GPS Insight, a provider of fleet software for organizations, announced the acquisition of ServiceBridge.

New A2L-related code requirements will impact HVAC system installation and include warning labels, ventilation, leak detection, and limits on refrigerant amounts for comfort air conditioning.

In the latest episode of Ask the Expert, Kevin Mardegian and Tess Huge share their expertise on estimating within the restoration industry. Discover key strategies for onboarding homeowners, negotiating with adjusters, and enhancing cash flow while building a collaborative network that elevates the entire industry. Join us to learn how mastering the art of estimating can drive success in your restoration business.

Senior Research Associate Stephen Hoskins CREA The issues facing a growing silver population are gaining ground. Singapore’s baby boomers are now exiting the workforce. Would those approaching retirement have enough resources to maintain their current standard of living? Would future policy changes in healthcare, housing and pension impact their retirement adequacy? Facing a rapidly ageing population, Singapore is presented with urgent policy challenges. Yet there is very little data on the economic, health and family circumstances of older Singaporeans. In response, the Centre for Research on the Economics of Ageing, or CREA, at the Singapore Management University has been collecting monthly data on a panel of Singaporeans aged between 50 and 70 years, resulting in the Singapore Life Panel®, or SLP. SMU’s Prof Bryce Hool and Prof Rhema Vaithianathan detail the methodology by which the SLP was constructed, in a published paper titled High-Frequency Internet Survey of a Probability Sample of Older Singaporeans: The Singapore Life Panel®. In this podcast, Stephen Hoskins, Senior Research Associate at CREA introduces the SLP and how it yields rich and remarkable insights to Singapore’s ageing situation. Additional Info High-frequency Internet survey of a probability sample of older Singaporeans: The Singapore Life Panel - by Rhema Vaithianathan, Bryce Hool, Michael D. Hurd, Susann Rohwedder

Trust is an important building block for organisational success, whether it is trust between managers and their subordinates or a brand and its customers. Tan Hwee Hoon is an Associate Professor of Human Resources & Organisational Behaviour at SMU’s Lee Kong Chian School of Business. She has been involved in a multi-year study on trust that spans 30 countries across six continents. In this podcast, she shares her insights into the research which examines how factors of trustworthiness – that is, ability, benevolence and integrity – vary in terms of importance in trust-building across countries; and how one’s general willingness to trust, also termed ‘propensity to trust’, affects relationship-building in different countries.

The shift from rigid to flexible packaging has been evident for some time now – and it’s only growing.

Labelexpo Americas 2024 in Rosemont, Illinois, was a key event for the label and package printing industry, featuring over 450 exhibitors. It offered live demonstrations and showcased the latest advancements in machinery and materials, underscoring its significance as a premier platform for industry innovation and networking since 1989.

Good morning, afternoon and evening all. Any charts, technical analysis, trade ideas, thoughts, views, ForexLive traders would like to share and discuss with fellow ForexLive traders, please do so:

Washington, D.C. -- Actor, director and educator LeVar Burton will receive the first-ever Insight Award from the Library of American Broadcasting Foundation (LABF) in recognition of his extraordinary contributions to broadcasting, history and American culture. Burton will be honored during the NAB Show Welcome on Monday, April 25 in Las Vegas, Nev.

Washington, D.C. – A new three-part Radio Experience at NAB Show New York will feature a special Radio Insights Executive Seminar presented by Bloomberg. Exclusively for NAB members, the limited capacity executive program will take place in New York on October 19 at the Javits Center in the morning and continue in the afternoon at Bloomberg’s headquarters.

WASHINGTON, D.C. -- The National Association of Broadcasters (NAB) today hosted a virtual town hall to brief NAB members on advocacy and business issues facing the broadcast industry for the remainder of the year. NAB President and CEO Curtis LeGeyt was joined by senior executives and public policy staffers to offer updates on the association’s work, priorities and initiatives.

Venerated television news magazine “60 Minutes” will receive the second annual Insight Award from the Library of American Broadcasting Foundation (LABF) during the Welcome Session at the 2023 NAB Show on April 17 in Las Vegas, Nev. The award recognizes the iconic program’s 55-year history of excellence in broadcast journalism.

WASHINGTON, D.C. – NAB Show New York is proud to introduce the new Broadcast Content Summit, offering customized tracks for television and radio. Produced by the National Association of Broadcasters (NAB), this exclusive conference scheduled for Thursday, October 26, is tailored for content creators, programmers, talent and station managers.

Washington, D.C. – The Library of American Broadcasting Foundation (LABF) today announced Emmy Award-winning broadcaster, author and philanthropist Soledad O’Brien as the third annual Insight Award recipient. O’Brien will be honored during the NAB Show Welcome, April 15 at 9:30 a.m. PT.

Washington, D.C.— From creative collaboration to game-changing AI technology in sports, media and entertainment and sustainability to delivering premium experiences on the smallest to largest screens, thought leaders in the broadcast, media and entertainment industries will lead deep-dive conversations into the future of content, connection and monetization strategies.

NEW YORK — The 2024 NAB Show New York officially opens its doors at the Jacob K. Javits Convention Center, showcasing some 250 Exhibitors and welcoming attendees to the premier East Coast event for the broadcast, media and entertainment industry. With hundreds of new products on display, 20 new product launches and nearly 50 first-time Exhibitors, this year’s Show promises to deliver the latest innovations in AI, sports media, and content creation.

User Interface (UI) design serves as the critical link connecting users with digital products, culminating in seamless and delightful experiences. UI design is more than just entertaining visuals; it’s the magic wand that transforms digital interactions into seamless and pleasant experiences. Whether you’re a seasoned UI design expert or someone just beginning to explore this […]

The post Unveiling Inspiring UI Design Examples and Insights appeared first on Usability Geek

Get a firsthand look at the most recent State of the Industry survey results to better gauge the marketplace as we settle into 2022.

Learn more about Erie Home, which earned the #4 spot on the 2023 Top 100 list, and how it succeeds from CEO Jenilee Common.

o9 Solutions, the enterprise AI software platform provider for transforming planning and decision-making, and analyst firm Supply Chain Insights, has announced that LKQ Europe captured significant supply chain planning insights as a result of the company’s participation in a pilot programme designed to test outside-in planning concepts through Project Zebra.

Granicus’ Angy Peterson says effective data management allows agencies to make evidence-based decisions on customer outreach and engagement.

The post How to refine CX outreach through data-driven insights first appeared on Federal News Network.

Hear from federal sales executives who are thought leaders in our space. They will share their insights on 3 important areas for successful federal sales and marketing organizations.

The post Episode 24: Insights from expert Federal Sales Leaders: Standing up your federal sales organization and effectively driving revenue at end of fiscal year first appeared on Federal News Network.

Learn how the Coast Guard, NSF and USAID are not only improving their enterprise environments but doing so in ways that best support their workforces in delivering services while also keeping federal data secure. | Download our new ebook

The post Taking the leap: Real-world agency transformation insights first appeared on Federal News Network.

The Brand Registry Group (BRG) is the global association of companies and organizations working together to champion the use of .brand top-level domains and includes some of the world's most recognized consumer and B2B brands. In advance of the ICANN81 meeting in Istanbul Türkiye next week, the BRG is providing an update on ICANN's new gTLD program in several sessions that may be of interest to prospective .brand applicants.

Understanding Ssss On Your Boarding Pass: Key Insights

Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular architecture.1?

New application of Raman spectroscopy imaging allows scientists to probe the chemical composition of sailors lost at sea over 500 years ago.

Super Sparkle is returning to say au revoir…

While there's always an impressive power hearing a full symphony fill a room with sound, there's a stirring subtlety that can only be achieved via classic music on a smaller scale.  That's a sonic itch that the Spokane String Quartet is always happy to scratch. Before the Spokane String Quartet takes the stage at The Fox this Sunday for a program featuring special guest pianist Archie Chen, we caught up with violinist Amanda Howard-Phillips—who has played with the quartet since 2011 and  is also second violin in the Spokane Symphony — to chat about the communal expression of string quartet music, SSQ's upcoming shows, and the unique place the group occupies in Spokane…

The folk duo with Spokane connections wrestles with grief on its new album, 'Debris.' Loss is never easy. Loss during a pandemic is even tougher…

LLM-powered multiagent persona simulation for imagination enhancement and business insights. - microsoft/TinyTroupe

Google представила несколько нововведений для браузера Chrome на iPhone и iPad. В частности, функция Google Lens теперь позволяет одновременно искать по изображению и тексту.

Google today announced several new features for the Chrome browser that's available on the iPhone and the iPad, with the new additions aimed at providing users with more intuitive ways for finding information and completing tasks.


Google Lens now supports searching with images and text at the same time, rather than search being limited to just an image. Users can add words to a visual query to refine results and conduct more complex searches.

Google Drive and Google Photos users can now save content from the web directly to those services from Chrome, freeing up on-device storage space. To save a file to Google Drive from Chrome, tap on the Google Drive option. Saving an image to ‌Photos‌ from Chrome can be done by long pressing on the image and then selecting the Save in Google ‌Photos‌ option.

For U.S. users, Chrome on iOS is gaining Shopping Insights, which are designed to better surface deals. If Chrome has Shopping Insights for a product that a user is searching for, there will be a "Good Deal Now" notification in the address bar. The feature requires signing into Chrome and toggling on "Make Searches and Browsing Better."

When viewing a map of an address in Chrome, users will soon be able to tap an underlined address and see a more detailed mini-map of the location directly in the browser without having to swap over to Google Maps. Google says that it is experimenting with this feature and will roll it out globally over the coming months.

A Planetary Society-funded project to understand asteroids achieved its main goals and scientific objectives this year.

Everyone needs to read this woman's insightful Facebook post amidst the whole college admission's scandal dominating our news feeds. 

“Eagle Traffic Signals – 1970s” by RS 1990 is licensed via CC BY-NC-SA 2.0.. At the intersection of rapid advancements in generative AI and our ongoing strategy refresh, we’ve been deeply engaged in researching, analyzing, and fostering conversations about AI and value alignment. Our goal is to ensure that our legal and technical infrastructure remains…

The post Six Insights on Preference Signals for AI Training appeared first on Creative Commons.

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Russia–China defence and security relations: Insights from the expert community 13 September 2022 — 3:00PM TO 4:00PM Anonymous (not verified) 31 August 2022 Online

Experts share insights on Russia–China military, defence, and security relations. 

In the defence and security realms, Russia–China relations resemble more pragmatic cooperation based on shared, calculated interests than an alliance.

This event presents and discusses key findings from a recent expert survey conducted by Chatham House with the aim to gather insights on Russia–China military, defence, and security relations.

Survey responses helped identify areas of bilateral cooperation but also crucial friction points and obstacles that prevent the relationship from developing further, as well as policy pathways for the West.

Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal bacterium Ruminococcus gnavus, requires two radical SAM enzymes (RumMC1 and RumMC2) catalyzing the formation of four Cα-thioether bridges. These bridges, which are essential for RumC's antibiotic properties against human pathogens such as Clostridium perfringens, define two hairpin domains giving this sactipeptide (sulfur-to-α-carbon thioether–containing peptide) an unusual architecture among natural products. We report here the biochemical and spectroscopic characterizations of RumMC2. EPR spectroscopy and mutagenesis data support that RumMC2 is a member of the large family of SPASM domain radical SAM enzymes characterized by the presence of three [4Fe-4S] clusters. We also demonstrate that this enzyme initiates its reaction by Cα H-atom abstraction and is able to catalyze the formation of nonnatural thioether bonds in engineered peptide substrates. Unexpectedly, our data support the formation of a ketoimine rather than an α,β-dehydro-amino acid intermediate during Cα-thioether bridge LC–MS/MS fragmentation. Finally, we explored the roles of the leader peptide and of the RiPP precursor peptide recognition element, present in myriad RiPP-modifying enzymes. Collectively, our data support a more complex role for the peptide recognition element and the core peptide for the installation of posttranslational modifications in RiPPs than previously anticipated and suggest a possible reaction intermediate for thioether bond formation.

George H. Rothblat
May 1, 1999; 40:781-796
Reviews

Insights from Climate Policy: Engaging Subnational Governments in Global Platforms 10 June 2020 — 2:45PM TO 6:00PM Anonymous (not verified) 9 February 2021 Online

How have subnational governments shaped the global agenda and created momentum on climate change where national and international governance processes could not?

Can these advances be converted into meaningful collaboration channels for policy development? What works, or does not, when it comes to engagement with multilateral negotiation processes? What ingredients are necessary for success? What are the broader implications of these trends for inclusivity and innovation in international governance?

This event is part of the Inclusive Governance Initiative, which is examining how to build more inclusive models and mechanisms of global governance fit for purpose in today’s world.

α-Linked galactose is a common carbohydrate motif in nature that is processed by a variety of glycoside hydrolases from different families. Terminal Galα1–3Gal motifs are found as a defining feature of different blood group and tissue antigens, as well as the building block of the marine algal galactan λ-carrageenan. The blood group B antigen and linear α-Gal epitope can be processed by glycoside hydrolases in family GH110, whereas the presence of genes encoding GH110 enzymes in polysaccharide utilization loci from marine bacteria suggests a role in processing λ-carrageenan. However, the structure–function relationships underpinning the α-1,3-galactosidase activity within family GH110 remain unknown. Here we focus on a GH110 enzyme (PdGH110B) from the carrageenolytic marine bacterium Pseudoalteromonas distincta U2A. We showed that the enzyme was active on Galα1–3Gal but not the blood group B antigen. X-ray crystal structures in complex with galactose and unhydrolyzed Galα1–3Gal revealed the parallel β-helix fold of the enzyme and the structural basis of its inverting catalytic mechanism. Moreover, an examination of the active site reveals likely adaptations that allow accommodation of fucose in blood group B active GH110 enzymes or, in the case of PdGH110, accommodation of the sulfate groups found on λ-carrageenan. Overall, this work provides insight into the first member of a predominantly marine clade of GH110 enzymes while also illuminating the structural basis of α-1,3-galactoside processing by the family as a whole.

Carlota Oleaga
Nov 17, 2020; 0:jlr.RA120000964v1-jlr.RA120000964
Research Articles

Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins. In vivo, proteolysis may modulate amyloidogenesis and fibril stability. In light chain (AL) amyloidosis, fragmented light chains (LCs) are abundant components of amyloid deposits; however, site and timing of proteolysis are debated. Identification of the N and C termini of LC fragments is instrumental to understanding involved processes and enzymes. We investigated the N and C terminome of the LC proteoforms in fibrils extracted from the hearts of two AL cardiomyopathy patients, using a proteomic approach based on derivatization of N- and C-terminal residues, followed by mapping of fragmentation sites on the structures of native and fibrillar relevant LCs. We provide the first high-specificity map of proteolytic cleavages in natural AL amyloid. Proteolysis occurs both on the LC variable and constant domains, generating a complex fragmentation pattern. The structural analysis indicates extensive remodeling by multiple proteases, largely taking place on poorly folded regions of the fibril surfaces. This study adds novel important knowledge on amyloid LC processing: although our data do not exclude that proteolysis of native LC dimers may destabilize their structure and favor fibril formation, the data show that LC deposition largely precedes the proteolytic events documentable in mature AL fibrils.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by inducing the degradation of hepatic low-density lipoprotein receptor (LDLR). Plasma PCSK9 has two main molecular forms: a 62-kDa mature form (PCSK9_62) and a 55-kDa, furin-cleaved form (PCSK9_55). PCSK9_55 is considered less active than PCSK9_62 in degrading LDLR. We aimed to identify the site of PCSK9_55 formation (intra- vs. extracellular) and to further characterize the LDLR-degradative function of PCSK9_55 relative to PCSK9_62. Co-expressing PCSK9_62 with furin in cell culture induced formation of PCSK9_55, most of which was found in the extracellular space. Under the same conditions we found that: i) adding a cell-permeable furin inhibitor preferentially decreased the formation of PCSK9_55 extracellularly; ii) using pulse-chase, we observed the formation of PCSK9_55 exclusively extracellularly in a time-dependent manner. A recombinant form of PCSK9_55 was efficiently produced but displayed impaired secretion that resulted in its intracellular trapping. However, the non-secreted PCSK9_55 was able to induce degradation of LDLR, though with 50% lower efficiency compared with PCSK9_62. Collectively, our data show that PCSK9_55 is generated in the extracellular space, and that intracellular PCSK9_55 is not secreted but retains the ability to degrade the LDLR through an intracellular pathway.

The demand for high-performance computing (HPC) and artificial intelligence (AI) is rising dramatically as organizations rush to put their data to work. Several industries see a significant increase in HPC […]

The post Harness Insights with Cutting-edge AI Capabilities from HPE appeared first on HPCwire.

It’s a wrap! The Texas Advanced Computing Center (TACC) at UT Austin welcomed more than 100 participants for the 7th annual TACC Symposium for Texas Researchers (TACCSTER). The event exists […]

The post Research Insights, HPC Expertise, Meaningful Collaborations Abound at TACCSTER 2024 appeared first on HPCwire.

Teachers in Tennessee have an important voice in shaping state initiatives and policies.

Yasmin L. Hurd
Oct 16, 2019; 39:8250-8258
Symposium and Mini-Symposium

A museum in Fort McMurray is helping visitors gain a deeper understanding of Canada’s role in previous wars. The Wood Buffalo Military Museum Centre is offering a chance to get up close to military artifacts. Young visitors say seeing the remnants of conflict gives them a new understanding of Remembrance Day's meaning.