NEW CASTLE (Nov. 4, 2022) – The Division of Substance Abuse and Mental Health, in collaboration with the Lt. Governor’s Office and the Delaware Art Museum, is seeking personal stories and photos from Delaware families who have lost loved ones to drug overdoses. The submissions will be used to create an emotional and educational exhibition […]

Apple now lets you share location of lost items with third parties via Find My accessories and AirTags.

Jon Stewart spoke about why the Democrats lost the 2024 election during his "Daily Show" monologue.

Timothée Chalamet was told to gain weight to get more roles.Timothée Chalamet doesn’t struggle to land big roles for movies anymore.However, there was a time when the Wonka star was rejected from two movie roles at the initial stages of his career.On Monday, November 11th,...

When your gym class is online at home, you don't necessarily need to miss out on the benefits that come from exercising in-person with others

Netflix’s Ancient Apocalypse peddles the idea that we have overlooked an extraordinary ancient civilisation. Flint Dibble explains why that is wrong, and why real archaeology is more exciting

Soil core samples show an ancient riverbed under the desert near many Egyptian pyramids, revealing an ancient waterway that dried up thousands of years ago

Analysis of DNA from a Neanderthal fossil found in a French cave indicates that it belonged to a group that was isolated for more than 50,000 years

Netflix’s Ancient Apocalypse peddles the idea that we have overlooked an extraordinary ancient civilisation. Flint Dibble explains why that is wrong, and why real archaeology is more exciting

Ketamine is a glutamate receptor antagonist that was developed over 50 years ago as an anesthetic agent. At subanesthetic doses, ketamine and some metabolites are analgesics and fast-acting antidepressants, presumably through targets other than glutamate receptors. We tested ketamine and its metabolites for activity as allosteric modulators of opioid receptors expressed as recombinant receptors in heterologous systems and with native receptors in rodent brain; signaling was examined by measuring GTP binding, β-arrestin recruitment, MAPK activation, and neurotransmitter release. Although micromolar concentrations of ketamine alone had weak agonist activity at μ opioid receptors, the combination of submicromolar concentrations of ketamine with endogenous opioid peptides produced robust synergistic responses with statistically significant increases in efficacies. All three opioid receptors (μ, , and ) showed synergism with submicromolar concentrations of ketamine and either methionine-enkephalin (Met-enk), leucine-enkephalin (Leu-enk), and/or dynorphin A17 (Dyn A17), albeit the extent of synergy was variable between receptors and peptides. S-ketamine exhibited higher modulatory effects compared with R-ketamine or racemic ketamine, with ~100% increase in efficacy. Importantly, the ketamine metabolite 6-hydroxynorketamine showed robust allosteric modulatory activity at μ opioid receptors; this metabolite is known to have analgesic and antidepressant activity but does not bind to glutamate receptors. Ketamine enhanced potency and efficacy of Met-enkephalin signaling both in mouse midbrain membranes and in rat ventral tegmental area neurons as determined by electrophysiology recordings in brain slices. Taken together, these findings support the hypothesis that some of the therapeutic effects of ketamine and its metabolites are mediated by directly engaging the endogenous opioid system.

Tim Miller hopes Amazon's anthology series will help viewers appreciate the "blood, sweat, and tears" Firewalk Studios put into the scrapped game.

Kelley hoards all the PS5s. Chris needs a build for the I'm Bad playstyle. And Josh gets treatment for his cat's demon tapeworm.

The post RPG Cast – Episode 645: “Rob Zombie’s Drag-Gula Lost” appeared first on RPGamer.

Halo Infinite recently received a big update in the form of Delta Arena, a playlist that features recreations of Halo 2's most popular maps and a special third-person mode. The true highlight, though, is yet to come. And that's through an entirely different Halo game: The Master Chief Collection. Soon enough, you'll be able to play Halo 2's lost E3 demo on it, thanks to some lovely modders.

Read more

Brianna Ghey's mother, Esther Ghey, is now campaigning to raise awareness about the dangers of social media and the "toxic" online world which her daughter came to inhabit. She wants tighter regulation on internet access and more parental controls.

Patriots are regaining control over this country in January. However, we all need to prepare for what’s to come because the road ahead won't be easy. And that’s why we need to play the long game.

The post Trump Won. Woke Lost. Here’s Your Financial Battle Plan appeared first on Breitbart.

Dozens of previously hard-to-access games can now be synced via Virtual Machine.

Aamir Khan recently kicked off the campaign at New York’s Indian restaurant, The Bungalow, where he was joined by Kiran Rao and hosted by chef Vikas Khanna

Rachelle and Kelly Swan bought their house in Spiritwood two years ago. They gave up their keys to the bank voluntarily in May, closing the door on the bat-infested house.  

If you have an iPhone that can run iOS 18, you can now download and install the public beta of iOS 18.2. One of the most useful new features is the capability to share the location of a lost item connected to Apple's Find My network with a third party. You can already share an item's location with people in your contacts list, but Apple says this could help in instances wherein you have to rely on the help of a stranger.

When you choose "Share Item Location" in the Find My app on iPhone, iPad or Mac, you'll get the option to share a link that shows the location of your missing item. The link's recipient will be able to open it on any device, and they'll also be able to see your Apple account email and/or phone number so that they can get in touch with you. You'll be able to see how many people visited the link, which expires after you're reunited with your lost belonging or after a week if you haven't found it by then.

Along with benevolent strangers, you'll be able to share the locations of misplaced AirTags and Find My accessories with select airlines. Apple has worked with several of them to integrate this feature into their systems. Only a small number of airline staff can access each Share Item Location link, and Apple says they'll first need to authenticate themselves with an Apple Account or partner email address.

More than 15 airlines will start supporting this feature in the coming months, including Aer Lingus, Air Canada, Air New Zealand, Austrian Airlines, British Airways, Brussels Airlines, Delta Air Lines, Eurowings, Iberia, KLM Royal Dutch Airlines, Lufthansa, Qantas, Singapore Airlines, Swiss International Air Lines, Turkish Airlines, United, Virgin Atlantic and Vueling. Apple says that more airlines will get involved over time to help track down mishandled or delayed bags.

Air transport tech company SITA is also incorporating Share Item Location into WorldTracer, its baggage-tracing system. According to Apple, this is used by more than 500 airlines and ground handlers at more than 2,800 airports.

Of course, installing beta software does have its downsides. There's a higher chance of running into bugs, and some apps or features might still not work as Apple had intended. If you don't mind and want to test iOS 18.2, you'll have to enable Beta Updates under Software Updates in your device's Settings menu. Apple is expected to roll out iOS 18.2 proper in December.

Meanwhile, as luck would have it, there's an early Black Friday deal on AirTags at the time of writing. You can scoop up a four-pack for a record low of $70.

Update, November 5 2024, 9:10AM ET: This story has been updated to clarify that these new features are in the developer beta of iOS 18.2. The public beta for that software isn't available just yet.

Update, November 11, 2024, 3:12PM ET: This story has been updated to include details of the airline integration and to note that a public beta of iOS 18.2 is now available.

Brad & Jenny Lost 400 lbs. Together

a confederacy of dunces (four of them are Yay)

A noble death

The BBC's Georgina Rannard shows a virtual rendition of Valeriana - which has been discovered centuries after it disappeared under the jungle canopy in Mexico.

UN agencies reported that almost 6,500 adolescent girls die in childbirth annually in South Asia, urging prioritization of girls' and adolescents' health in the region (!--ref1--).

medlinkTobacco/medlink is responsible for the deaths of 1.3 million people annually in India, according to the Union Minister of State for Health and Family Welfare.

The Russian App Store has lost 6,982 mobile apps since the start of the Ukraine invasion, as numerous companies have now pulled their apps and games from Apple’s iPhone and iPad App Stores in the country, according to data shared with TechCrunch by app intelligence firm Sensor Tower. To date, those apps had been downloaded […]

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A dozen years ago, Groupon shot to fame popularizing the online group buying format, confidently rejecting a $6 billion acquisition offer from Google and instead going public with a $17.8 billion market cap. The company today says it has 14 million active users, but almost consistently for the last decade, its financial position has been […]

© 2024 TechCrunch. All rights reserved. For personal use only.

He joined the company as a management graduate and initially spent eight years in sales.

Edinburgh : Edinburgh University Press, [2023]

The way Salman confronted Swami Om, there is hope for Bigg Boss.

'The commoners made fun of our struggles and achievements.''They used the word 'celeb' like an abuse.'

Laforce, Grégoire, author

While the JPC report on 2G has created a political storm, everyone has missed the real point- what should be done to resolve issues facing the telecom sector

Macfarlane, Robert, 1976- author

According to the BCC, the prince has been a supporter of Aston Villa since his school days.

Every year, nearly 25 million bags are lost in transit out of 4.3 billion 

'People had a perception that I may be angry as a person.''Or I'm older than I really am.''Or I can't speak in English because of the characters I've done at the beginning of my career.'

'The war ended in 2009 and I believe the new generation of Tamils don't know what was going on there.''I felt it was my duty to tell our story.''Since 2009, it seems like we are sleeping.'

A group of Indian Ocean islanders, forcibly removed from their homes 50+ years ago and deported to England, are still fighting for recognition and basic rights. By Alexi Demetriadi.

[France] : uniFrance films, [2015]

Albany : SUNY Press, [2017-2018]

Stroud, Gloucestershire : Amberley, 2020.

Princeton ; Oxford : Princeton University Press, 2013.

There was a time not all that long ago when Facebook was considered to be the absolute pinnacle of social media in general. Because of the fact that this is the sort of thing that could potentially end up being no longer the case without widespread innovation, Facebook has worked quite hard to diversify its offerings. However, recent data suggests that in spite of the fact that this is the case, Facebook has now lost its dominance among key demographics as well as social media users in general.

According to research conducted by the EdisonResearch, two very intriguing statistics have emerged. The first is that Facebook is no longer the social media platform of choice for people between the ages of 12 and 34. This is arguably the single most important demographic out there due to the reason that these are the people that the vast majority of advertisers are going to want to target at any given point in time. Only 21% of users between 12 and 34 years of age say that Facebook is their social media brand of choice.

Telangana CM lists the initiatives taken, exams conducted, jobs secured in the last 10 months

Djokovic finishes a year without claiming at least one major championship for the first time since 2017. Before that, it hadn't happened since 2010.

Sheikh Hasina presided over the country’s exceptional economic turnaround but paid a heavy price for losing the mass connect that once propelled her to high office