q AT#218 - Travel to the Marquesas Islands By pacific.amateurtraveler.com Published On :: Sat, 06 Feb 2010 15:00:00 +0000 The Amateur Traveler talks to Stefanie Michaels (better known as @AdventureGirl) about a recent trip to the Marquesas Islands which are near Tahiti (or part of Tahiti depending on who you ask). Stefanie sailed on the freighter Aranui from Tahiti out to these remote islands. She encountered a warm people living in a tropical paradise… with very nice cars and nowhere to drive. Full Article
q AT#293 - Travel to Northern Iraq By asia.amateurtraveler.com Published On :: Sat, 13 Aug 2011 14:00:00 +0000 The Amateur Traveler talks to Anil Polat who blogs under the name foxnomad about a recent trip to Northern Iraq. Anil is out to visit every country in the world which might lead him to visit a country before some others would deem it safe. Anil did not travel to the green zone but traveled in the Northern or Kurdish region of Iraq. Anil’s trip was made all the more interesting as he is ethnically Turkish. Says Anil: Honestly that was one of my concerns before going. I did not know how people would respond to me, if people would not like me being there. The whole idea of a Kurdistan in Northern Iraq is a very controversial topic in Turkey to say the least.And also I had some security and safety concerns just because of the location. However, people were very friendly to me and it was a much more normal experience than I was expecting. Full Article
q AT#300 - Travel to Quebec, Canada By canada.amateurtraveler.com Published On :: Sun, 23 Oct 2011 00:19:19 +0000 The Amateur Traveler talks to Ira Berstein again, this time about the Canadian Provence of Quebec. Ira suggests seeing both Montreal and Quebec City because of the contrasts in the two major cities in this French-speaking part of Canada.Ira would personally recommend spending more time in Montreal but would understand those who like Quebec city better. Montreal is an international city with more than just French and English influence, all of which add their influence to a lively restaurant scene. Montreal sits on the Saint Lawrence River and at the base on Mount Royal from which it derives its name.Quebec City is possibly the most European city in North America and one of the only walled cities. The city is so popular with American’s that we tried to capture it during both the Revolutionary War and the War of 1812. Le Chateau Frontenac dominates the Quebec skyline as it has for more than 100 years. Full Article
q AT#311 - Travel to Northern Queensland, Australia By australia.amateurtraveler.com Published On :: Sun, 15 Jan 2012 05:32:28 +0000 The Amateur Traveler talks to Dave Kerwin about his recent trip to Northern Queensland. Dave recommends 2 main stops on your trip: the Atherton Tablelands, Daintree National Park and the Great Barrier Reef. Full Article
q AT#353 - Travel to Queensland’s Sunshine Coast By australia.amateurtraveler.com Published On :: Sat, 22 Dec 2012 22:40:35 +0000 Hear about Queensland's Sunshine Coast north of Brisbane Australia from Annabel Candy. Long white sand beachs, hiking trails, a tropical zoo in the tropics. Full Article
q AT#392 - Trekking in Ecuador’s Quilotoa Loop By southamerica.amateurtraveler.com Published On :: Sat, 26 Oct 2013 12:30:00 +0000 Hear about trekking in Ecuador’s Quilotoa Loop as the Amateur Traveler talks to Kim Mance about her recent trip to that country. Kim spent 3 weeks in Ecuador including one week on the Quilotoa Loop. Full Article
q AT#393 - Travel to Arequipa, Peru By southamerica.amateurtraveler.com Published On :: Sat, 02 Nov 2013 18:06:39 +0000 Hear about travel to Arequipa, Peru as the Amateur Traveler talks to Sam from Indefinite Adventure. Arequipa is Peru’s second largest city after Lima. It is in the south, inland, west of Lake Titicaca and south of Cusco. Sam heard about Arequipa from other travelers and lived and worked there for a month as a temporary local. Full Article
q AT#401 - Travel to Vieques, Puerto Rico By caribbean.amateurtraveler.com Published On :: Sat, 04 Jan 2014 13:30:00 +0000 Hear about travel to the island of Vieques off Puerto Rico as the Amateur Traveler talks to Ira Winston from Philadelphia about his recent trip there. Vieques is an island thais 8 miles off the coast of Puerto Rico. Full Article
q AT#487 - Travel to Queens, New York By usa.amateurtraveler.com Published On :: Sun, 18 Oct 2015 12:16:10 +0000 Hear about travel to the borough of Queens in New York City as the Amateur Traveler talks to Brian Cicioni from imayroam.com about this less visited part of the city. Full Article
q AT#505 - Travel to Mozambique By africa.amateurtraveler.com Published On :: Sat, 05 Mar 2016 15:00:00 +0000 Hear about travel to Mozambique as the Amateur Traveler talks to Simon Lewis from TarvelConceptSolution.com about this long thin country in Southeastern Africa. Full Article
q AT#530 - Travel to Qatar By asia.amateurtraveler.com Published On :: Sat, 24 Sep 2016 14:30:00 +0000 Hear about travel to Qatar as the Amateur Traveler talks to Richard Parr from the Best In the World Podcast about this middle eastern country where he lived for 6 years. Full Article
q AT#583 - Travel to Albuquerque, New Mexico By usa.amateurtraveler.com Published On :: Sat, 18 Nov 2017 23:12:12 +0000 Hear about travel to Albuquerque as Chris Christensen, the Amateur Traveler himself, talks about his trip to Albuquerque during the Albuquerque Balloon Fiesta. Full Article
q AT#587 - Travel to Quebec By canada.amateurtraveler.com Published On :: Sat, 16 Dec 2017 15:00:00 +0000 Hear about travel to the province of Quebec as the Amateur Traveler talks to Margarita Ibbott from downshiftingpro.com about a 7-10 day Itinerary to Montreal, Quebec City and Quebec Maritime. Full Article
q AT#611 - Basque Spain By amateurtraveler.com Published On :: Sat, 16 Jun 2018 14:00:00 +0000 Hear about travel to the Basque Region of Spain as the Amateur Traveler talks to David Bumstead about his adopted country and region. Full Article
q AT#614 - Travel to Qingdao, China By amateurtraveler.com Published On :: Sat, 07 Jul 2018 14:00:00 +0000 Hear about travel to Qingdao as the Amateur Traveler talks to Joseph Weiner about travel to the coastal city in China. Full Article
q ‘The Squad’ Pushes for Huge Student Loan Cancellation in Next Relief Bill By www.westernjournal.com Published On :: Sat, 09 May 2020 17:34:14 +0000 Some House Democrats have decided that the COVID-19 pandemic is an appropriate time to implement a key plank of the campaign of former Democratic presidential candidate Sen. Bernie Sanders of Vermont. Reps. Ilhan Omar of Minnesota, Rashida Tlaib of Michigan, Alexandria Ocasio-Cortez of New York and Ayanna Pressley of Massachusetts — who make up the… The post ‘The Squad’ Pushes for Huge Student Loan Cancellation in Next Relief Bill appeared first on The Western Journal. Full Article News Alexandria Ocasio-Cortez Ayanna Pressley Democrat policy Education Ilhan Omar politics Rashida Tlaib student US News
q An Open Letter To American Corporations: It’s Good Business (and Smart Marketing) To Support Quality Journalism By feedproxy.google.com Published On :: Mon, 06 Apr 2020 15:32:15 +0000 “Outbreaks have sparked riots and propelled public-health innovations, prefigured revolutions and redrawn maps.” – The New Yorker, April 2020 “Nothing will be the same.” That’s the overwhelming takeaway I’ve heard from dozens of conversations I’ve had with C-suite leaders, physicians, policy experts and media professionals these past few weeks. When it comes to the business … Continue reading "An Open Letter To American Corporations: It’s Good Business (and Smart Marketing) To Support Quality Journalism" Full Article Internet Big Five Media/Tech Business Models The Conversation Economy branding brands journalism marketing media news
q America, Iraq and the Legacy of Ahmad Chalabi By feedproxy.google.com Published On :: Thu, 05 Nov 2015 14:08:49 EST Ahmad Chalabi helped lead the U.S. into war in Iraq, but if he ever had regrets about his role in the invasion, and the years of violence it unleashed, "he never voiced them to me," writes FRONTLINE correspondent Martin Smith. Full Article
q On Beat Fitness is a dance party disguised as a workout for any quarantine mood By feedproxy.google.com Published On :: Sat, 09 May 2020 15:00:00 +0000 Work(out) From Home is a weekly column where we review smart fitness machines and apps in the wake of the coronavirus outbreak. Thanks to technology, there are still plenty of ways to exercise if your gym is closed. Read more... On Beat Fitness $120 (annual) View Product The Good Super fun workouts • Classes grouped by mood • Equipment-free workout options • Growing library of classes The Bad Lack of workout history • Expensive subscription • Inability to filter search The Bottom Line On Beat Fitness offers a variety of classes that cater to both your taste in music and your mood for the day. Not only are the workouts fun and effective, but exercising to the beat of the music makes it a lot easier to follow along. ⚡ Mashable Score 4.75 😎 Cool Factor 4.5 📘Learning Curve 5.0 💪Performance 5.0 💵Bang for the Buck 4.0 More about Apps, Fitness, Beauty, Fitness App, and Workout From Home Full Article Apps Fitness Beauty Fitness App Workout From Home
q In quarantine, Thomas Dolby's kids turn dad's hit "Europa..." into "Corona..." By feedproxy.google.com Published On :: Fri, 08 May 2020 07:00:30 PDT A couple of days ago, Thomas Dolby posted this video to Twitter and YouTube of a track called "Corona and the Pirate Twins," a spoof of his 1982 hit, "Europa and the Pirate Twins." The song is credited to Dolby Kids. Thomas included the following note: "This is what my mischievous offspring have been getting up to during the Lockdown." Here is the original video for "Europa..." Bonus track: And here is Thomas Dolby doing a touching home solo version of his achingly beautiful "Screen Kiss" from 1984's Flat Earth. He did it as a tribute to Matthew Seligman, the celebrated bassist who recently died of COVID-19. Seligman played bass on Dolby's recordings, including Flat Earth, and also played for Bowie, Robyn Hitchcock, Peter Murphy, and countless others. He was also a member of the Soft Boys. Image: YouTube Read the rest Full Article Post pop music Shut In Sounds social distancing Thomas Dolby
q "Leopards ate my face" subreddit bans posts about coronavirus scoffers who later die of it By feedproxy.google.com Published On :: Fri, 08 May 2020 07:19:06 PDT The Leopards Ate My Face subreddit is dedicated to mocking people who thought the Republican party would hurt their enemies only to be surprised to find that it hurts them, too. Inspired by a tweet by Adrian Bott—'I never thought leopards would eat MY face,' sobs woman who voted for the Leopards Eating People's Faces Party—it has now banned posts about people who claimed Covid-19 was bullshit only to die of Covid-19. There are simply too many, and it's getting depressing. "We've seen a billion of them in the past two weeks and the vast majority of them don't fit the subreddit," writes moderator u/ROBOT_OF_WORLD. "People dying from their decisions isn't justice, karmic, or funny." Read the rest Full Article Post depressing rona
q Jupiter looks pretty angry in "lucky" infrared shot By feedproxy.google.com Published On :: Fri, 08 May 2020 07:47:42 PDT It took hundreds of exposures and a complex method of removing occlusions, but this "lucky" shot is the result: a depiction of the hot regions lurking under Jupiter's uppermost clouds. The picture was captured in infared by the Gemini North Telescope in Hawaii, and is one of the sharpest observations of the planet ever made from the ground. To achieve the resolution, scientists used a technique called "lucky imaging" which scrubs out the blurring effect of looking through Earth's turbulent atmosphere. This method involves acquiring multiple exposures of the target and only keeping those segments of an image where that turbulence is at a minimum. Read the rest Full Article Post Space
q Soap promises to make you smell like "Naval Supremacy" By feedproxy.google.com Published On :: Fri, 08 May 2020 08:04:35 PDT Ironic toxic masculinity is in fashion! The Duke Cannon Naval Supremacy Big Brick of Bar Soap for Men [Amazon] promises that those thusly-soaped will smell of "naval supremacy", "productivity" or other humorously-abstract scents. (More traditionally "manly" odors such as tobacco, leather, burned vegetation, etc. are also available). The veil of humor is threadbare -- "get clean and smell good without using feminine shower gels and accessories" -- but I'll admit that I do bathe in warm turpentine and it really helps. Are you ready for images of the best “soap but for MEN” product you’ve ever seen? pic.twitter.com/kVAWb57UlF — Shayna Moon, Unity Lich (@qorquiq) May 8, 2020 UPDATE: Here's a balding treatment called "Lethal Uprising", spotted by Greg Sideyr. I'll see your Naval Supremacy, and raise you pic.twitter.com/UJE9wxeRvp — ????Greg | Applied Eschatology ???? (@Greg_Sideyr) May 8, 2020 Looking forward to Internecine Violence Toothpaste, Shambolic Venezeulan Coup Ice Cream, and Silently Endure Prison Abuse Hemmorhoid Cream with Aloe Vera. Read the rest Full Article Post self care
q Watch this Klingon perform "Somewhere Over the Rainbow" in her native tongue By feedproxy.google.com Published On :: Fri, 08 May 2020 08:20:32 PDT Jennifer Usellis-Mackay, aka the Klingon Pop Warrior, sings "Somewhere Over the Rainbow" in her native tongue. The performance took place in 2015 at Chicago's iO Theater. From the video description: Opening for Improvised Star Trek, I sang a new (old) song. Got some newly translated words the day of the performance... enjoy this little slice of nerdiness... or don't. Vocals - The Klingon Pop Warrior (Jennifer Usellis-Mackay) Guitar - The Red Shirt (Joe Mizzi) Translation - Admiral qurgh (Christopher Lipscombe) Video - Eric Scull (via r/ObscureMedia) Read the rest Full Article Video music star trek trekkers
q The "psychobiome" is bacteria in your gut that affects how you think and act By feedproxy.google.com Published On :: Fri, 08 May 2020 09:50:34 PDT An array of scientific evidence suggest that in some cases, the bacteria in your gut–your microbiome–could be tied to neurological and psychological disorders and differences, from anxiety and autism to Parkinson's and schizophrenia. The journal Science published a survey of the field and the Cambridge, Massachusetts start-up Holobiome that hopes to use insight into this "psychobiome" to develop treatments for depression, insomnia, and other conditions with a neurological side to them. From Science: For example, many people with irritable bowel syndrome are also depressed, people on the autism spectrum tend to have digestive problems, and people with Parkinson’s are prone to constipation. Researchers have also noticed an increase in depression in people taking antibiotics—but not antiviral or antifungal medications that leave gut bacteria unharmed. Last year, Jeroen Raes, a microbiologist at the Catholic University of Leuven, and colleagues analyzed the health records of two groups—one Belgian, one Dutch—of more then 1000 people participating in surveys of their types of gut bacteria. People with depression had deficits of the same two bacterial species, the authors reported in April 2019 in Nature Microbiology. Researchers see ways in which gut microbes could influence the brain. Some may secrete messenger molecules that travel though the blood to the brain. Other bacteria may stimulate the vagus nerve, which runs from the base of the brain to the organs in the abdomen. Bacterial molecules might relay signals to the vagus through recently discovered “neuropod” cells that sit in the lining of the gut, sensing its biochemical milieu, including microbial compounds. Read the rest Full Article Post biology brains medicine mental health microbiome neuroscience
q Colt Clark and the Quarantine Kids play "Come Together" By feedproxy.google.com Published On :: Fri, 08 May 2020 10:01:09 PDT A family in lockdown performs the Beatles' "Come Together." Read the rest Full Article Video beatles family
q Folks are getting creative with flyers in this quarantine By feedproxy.google.com Published On :: Sat, 09 May 2020 09:23:37 PDT My pal Jake has been taking regular "cigar walks" (as he calls them) here in our lovely island city of Alameda, California. On those walks, he started spotting some creative flyers... (I saved the best two for last...) photos by Jake Schaffer, used with permission Thanks, Susie! Read the rest Full Article Post Alameda california flyering flyers pop culture Save Ferris
q Quebec records 61 more COVID-19 deaths and 836 new confirmed cases By montreal.ctvnews.ca Published On :: Sat, 9 May 2020 11:13:00 -0600 Quebec public health officials announced Saturday that a total of 2,786 people have died from COVID-19 and there are now 36,986 confirmed cases. Full Article
q 10 Quick Link Building Tactics For Beginners By feedproxy.google.com Published On :: Mon, 27 Apr 2020 15:47:15 +0000 Link building, according to a lot of digital marketers, is a very old and very traditional digital marketing method. However, just because it’s all that antiquated doesn’t mean it’s useless. In fact, we may consider link building as one of the most timeless yet most effective digital marketing strategies out there. Link Building: A Quick […] The post 10 Quick Link Building Tactics For Beginners appeared first on Dumb Little Man. Full Article Business Freelancing
q Live Q&A on remote working, working from home, and running a business remotely By feedproxy.google.com Published On :: Wed, 25 Mar 2020 14:43:34 +0000 In this livesteam, David and I answer audience questions about how to work remotely. At Basecamp we’ve been working remotely for nearly 20 years, so we have a lot of experience to share. This nearly 2-hour video goes into great detail on a wide variety of topics. Highly recommended if you’re trying to figure out… keep reading Full Article Uncategorized
q Take Prof Regan's food quiz By www.bbc.co.uk Published On :: 2008-02-26T16:20:00 Part of the Food for thought promo for the BBC UK Homepage Full Article
q Video: "Broken Meetings (and how you'll fix them)" By feedproxy.google.com Published On :: Wed, 06 Oct 2010 19:40:08 +0000 A couple weeks ago, my pals at Twitter were kind enough to invite me in to visit with their (rapidly growing) team. The topic was meetings, so I used it as an opportunity to publicly premiere a talk I've been presenting to private clients over the past few months. I hope you'll enjoy, Broken Meetings (and how you'll fix them). Slides: Supplementary links and commentary forthcoming, but I wanted to go ahead and post the talk as quickly as the video was available. Special thanks to Michelle, Jeremy, and the crackerjack Twitter crew for a swell afternoon. I really like this talk and sincerely hope you will find it useful in helping to un-break your own meetings. ”Video: "Broken Meetings (and how you'll fix them)"” was written by Merlin Mann for 43Folders.com and was originally posted on October 06, 2010. Except as noted, it's ©2010 Merlin Mann and licensed for reuse under CC BY-NC-ND 3.0. "Why a footer?" Full Article Meetings Merlin Speaking Twitter Videos world of work
q "Back to Work" - Merlin's New Thing with Dan Benjamin at 5by5.tv By feedproxy.google.com Published On :: Tue, 18 Jan 2011 16:15:15 +0000 [update 2011-01-18 @ 16:07:40: We're up!] 5by5 Live Before Christ was a corporal, Dan Benjamin was already a bit of a hero to me. Since the early aughts–long before his insanely great 5by5.tv podcast network–Dan’s Hivelogic Enkoder was saving us millions of spam messages. His thoughtful tutorials on OS X (including unmissable advice on doing sane installs of MySQL and Rails, among others) are among the best on the web. His CSS has been widely stolen and reused without acknowledgment by thieves as diverse as other people and me. And his polymath posts on everything from Buddhism to The Paleo Diet to how to record a “Double-ender” have shown a charming combination of curiosity and empathy that, amongst numerous other reasons, clearly makes Dan a better human than me. A propos of nothing, Dan’s also the guy who conducted one of (mp3) the three best interviews with me in which it’s been my good fortune to participate.1 Today, I’m honored to say that Dan and I are starting a thing together. If it suits you, drop by 5by5.tv/live in about 35 minutes–at Noon Eastern/9am Pacific–to find out what we’re up to. I think it might be good. I’ll just say I’m as excited about this as I’ve been about any new project I’ve started in the past year or so. Anyway. You can judge for yourself. Whether you can tolerate me or otherwise, definitely do not miss the work Dan’s doing at 5by5. Because it really is outstanding and very polished stuff. As for our thing? My own goal, to paraphrase a bit from that interview with Dan, is to help you get excited, get better–and then?–Back to Work. More soon. Thanks. Favorite interviews. Just for the sake of completion, my all-time favorite interview was conducted by Colin Marshall for The Marketplace of Ideas (mp3); Dan’s “The Pipeline” eppy with me was a close second; and David and Katie’s recent nerderrific interview on my Mac workflow (mp3) on Mac Power Users has turned out to be a lot of peoples’ favorite thing I’ve done in years (love LOVE David’s stuff). ↩ And...we're up Back to Work | Ep.#1: Alligator in the Bathroom Download MP3 of "'Back to Work,' Ep. 1" In the inaugural episode of Back to Work, Merlin Mann and Dan Benjamin discuss why they’re doing this show, getting back to work instead of buying berets, the lizard brain, and compare the Shadow of the Mouse to San Francisco, and eventually get to some practical tips for removing friction. It's a start. Sexy Audio RSS Feed Sexy Subscription via iTunes Episode Links Welcome to BrettTerpstra.com, home of Brett Terpstra and his nerdery carlhuda/janus – GitHub practically efficient — technology, workflows, life MacSparky – Blog The Brooks Review And now it’s all this Dan Rodney’s List of Mac OS X Keyboard Shortcuts & Keystrokes 43f Podcast: John Gruber & Merlin Mann’s Blogging Panel at SxSW | 43 Folders waffle software · ThisService One Thing Well html2text: THE ASCIINATOR (aka html2txt) The Conversation #27: Missionless Statements – 5by5 ”"Back to Work" - Merlin's New Thing with Dan Benjamin at 5by5.tv” was written by Merlin Mann for 43Folders.com and was originally posted on January 18, 2011. Except as noted, it's ©2010 Merlin Mann and licensed for reuse under CC BY-NC-ND 3.0. "Why a footer?" Full Article hacer pimping Podcasts
q 'Quaranscream': Wine spritzer company opens Mother's Day venting hotline By www.ctvnews.ca Published On :: Sat, 9 May 2020 08:12:00 -0600 A beverage company in the U.S. is inviting moms to let out a ‘quaranscream’ this Mother’s Day on a designated ‘zero-judgement venting hotline’ for a chance to win its wine spritzers. Full Article
q A comprehensive evaluation of a typical plant telomeric G-quadruplex (G4) DNA reveals the dynamics of G4 formation, rearrangement, and unfolding [Plant Biology] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Telomeres are specific nucleoprotein structures that are located at the ends of linear eukaryotic chromosomes and play crucial roles in genomic stability. Telomere DNA consists of simple repeats of a short G-rich sequence: TTAGGG in mammals and TTTAGGG in most plants. In recent years, the mammalian telomeric G-rich repeats have been shown to form G-quadruplex (G4) structures, which are crucial for modulating telomere functions. Surprisingly, even though plant telomeres are essential for plant growth, development, and environmental adaptions, only few reports exist on plant telomeric G4 DNA (pTG4). Here, using bulk and single-molecule assays, including CD spectroscopy, and single-molecule FRET approaches, we comprehensively characterized the structure and dynamics of a typical plant telomeric sequence, d[GGG(TTTAGGG)3]. We found that this sequence can fold into mixed G4s in potassium, including parallel and antiparallel structures. We also directly detected intermediate dynamic transitions, including G-hairpin, parallel G-triplex, and antiparallel G-triplex structures. Moreover, we observed that pTG4 is unfolded by the AtRecQ2 helicase but not by AtRecQ3. The results of our work shed light on our understanding about the existence, topological structures, stability, intermediates, unwinding, and functions of pTG4. Full Article
q The FKH domain in FOXP3 mRNA frequently contains mutations in hepatocellular carcinoma that influence the subcellular localization and functions of FOXP3 [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC. Full Article
q Heterotrimeric Gq proteins as therapeutic targets? [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Heterotrimeric G proteins are the core upstream elements that transduce and amplify the cellular signals from G protein–coupled receptors (GPCRs) to intracellular effectors. GPCRs are the largest family of membrane proteins encoded in the human genome and are the targets of about one-third of prescription medicines. However, to date, no single therapeutic agent exerts its effects via perturbing heterotrimeric G protein function, despite a plethora of evidence linking G protein malfunction to human disease. Several recent studies have brought to light that the Gq family–specific inhibitor FR900359 (FR) is unexpectedly efficacious in silencing the signaling of Gq oncoproteins, mutant Gq variants that mostly exist in the active state. These data not only raise the hope that researchers working in drug discovery may be able to potentially strike Gq oncoproteins from the list of undruggable targets, but also raise questions as to how FR achieves its therapeutic effect. Here, we place emphasis on these recent studies and explain why they expand our pharmacological armamentarium for targeting Gq protein oncogenes as well as broaden our mechanistic understanding of Gq protein oncogene function. We also highlight how this novel insight impacts the significance and utility of using G(q) proteins as targets in drug discovery efforts. Full Article
q N{alpha}-Acetylation of the virulence factor EsxA is required for mycobacterial cytosolic translocation and virulence [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-04-24T06:08:45-07:00 The Mycobacterium tuberculosis virulence factor EsxA and its chaperone EsxB are secreted as a heterodimer (EsxA:B) and are crucial for mycobacterial escape from phagosomes and cytosolic translocation. Current findings support the idea that for EsxA to interact with host membranes, EsxA must dissociate from EsxB at low pH. However, the molecular mechanism by which the EsxA:B heterodimer separates is not clear. In the present study, using liposome-leakage and cytotoxicity assays, LC-MS/MS–based proteomics, and CCF-4 FRET analysis, we obtained evidence that the Nα-acetylation of the Thr-2 residue on EsxA, a post-translational modification that is present in mycobacteria but absent in Escherichia coli, is required for the EsxA:B separation. Substitutions at Thr-2 that precluded Nα-acetylation inhibited the heterodimer separation and hence prevented EsxA from interacting with the host membrane, resulting in attenuated mycobacterial cytosolic translocation and virulence. Molecular dynamics simulations revealed that at low pH, the Nα-acetylated Thr-2 makes direct and frequent “bind-and-release” contacts with EsxB, which generates a force that pulls EsxB away from EsxA. In summary, our findings provide evidence that the Nα-acetylation at Thr-2 of EsxA facilitates dissociation of the EsxA:B heterodimer required for EsxA membrane permeabilization and mycobacterial cytosolic translocation and virulence. Full Article
q Zinc promotes liquid-liquid phase separation of tau protein [Protein Structure and Folding] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Tau is a microtubule-associated protein that plays a major role in Alzheimer's disease (AD) and other tauopathies. Recent reports indicate that, in the presence of crowding agents, tau can undergo liquid–liquid phase separation (LLPS), forming highly dynamic liquid droplets. Here, using recombinantly expressed proteins, turbidimetry, fluorescence microscopy imaging, and fluorescence recovery after photobleaching (FRAP) assays, we show that the divalent transition metal zinc strongly promotes this process, shifting the equilibrium phase boundary to lower protein or crowding agent concentrations. We observed no tau LLPS-promoting effect for any other divalent transition metal ions tested, including Mn2+, Fe2+, Co2+, Ni2+, and Cu2+. We also demonstrate that multiple zinc-binding sites on tau are involved in the LLPS-promoting effect and provide insights into the mechanism of this process. Zinc concentration is highly elevated in AD brains, and this metal ion is believed to be an important player in the pathogenesis of this disease. Thus, the present findings bring a new dimension to understanding the relationship between zinc homeostasis and the pathogenic process in AD and related neurodegenerative disorders. Full Article
q The Struggle for Reform in Iraq and Lebanon By feedproxy.google.com Published On :: Tue, 19 Nov 2019 16:45:01 +0000 Research Event 3 December 2019 - 9:30am to 10:45am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Renad Mansour, Research Fellow, Middle East and North Africa Programme, Chatham HouseAlia Moubayed, Managing Director, JefferiesChair: Lina Khatib, Head, Middle East and North Africa Programme, Chatham House Over recent weeks, widespread popular protests have engulfed Iraq and Lebanon. What began as calls for reform in the context of high unemployment and endemic corruption have evolved into direct challenges to the existing political order in both countries.In response, ruling elites have moved to protect the systems from which they draw power. In Iraq, the state has responded to protests with violence, killing more than 300 people and injuring over 15,000. In Lebanon, protesters are facing attempts at co-optation and intransigence by their leaders. These developments have served to underline the widening gap between elites and ordinary citizens and to highlight geopolitical tensions in the region that have contributed to both countries' woes.This event will delve into what is at stake for those mobilizing in Iraq and Lebanon. Speakers will discuss the obstacles to meaningful reform and possible routes out of the current crises.To attend this event, please e-mail Reni Zhelyazkova. Department/project Middle East and North Africa Programme Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
q Webinar – Analysis: Protests in Iraq and Lebanon By feedproxy.google.com Published On :: Tue, 26 Nov 2019 10:45:01 +0000 Invitation Only Research Event 3 December 2019 - 2:30pm to 3:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Dr Lina Khatib, Head, Middle East and North Africa Programme, Chatham HouseDr Renad Mansour, Research Fellow, Middle East and North Africa Programme, Chatham House Over recent weeks, widespread popular protests have engulfed Iraq and Lebanon. What began as calls for reform in the context of high unemployment and endemic corruption have evolved into direct challenges to the existing political order in both countries. How have the ruling elites responded to the popular uprisings? What do these developments mean for the future of the two countries and the region more broadly?Dr Lina Khatib and Dr Renad Mansour will discuss what is at stake for protesters and what are the obstacles to meaningful and sustainable reform in Iraq and Lebanon.Please note this webinar is for Middle East and North Africa Programme supporters only and will be taking place online. Department/project Middle East and North Africa Programme Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
q Iraq's Reconstruction: In Conversation with Governor of Anbar Ali Farhan Hamid By feedproxy.google.com Published On :: Mon, 09 Dec 2019 16:30:01 +0000 Invitation Only Research Event 18 December 2019 - 9:00am to 10:30am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Ali Farhan Hamid, Governor of Anbar ProvinceChair: Dr Renad Mansour, Senior Research Fellow, Middle East and North Africa Programme, Chatham House In the aftermath of the liberation from ISIS, the government of Iraq was left to count the cost of three years of brutal conflict, only the most recent phase in the ongoing cycle of conflict and stabilization that has plagued Iraq for 16 years. While reconstruction has been a focus of both the Iraqi government and international policymakers since 2003, billions of dollars in pledged funds have continually failed to reach the places they are most needed. At this roundtable, Ali Farhan Hamid will discuss the efforts of his provincial government to rebuild the cities and towns worst-hit by the conflict. He will provide insights into the practical and structural impediments to reconstruction efforts in both Anbar and neighbouring provinces such as Ninewah where the worst damage was sustained under ISIS but where little in the way of reconstruction has been achieved thereby leaving the door open to the potential resurgence of conflict.The roundtable is part of the Chatham House Iraq Initiative. Event attributes Chatham House Rule Department/project Middle East and North Africa Programme, Iraq Initiative Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
q Iraq in 2020 By feedproxy.google.com Published On :: Mon, 06 Jan 2020 16:45:01 +0000 Invitation Only Research Event 20 January 2020 - 4:00pm to 5:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Toby Dodge, Associate Fellow, Middle East and North Africa Programme, Chatham HouseAhmed Tabaqchali, Chief Investment Officer, AFC Iraq Fund; Senior Fellow, Institute of Regional & International StudiesBelkis Wille, Senior Iraq Researcher, Human Rights WatchChair: Renad Mansour, Senior Research Fellow, Middle East and North Africa Programme, Chatham House Following the tumultuous final months of 2019, the new year opened with a substantial threat to Iraq’s security and stability. The killing of Qassem Soleimani, commander of the Iranian Revolutionary Guards' Quds force, and Abu Mahdi al-Muhandis, deputy head of the Popular Mobilisation Forces threatens to reshape the country’s political environment, undermine the hard-fought gains of the international coalition against ISIS and to transform the country to a battleground once more in the conflict between the US and Iran. Meanwhile, the root causes of the protest movement remain, Iraq’s stunted economy continues to fester and reconstruction efforts in many of the areas worst-hit by the occupation of ISIS have stalled.At this roundtable, part of the Iraq Initiative project, experts will discuss the latest developments and posit what the likely escalation of conflict will mean for Iraq’s politics, society and economy in 2020.Attendance at this event is by invitation only. Event attributes Chatham House Rule Department/project Middle East and North Africa Programme, Iraq Initiative Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
q After Latest Turn, Is Muqtada al-Sadr Losing Influence in Iraq? By feedproxy.google.com Published On :: Wed, 12 Feb 2020 14:23:04 +0000 12 February 2020 Dr Renad Mansour Senior Research Fellow, Middle East and North Africa Programme; Project Director, Iraq Initiative @renadmansour Ben Robin-D'Cruz Researcher on Iraqi Politics, University of Edinburgh The populist cleric has repositioned himself in Iraqi politics multiple times, but his recent shift against youth-led protestors may signal his decline as an autonomous political force. 2020-02-12-Sadr.jpg Muqtada al-Sadr in Najaf in October. Photo: Getty Images. Following the US strike on Qassem Solaimani and Abu Mehdi al-Muhandis, populist cleric Muqtada al-Sadr has violently cracked down on youth-led protests in Iraq.His paramilitaries and ‘blue hats’ – supposedly created to protect protestors from state and allied parastatal security forces – sought to end the months-long demonstrations by attacking the places where protesters have camped since October. In Baghdad’s Tahrir Square, they successfully captured the famous Turkish restaurant which had become a symbol of Iraq’s ‘October revolution’. Once the champion of Iraq’s protest movement, Sadr has seemingly changed course and now leads the counter-protests. This reversal has mystified many, from Iraqis who saw Sadr as an ally in their struggle for reform against an impenetrable elite to foreign diplomats who hoped Sadr could help pushback against Iranian influence in Iraq. Yet this is not the first time that Sadr has drastically redefined his position. Since 2003, he has gone from Shia sectarian militia leader to pro-democracy reformist and Iraqi nationalist.And in the past few months, he has given mixed signals, both supporting and criticising the protesters. The most recent incidents of Sadrist violence targeting demonstrators provoked a societal backlash, prompting Sadr to change tack once more and announce that he would disband the blue hats and investigate their crimes against protesters.Sadr and the paramilitariesSadr’s latest change of course may seem to flow directly from the US assassination of Qassem Soleimani and Abu Mahdi al-Muhandis and the ensuing vacuum in the Shia paramilitary sphere. Prior to this move, the Sadrists were on the defensive, outflanked and outgunned by the growing coercive and political power of a constellation of Shia armed groups coalescing under Muhandis’s de facto leadership. Many of these groups competed for Sadr’s base, including Qais al-Khazali’s Asa’ib ahl al-Haq and Akram al-Kaabi’s Harakat Hezbollah al-Nujaba. With Muhandis out of the picture, Sadr could reclaim the space by pushing his own right hand, Kadhem al-Issawi (Abu Do’a), to be the new centre of the paramilitary field and forcing competitors, including Khaza’li and Kaabi, to rally around his leadership.Iran, in the short term, appears to be going along with this solution to bring more coherence to its allied forces in Iraq as it seeks to counter what it regards as US aggression. Iran also hopes that bringing Sadr back in will help neutralize the protest movement which threatens its stake in Iraqi politics. The most visible sign of this Iran-brokered rapprochement was the 13 January meeting in Qom attended by Sadr, Issawi and several senior militia commanders including Laith al-Khazali (Qais al-Khazali’s brother). Following the Qom meeting, a pattern of tit-for-tat violence and assassinations between the Sadrists’ Saraya al-Salam and Asa’ib Ahl al-Haq – ongoing since the start of the October protests in Iraq – ceased.A fragmented movement?However, while the US strikes certainly changed Sadr’s political calculations, there are more persistent fundamentals at work that help explain his change of course. The first of these relates to long-standing fragmentation within the movement. This exists not only within Sadrist paramilitaries, but within the movement’s clerical networks, and also applies to the ties that bind the Sadrist leadership to its popular base. This fragmentation makes it difficult for Sadr to impose a coherent politics on his followers from the top down.There are signs that Sadr’s recent shift in position has exacerbated this fragmentation. His attempt to reposition the movement’s base within the ‘resistance axis’ that supports the Shia militias in Iraq has only been partially successful. On 24 January, responding to the US assassinations, Sadr called for a million-man march focused on expelling US forces from Iraq. However, turnout was poor, especially given the huge logistical support for the march, and it lasted only a few hours.Equally revealing, when Sadr called on his supporters to vacate the squares, many refused. One Sadrist protester in Baghdad’s Tahrir Square told the authors: ‘We’ve been camping with our brothers and sisters for four months. Why should we leave them to die?’Meanwhile, fissures have also opened up within the Sadrists’ clerical elite. One senior Sadrist cleric, for example, is openly defying Sadr’s authority and siding with the revolutionaries in Nasiriyah. Sadr’s attempt to dominate the paramilitary sphere is also unlikely to prove any more successful than his many previous failed attempts since 2003. He is neither trusted nor respected by the leaders of other groups. The Iran-brokered rapprochement is already showing signs of weakness. Two recent assassinations of Saraya al-Salam leaders in Basra and Maysan indicate a potential renewal of power struggles between the Sadrist militia and Asa’ib Ahl al-Haq. Sadr is not a revolutionarySadr has never been a revolutionary, but someone who seeks to leverage a role as both ‘spoiler’ and ‘stabilizer’ to maximise his political leverage. This strategy is ultimately oriented towards sustaining Iraq’s extant political system, not its overthrow. Forced to choose between the roles of revolutionary or maintainer of the status quo, he has opted for the latter. The protests that erupted in 2019 were not the same movement that Sadr led from 2015. The 2015 protests were an elite-driven phenomenon, integrated into the political field and carefully calibrated to exert pressure on the elite towards gradual reform. By contrast, the 2019 demonstrations spring from a youth-led, bottom-up mobilization that rejects politicization and seeks a more radical form of change. Chatham House surveys in a forthcoming paper reveal that the protesters are younger that those who protested in 2015-16. Fewer have permanent employment. Instead of demanding better services or jobs, they are focusing wholesale transformation of the post-2003 political system.A Sadrist official told the authors that their movement initially joined the protests in October 2019 expecting a similar reform-orientation to the protests which Sadr had previously led. However, according to him, the protesters failed to come forward with reasonable demands or alternative names for prime minister. He believed the protests would fade, and many would regret the ‘wasted time and blood’. Sadr’s relations with IranA final long-term factor at play is Sadr’s receding autonomy from Iran. Ever since his movement’s electoral victory in May 2018, Sadr came under enormous pressure to reconcile with the political wing of the Iranian-allied parastatal armed groups in the formation of a new government acceptable to Iran.Over the last year, Sadr has moved even closer to Iran, spending more time in Qom. Iran has offered Sadr security from his paramilitary rivals (such as Asa’ib ahl al-Haq), convincing Sadr that he is safer in Iran than Iraq. Moreover, Sadr is undertaking religious training in Qom, and may see this as a chance to enhance his standing in the Shia religious field as many look towards a future beyond the elderly Najaf-based marja Ali al-Sistani.By keeping Sadr in Qom, Iran appears to be trying to isolate him from what they regard as negative influences. As tensions between the Sadrists and other protest groups intensified, efforts were made by some protest leaders and allied political groups to reach Sadr in Qom and try to persuade him to change course or restrain the worst abuses of his forces. However, this delegation was unable to make contact with Sadr. Those involved told the authors they have resorted to communicating with local Sadrist leaders in Najaf, Babil, Basra and Baghdad. Crossing a lineThis is a transformative moment for the Sadrists. Sadr is now defying the popular sentiments driving protests across central and southern Iraq. The sense of betrayal among former allies and friends of the Sadrists is palpable. One senior activist involved in cooperation with the Sadrists wrote that, no matter what moves Sadr makes next, the cleric has ‘terminated all partnership with the protesters,’ and ‘shattered the framework for cooperation’. A line has thus been crossed that Sadr cannot reverse; he will not be able to recover what he has now lost. Iran, also, does not see Sadr as a dependable ally, and will look to isolate and side-line the cleric when the opportunity arises. Thus, in seeking to exploit a crisis for short-term gain, Sadr may well have sealed his fate – in the long term – as a declining force in Iraqi politics. Full Article
q Conflict and the Water Crisis in Iraq By feedproxy.google.com Published On :: Mon, 24 Feb 2020 13:15:01 +0000 Invitation Only Research Event 9 March 2020 - 9:00am to 10:30am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Dr Azzam Alwash, Founder & CEO, Nature IraqPeter Schwartzstein, Independent Journalist; Non-Resident Fellow, Centre for Climate SecurityDiscussant: Dr Jehan Baban, Founder & President, The Iraqi Environment and Health Society-UKChair: Dr Glada Lahn, Senior Research Fellow, Energy, Environment and Resources Department, Chatham House Water is a critical issue for Iraq’s future stability and prosperity. Only a few decades ago, the country was one of the most fertile in the region, with two major rivers flowing through it. Today, national and transboundary pollution, mismanagement, and debilitating cycles of conflict have contributed to a situation where only half of current water needs are being met, and where an 80% reduction in the flow of water down the Tigris and Euphrates rivers has led to the loss of millions of acres of formerly productive land and the displacement of rural communities.Water scarcity can be a driver of violence and conflict. Tribal conflicts over water sources have erupted sporadically in the south and the contamination of municipal water which led to the hospitalization of some 118,000 citizens was a trigger for the large-scale protests in Basra in late 2018. Without concerted action by national and local governments, companies and international agencies, the situation will only worsen as higher temperatures and reduced rainfall drive rural-to-urban migration and increase the risk of drought, food insecurity and water-related diseases.At this roundtable, part of the Chatham House Iraq Initiative, experts will discuss the domestic, regional and international factors that continue to exacerbate the water crisis in Iraq, and propose solutions, including technical innovation, public sector capacity-building and greater international cooperation, that might contribute to effective state-building, build resilience to the effects of climate change and reduce the risk of further conflict. Event attributes Chatham House Rule Department/project Middle East and North Africa Programme, Iraq Initiative Georgia Cooke Project Manager, Middle East and North Africa Programme +44 (0)20 7957 5740 Email Full Article
q Virtual Roundtable: Iraq in Uncertain Times By feedproxy.google.com Published On :: Thu, 26 Mar 2020 10:40:01 +0000 Invitation Only Research Event 30 March 2020 - 2:00pm to 3:30pm Event participants Toby Dodge, Associate Fellow, MENA Programme, Chatham HouseMac Skelton, Director, IRIS, American University of Iraq-SulaimaniAhmed Tabaqchali, Chief Investment Officer, AFC Iraq FundHanaa Edwar, Co-founder and Chairperson, Iraqi Al-Amal AssociationChair: Renad Mansour, Senior Research Fellow, MENA Programme, Chatham House The first months of 2020 have proven tumultuous for Iraq. The US killing of Iranian General Qassem Soleimani in January threatened to engulf the region in war and led to continued tit-for-tat violence between the US and Iran that has become almost a daily reality in Baghdad.Amid the ongoing protests that since last October have challenged the social contract and led to a violent response claiming 600 deaths and injuring tens of thousands, the government is still without a prime minister after Adil abd al-Mehdi's resignation in November 2019, leaving the country directionless.Most recently, the spread of COVID-19 threatens to expose a mismanaged healthcare system. At the same time, the rapid fall in the price of oil has impacted the government's ability to respond to or cope with these crises.At this virtual roundtable, part of the Chatham House Iraq Initiative, experts explore these developments and try to unpack the implications for Iraq’s fragile peace and stability. Department/project Middle East and North Africa Programme, Iraq Initiative Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
q COVID 19: Assessing Vulnerabilities and Impacts on Iraq By feedproxy.google.com Published On :: Tue, 07 Apr 2020 14:33:01 +0000 7 April 2020 Dr Renad Mansour Senior Research Fellow, Middle East and North Africa Programme; Project Director, Iraq Initiative @renadmansour Dr Mac Skelton Director, Institute of Regional and International Studies (IRIS), American University of Iraq, Sulaimani; Visiting Fellow, Middle East Centre, London School of Economics Dr Abdulameer Mohsin Hussein President of the Iraq Medical Association Following 17 years of conflict and fragile state-society relations, the war-torn country is particularly vulnerable to the pandemic. 2020-04-07-Iraq-COVID-spray Disinfecting shops in Baghdad's Bayaa neighbourhood as a preventive measure against the spread of COVID-19. Photo by AHMAD AL-RUBAYE/AFP via Getty Images. Iraq is a country already in turmoil, suffering fallout from the major military escalation between the US and Iran, mass protests calling for an end to the post-2003 political system, and a violent government crackdown killing more than 600 and wounding almost 30,000 - all presided over by a fragmented political elite unable to agree upon a new prime minister following Adil abd al-Mehdi’s resignation back in November.COVID-19 introduces yet another threat to the fragile political order, as the virus exposes Iraq’s ineffective public health system dismantled through decades of conflict, corruption and poor governance.Iraqi doctors are making every effort to prepare for the worst-case scenario, but they do so with huge structural challenges. The Ministry of Health lacks enough ICU beds, human resources, ventilators, and personal protective equipment (PPE). Bogged down in bureaucracy, the ministry is struggling to process procurements of equipment and medications, and some doctors have made purchases themselves.But individual efforts can only go so far as many Iraqi doctors are concerned the official numbers of confirmed COVID-19 cases do not reflect the complexity of the situation on the ground.The ministry relies predominately upon patients self-presenting at designated public hospitals and has only just begun community-based testing in areas of suspected clusters. Reliance on self-presentation requires a level of trust between citizens and state institutions, which is at a historic low. This gap in trust – 17 years in the making – puts Iraq’s COVID-19 response particularly at risk.Iraq’s myriad vulnerabilitiesCertain social and political factors leave Iraq uniquely exposed to the coronavirus. The country’s vulnerability is tied directly to its social, religious and economic interconnections with Iran, an epicenter of the pandemic.Exchanges between Iran and Iraq are concentrated in two regions, with strong cross-border links between Iraqi and Iranian Kurds in the north-east, and Iraqi and Iranian Shia pilgrims in the south. Cross-border circulation of religious pilgrims is particularly concerning, as they can result in mass ritual gatherings.The high number of confirmed cases in the southern and northern peripheries of the country puts a spotlight on Iraq's failure in managing healthcare. The post-2003 government has failed to either rebuild a robust centralized healthcare system, or to pave the way for a federalized model.Caught in an ambiguous middle between a centralized and federalized model, coordination across provinces and hospitals during the coronavirus crisis has neither reflected strong management from Baghdad nor robust ownership at the governorate level.This problem is part of a wider challenge of managing centre-periphery relations and federalism, which since 2003 has not worked effectively. Baghdad has provided all 18 provinces with instructions on testing and treatment, but only a handful have enough resources to put them into practice. Advanced testing capacity is limited to the five provinces with WHO-approved centers, with the remaining 13 sending swabs to Baghdad.But the greatest challenge to Iraq’s COVID-19 response is the dramatic deterioration of state-society relations. Studies reveal a profound societal distrust of Iraq’s public healthcare institutions, due to corruption and militarization of medical institutions. Numerous videos have recently circulated of families refusing to turn over sick members - particularly women - to medical teams visiting households with confirmed or suspected cases.As medical anthropologist Omar Dewachi notes, the ‘moral economy of quarantine’ in Iraq is heavily shaped by a history of war and its impact on the relationship between people and the state. Although local and international media often interpret this reluctance to undergo quarantine as a matter of social or tribal norms, distrusting the state leads many families to refuse quarantine because they believe it resembles a form of arrest.The management of coronavirus relies upon an overt convergence between medical institutions and security forces as the federal police collaborate with the Ministry of Health to impose curfews and enforce quarantine. This means that, troublingly, the same security establishment which violently cracked down on protesters and civil society activists is now the teeth behind Iraq’s COVID-19 response.Without trust between society and the political class, civil society organizations and protest movements have directed their organizational structure towards awareness-raising across Iraq. Key religious authorities such as Grand Ayatollah Sistani have called for compliance to the curfew and mobilized charitable institutions.However, such efforts will not be enough to make up for the lack of governance at the level of the state. In the short-term, Iraq’s medical professionals and institutions are in dire need of technical and financial support. In the long-term, COVID-19 is a lesson that Iraq’s once robust public healthcare system needs serious investment and reform.COVID-19 may prove to be another catalyst challenging the ‘muddle through’ logic of the Iraqi political elite. International actors have largely been complicit in this logic, directing aid and technical support towards security forces and political allies in the interest of short-term stability, and neglecting institutions which Iraqis rely on for health, education, and well-being.The response to the crisis requires cooperation and buy-in of a population neglected by 17 years of failed governance. This is a seminal event that may push the country to the brink, exposing and stirring underlying tensions in state-society relations.This analysis was produced as part of the Iraq Initiative. Full Article
q Same Old Politics Will Not Solve Iraq Water Crisis By feedproxy.google.com Published On :: Wed, 15 Apr 2020 15:36:21 +0000 15 April 2020 Georgia Cooke Project Manager, Middle East and North Africa Programme Dr Renad Mansour Senior Research Fellow, Middle East and North Africa Programme; Project Director, Iraq Initiative @renadmansour Glada Lahn Senior Research Fellow, Energy, Environment and Resources Programme @Glada_Lahn Addressing Iraq’s water crisis should be a priority for any incoming prime minister as it is damaging the country’s attempts to rebuild. But successive governments have allowed the problem to fester. 2020-04-15-Iraq-Water Punting in the marshes south of the Iraqi city of Ammarah. Photo by Ghaith Abdul-Ahad/Getty Images. Historically, Iraq lay claim to one of the most abundant water supplies in the Middle East. But the flow of the Tigris and Euphrates rivers has reduced by up to 40% since the 1970s, due in part to the actions of neighbouring countries, in particular Turkey, upstream.Rising temperatures and reduced rainfall due to climate change are also negatively impacting Iraq’s water reserves. Evaporation from dams and reservoirs is estimated to lose the country up to 8 billion cubic metres of water every year.A threat to peace and stabilityShortages have dried up previously fertile land, increasing poverty in agricultural areas. Shortages have also served to fuel conflict: communities faced with successive droughts and government inertia proved to be easy targets for ISIS recruiters, who lured farmers into joining them by offering money and food to feed their families. Economic hardship for those whose livelihoods relied upon river water has also driven rural to urban migration, putting significant strain on already over-populated towns and cities, exacerbating housing, job and electricity shortages, and widening the gap between haves and have-nots.But scarcity isn’t the most crucial element of Iraq’s water crisis – contamination is. Decades of local government mismanagement, corrupt practices and a lack of regulation of dumping (it is estimated up to 70% of Iraq’s industrial waste is dumped directly into water) has left approximately three in every five citizens without a reliable source of potable water.In 2018, 118,000 residents of Basra province were hospitalised with symptoms brought on by drinking contaminated water, which not only put a spotlight on the inadequacies of a crumbling healthcare system but sparked mass protests and a subsequent violent crackdown.The water crisis is also undermining the stability of the country’s federal governance model, by occasionally sparking disputes between Baghdad and the Kurdistan Regional Government, as well as between governorates in the south.The crisis is both a symptom and a cause of poor governance. Iraq is stuck in a cycle whereby government inaction causes shortages and contamination, which result in economic losses, reduced food supply, increased prices and widespread poor health. This in turn leads to increasing levels of poverty, higher demand on services and civil unrest, increasing the pressure on a weak, dysfunctional system of government.What can be done?The first priority should be modernising existing water-management infrastructure - a relic of a time when the problem was an excess rather than a shortage of water (the last time Iraq’s flood defences were required was 1968). Bureaucratic hurdles, widespread corruption and an endless cycle of other crises taking precedent prevent good initiatives from being implemented or scaled up.Diversifying energy sources to improve provision is crucial. Baghdad has a sewage treatment plant that originally ran on its own electricity source, but this capacity was destroyed in 1991 and was never replaced. The city continues to suffer from dangerous levels of water pollution because the electricity supply from the grid is insufficient to power the plant. Solar energy has great potential in sun-drenched Iraq to bridge the gaping hole in energy provision, but successive governments have chosen to focus on fossil fuels rather than promoting investment to grow the renewables sector.Heightened tension with upstream Turkey could turn water into another cause of regional conflict. But, if approached differently, collaboration between Iraq and its neighbour could foster regional harmony.Turkey’s elevated geography and cooler climate mean its water reserves suffer 75% less evaporation than Iraq’s. Given that Turkey’s top energy priority is the diversification of its supply of imported hydrocarbons, a win-win deal could see Turkey exchange access to its water-management infrastructure for delivery of reduced cost energy supplies from Iraq.German-French cooperation on coal and steel in the 1950s and the evolution of economic integration that followed might provide a model for how bilateral cooperation over one issue could result in cooperation with other regional players (in this case Iran and Syria) on a range of other issues. This kind of model would need to consider the future of energy, whereby oil and gas would be replaced by solar-power exports.These solutions have been open to policymakers for years and yet they have taken little tangible action. While there are leaders and bureaucrats with the will to act, effective action is invariably blocked by a complex and opaque political system replete with vested interests in maintaining power and wealth via a weak state and limited services from central government.Breaking the cycleTo break this cycle, Iraq needs a group of professional and able actors outside of government to work with willing elements of the state bureaucracy as a taskforce to pressure for action and accountability. Publishing the recommendations from a hitherto withheld report produced in the aftermath of Basra’s 2018 heath crisis would be a great start.In time, this taskforce could champion the prioritisation of water on the national agenda, the implementation of infrastructure upgrades, and hold more productive conversations with neighbour states.With such a high degree of state fragmentation and dysfunction in Iraq, looking to the central government to provide leadership will not yield results. Engagement with a coalition of non-state actors can begin to address the water crisis and also open a dialogue around new models of governance for other critical issues. This might even be a starting point for rewriting the tattered social contract in Iraq.This piece is based on insights and discussion at a roundtable event, Conflict and the Water Crisis in Iraq, held at Chatham House on March 9 as part of the Iraq Initiative. Full Article
q Why is it So Hard for Iraq to Form A Government? By feedproxy.google.com Published On :: Sat, 25 Apr 2020 17:03:58 +0000 25 April 2020 Dr Renad Mansour Senior Research Fellow, Middle East and North Africa Programme; Project Director, Iraq Initiative @renadmansour Mustafa al-Kadhimi has emerged as the compromise prime minister designate, but his potential appointment is built on shaky foundations. 2020-04-25-Iraq-Security-COVID A member of Iraqi security forces stands guard behind a yellow line after the government declared curfew due to coronavirus. Photo by Fariq Faraj Mahmood/Anadolu Agency via Getty Images. On April 9, Iraqi President Barham Salih gathered the Shia, Kurdish and Sunni political blocs at the presidential palace to task head of intelligence Mustafa al-Kadhimi with forming a government.Kadhimi is the third prime minister-designate assigned since Prime Minister Adil abd al-Mehdi resigned in November, in the wake of mass protests against government corruption and the country’s ethno-sectarian based political system.Kadhimi’s two predecessors, Muhammad Tawfiq Allawi and Adnan al-Zurfi, both failed to form a government. This third attempt came as Iraq struggles with repeated crises since October 2019, when the government began responding with deadly force to large-scale mass protests, killing more than 600 and injuring tens of thousands.In January, the assassination of Qasem Soleimani escalated tensions between the United States and Iran, with Iraq stuck in the middle and becoming the home for regular tit-for-tat attacks. The Islamic State — never completely defeated — took advantage of these crises and increased its attacks in disputed territories.The outbreak of COVID-19 challenges the country’s fragile public health sector, while the decline in the price of oil will make it harder for leaders to pay the public salaries that keep the system (and patronage) moving.What does the delay in forming a government amid multiple crises mean for the post-2003 Iraqi political system? Iraq’s post-2003 political system is designed to withstand crisis. Over the years, political parties reflecting the country’s ethnic and sectarian divides have had a tacit understanding that crises represent a risk to their collective interests. These elite stakeholders have together weathered civil war, insurgency and multiple protests — despite deep conflicts with one another.For instance, in September 2018 protesters attacked most major political party headquarters and the Iranian consulate in Basra, and authorities killed some 20 protesters.Since the May election of that year, the fragmented Shia elite had been unable to even declare which side has the largest parliamentary bloc, let alone decide on a government.But after the September crisis, the previously gridlocked parties swiftly came together to form an “understanding” that pushed through the impasse leading to the Mehdi government. In 2020, however, Iraq’s political parties were slower to come back together despite the multiple crises — far greater than 2018. The system is less able to swiftly fix itself, based primarily on the fragmentation of the elite — and their determination to prevent any challenge to their rule.Why did the two prior attempts fail? The two previous prime minister-designates each fell short for different reasons. When I met Allawi in February at the prime minister’s guesthouse in Baghdad, he was very clearly convinced that his mandate was to sideline the parties.He hoped that simply choosing technocratic ministers outside the elite pact, with the support of Moqtada al-Sadr behind him, would garner support from protesters and the disillusioned public. He failed, however, because his cabinet had to go through parliament and the parties rejected what they saw a threat to the elite pact and the system.Zurfi similarly failed after being directly appointed in March by Salih after the Shia parties failed to come up with a candidate. From the beginning, then, Zurfi faced challenges because parties were not in agreement. He attempted to directly confront his opposition, and spoke out against Iranian influence in Iraq. As a result, Zurfi was unable to even get to parliament with his proposed cabinet, as the Shia parties got back together to bring him down.The failure of both strategies — Allawi attempting to work outside the elite party system and Zurfi trying to target certain parties — reveals tensions in Iraq’s political system. This fragmentation strains the parties’ ability to swiftly unite, and the system’s ability to withstand crises.The endemic problems are a consequence of fragmentation, including the failure following the 2018 elections to declare governing parliamentary bloc. Moreover, after that election, newcomers into the political system (two-thirds of the MPs are serving their first term) are increasingly making their own demands and less willing to blindly toe party lines.Can Kadhimi overcome the impasse?Kadhimi’s appointment as prime minister-designate nonetheless is on shaky foundations. His appointment had previously faced a veto from Iran and its allied groups which make up the Fateh bloc. Kataeb Hezbollah, an armed group close to Iran and linked to the Popular Mobilization Units, issued a statement accusing Kadhimi with blood on his hands for the deaths of Soleimani and Abu Mahdi al-Muhandis.Many Fateh bloc members had for months vetoed Kadhimi’s name due to this allegation. Immediately before Kadhimi addressed the nation for the first time, Iraqi state television broadcast a prerecorded statement by PMU (and Fateh) leader Qais al-Khazali, who had also previously accused Kadhimi of spying for the Americans and being complicit in the two killings.Khazali, who commands the second-largest party within Fateh, accepted the party line to back Kadhimi but came out with his own conditions on television. However, the concerns about the COVID-19 crisis and the collapse of the price of oil finally brought all sides to compromise — a design of the political system.Kadhimi has signalled he will play by the old rules with these stakeholders. Because of the magnitude of these simultaneous crises, Iraqi politics is moving back to the post-2003 norm. The ethno-sectarian based political system is geared to weather such existential crises more than it is to handling day-to-day governance. Despite the notion of “post-sectarianism” in Iraq, this system is based on ethno-sectarian political party compromise.In his television address, Khazali, who had previously attempted to move away from sectarian language, explained that the process of selecting a prime minister is reserved to the Shia, who have the right as the majority, and not to Salih, a Kurd.Over the years Kadhimi has expressed an admiration of the bravery of the protesters and of the importance of civil society. Many Iraqi civil society activists owe their lives to the work of the former intelligence chief. However, he has also been part of the same system that has violently suppressed protesters.As the compromise prime minister-designate, he will find it difficult to transform his country as long as he plays by the rules of post-2003 Iraq — an irony not lost on the protesters who immediately rejected the candidacy of a man whom until recently many protesters had supported.This article was originally published in The Washington Post Full Article
q Webinar: Will COVID-19 Mark the Endgame for Iraq's Muhasasa Ta'ifia? By feedproxy.google.com Published On :: Mon, 27 Apr 2020 13:50:01 +0000 Research Event 30 April 2020 - 2:00pm to 3:00pm Event participants Ahmed Tabaqchali, Chief Investment Officer, Asia Frontier Capital Iraq Fund; Adjunct Assistant Professor, American University of Iraq SulaimaniModerator: Renad Mansour, Senior Research Fellow, Middle East and North Africa Programme, Chatham House Control of oil rents underpins Iraq’s post-2003 political order. This political order, known as Muhasasa Ta’ifia (ethno-sectarian apportionment), features an elite bargain inclusive of all major ethnic and sect-based political groups. It has enabled the state's continuity and apparent stability through multiple crises, including the 2008 financial crisis, the 2014 oil crisis, and the war with ISIS.In a recent article, Ahmed Tabaqchali examines how the crash in oil rents, brought about by COVID-19’s disruption of the world economy, exposes the structural inconsistencies and inherent contradictions of the Muhasasa Tai’fia system. The article argues that the current Iraqi political elite is ill-equipped to resolve the multi-faceted challenge facing the country because of its increasing fragmentation and the erosion of its legitimacy, advanced institutional decay and fundamentally different oil dynamics.In this webinar, part of the Chatham House project on the future of the state in the Middle East and North Africa, the article’s author will discuss the deficiencies of the Muhasasa Ta’ifia system and will offer his insight into the future of this governance model in the context of a worsening economic crisis resulting from the COVID-19 pandemic and existing demographic pressures. You can express your interest in attending by following this link. You will receive a Zoom confirmation email should your registration be successful. Alternatively, you can watch the event live on the MENA Programme Facebook page. Department/project Middle East and North Africa Programme, The Future of the State in the Middle East Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email