Under Armour's shares surged 20% after the company raised its annual profit forecast, driven by cost-cutting measures and a focus on full-price sales. Founder and CEO Kevin Plank's strategy of reducing discounts and inventory helped boost gross margins, signaling a potential turnaround for the sportswear brand.

Salvation is not a one-time thing but an ongoing, following, surrender to the King. Are we more afraid of what the devil is going to do with our life, or have more faith of what Jesus can do?

Why should we go to church on Sabbath? How did Jesus observe Sabbath?

Today, a local Iranian farmer grows the herbs of home. Then, an art exhibit encourages visitors to look inside themselves to feel empowered. And, Bay Poets brings us an oracle.

Salvation is not a one-time thing but an ongoing, following, surrender to the King. Are we more afraid of what the devil is going to do with our life, or have more faith of what Jesus can do?

Why should we go to church on Sabbath? How did Jesus observe Sabbath?

The true healing of our nation is a long journey. It will come from the people, not political wishing.

He's an R&B hit-making machine.

The Government said they are “committed to ensuring that it introduces solutions to assist hard working residents” and also encouraged residents to implement energy-saving measures. A Government spokesperson said, “The Government of Bermuda is committed to ensuring that it introduces solutions to assist hard working residents. That’s why it has taken decisive action to alleviate […]

Frank Biasi, Director, Conservation and Special Projects
National Geographic Maps

We all know (or should know!) that geography is the study of the Earth and its lands, features, inhabitants, and phenomena. This breadth of fascinating subjects is what led me to become a geographer 25 years ago. The sub-discipline of cartography allowed me to combine my earlier interest in visual art with my newfound passion for geography. I was lucky to come of age early in the growth of computer mapping technologies, including Geographic Information Systems (GIS). Seeing the potential of GIS to make a difference in the world and to build a career, I quickly jumped on that bandwagon.

I first used GIS to do maps and analysis for geography courses, and to inventory property parcels around my campus as part of an internship. After graduation, I worked for a regional planning agency to help design transportation corridors that maximize business opportunities and minimize environmental impacts. I went on to work for a state environmental agency where I helped to map all of the wetlands in Massachusetts to aid in the permitting of development and construction projects.

I further developed my geographic thinking and skills working for The Nature Conservancy, where I used GIS to help conservation planners and preserve managers map biodiversity and design and execute ways to save it. I realized that conservation, as with many other fields, deals with a wide variety of systems operating across the landscape, including biological, geological, hydrological, climatological, political, transportation, and economic systems. GIS provides a powerful platform to create and combine data layers representing each of these systems in order to make maps and answer questions about the world. Seeing these maps and answering these questions helps organizations across all sectors make informed decisions about what to do and where to do it.

Recently, we as individuals have begun using simple GIS tools on our PCs and mobile phones to make maps and answer spatial questions to help us decide where to eat, shop, travel, and invest. The growing phenomena of geo-browsing and geo-searching are enabled by interactive mapping services by Google, Microsoft, Yahoo, MapQuest, and others. These services are becoming increasingly personalized through GPS-enabled mobile phones and apps that tell us who and what is near us, wherever we are. The initial applications of these services have been for commercial and social uses. However, they can also help us discover and decide how we can make a positive difference in the world.

Many people are unaware of the fact that there are hundreds of thousands of dedicated nonprofit organizations working around the world to reduce human suffering, protect wildlife and ecosystems, preserve cultures, and advance scientific knowledge. These heroic people and organizations are stepping in to fill critical gaps that governments and businesses are unable or unwilling to fill. Most of the organizations have very limited financial and human resources to accomplish their objectives, yet they still manage to make an enormous difference in the lives of people, animals, and society at large.

At National Geographic, we have begun an initiative called the Global Action Atlas to highlight the work of these heroic nonprofits, and to give our audience tangible opportunities to discover and get involved in this work by donating, volunteering, advocating, visiting, and sharing with their social networks. Although it is still a beta site, ActionAtlas.org has over 400 on-the-ground projects by more than 100 reputable nonprofits around the world. Users can browse projects on an interactive global map or by themes including Conservation, Humanitarian, Cultures, Exploration, Climate Change, and Energy. They can also enter keywords to get a list of relevant projects in the U.S and around the world.
Every project has an interactive profile where the organization summarizes the issues the project is working to address, their goals, and the progress being made. They also include photos, videos, documents, blogs, maps, links to more information, and lists of similar and nearby projects. Once a user has found a project that interests them, they can become a fan or comment on the project, as well as donate, volunteer, visit, or share the project with their Facebook friends. Users can build up a portfolio of their favorite projects to follow and interact with over time, thus establishing their own “Geography of Action.” We plan to add thematic layers to the map viewer such as infant mortality, biodiversity, and cultural hotspots to help people decide where they should invest their time and resources in making a difference.

We hope that the Global Action Atlas provides the public a useful and trusted service that advances National Geographic’s mission of “inspiring people to care about the planet,” by enabling them to turn inspiration into action. Over the past century National Geographic’s writers, photographers, and filmmakers have richly documented places and cultures and the challenges facing communities and the planet. Our Mission Programs have funded thousands of field-based projects to understand and conserve wildlife and cultures and advance the frontiers of science. The Global Action Atlas is the beginning of a new effort to deeply engage our audience in this wonderful, but challenged world, and to help them become active participants in making it more wonderful.

This was a big week in space, from Curiosity stumbling upon sulfur crystals to an exoplanet discovery and a major advocacy effort.

Unless it’s absolutely necessary, do not accept a provisional ballot. Watch this clip from our recent Save Your Vote broadcast to find out why — and what to do if someone tries to shunt you to a provisional "placebo" ballot.... READ MORE

The dream of every gardener is to see endless fields of green grass in their backyard. With determination, most gardeners manage to attain this dream, but at a cost. Within no time, there is a need to mow and control weeds. After mowing, it needs watering to grow again. This cycle continues for as long as the gardener wants to enjoy the beauty of green turf.[...]

By Frosty Wooldridge, Well, what do you know? Trump won! How do you feel? What is the Golden Age of America? How does the other half of the country feel? When will we all get on the same page? And please, Jimmy Kimmel, you’re not funny. Stop crying. One talking head said, “If you’re in […]

The post Wooldridge: Saving Our Republic from the Invasion & Kamala appeared first on The Lid.

Financial Realities for Single Female Home Buyers

TED Fellow and renewable energy expert Norah Magero envisions an Africa that pioneers its own technological future, shifting the narrative from dependence and consumption to self-reliance and innovation. She shares how she developed VacciBox — a solar-powered refrigeration system made in Kenya to keep vaccines cold in off-grid areas — and highlights the power of homegrown solutions to transform health care.

The answer depends on how you feel about cluster headaches

Building captive colonies for eventual re-introduction to the wild, scientists from Atlanta rescue endangered frogs and other amphibians threatened with extinction by a fatal fungus spreading through South American forests

After a dog digs up a rabbit's nest and leaves a litter exposed, the team at the Toronto Wildlife Center must rehabilitate the malnourished babies before they can be released back into the wild.

Margaret Wertheim talks about how math and climate change inspired her to start the Hyperbolic Crochet Coral Reef project. Read more at: https://www.smithsonianmag.com/arts-culture/how-to-crochet-a-coral-reef-69064479/

SolidWorks Design, Simulation, and Publishing Software Contribute to Halving of Design Cycle, 20 Percent Materials Saving, and Paperless Assembly

U.K.-based electrical connector manufacturer speeds product development with 3D mechanical design and product data management software

Oregon

Medical industry manufacturer reducing R&D costs, time to market, and scrap by up to 50 percent

JustMoney.co.za marketing manager Shafeeka Anthony lists the implications to consider before withdrawing savings or investments.

Early withdrawals reduce the overall value of your retirement savings, which will have a significant impact on future retirement income.

OM team leader in Hamburg, where 400-500 refugees arrive daily, shares about meeting two young refugees who hunger to know the truth.

Successes in serving residents continue The Delaware Department of Insurance (DOI) today published performance and productivity data for 2021. While the pandemic necessitated continued operational adjustments, staff continued to focus efforts on consumer services and saw great success. The department also released an infographic of key statistics. “Year after year, our DOI team delivers for […]

Delaware State Treasurer Colleen Davis, alongside U.S. Senators Tom Carper and Chris Coons, celebrated the first-ever ABLE Savings Day, highlighting the importance of Achieving a Better Life Experience (ABLE) accounts. This new initiative aims to boost awareness and participation in ABLE accounts, which are instrumental in enhancing financial independence for individuals with disabilities. “ABLE accounts […]

The DE529 Education Savings Plan, Delaware’s tax-advantaged program designed to help pay for higher education expenses, received “Silver” status from Morningstar, the country’s most widely cited and influential investment plan rating group. This is the second consecutive year DE529 received the rating after being upgraded from “Bronze” status in 2023. “With higher education costs remaining […]

Verisium SimAI App harnesses the power of machine learning technology with the Cadence Xcelium Logic Simulator - the ultimate breakthrough in accelerating verification closure. It builds models from regressions run in the Xcelium simulator, enabling the generation of new regressions with specific targets. The Verisium SimAI app also features cousin bug hunting, a unique capability that uses information from difficult-to-hit failures to expose cousin bugs. With these advanced machine learning techniques, Verisium SimAI offers the potential for a significant boost in productivity, promising an exciting future for our users.

Figure 1: Regression compression and coverage maximization with Verisium SimAI 

What can I do with Verisium SimAI?

You can exercise different use cases with Verisium SimAI as per your requirements. For some users, the goal might be regression compression and improving coverage regain. Coverage maximization and hitting new bins could be another goal. Other users may be interested in exposing hard-to-hit failures, bug hunting for difficult to find issues. Verisium SimAI allows users to take on any of these challenges to achieve the desired results.

Let's go into some more details of these use cases and scenarios where using SimAI can have a big positive impact.

1. Using SimAI for Regression Compression and Coverage Regain

Unlock up to 10X compute savings with SimAI!

Verisium SimAI can be used to compress regressions and regain coverage. This flow involves setting up your regression environment for SimAI, running your random regressions with coverage and randomization data followed by training, and finally, synthesizing and running the SimAI-generated compressed regressions. The synthesized regression may prune tests that do not help meet the goal and add more runs for the most relevant tests, as well as add run-specific constraints. This flow can also be used to target specific areas like areas involving a high code churn or high complexity.

You can check out the details of this flow with illustrative examples in the following Rapid Adoption Kits (RAK) available on the Cadence Learning and Support Portal (Cadence customer credentials needed):

• Using SimAI with vManager (For Regression Compression and Coverage Regain) (RAK) 
• Using SimAI with a Generic Runner (For Regression Compression and Coverage Regain) (RAK)

2. Using SimAI for Coverage Maximization and Targeting coverage holes

Reduce your Functional Coverage Holes by up to 40% using SimAI!

Verisium SimAI can be used for iterative coverage maximization. This is most effective when regressions are largely saturated, and SimAI will explicitly try to hit uncovered bins, which may be hard-to-hit (but not impossible) coverage holes. This is achieved using iterative learning technology where with each iteration, SimAI does some exploration and determines how well it performed. This technique can also be used for bug hunting by using holes as targets of interest.

See more details on the Cadence Learning and Support Portal:

• Using SimAI for Coverage Maximization - vManager flow (RAK) 
• Using SimAI for Coverage Maximization - Generic Runner Flow (RAK)

3. Using SimAI for Bug Hunting

Discover and fix bugs faster using SimAI!

Verisium SimAI has a new bug hunting flow which can be used to target the goal of exposing hard-to-hit failure conditions. This is achieved using an iterative framework and by targeting failures or rare bins. The goal to target failures is best exercised when the overall failure rate is typically low (below 5%). Iterative learning can be used to improve the ability to target specific areas. Use the SimAI bug hunting use case to target rare events, low hit coverage bins, and low hit failure signatures.

See more details on the Cadence Learning and Support Portal:

• Using SimAI for Bug Hunting with vManager (RAK) 
• Using SimAI for Bug Hunting – Generic runner flow (RAK) 

Unlock compute savings, reduce your functional coverage holes, and discover and fix bugs faster with the power of machine learning technology now enabled by Verisium SimAI!

Please keep visiting  https://support.cadence.com/raks to download new RAKs as they become available.

Please note that you will need the Cadence customer credentials to log on to the Cadence Online  Support  https://support.cadence.com/, your 24/7 partner for getting help in resolving issues related to Cadence software or learning Cadence tools and technologies.

Happy Learning!

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

[WFP] Geneva -- This is a summary of what was said by Chi Lael, WFP Spokesperson for Nigeria (speaking from Abuja via Zoom) - to whom quoted text may be attributed - at today's press briefing at the Palais des Nations in Geneva.

Endangered succulents in the Richtersveld have been given a lifeline from poaching, mining, overgrazing, and climate change

Imagine living with water up to your knees for half of the year, where homes are flooded, and people constantly fear that the sea might one day engulf the town and everyone in it. This is the reality for the sinking islands in the Philippines—a cluster of four island barangays in Tubigon located in the […]

Title: Initial Savings May Hide True Cost of Prostate Cancer Care
Category: Health News
Created: 8/23/2010 12:10:00 PM
Last Editorial Review: 8/24/2010 12:00:00 AM

So far, the Israeli leadership seems unmoved by U.S. President Biden’s quiet suggestions for a pause in hostilities in Gaza.

The post Saving Palestinian lives will save Israeli lives appeared first on rabble.ca.

Martin Lewis has warned Tesco customers of a piece of small print that could see £18m worth of Clubcard points wasted.

MORE than 100 defibrillators will be placed in all sport venues in Blacktown making it the first council in the state to roll out the life-saving machines.

When chemist Dora Richardson’s employer decided to terminate the breast cancer research on the drug Tamoxifen in the early 1970s, she and her colleagues continued the work in secret.

Tech startups are stepping up to meet the needs of 60 million people worldwide who use opioids, representing about 1 percent of the world’s adult population. In the United States, deaths involving synthetic opioids have risen 1,040 percent from 2013 to 2019. The COVID-19 pandemic and continued prevalence of fentanyl have since worsened the toll, with an estimated 81,083 fatal overdoses in 2023 alone.

Innovations include biometric monitoring systems that help doctors determine proper medication dosages, nerve stimulators that relieve withdrawal symptoms, wearable and ingestible systems that watch for signs of an overdose, and autonomous drug delivery systems that could prevent overdose deaths.

Helping Patients Get the Dosage They Need

For decades, opioid blockers and other medications that suppress cravings have been the primary treatment tool for opioid addiction. However, despite its clinical dominance, this approach remains underutilized. In the United States, only about 22 percent of the 2.5 million adults with opioid use disorder receive medication-assisted therapy such as methadone, Suboxone, and similar drugs.

Determining patients’ ideal dosage during the early stages of treatment is crucial for keeping them in recovery programs. The shift from heroin to potent synthetic opioids, like fentanyl, has complicated this process, as the typical recommended medication doses can be too low for those with a high fentanyl tolerance.

A North Carolina-based startup is developing a predictive algorithm to help clinicians tailor these protocols and track real-time progress with biometric data. OpiAID, which is currently working with 1,000 patients across three clinical sites, recently launched a research pilot with virtual treatment provider Bicycle Health. Patients taking Suboxone will wear a Samsung Galaxy Watch6 to measure their heart rate, body movements, and skin temperature. OpiAID CEO David Reeser says clinicians can derive unique stress indications from this data, particularly during withdrawal. (He declined to share specifics on how the algorithm works.)

“Identifying stress biometrically plays a role in how resilient someone will be,” Reeser adds. “For instance, poor heart rate variability during sleep could indicate that a patient may be more susceptible that day. In the presence of measurable amounts of withdrawal, the potential for relapse on illicit medications may be more likely.”

Nerve Stimulators Provide Opioid Withdrawal Relief

While OpiAID’s software solution relies on monitoring patients, electrical nerve stimulation devices take direct action. These behind-the-ear wearables distribute electrodes at nerve endings around the ear and send electrical pulses to block pain signals and relieve withdrawal symptoms like anxiety and nausea.

The U.S. Food and Drug Administration (FDA) has cleared several nerve stimulator devices, such as DyAnsys’ Drug Relief, which periodically administers low-level electrical pulses to the ear’s cranial nerves. Others include Spark Biomedical’s Sparrow system and NET Recovery’s NETNeuro device.

Masimo’s behind-the-ear Bridge device costs US $595 for treatment providers.Masimo

Similarly, Masimo’s Bridge relieves withdrawal symptoms by stimulating the brain and spinal cord via electrodes. The device is intended to help patients initiating, transitioning into, or tapering off medication-assisted treatment. In a clinical trial, Bridge reduced symptom severity by 85 percent in the first hour and 97 percent by the fifth day. A Masimo spokesperson said the company’s typical customers are treatment providers and correctional facilities, though it’s also seeing interest from emergency room physicians.

Devices Monitor Blood Oxygen to Prevent Overdose Deaths

In 2023, the FDA cleared Masimo’s Opioid Halo device to monitor blood oxygen levels and alert emergency contacts if it detects opioid-induced respiratory depression, the leading cause of overdose deaths. The product includes a pulse oximeter cable and disposable sensors connected to a mobile app.

Opioid Halo utilizes Masimo’s signal extraction technology, first developed in the 1990s, which improves upon conventional oxygen monitoring techniques by filtering out artifacts caused by blood movement. Masimo employs four signal-processing engines to distinguish the true signal from noise that can lead to false alarms; for example, they distinguish between arterial blood and low-oxygen venous blood.

Masimo’s Opioid Halo system is available over-the-counter without a prescription. Masimo

Opioid Halo is available over-the-counter for US $250. A spokesperson says sales have continued to show promise as more healthcare providers recommend it to high-risk patients.

An Ingestible Sensor to Watch Over Patients

Last year, in a first-in-human clinical study, doctors used an ingestible sensor to monitor vital signs from patients’ stomachs. Researchers analyzed the breathing patterns and heart rates of 10 sleep study patients at West Virginia University. Some participants had episodes of central sleep apnea, which can be a proxy for opioid-induced respiratory depression. The capsule transmitted this data wirelessly to external equipment linked to the cloud.

Celero’s Rescue-Rx capsule would reside in a user’s stomach for one week.Benjamin Pless/Celero Systems

“To our knowledge, this is the first time anyone has demonstrated the ability to accurately monitor human cardiac and respiratory signals from an ingestible device,” says Benjamin Pless, one of the study’s co-authors. “This was done using very low-power circuitry including a radio, microprocessor, and accelerometer along with software for distinguishing various physiological signals.”

Pless and colleagues from MIT and Harvard Medical School started Celero Systems to commercialize a modified version of that capsule, one that will also release an opioid antagonist after detecting respiratory depression. Pless, Celero’s CEO, says the team has successfully demonstrated the delivery of nalmefene, an opioid antagonist similar to Narcan, to rapidly reverse overdoses.

Celero’s next step is integrating the vitals-monitoring feature for human trials. The company’s final device, Rescue-Rx, is intended to stay in the stomach for one week before passing naturally. Pless says Rescue-Rx’s ingestible format will make the therapy cheaper and more accessible than wearable autoinjectors or implants.

Celero’s capsule can detect vital signs from within the stomach. www.youtube.com

Autonomous Delivery of Overdose Medication

Rescue-Rx isn’t the only autonomous drug-delivery project under development. A recent IEEE Transactions on Biomedical Circuits and Systems paper introduced a wrist-worn near-infrared spectroscopy sensor to detect low blood oxygen levels related to an overdose.

Purdue University biomedical engineering professor Hugh Lee and graduate student Juan Mesa, who both co-authored the study, say that while additional human experiments are necessary, the findings represent a valuable tool in counteracting the epidemic. “Our wearable device consistently detected low-oxygenation events, triggered alarms, and activated the circuitry designed to release the antidote through the implantable capsule,” they wrote in an email.

Lee and Purdue colleagues founded Rescue Biomedical to commercialize the A2D2 system, which includes a wristband and an implanted naloxone capsule that releases the drug if oxygen levels drop below 90 percent. Next, the team will evaluate the closed-loop system in mice.

This story was updated on 27 August 2024 to correct the name of Masimo’s Opioid Halo device.

The Pakistan Air Force (PAF) has requested $1 billion in additional FMF support for the F-16 program