This couple's love affair was sparked by an innocent remark about mince pies during the interval of a show many years ago.

Firefighters have praised the "gutsy" efforts of police who helped them rescue an 18-month-old boy from a burning house in Rockhampton last night.

Rachel and Daniel Weeks are living on a national park in the middle of Bass Strait, embracing their isolation. But they feel like they are missing out on nothing during the COVID-19 crisis thanks to the crowds now on popular apps.

A judge jails a Melbourne couple for fraud, acknowledging their imprisonment will be difficult for their young daughters and the family members who will need to look after the girls while their parents are in jail.

After six weeks in lockdown and quarantine, a couple who contracted COVID-19 while on an Antarctic expedition have finally made it home.

With their kids peering over the neighbour's fence, a Melbourne couple forges ahead with wedding plans amid coronavirus restrictions.

A couple charged with the criminal neglect of their baby boy fails to explain what happened to the child who was taken to hospital "close to death", a court hears.

Running on a wedding day is normally a sign something has gone very wrong but not when you are running together, at a parkrun event.

Young, adventurous and enterprising couple Jess Davidson and Andy Hoffman quit their jobs to follow a dream more than a year ago.

Irish empty-nesters Derek and Jackie Edwards are living the dream on the other side of the world, working on farms for food and board in Australia.

A Tasmanian great-grandmother-to-be was shocked to discover she was forking out for private health services she didn't ask for and didn't need. But her insurer said it was simply a case of 'buyer beware'.

For Luke and Mary-Anne McNeven, participating in polocrosse takes serious dedication averaging a two-day, 1,700-kilometre journey for each competition during the season.

A Gippsland couple missing in Victoria's High Country since Monday has been found safe and well.

The deaths of Evan Fielder, 19, and his girlfriend Lauren Quabba, 16, in a head-on crash sends shockwaves through a Far North Queensland community.

The woman, 32, and man, 24, were reported missing in the Cairns area yesterday after they both failed to show up for work.

A Queensland couple have climbed the biggest sand dune in the Simpson Desert to get married at the world's most remote music festival.

It has been more than a century since anyone was married in a cultural union ceremony on the land of the Port Curtis Coral Coast people, but now a Queensland couple hopes their action will revive the tradition.

Tom never gave up hope that he would be reunited with the lost fiancee of his youth, diligently attending their graduate reunion every 10 years in the hopes Judith would be there.

You can't deny the chemistry in these new photos.

The artsy couple loves a mix of high-fashion and vintage.

An officer was shot and killed.

Revolutionario North African Tacos has become a food bank feeding Asian American and African American seniors and L.A.'s skid row.

The police showed up at their door after their photos were shared on Facebook

Netflix documentary "Circus of Books" looks at the strange history of this now-closed West Hollywood institution of gay culture.

Beong-Soo Kim and Bonnie Wongtrakool play cello and piano every weekend. For neighbors in lockdown, the music provides an escape, if only for an hour.

YOU might say the odds have always been stacked against age-gap relationships. The tut-tutters predict doom the moment they so much as sniff a union between May and December. "What does that old fool possibly think that beautiful damsel sees in him?" they ask. "How could that ancient crone believe that hunky young buck finds her attractive?"

YOU might say the odds have always been stacked against age-gap relationships. The tut-tutters predict doom the moment they so much as sniff a union between May and December. "What does that old fool possibly think that beautiful damsel sees in him?" they ask. "How could that ancient crone believe that hunky young buck finds her attractive?"

Police are investigating a house robbery in which a couple in Amanzimtoti, on the south coast of KwaZulu-Natal, believed to be in their 50s was stabbed.

Allostery exploits the conformational dynamics of enzymes by triggering a shift in population ensembles toward functionally distinct conformational or dynamic states. Allostery extensively regulates the activities of key enzymes within biosynthetic pathways to meet metabolic demand for their end products. Here, we have examined a critical enzyme, 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS), at the gateway to aromatic amino acid biosynthesis in Mycobacterium tuberculosis, which shows extremely complex dynamic allostery: three distinct aromatic amino acids jointly communicate occupancy to the active site via subtle changes in dynamics, enabling exquisite fine-tuning of delivery of these essential metabolites. Furthermore, this allosteric mechanism is co-opted by pathway branchpoint enzyme chorismate mutase upon complex formation. In this study, using statistical coupling analysis, site-directed mutagenesis, isothermal calorimetry, small-angle X-ray scattering, and X-ray crystallography analyses, we have pinpointed a critical node within the complex dynamic communication network responsible for this sophisticated allosteric machinery. Through a facile Gly to Pro substitution, we have altered backbone dynamics, completely severing the allosteric signal yet remarkably, generating a nonallosteric enzyme that retains full catalytic activity. We also identified a second residue of prime importance to the inter-enzyme communication with chorismate mutase. Our results reveal that highly complex dynamic allostery is surprisingly vulnerable and provide further insights into the intimate link between catalysis and allostery.

(Printed in Austria)

Antony Overstall, James McGree.

Source: Bayesian Analysis, Volume 15, Number 1, 103--131.

Abstract:
A Bayesian design is given by maximising an expected utility over a design space. The utility is chosen to represent the aim of the experiment and its expectation is taken with respect to all unknowns: responses, parameters and/or models. Although straightforward in principle, there are several challenges to finding Bayesian designs in practice. Firstly, the utility and expected utility are rarely available in closed form and require approximation. Secondly, the design space can be of high-dimensionality. In the case of intractable likelihood models, these problems are compounded by the fact that the likelihood function, whose evaluation is required to approximate the expected utility, is not available in closed form. A strategy is proposed to find Bayesian designs for intractable likelihood models. It relies on the development of an automatic, auxiliary modelling approach, using multivariate Gaussian process emulators, to approximate the likelihood function. This is then combined with a copula-based approach to approximate the marginal likelihood (a quantity commonly required to evaluate many utility functions). These approximations are demonstrated on examples of stochastic process models involving experimental aims of both parameter estimation and model comparison.

The pint-sized institution, which opened last year, is filled with 1,000 feline-themed knickknacks that journeyed with their owners from Ukraine

The story of two bored art lovers who found a way to "a-mouse" themselves

Justin Young and Justine Manuel in Kamloops, B.C., shaved off their eyebrows as extra incentive to stay home and avoid socializing.

A B.C. couple who shaved their eyebrows off in the spirit of forcing themselves to stay at home has tackled another isolation challenge — home haircuts. 

A search warrant executed by Hamilton police vice and drugs officers at an address in the city’s east end has resulted in the arrest of a couple and multiple charges, police said in a Friday release.

One of the country's most-loved couples returned to Channel 4 this week with Richard & Judy: Keep Reading And Carry On. The presenters talk to Georgia Humphreys about marriage, their love of books, and filming in lockdown.

Drs. William and Jean Lovrinic have made an estate commitment to Penn State that will establish a $100,000 scholarship fund at Penn State Hazleton.