Aim/Purpose: This study examines the impact of transitioning from in-person classrooms to remote online business education and provides analysis of key factors impacting course and instructor ratings as well as strategies for higher education institutions to provide engaging instruction. Background: “Zoom”ing into teaching and moving out of traditional classrooms during the COVID-19 pandemic has been a path full of twists and has impacted student perceptions of courses as well as instructors. One challenge has been to make the quality of synchronous online instruction perceived by students as positive as classroom-delivered ones. Methodology: We analyze primary data collected in the course evaluation process from Business & Accounting students over six semesters between Fall 2019 to Spring 2022, covering pre-pandemic instruction in the classroom and the conversion to virtual instruction via Zoom. A total of 1782 observations for 38 courses were examined using mean comparison, regression and correlation analyses, and pairwise comparisons. Contribution: We provide insights from the evaluation of those instructors who were able to make their Zoom-delivered courses perceived by students as equivalent or better than room-delivered ones. Specifically, clear presentation, stimulating delivery, providing feedback and encouraging discussion were positively correlated with successful online classes. Findings: We find that there is a clear downward shift in course and instructor ratings as the change to synchronous online delivery was made. However, in the Spring of 2022, even though instructors and students were still not completely back in the classroom, both instructor and course ratings moved back closer to the pre-pandemic levels. The parameters associated with instructor ratings, such as providing feedback, clear presentations, stimulating sessions, and encouraging discussion, showed similar downward fluctuations. Also, aspects related to course content were affected by the transition to online modality, including training on critical thinking quantitative analysis, research and writing abilities, and overall usefulness of the content. Moore’s model of Transactional Distance helps explain these changes. Recommendations for Practitioners: We recommend that practitioners allow sufficient time for students and faculty to learn through online instruction delivery and supply training for both populations in adapting to learning in this delivery mode. Recommendation for Researchers: The disruption in higher education caused by COVID-19 has provided a wealth of information on the pluses and minuses of online delivery. Careful inspection of trends can help provide guidance to higher education leaders. Impact on Society: One of the many changes the COVID-19 pandemic brought was the opportunity to try alternate ways of connecting and learning. This study shows how this experience can be used to guide the future of higher education. Future Research: Further research is needed to explore the in-depth reactions of students and faculty to the switch from classroom to online delivery, to explore whether these findings can be more broadly applied to other subjects and other types of universities.

Aim/Purpose: In a world of rapidly expanding complexity and exponentially increasing data availability, IT-based knowledge management tools will be needed to manage and curate available information. This paper looks at a particular tool architecture that has been previously proposed: The Personal Knowledge Management System (PKMS). The specific focus is on how the proposed architecture conforms to design science principles that relate to how it is likely to evolve. Background: We first introduce some recent informing science and design science research frameworks, then examine how the PKMS architecture would conform to these. Methodology: The approach taken is conceptual analysis. Contribution: The analysis provides a clearer understanding of how the proposed PKMS would serve the diverse-client ambiguous-target (DCAT) informing scenario and how it could be expected to evolve. Findings: We demonstrate how the PKMS informing architecture can be characterized as a “social machine” that appears to conform to a number of principles that would facilitate its long-term evolution. Future Research: The example provided by the paper could serve as a model future research seeking to integrate design science and informing science in the study of IT artefacts.

If partnering with local firms is an intuitive strategy with which to mitigate uncertainty in foreign ventures, then why don't organizations always partner with local firms, especially in uncertain settings? We address this question by unbundling the effects of uncertainty in foreign ventures at the venture and country levels. We contend that, while both levels increase the need for partnering with local firms in foreign ventures, country-level uncertainty increases the difficulty of partnering with local firms and decreases the likelihood of such partnerships. We also posit that experiential learning helps firms manage the two types of uncertainty, and thereby reduces the need for partnering—yet, experience in the host country makes partnering more feasible and increases the likelihood of such partnerships. To test our hypotheses, we conceptualize the decision to partner with a local firm in a foreign venture as a multilayered decision, and model it accordingly. Using a global sample of venture capital investments made between 1984 and 2011, we find support for the distinct effects of venture- and country-level uncertainty as well as for corresponding levels of experiential learning. These findings have implications for the literature on cross-border venture capital investment and international business in general.

Organizational theorists are increasingly interested in the antecedents of terminating interorganizational relationships, but have paid little attention to the disruptive consequences of such terminations on future tie formation. To redress this imbalance, the present study focuses on how venture capital (VC) firms' withdrawals from VC syndicates are associated with their subsequent syndication over the 1985 through 2008 period. We argue that withdrawals disrupt the relationships of the withdrawing VC firms with the coinvestors and reduce the likelihood of them entering into subsequent exchange (relational consequences). Furthermore, public information on the withdrawals can undermine the withdrawing VC firm's reputation for reliability, making it a less desirable exchange partner overall (global reputational consequences). Finally, we find that abandoned coinvestors can spread negative, private information about the withdrawing firm, reducing its chances of syndication with their other network contacts (local reputational consequences). We also show that the global and local reputational consequences attenuate each other, due to redundancy in the content of information each provides. We discuss the implications of our theory for the research on network dynamics and reputation.

If what former ABC News journalist Mark Halperin said last month about there being a national mental health crisis in the event of a second Trump presidency, as a "deplorable" I want to ensure that my friends and relatives suffering from Trump Derangement Syndrome stay fully calm.

The 3rd International Conference on Biodiversity and the UN Millennium Development Goals will take place between October 29-31, 2014 in Aix-en-Provence, France. under the tematic title "Biodiversity and Food Security – From Trade-offs to Synergies".

The goal is to identify science-based solutions for global sustainability focusing on the issues of biodiversity and food security. Current ecological, economic and societal challenges for development require a holistic understanding of food security and environmental management: from this perspective, biodiversity can be seen as key to overcome trade-offs and to develop synergies between the food system and the conservation of landscapes, ecosystems, and species. The conference seeks to attract scientists from basic and applied research. It involves policy makers and other stakeholders concerned with biodiversity and food security themes who are interested in developing new solutions and strategies. It will connect researchers and stakeholders from natural sciences, social sciences, economics, humanities, technology and related fields.

http://biodiv2014.sciencesconf.org/

BURNED OUT  Burnout can occur for many reasons, and is common in certain professions, including the military, clergy, and healthcare. As a busy physician with young children, Dr. Saundra Dalton-Smith was a prime candidate. She remembers the day her chaotic life simply stopped her in her tracks: “So I did what any burned-out human would do after picking up the kids from day care. I set them in front of the TV with a snack, and I lay on the floor.” She remained there for quite a while. “The smile...

Computer vision syndrome, also referred to as digital eyestrain, encompasses a group of vision-related problems that result from prolonged computer, tablet, e-reader and smartphone use, according to the American Optometric Association.

Qumulex is a Fishers, Ind.-based provider of cloud-based video surveillance and access control solutions.

Workers, do you use the edge of the palm of your hand to grind, push or twist hard objects? If you do this often, you’re at risk of hypothenar hammer syndrome – a condition caused when blood flow to the fingers is reduced.

What is carpal tunnel syndrome, and where is the carpal tunnel? Mayo Clinic explains: The carpal tunnel is a narrow passageway located on the palm-side of your wrist that “protects a main nerve to your hand and the nine tendons that bend your fingers.” Carpal tunnel syndrome results from compressing this nerve, which produces “numbness, tingling and, eventually, hand weakness.”

Raynaud’s phenomenon – sometimes called Raynaud’s syndrome or disease – is a disorder of blood circulation in the fingers and toes (and less commonly in the ears and nose). The cause: Several.

Visitors to booth #BC9419 can sample several prototypes, including a delicious hot dog bite that features FFP’s performance and protection ingredient solutions, showcasing how easily they can achieve a fully clean label with maximum protection, and better texture and flavor.

Echo Antioxidant Water™ is simply water infused with hydrogen gas. Hydrogen serves as a powerful selective antioxidant. While other sources of antioxidants, like blueberries, may promote healthy oxidation on a low level, hydrogen selectively neutralizes cytotoxic free radicals, helping eliminate oxidative stress and inflammation.

Through this partnership, Shaw Sports Turf will showcase its innovative, differentiated products throughout the event spaces leading up to the 2024 national championship game, slated for January 8, 2023, at Houston’s NRG Stadium.

Vince Lowe, senior VP and general manager home specialty and flooring with Synchrony, talks through the high points on“The Future of Retail” report, reveals more about consumer shopping trends, how technology is shaping the shopping experience and where technology is heading in the next six years.

The structured pattern in warm and cool neutrals with unique accent colors provides a sophisticated look for workplace, retail, education, multifamily, and healthcare spaces

The vertical bagger has a compact machine layout for small footprint and good accessibility from all sides.

Journal of Intellectual Disabilities, Ahead of Print. This scoping review examined available scientific evidence according to the PRISMA-ScR guideline on the subject of treatment interventions by speech and language therapists of speech, language, and communication needs in people with Down syndrome. A literature search in PubMed, Embase, Cinahl, Cochrane, and Web of Science yielded 41 […]

The post Evidence-based decision-making in the treatment of speech, language, and communication disorders in Down syndrome; a scoping review was curated by information for practice.

Accurate reporting of outcomes is crucial for interpreting the results of randomized controlled trials (RCTs). However, selectively reporting outcomes in publications to achieve researchers’ anticipated result… Read the full article ›

The post Impact of selective reporting bias on stroke trials: potential compromise in evidence synthesis – A cross-sectional study was curated by information for practice.

On September 15, 2021, US Defense Secretary Lloyd Austin ordered all military personnel, Defense Department civilian officials and contractors to report any symptoms of Havana syndrome, a mysterious disease that affected US diplomatic missions in many countries around the world. Reference: The mysterious disease manifested itself for the first time in 2016 in Havana, Cuba, where it literally wiped out the staff of the US Embassy. The victims reported that at first they heard strange grinding and ringing sounds, and then they either lost consciousness, or began to experience severe migraines, dizziness and disorientation. The diplomatic mission had to be closed, and the personnel had to be repatriated. At least 59 Americans in Cuba and China have been screened or treated for the unknown illness. The total number of patients amounts to at least 130 people.

Alexander Solzhenitsyn, Dostoyevsky of 20th century, dies of heart failureAlexander Solzhenitsyn died in Moscow at age 89. President Dmitry Medvedev presented his condolences to writer’s wife and sons. Stepan Solzhenitsyn told The Associated Press his father died late Sunday of heart failure, but declined further comment. Solzhenitsyn's unflinching accounts of torment and survival in the Soviet Union's labor camps riveted his countrymen, whose secret history he exposed. They earned him 20 years of bitter exile, but international renown. And they inspired millions, perhaps, with the knowledge that one person's courage and integrity could, in the end, defeat the totalitarian machinery of an empire.

Formula 1 (F1) has been striving to become more environmentally friendly in recent years while still remaining relevant beyond the race track. The series has included more technology that is seen in street cars, such as small-displacement engines with turbos and hybridization. However, F1's CEO, Stefano Domenicali, has said in an interview with an Italian paper that the series will "never go electric." F1 sees synthetic fuels, also known as e-fuels, as the future of the series. These lab-created fuels are already in limited production but come with an extreme cost. However, this is not a problem for motorsport. F1's goal is to have e-fuels powering the grid by 2026 and then working towards finding a way to use them in passenger cars as combustion bans start to take effect in nations in the 2030s, just as F1 hopes to become carbon neutral.

(Time-resolved) macromolecular crystallography at the new ESRF-ID29 beamline is described.

A detailed structural characterization of the δ1-MnZn9.7 phase is presented.

A detailed structural analysis of the Zn-rich δ1-MnZn9.7 phase using single-crystal X-ray diffraction is presented. The δ1 phase has been synthesized by the high-temperature synthetic route. The structure crystallizes in space group P63/mmc (Pearson symbol hP556) with unit-cell parameters: a = b = 12.9051 (2) Å and c = 57.640 (1) Å. The 556 atoms are distributed over 52 Wyckoff positions in the hexagonal unit cell: seven ordered Mn sites, 37 ordered Zn sites and eight positionally disordered Zn sites. The structure predominantly consists of Frank–Kasper polyhedra (endohedral icosahedra Zn12 and icosioctahedron Zn16) and four distinct types of glue Zn atoms. The structure comprises a 127-atom supercluster (Mn13Zn114), a 38-atom extended Pearce cluster (Mn3Zn35), a 46-atom L-tetrahedron (Mn4Zn42), a Friauf polyhedron (Zn17), a disordered icosahedral cluster (MnZn12) and four glue Zn atoms. Positionally disordered Zn sites around an Mn site can be visualized as the superimposition of three differently oriented Zn12 icosahedra.

The synthesis of a chiral isothiourea, namely, (4aR,8aR)-3-phenyl-4a,5,6,7,8,8a-hexahydrobenzo[4,5]imidazo[2,1-b]thiazol-9-ium bromide, C15H17N2S+·Br−, with potential organocatalytic and anti-inflammatory activity is reported. The preparation of the heterocycle of interest was carried out in two high-yielding steps. The hydrobromide salt of the isothiourea of interest provided suitable crystals for X-ray diffraction analysis, the results of which are reported. Salient observations from this analysis are the near perpendicular arrangement of the phenyl ring and the mean plane of the heterocycle. This conformational characteristic may be relevant with regard the stereoselectivity induced by the chiral isothiourea in asymmetric reactions. Furthermore, evidence was found for the existence of an S...Br− halogen bond.

We report the structural characterization of a new quaternary telluride, Ba2Y0.87(1)Mn1.71(1)Te5, which was synthesized by the direct reaction of the elements inside a vacuum-sealed fused-silica tube. The quaternary phase is the first member of the Ba–M–Mn–Te system (M = Sc and Y). The composition and structure of the phase were elucidated using SEM–EDX (scanning electron microscopy–energy dispersive X-ray spectrometry) and single-crystal X-ray diffraction (SCXRD) studies. The title phase is nonstoichiometric and crystallizes in the monoclinic system (space group C2/m) having the refined unit-cell parameters a = 15.1466 (8), b = 4.5782 (3), c = 10.6060 (7) Å and β = 116.956 (2)°, with two formula units (Z = 2). The pseudo-two-dimensional crystal structure of Ba2Y0.87(1)Mn1.71(1)Te5 consists of distorted YTe6 octahedra and MnTe4 tetrahedra as the building blocks of the structure. The YTe6 octahedra are arranged to form infinite one-dimensional chains by sharing edges along the [010] direction. These chains are further connected to the MnTe4 tetrahedra along the c axis to create layered two-dimensional polyanionic [Y0.87(1)Mn1.71(1)Te5]4− units. The stuffing of Ba2+ cations in between the layers of [Y0.87(1)Mn1.71(1)Te5]4− anions brings the charge neutrality of the structure. Each Ba atom in the structure sits at the centre of a distorted monocapped trigonal prism-like polyhedron of seven Te atoms.

Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is the enzyme responsible for the first step of carbon dioxide (CO2) fixation in plants, which proceeds via the carboxylation of ribulose 1,5-biphosphate. Because of the enormous importance of this reaction in agriculture and the environment, there is considerable interest in the mechanism of fixation of CO2 by RuBisCO. Here, a serial synchrotron crystallography structure of spinach RuBisCO is reported at 2.3 Å resolution. This structure is consistent with earlier single-crystal X-ray structures of this enzyme and the results are a good starting point for a further push towards time-resolved serial synchrotron crystallography in order to better understand the mechanism of the reaction.

Crystallographic fragment screening has become a pivotal technique in structure-based drug design, particularly for bacterial targets with a crucial role in infectious disease mechanisms. The enzyme CdaA, which synthesizes an essential second messenger cyclic di-AMP (c-di-AMP) in many pathogenic bacteria, has emerged as a promising candidate for the development of novel antibiotics. To identify crystals suitable for fragment screening, CdaA enzymes from Streptococcus pneumoniae, Bacillus subtilis and Enterococcus faecium were purified and crystallized. Crystals of B. subtilis CdaA, which diffracted to the highest resolution of 1.1 Å, were used to perform the screening of 96 fragments, yielding data sets with resolutions spanning from 1.08 to 1.87 Å. A total of 24 structural hits across eight different sites were identified. Four fragments bind to regions that are highly conserved among pathogenic bacteria, specifically the active site (three fragments) and the dimerization interface (one fragment). The coordinates of the three active-site fragments were used to perform an in silico drug-repurposing screen using the OpenEye suite and the DrugBank database. This screen identified tenofovir, an approved drug, that is predicted to interact with the ATP-binding region of CdaA. Its inhibitory potential against pathogenic E. faecium CdaA has been confirmed by ITC measurements. These findings not only demonstrate the feasibility of this approach for identifying lead compounds for the design of novel antibacterial agents, but also pave the way for further fragment-based lead-optimization efforts targeting CdaA.

Guanosine 5'-monophosphate (GMP) synthetase (GuaA) catalyzes the last step of GMP synthesis in the purine nucleotide biosynthetic pathway. This enzyme catalyzes a reaction in which xanthine 5'-monophosphate (XMP) is converted to GMP in the presence of Gln and ATP through an adenyl-XMP intermediate. A structure of an XMP-bound form of GuaA from the domain Bacteria has not yet been determined. In this study, the crystal structure of an XMP-bound form of GuaA from the thermophilic bacterium Thermus thermophilus HB8 (TtGuaA) was determined at a resolution of 2.20 Å and that of an apo form of TtGuaA was determined at 2.10 Å resolution. TtGuaA forms a homodimer, and the monomer is composed of three domains, which is a typical structure for GuaA. Disordered regions in the crystal structure were obtained from the AlphaFold2-predicted model structure, and a model with substrates (Gln, XMP and ATP) was constructed for molecular-dynamics (MD) simulations. The structural fluctuations of the TtGuaA dimer as well as the interactions between the active-site residues were analyzed by MD simulations.

Fixed targets (`chips') offer efficient, high-throughput microcrystal delivery for serial crystallography at synchrotrons and X-ray free-electron lasers (XFELs). Within this family, sheet-on-sheet (SOS) chips offer noteworthy advantages in cost, adaptability, universality and ease of crystal loading. We describe our latest generation of SOS devices, which are now in active use at both synchrotrons and XFELs.

The correct determination of X-ray transmission at X-ray nanoprobes equipped with small beamstops for small- and wide-angle X-ray scattering collection is an unsolved problem with huge implications for data correction pipelines. We present a cost-effective solution to detect the transmission via the X-ray fluorescence of the beamstop with an avalanche photodiode.

The position- and time-resolved monitoring of a mechanochemical reaction using synchrotron powder X-ray diffraction revealed a position-independent increase rate of product in the jar of a shaker mill.

In the title compound, the tellurium(VI) and vanadium(V) atoms are statistically disordered over two of the ten metal-atom sites in the unprotonated [TeV9O28]5– heteropolyanion.