H/H⋯C (21.3%), Br⋯H/H⋯Br (12.8%) and O⋯H/H⋯O (12.4%) inter­actions. The volume of the crystal voids and the percentage of free space were calculated to be 251.24 Å3 and 11.71%, respectively, showing that there is no large cavity in the crystal packing. Evaluation of the electrostatic, dispersion and total energy frameworks indicate that the stabilization is dominated by the dispersion energy.

Using a 5 µm-diameter X-ray beam, we collected scanning X-ray microdiffraction in both the small-angle (SAXS) and the wide-angle (WAXS) regimes from thin sections of fixed human brain tissue from Alzheimer's subjects. The intensity of scattering in the SAXS regime of these patterns exhibits essentially no correlation with the observed intensity in the WAXS regime, indicating that the structures responsible for these two portions of the diffraction patterns, which reflect different length scales, are distinct. SAXS scattering exhibits a power-law behavior in which the log of intensity decreases linearly with the log of the scattering angle. The slope of the log–log curve is roughly proportional to the intensity in the SAXS regime and, surprisingly, inversely proportional to the intensity in the WAXS regime. We interpret these observations as being due to the presence of sub-micrometre-sized voids formed during dehydration of the fixed tissue. The SAXS intensity is due largely to scattering from these voids, while the WAXS intensity derives from the secondary structures of macromolecular material surrounding the voids. The ability to detect and map the presence of voids within thin sections of fixed tissue has the potential to provide novel information on the degradation of human brain tissue in neurodegenerative diseases.

The Alabama Court of Civil Appeals ruled that a circuit court lacked jurisdiction over a worker’s claim for compensation for a work-related injury and that an individual member of the…

With his command of the tournament slipping away, Matsuyama rolled in a 25-foot birdie putt on the 17th hole to regain the lead and then hit two shots as precise as any he hit all day for one last birdie to win a wild PGA Tour postseason opener at the FedEx St. Jude Championship.

The ruling comes just over three months after a Denver Post investigation found Pueblo municipal judges routinely used contempt of court charges to inflate jail sentences for defendants facing low-level charges that carried little to no jail time.

By-elections were seen as an indicator of the two main parties' prospects at a time when voters are struggling with high inflation, strikes and rising mortgage rates.

Curious about Tim Hardaway Jr.‘s condition following his recent on-court injury? As fans discuss the Detroit Pistons’ nail-biting NBA Cup opener against the Miami Heat, many are also concerned about Hardaway’s recovery and when he might return to the lineup. Here’s a quick look at Tim Hardaway’s injury, recovery, and its impact on the Pistons. […]

The post Pistons’ Tim Hardaway Avoids Serious Injury After Head Collision appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

Deepika on Instagram shared a picture of her daugther's feet and wrote Dua Padukone Singh. 'Dua': meaning a Prayer. Because She is the Answer to our Prayers, our hearts are filled with Love & Gratitude. Deepika & Ranveer."

Berlin ; Boston : De Gruyter, [2023]

November natural gas futures were trading at ₹254.50 on MCX during the initial hour of trading on Monday against the previous close of ₹258.20, down by 1.43 per cent

Analysis of the operation of a novel, micro-scale anaerobic digester has shown that this technology could provide a useful means of processing food waste in urban areas. The study found that the digester, located in London and fed mainly with local food waste, avoided 3.9 tonnes of greenhouse gas emissions, while providing biogas for cooking, heat and power. Anaerobic digestion on this scale could play a part in reducing the amount of food waste that goes to landfill1 and contribute to the circular economy.

An audio drama inspired by Reveal’s investigation into a deadly explosion at a Mississippi shipyard, produced by our partners at StoryWorks, a documentary theater company.

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A Narrogin man, who admitted to indecent dealing with his underage stepdaughter, has avoided an immediate jail term.

A Dubbo man is handed a community correction order and community service after pleading guilty to animal cruelty following his appearance in a video of an emu being plucked.

Yida Benny Xiong ripped off two female foreign investors in excess of $300,000 in a property scam that was used to fund his luxurious lifestyle, an Adelaide court hears.

A 24-year-old Kalgoorlie woman who crashed into an old courthouse building and fled the scene has avoided jail for reckless driving, telling a Magistrate she had "poor recollection" of the incident after hitting her head.

A man who assaulted a South Australian paramedic while she attempted to help him while he was having a mental episode has avoided jail time.

A former Australian Federal Police employee who messaged his partner's 11-year-old daughter over Instagram in order to groom her into having sex with him, avoids jail.

Canberra star Josh Papalii avoids suspension to be cleared for the NRL season decider, as the Raiders look to win their first premiership since their glory days 25 years ago.

After pleading guilty to drug possession and admitting he uses steroids, Afghanistan veteran and former Invictus Games competitor Tyrone Gawthorne is handed a suspended sentence for steroid and cocaine possession.

Convicted Bali Nine drug smuggler, Renae Lawrence, has avoided a prison sentence for stealing a car and leading police on a high-speed car chase in 2005.

Nigeria’s apex court, the Supreme Court has voided the conviction and 12-year prison sentence handed down to former governor of Abia State, Orji Uzor Kalu. An Appeal Court had found Orji Uzor guilty of corruption and embezzlement and he was sent to 12 years in prison. More details shortly…

The post Supreme Court voids Orji Kalu’s 12-year sentence appeared first on Hallmarknews.

Human adenoviruses have many attractive features for gene therapy applications. However, the high prevalence of preexisting immunity against these viruses in general populations worldwide has greatly limited their clinical utility. In addition, the most commonly used human adenovirus, human adenovirus subgroup C serotype 5 (HAd5), when systemically administered, triggers systemic inflammation and toxicity, with the liver being the most severely affected organ. Here, we evaluated the utility and safety of a new low-seroprevalence gorilla adenovirus (GAd; GC46) as a gene transfer vector in mice. Biodistribution studies revealed that systemically administered GAd had a selective and robust lung endothelial cell (EC) tropism with minimal vector expression throughout many other organs and tissues. Administration of a high dose of GAd accomplished extensive transgene expression in the lung yet elicited no detectable inflammatory histopathology in this organ. Furthermore, GAd, unlike HAd5, did not exhibit hepatotropism or induce liver inflammatory toxicity in mice, demonstrating the exceptional safety profile of the vector vis-à-vis systemic utility. We further demonstrated that the GAd capsid fiber shared the flexibility of the HAd5 equivalent for permitting genetic modification; GAd with the pan-EC-targeting ligand myeloid cell-binding peptide (MBP) incorporated in the capsid displayed a reduced lung tropism and efficiently retargeted gene expression to vascular beds in other organs.

IMPORTANCE In the aggregate, our mouse studies suggest that GAd is a promising gene therapy vector that utilizes lung ECs as a source of therapeutic payload production and a highly desirable toxicity profile. Further genetic engineering of the GAd capsid holds the promise of in vivo vector tropism modification and targeting.

Comedy sketch also saw Stephen Fry reprise one of his most famous Blackadder characters

Germany's leadership, history help stave off catastrophe from the coronavirus crisis — so far

US car rental group backed by billionaire Carl Icahn extends crucial payment deadline

The 24-year-old Australian was given a six-month probation period and faces a lengthy suspension if he doesn't promise to be on his best behaviour for six months.

The 21-year-old makeup mogul stopped in her tracks when she saw the singer who recently took to Twitter to bash Travis Scott and their baby girl Stormi after the release of his album Astroworld.

WILL KELLEHER: Ken Owens might have avoided a suspension thanks to his wife, joked Warren Gatland. The Wales hooker was yellow-carded for a tip-tackle of Fiji No 8 Viliame Mata.

Shane Andrew Whitall, 28, was ordered to serve an intensive correction order (ICO) and attend a rehab centre after being found guilty of reckless and dangerous driving.

Vera Zinger, 23, was pulled over by police in Barangaroo near Sydney's CBD, on November 29 where officers allegedly found four bags containing 2kg worth of drugs and $2,150 in cash.

Labour's John McDonnell has accused Prime Minister Boris Johnson of 'running scared' after he refused to take part in a one-on-one interview with the BBC's Andrew Neil.

A Sydney accountant who used a corkscrew to poke a Tony Abbott supporter has avoided jail time. 

Disciplinary chiefs handed immigration law specialist Rashid Ahmed just a three-month suspension after he left his junior colleague covered in blood on the ground on King's Road in Chelsea.

The Project's Peter Helliar, 42, avoids discussing PMS symptoms with his co-hosts, in hilarious segment on Tuesday's program.

The Lonely Together singer, 29, gave her latest photoshoot as she posed against the backdrop of the Atlantic Ocean.

Ted Cruz avoided speaking with his freshman year roommate Craig Mazin at their Princeton reunion this weekend.

Margot looked fantastic on the red carpet in Rome with co-star Leonardo DiCaprio, but the moment she started moving, she discovered why normal women don't wear such flimsy dresses.

The Little Mix singer risked a wardrobe malfunction on Sunday as she cosied up to the camera for an Instagram snap while wearing a low cut bustier.

CHRIS STOCKS IN JOHANNESBURG: Ben Stokes has avoided a ban for swearing at a fan against South Africa after accepting a charge for uttering an 'audible obscenity'.

Wealthy businessman James Froomberg, 63, who lives in a five-bedroom detached house in Edgware, North London, admitted three charges of making the indecent images.