OM Sweden's newest team members - a van and a trailer - bring new opportunities for sharing and recruiting.

Veterans face unique health challenges, and Penn State Health is committed to providing care respecting their experiences. Veterans/employees Mark and Julie Chesney advocate for awareness of those health needs.

A woman was left shocked when she was offered food at a BBQ only after there were some leftovers.

DOVER, DEL. (August 20, 2024) – The Division of Public Health (DPH) Office of Animal Welfare’s (OAW) Delaware Animal Services (DAS) announces the arrest of a man and woman after 20 dogs were rescued from a home in Bridgeville. Ray Anderson, age 42, and Melissa Layton, age 40, of Bridgeville were arraigned Aug. 15. DAS […]

A Bengaluru couple found themselves in legal trouble after they posted videos of their balcony garden on Facebook. The posts included images of plants later identified as ganja.

Hello everyone,

For my cross-coupled oscillator design, I have a problem with stability analysis. Based on my achieved results which are attached, where is my design problem?

Best,

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Title: Sex Lives Best When Couples Share Child Care Duties, Survey Shows
Category: Health News
Created: 8/23/2015 12:00:00 AM
Last Editorial Review: 8/24/2015 12:00:00 AM

Title: Couples At Risk During 'Divorce Season'
Category: Health News
Created: 8/21/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM

Title: Neighborhood May Affect a Couple's Odds of Conceiving
Category: Health News
Created: 8/3/2022 12:00:00 AM
Last Editorial Review: 8/3/2022 12:00:00 AM

Title: Vaginal or C-Section, Method of Childbirth Won't Affect a Couple's Sex Life Later
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Antifolates are important for chemotherapy in non–small cell lung cancer (NSCLC). They mainly rely on reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT) to enter cells. PCFT is supposed to be the dominant transporter of the two in tumors, as it operates optimally at acidic pH and has limited transport activity at physiological pH, whereas RFC operates optimally at neutral pH. In this study, we found RFC showed a slightly pH-dependent uptake of antifolates, with similar affinity values at pH 7.4 and 6.5. PCFT showed a highly pH-dependent uptake of antifolates, with an optimum pH of 6.0 for pemetrexed and 5.5 for methotrexate. The Michaelis-Menten constant (K_m) value of PCFT for pemetrexed at pH 7.4 was more than 10 times higher than that at pH 6.5. Interestingly, we found that antifolate accumulations mediated by PCFT at acidic pH were significantly affected by the efflux transporter, breast cancer resistance protein (BCRP). The highest pemetrexed concentration was observed at pH 7.0–7.4 after a 60-minute accumulation in PCFT-expressing cells, which was further evidenced by the cytotoxicity of pemetrexed, with the IC₅₀ value of pemetrexed at pH 7.4 being one-third of that at pH 6.5. In addition, the in vivo study indicated that increasing PCFT and RFC expression significantly enhanced the antitumor efficacy of pemetrexed despite the high expression of BCRP. These results suggest that both RFC and PCFT are important for antifolates accumulation in NSCLC, although there is an acidic microenvironment and high BCRP expression in tumors.

The class F of G protein-coupled receptors (GPCRs) consists of 10 Frizzleds (FZD_1–10) and Smoothened (SMO). FZDs bind and are activated by secreted lipoglycoproteins of the Wingless/Int-1 (WNT) family, and SMO is indirectly activated by the Hedgehog (Hh) family of morphogens acting on the transmembrane protein Patched. The advance of our understanding of FZDs and SMO as dynamic transmembrane receptors and molecular machines, which emerged during the past 14 years since the first-class F GPCR IUPHAR nomenclature report, justifies an update. This article focuses on the advances in molecular pharmacology and structural biology providing new mechanistic insight into ligand recognition, receptor activation mechanisms, signal initiation, and signal specification. Furthermore, class F GPCRs continue to develop as drug targets, and novel technologies and tools such as genetically encoded biosensors and CRISP/Cas9 edited cell systems have contributed to refined functional analysis of these receptors. Also, advances in crystal structure analysis and cryogenic electron microscopy contribute to the rapid development of our knowledge about structure-function relationships, providing a great starting point for drug development. Despite the progress, questions and challenges remain to fully understand the complexity of the WNT/FZD and Hh/SMO signaling systems.

The appointment of a political outsider like Musk could help Trump cut regulations and rein in government bureaucracy, even if the moves are unpopular

Ajai Kesavan’s The Odd Couple attempts to bring laughter and nostalgia to Bengaluru with a fresh take on Neil Simon’s beloved comedy about unlikely roommates

I have had a long-standing interest in South Africa, and in 1995 briefly contemplated moving there to work. The country had just had its first multi-racial election, and the great Nelson Mandela had been elected President. I was deeply curious to see, at first-hand, what the land and its people would make of their hard [...]

Shahid Kapoor and Kareena Kapoor were once the hottest love birds of Bollywood, but something went wrong in their relationship, leading them to part ways. However, before breaking-up, they had hit more headlines than any other couple in B-town. Notably, over their on-screen and off-screen kisses!

The edited image humorously captioned with "Pov: the one day you miss school," touched fans empathised with Dinesh's plight. Many of them hoped for Virat and Anushka's visit just for Dinesh.

On Saturday's episode co-founder of Infosys Narayana Murthy and his wife Sudha Murthy, Zomato CEO Deepinder Goyal and his wife Grecia Munoz graced the Kapil Sharma show. The couple delighted the viewers with their charming personalities and candid stories.

For many couples, the journey to happiness is evolving, and the traditional path of parenthood isn't the only route to fulfilment. Increasingly, couples are finding joy in a childfree lifestyle, embracing the freedom and possibilities it brings. Choosing to live without

Every good partnership has its highs and lows. Think of it like learning to dance. Sometimes you're in perfect sync, and at other times you stumble over each other's feet. It's all part of figuring out how to move together. Relationships

This is the couple's first child.

Namrata Thakker looks at Bigg Boss couples, who have been setting #RelationshipGoals.

What do *you* think?

Raashii goes gray... Kriti welcomes her birthday month... Neha celebrates her 'superhero'...

In partnership with Museum of London: London has long been a magnet for talent and investment, attracting the brightest minds from every corner of the globe. It is now Europe’s largest and most vibrant tech hub – but what is it about this drizzly grey metropolis that contributes to the astonishing success of migrant start-ups? In partnership with the Museum of London as part of their City Now City Future season, we look to Sadiq Khan, thriving migrant entrepreneurs, and global tech pioneers to understand what London’s got that nowhere else has – uncovering why being an outsider could be the key to disruptive innovations.