Reviews of The Cure's Songs of a Lost World. Video sent out by The Cure via Whatsapp.

Update: Now available in the UK store too, but only until midnight tonight (Nov. 7th).

It's now available in the EU and AU shops as well.

Available from The Cure shop (US only, but there are ways around that):

THE CURE SONGS OF A LOST WORLD (DELUXE) DIGITAL DOWNLOAD (MP3 & FLAC)

US $4.99

DELUXE DIGITAL ALBUM FEATURES SONGS OF A LOST WORLD STANDARD TRACKLIST PLUS FIVE LIVE BONUS TRACKS RECORDED AT SHORELINE AMPHITHEATER IN 2023.

TRACKLIST:

1.ALONE

2.AND NOTHING IS FOREVER

3.A FRAGILE THING

4.WARSONG

5.DRONE:NODRONE

6.I CAN NEVER SAY GOODBYE

7.ALL I EVER AM

8.ENDSONG

9.ALONE : LIVE @ SHORELINE AMPHITHEATER 2023

10.AND NOTHING IS FOREVER : LIVE @ SHORELINE AMPHITHEATER 2023

11.A FRAGILE THING : LIVE @ SHORELINE AMPHITHEATER 2023

12.I CAN NEVER SAY GOODBYE : LIVE @ SHORELINE AMPHITHEATER 2023

13.ENDSONG : LIVE @ SHORELINE AMPHITHEATER 2023

LIVE @ SHORELINE AMPHITHEATER 2023

From Music Week:

Update: also debuts at #1 in Scotland, Germany and on these other UK charts - Vinyl, Record Store, Physical Albums and Album Downloads. #3 in Ireland.

From Official Charts:

The Cure's Songs Of A Lost World becomes band's first Number 1 album in 32 years

The band's 14th studio LP outsells the rest of the Top 5 combined to reach the summit

By Carl Smith

The English rock legends, whose current line-up comprises Robert Smith, Simon Gallup, Roger O’Donnell, Perry Bamonte, Jason Cooper and Reeves Gabrels, last topped the Official Albums Chart with 1992 record Wish. 

16 years in the making, Songs Of A Lost World outsells the rest of the Top 5 combined to reach the summit, and earns the group a 23rd Top 40 album overall.

Reacting to the news, The Cure’s Robert Smith says: 

“It is enormously uplifting, genuinely heartwarming to experience such a wonderful reaction to the release of the new Cure album. 

“To everyone who has bought it, listened to it, loved it, believed in us over the years - THANK YOU!”

Song Of A Lost World also tops the Official Vinyl Albums Chart, the week’s biggest seller on wax, and the Official Record Store Chart, proving the most popular LP of the past seven days in independent UK record shops. 

The record’s release reignites interest in The Cure’s back catalogue, too. 2001’s Greatest Hits returns to the Top 40 for the first time in five years, vaulting 76 spots (30).

The Cure's Songs of a Lost World debuts at #4 on the Billboard 200 in the US.

From Billboard:

The Cure achieves its highest charting album in over 30 years, and first top 10 in over 20 years, with the No. 4 debut of Songs of a Lost World.

Songs of a Lost World bows with 57,000 equivalent album units earned (the act’s best week by units). Of that sum, album sales comprise 53,000 (The Cure’s biggest sales week since 2004, when its self-titled album launched with 91,000), SEA units comprise 4,000 (equaling 5.02 million on-demand official streams of the album’s songs) and TEA units comprise a negligible sum. Songs of a Lost World also debuts at No. 1 on Top Album Sales; the first leader for The Cure on the 33-year-old chart. The new album’s first-week sales were bolstered by its availability across five vinyl variants (which sold a combined 23,000 copies; the band’s best week on vinyl since Luminate began tracking sales in 1991), a standard CD, a CD/blu-ray audio package, two cassettes, a standard digital download and a deluxe digital download with five bonus live tracks (exclusive to the band’s webstore).

Songs of a Lost World debuts at:

Australia - #5

Austria - #1

Belgium (Flemish and Wallonian) - #1

Canada - #12

Denmark - #1

Dutch - #1

France - #1

Germany - #1

Ireland - #3

Italy - #2

New Zealand - #3

Scotland - #1

Spain - #2

Sweden - #1

Switzerland - #1

UK - #1

US - #4

From Variety:

From Billboard:

The Cure’s ‘Songs of a Lost World’ Debuts at No. 1 on Multiple Billboard Charts

The set marks the group's first leader on the 33-year-old Top Album Sales chart, and the band's highest-charting album on the Billboard 200 since 1992.

By Keith Caulfield 

The Cure make a striking return to Billboard’s album charts (dated Nov. 16) with the arrival of Songs of a Lost World. It’s the band’s first No. 1 on the 33-year-old Top Album Sales chart and the act’s highest-charting effort on the Billboard 200 (No. 4) since 1992. It also bows at No. 1 on Top Rock & Alternative Albums, Top Rock Albums, Top Alternative Albums, Vinyl Albums and Indie Store Album Sales.

Songs of a Lost World is the group’s first album of new material since 2008. The new album is the act’s third top 10-charting set on the Billboard 200, following its self-titled effort (No. 7 in July 2004) and Wish (No. 2 in May 1992)

Equivalent album units comprise album sales, track equivalent albums (TEA) and streaming equivalent albums (SEA). Each unit equals one album sale, or 10 individual tracks sold from an album, or 3,750 ad-supported or 1,250 paid/subscription on-demand official audio and video streams generated by songs from an album. Nov. 16, 2024-dated charts will be posted in full on Billboard’s website on Tuesday, Nov. 12.

Songs of a Lost World bows with 57,000 equivalent album units earned (the act’s best week by units) in the United States in the week ending Nov. 7, according to Luminate. Of that sum, album sales comprise 53,000 (The Cure’s biggest sales week since 2004, when its self-titled album launched with 91,000), SEA units comprise 4,000 (equaling 5.02 million on-demand official streams of the album’s songs) and TEA units comprise a negligible sum.

The new album’s first-week sales were bolstered by its availability across five vinyl variants (which sold a combined 23,000 copies; the band’s best week on vinyl since Luminate began tracking sales in 1991), a standard CD, a CD/blu-ray audio package, two cassettes, a standard digital download and a deluxe digital download with five bonus live tracks (exclusive to the band’s webstore).

The set’s “A Fragile Thing” rises 25-22 on Alternative Airplay (a new peak and its highest charting song since 2004) and 12-10 on Adult Alternative Airplay (The Cure’s first top 10, and third charting hit, since the list began in 1996).

These musicians bring both sensitivity and creativity to their work, blending tradition with innovation in a way that’s sure to make this concert an unforgettable experience.

By Harold Hutchison Former Acting Secretary of Homeland Security Chad Wolf told CNN host Jim Acosta Tuesday that the incoming Trump administration would “initiate a pretty large program” to locate children the Biden-Harris administration lost track of. At least 85,000 children placed into the custody of the Office of Refugee Resettlement (ORR) are unaccounted for, […]

The post Former Trump Official Reminds Jim Acosta Of ‘Over 330,000 Children’ Biden-Harris Admin Lost Track Of At Border appeared first on Liberty Unyielding.

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The following article, Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights, was first published on Conservative Firing Line.

(Natural News) Liberals have been working hard to portray Trump as a misogynist, and it worked on a lot of women – with some of them buying into the false narrative that he will work against women so wholeheartedly that they are now having very public meltdowns over his victory. Revolver put together some of the …

Continue reading Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights ...

If Democrat politicians want our votes in the future then it would be nice if they said they were sorry for what they have done in the past. We don’t have far to look. Let’s see at why they lost and how they can win.

The post Why Democrats Lost the 2024 Elections appeared first on Clash Daily.

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Phospholipase Cε (PLCε) is activated downstream of G protein–coupled receptors and receptor tyrosine kinases through direct interactions with small GTPases, including Rap1A and Ras. Although Ras has been reported to allosterically activate the lipase, it is not known whether Rap1A has the same ability or what its molecular mechanism might be. Rap1A activates PLCε in response to the stimulation of β-adrenergic receptors, translocating the complex to the perinuclear membrane. Because the C-terminal Ras association (RA2) domain of PLCε was proposed to the primary binding site for Rap1A, we first confirmed using purified proteins that the RA2 domain is indeed essential for activation by Rap1A. However, we also showed that the PLCε pleckstrin homology (PH) domain and first two EF hands (EF1/2) are required for Rap1A activation and identified hydrophobic residues on the surface of the RA2 domain that are also necessary. Small-angle X-ray scattering showed that Rap1A binding induces and stabilizes discrete conformational states in PLCε variants that can be activated by the GTPase. These data, together with the recent structure of a catalytically active fragment of PLCε, provide the first evidence that Rap1A, and by extension Ras, allosterically activate the lipase by promoting and stabilizing interactions between the RA2 domain and the PLCε core.

Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme and transcriptional coactivator and is critical for tumor metabolism. In cancer cells, native tetrameric PKM2 is phosphorylated or acetylated, which initiates a switch to a dimeric/monomeric form that translocates into the nucleus, causing oncogene transcription. However, it is not known how these post-translational modifications (PTMs) disrupt the oligomeric state of PKM2. We explored this question via crystallographic and biophysical analyses of PKM2 mutants containing residues that mimic phosphorylation and acetylation. We find that the PTMs elicit major structural reorganization of the fructose 1,6-bisphosphate (FBP), an allosteric activator, binding site, impacting the interaction with FBP and causing a disruption in oligomerization. To gain insight into how these modifications might cause unique outcomes in cancer cells, we examined the impact of increasing the intracellular pH (pHi) from ∼7.1 (in normal cells) to ∼7.5 (in cancer cells). Biochemical studies of WT PKM2 (wtPKM2) and the two mimetic variants demonstrated that the activity decreases as the pH is increased from 7.0 to 8.0, and wtPKM2 is optimally active and amenable to FBP-mediated allosteric regulation at pHi 7.5. However, the PTM mimetics exist as a mixture of tetramer and dimer, indicating that physiologically dimeric fraction is important and might be necessary for the modified PKM2 to translocate into the nucleus. Thus, our findings provide insight into how PTMs and pH regulate PKM2 and offer a broader understanding of its intricate allosteric regulation mechanism by phosphorylation or acetylation.

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Clostridium difficile is an anaerobic and spore-forming bacterium responsible for 15–25% of postantibiotic diarrhea and 95% of pseudomembranous colitis. Peptidoglycan is a crucial element of the bacterial cell wall that is exposed to the host, making it an important target for the innate immune system. The C. difficile peptidoglycan is largely N-deacetylated on its glucosamine (93% of muropeptides) through the activity of enzymes known as N-deacetylases, and this N-deacetylation modulates host–pathogen interactions, such as resistance to the bacteriolytic activity of lysozyme, virulence, and host innate immune responses. C. difficile genome analysis showed that 12 genes potentially encode N-deacetylases; however, which of these N-deacetylases are involved in peptidoglycan N-deacetylation remains unknown. Here, we report the enzymes responsible for peptidoglycan N-deacetylation and their respective regulation. Through peptidoglycan analysis of several mutants, we found that the N-deacetylases PdaV and PgdA act in synergy. Together they are responsible for the high level of peptidoglycan N-deacetylation in C. difficile and the consequent resistance to lysozyme. We also characterized a third enzyme, PgdB, as a glucosamine N-deacetylase. However, its impact on N-deacetylation and lysozyme resistance is limited, and its physiological role remains to be dissected. Finally, given the influence of peptidoglycan N-deacetylation on host defense against pathogens, we investigated the virulence and colonization ability of the mutants. Unlike what has been shown in other pathogenic bacteria, a lack of N-deacetylation in C. difficile is not linked to a decrease in virulence.

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