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The report notes a shift in financial savings towards life insurance and equities, with a projected rise in equity holdings evidenced by the rapid surge in demat accounts

According to the commodities information services provider, India's oil demand decreased in September on a yearly basis, due to above normal rainfall, which affected road movement, construction, and mining activities

Start your day with InsuranceDekho CTO Ish Babbar’s morning mindfulness routine: deep breathing, stretching, running & more

Oxford : Oxford University Press, 2021.

Montreal : National Film Board of Canada, 2019

Abingdon, Oxon ; New York, NY : Routledge , 2025.

Young Arshdeep Singh is getting better continuously, and the left-arm seamer has attributed this to his ability to keep things simple and stay level-headed in pressure situations, which has helped him evolve into a death-overs specialist.

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.

Meeting Christian refugees praying for European governments made a deep impression on a Transform participant. For another, the term ‘refugee’ got a whole new meaning.

This week, we welcome Joanne Janzen, an Edmonton-based music life coach who also hosts her own podcast, fittingly titled The Music Life Coach Podcast. In this enlightening conversation with Jo, she teaches us what exactly a music life coach does and how she became one while also navigating her own career as a professional musician. We then get into career development, psychology, mental health, live performance, and how Jo's work differs from and complements that of an artist manager. She also gives us some tips on professional networking and developing a "personal mindset strategy" to propel your career forward.

http://musiclifecoach.joannejanzen.com/ http://canadianmusician.com