Switching to the Gutenberg Editor was probably the most controversial change in WordPress's history. I'll help you decide whether you should start using Gutenberg for your podcast's WordPress website.

Allein auf großer Fahrt – darauf freuen sich bundesweit Millionen Schüler und Azubis. Zu Jahresbeginn registrierten Kinder- und Jugendreiseveranstalter Buchungszuwächse – und trotz Corona-Krise gibt es kaum Stornierungen.

Bei der Smartphone-Wahl zählt für viele Nutzer heutzutage vor allem eines: Es muss beeindruckende Fotos machen können. Ein Handy mit guter Kamera zu finden, ist allerdings nicht immer leicht – worauf Sie bei der Wahl achten sollten und welche Modelle derzeit im Handel punkten können, erfahren Sie hier.

“Strawberries is kind of the quintessence of industrial agriculture in California. It’s the fifth highest value crop in the state. It also got the most heavy pesticide regime, by far, of any other crop in the state. And it kind of captures so much of the dynamics of what’s going on in California.“-Julie Guthman In...

A superior selection of dub-infused disco from one of soul’s most underrated talents.

Police investigate two fires in North Adelaide early this morning, including one which spread through the state branch office of the national doctors' union, causing up to $2 million damage.

Outback journalist Jaimee-lee Prow is on the spot in the southern Queensland town of Muckadilla as fire guts the local pub.

In musical circles, there's a mythical quality to that name, attached as it is to the father of American protest song, Woody Guthrie.

The Tasmanian Premier Peter Gutwein says public schools will remain open, but parents who wish to keep children home may do so.

Leaders show us their true colours during a crisis, and Tasmanian Premier Peter Gutwein — only in the job three months and following the popular Will Hodgman — is already giving clues as to how he will fare, writes Emily Baker.

Tasmanian Premier Peter Gutwein says the Chief Medical Officer's claims that the north-west Tasmanian coronavirus outbreak started with a dinner party of health workers are a rumour that will be followed up.

The shooting of Nambour director Chris Sun's fourth horror epic is underway in the small country town of Kandanga in the Mary Valley. If you are lucky enough to pass through the one street hamlet in the next month you will see some of Australia's finest actors. ABC Sunshine Coast spoke to a few of them about the experience.

Some koalas may be pickier eaters than others due to the mix of microbes in their lower gastrointestinal tract, but faecal transplants could help them diversify their diet, a new study suggests.

A life-changing adventure for a Broome based GP and his son: Dave and Tom Berger have flown 40,000km in a single-engine plane.

The Government believes the projects will create more than 600 jobs and generate enough clean energy to power more than 80,000 homes, while farmers have labelled the decision as "gutless".

The NBL grapples with the challenge of keeping an equal playing field between the haves and the 'have-lots', as professional basketball undergoes a lucrative renaissance in Australia.

(United States Second Circuit) - In a trademark suit brought by a provider of healthcare services against a provider of digital health-related content, the District Court's injunction which prohibited defendant from using its marks within plaintiff’s geographic service area, but placed no restriction on defendant's use of its marks on the Internet or outside plaintiff's service area, is affirmed but remanded for expansion of the injunction's scope, where the current limitations placed on defendant were based on an incorrect standard and fail to give plaintiff and the public adequate protection from likely confusion.

(California Court of Appeal) - Affirmed. Defendant was convicted of first-degree murder on a felony-murder theory. Defendant challenged his convictions in part based on Senate Bill 1437 that amended the felony-murder rule. The appeals court concluded that Defendant was not entitled to relief, but that relief could be available to other defendants by petitioning their trial courts.

(United States Ninth Circuit) - Affirmed in part, reversed in part. The panel affirmed that continued detention for five hours after the shooting violated plaintiffs’ clearly established Fourth Amendment rights. However, because no analogous case existed at the time of the shooting, the district court erred by denying Gutierrez qualified immunity for this claim.

Over the past year or so, Greta has grown particularly picky about eating. The biggest problem with this is that when she doesn't eat, she gets sick. Out both ends. And there's sometimes blood. This is unpleasant enough for Dan and I, but has to be even worse for her. The problem could usually be solved just by making absolutely sure that she ate her meals, but I recently took her to the vet to see if there was another problem.

Come to find out that GSDs often have digestive issues and now we are in the middle of trying to diagnose hers. It could be as simple as a parasite (though none shows up in the tests) or as complicated as IBD. For now, she is taking some antibiotics and just finished her first course of dewormer, so we'll see where things go from there. I'm happy to report that she's been eating well, at least, and hasn't had any issues.

Does anyone have any experience with this? I'm told it's very very common in GSDs, especially!

Viele Bluetooth-Kopfhörer liefern gute Klangqualität, sagt Peter Knaak von der Stiftung Warentest. Worauf Sie beim Kauf achten sollten.

Der Kabarettist Sebastian Pufpaff tritt nun notgedrungen ohne Publikum auf. Hier spricht er über die Stille nach der Pointe - und über den Angriff auf das Team der "heute-show".

To predict how diet shapes a person’s gut microbiome, researchers came up with a new way to categorize foods.

Public health experts are urging people to stay home to avoid spreading coronavirus. But that means some people could end up losing their homes.

Obama got Osama.

That's what some people chanted when the news of Osama Bin Laden's killing broke. But will it have any impact on the President Barack Obama's politics and popularity?

Mr Obama has gone out of his way to stress that "get Bin Laden" was his direct instruction and that the arch villain's death is, in part, his victory. White House officials are doing all they can to capitalise on what looks like a mood of nationwide elation.

Any president who "got" Bin Laden would benefit. Former President Bill Clinton's efforts were mocked by George W Bush. Then he failed too, losing Bin Laden in the caves along the border land, as US soldiers stood by.

But perhaps Mr Obama will benefit more than most. His style of decision making is to take time, to deliberate, to chew over every option. His critics call it dithering. There are now some excellent "tick tocks" as they are called here - blow by blow accounts of the decision making process. But you always have to remember all sources are in the circle, and liable to portray the president positively. It sounds as if Mr Obama gave this decision as much time and thought as all the others but away from the public gaze.

Not only did Mr Obama's security advisor John Brennan praise him, but Republicans have even called his decision "gutsy". He did not simply go for bombs or drones but rather a helicopter raid. One insider is quoted as saying that Black Hawk Down was mentioned a few times in the discussions. When that helicopter did go down, Mr Obama surely thought of Jimmy Carter and Iran.

So he's a risk taker, too. It also makes him look focused on what is truly in the US's national interest. You can argue Iraq wasn't, Libya wasn't, even Afghanistan no longer is. But getting the head of al-Qaeda clearly was a number one priority in the minds of many Americans, and Mr Obama decided it was his as well.

Even habitual enemies, indeed even Rush Limbaugh, have praised him. At a reception for Republicans and Democrats last night, he got a standing ovation.

So the wind is behind him. Whence will he sail? At a White House dinner for members of Congress, he used Bin Laden's killing as a call for unity.

He said: "We were reminded again that there is a pride in what this nation stands for, and what we can achieve, that runs far deeper than party, far deeper than politics."

From Bin Laden, he moved effortlessly to domestic public enemy number one, the deficit. "It is my fervent hope that we can harness some of that unity and some of that pride to confront the many challenges that we still face," Mr Obama said.

On Thursday, Mr Obama will travel to New York City to remember those who died in Bin Laden's assault on America. I expect more talk of unity but perhaps some big foreign policy themes as well. There are those who think the halo of success makes it easier for the president to confront a military that wants July's Afghanistan wind-down to be small and fairly insignificant. Others, however, think the momentum runs the other way, and that it gives all the more reason to stay and finish the job.

So the killing sends waves that will wash against these shores and those of a wider world. Some are saying this moment assures Mr Obama's re-election. It assures no such thing.
Apart from the obvious point that there can be many other unexpected events that will have an impact, positive or negative, It just doesn't work like that. However huge this event snow seems, wait a couple of months. In the relentless frenzy of the 24-hour media cycle, it will probably be half forgotten by the the time of the election.

This far out, only events that mean change to people's lives on a day-to-day basis have that sort of game changing impact. But image is important. The president has burnished his in the eyes of many Americans and looks like a resolute commander-in-chief. He knows it, and intends to milk the moment for all it is worth.

Woody Guthrie Center will honor John Mellencamp's career of spotlighting "the everyday man and woman, the less fortunate and the forgotten."

An array of scientific evidence suggest that in some cases, the bacteria in your gut–your microbiome–could be tied to neurological and psychological disorders and differences, from anxiety and autism to Parkinson's and schizophrenia. The journal Science published a survey of the field and the Cambridge, Massachusetts start-up Holobiome that hopes to use insight into this "psychobiome" to develop treatments for depression, insomnia, and other conditions with a neurological side to them. From Science:

For example, many people with irritable bowel syndrome are also depressed, people on the autism spectrum tend to have digestive problems, and people with Parkinson’s are prone to constipation.

Researchers have also noticed an increase in depression in people taking antibiotics—but not antiviral or antifungal medications that leave gut bacteria unharmed. Last year, Jeroen Raes, a microbiologist at the Catholic University of Leuven, and colleagues analyzed the health records of two groups—one Belgian, one Dutch—of more then 1000 people participating in surveys of their types of gut bacteria. People with depression had deficits of the same two bacterial species, the authors reported in April 2019 in Nature Microbiology.

Researchers see ways in which gut microbes could influence the brain. Some may secrete messenger molecules that travel though the blood to the brain. Other bacteria may stimulate the vagus nerve, which runs from the base of the brain to the organs in the abdomen. Bacterial molecules might relay signals to the vagus through recently discovered “neuropod” cells that sit in the lining of the gut, sensing its biochemical milieu, including microbial compounds.

The following article, Greg Gutfeld Levels Ilhan Omar With Epic Response To Her Claim That “White Privilege” Is Reason Charges Were Dropped Against General Flynn, was first published on 100PercentFedUp.com.

Yesterday, after 3 1/2 years of having his character and integrity called into question, President Trump's first NSA, General Michael Flynn was finally...

Continue reading: Greg Gutfeld Levels Ilhan Omar With Epic Response To Her Claim That “White Privilege” Is Reason Charges Were Dropped Against General Flynn ...

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews

Lee Call
Apr 29, 2020; 0:jlr.RA120000652v1-jlr.RA120000652
Research Articles

Multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis by an unknown mechanism. Here, we quantified liver function, bile acid pools, and gut microbial and metabolite profiles in premature, parenterally fed pigs given a soy-oil lipid emulsion, Intralipid (IL); a multi component lipid emulsion, SMOFlipid (SMOF); a novel emulsion with a modified fatty-acid composition (EXP); or a control enteral diet (ENT) for 22 days. We assayed serum cholestasis markers; measured total bile acid levels in plasma, liver, and gut contents; and analyzed colonic bacterial 16S rRNA gene sequences and metabolomic profiles. Serum cholestasis markers (i.e. bilirubin, bile acids, and g-glutamyl transferase) were highest in IL-fed pigs and normalized in those given SMOF, EXP, or ENT. Gut bile acid pools were lowest in the IL treatment and were increased in the SMOF and EXP treatments and comparable to ENT. Multiple bile acids, especially their conjugated forms, were higher in the colon contents of SMOF and EXP than in IL pigs. Colonic microbial communities of SMOF and EXP pigs had lower relative abundance of several Gram-positive anaerobes, including Clostridrium XIVa, and higher abundance of Enterobacteriaceae than those of IL and ENT pigs. Differences in lipid and microbial-derived compounds were also observed in colon metabolite profiles. These results indicate that multi-component lipid emulsions prevent cholestasis and restore enterohepatic bile flow in association with gut microbial and metabolomic changes. We conclude that sustained bile flow induced by multi-component lipid emulsions likely exerts a dominant effect in reducing bile acid–sensitive, Gram-positive bacteria.

Bile acids (BAs) serve multiple biological functions, ranging from the absorption of lipids and fat-soluble vitamins to serving as signaling molecules through the direct activation of dedicated cellular receptors. Synthesized by both host and microbial pathways, BAs are increasingly understood as participating in the regulation of numerous pathways relevant to metabolic diseases, including lipid and glucose metabolism, energy expenditure, and inflammation. Quantitative analyses of BAs in biological matrices can be problematic due to their unusual and diverse physicochemical properties, making optimization of a method that shows good accuracy, precision, efficiency of extraction, and minimized matrix effects across structurally distinct human and murine BAs challenging. Herein we develop and clinically validate a stable-isotope-dilution LC/MS/MS method for the quantitative analysis of numerous primary and secondary BAs in both human and mouse biological matrices. We also utilize this tool to investigate gut microbiota participation in the generation of structurally specific BAs in both humans and mice. We examine circulating levels of specific BAs and in a clinical case-control study of age- and gender-matched type 2 diabetes mellitus (T2DM) versus nondiabetics. BAs whose circulating levels are associated with T2DM include numerous 12α-hydroxyl BAs (taurocholic acid, taurodeoxycholic acid, glycodeoxycholic acid, deoxycholic acid, and 3-ketodeoxycholic acid), while taurohyodeoxycholic acid was negatively associated with diabetes. The LC/MS/MS-based platform described should serve as a robust, high-throughput investigative tool for studying the potential involvement of structurally specific BAs and the gut microbiome on both physiological and disease processes.

GPR120 is implicated as a lipid receptor in the oro-sensory detection of dietary fatty acids. However, the effects of GPR120 activation on dietary fat intake or obesity are not clearly understood. We investigated to determine whether the binding of TUG891, a novel GPR120 agonist, to lingual GPR120 modulates fat preference in mice. We explored the effects of TUG891 on obesity-related hormones and conducted behavioral choice tests on mice to better understand the physiologic relevance of the action of TUG891. In cultured mouse and human taste bud cells (TBCs), TUG891 induced a rapid increase in Ca²⁺ by acting on GPR120. A long-chain dietary fatty acid, linoleic acid (LA), also recruited Ca²⁺ via GPR120 in human and mouse TBCs. Both TUG891 and LA induced ERK1/2 phosphorylation and enhanced in vitro release of glucagon-like peptide-1 from cultured human and mouse TBCs. In situ application of TUG891 onto the tongue of anesthetized mice triggered the secretion of pancreatobiliary juice, probably via the tongue-brain-gut axis. Furthermore, lingual application of TUG891 altered circulating concentrations of cholecystokinin and adipokines, associated with decreased circulating LDL, in conscious mice. In behavioral tests, mice exhibited a spontaneous preference for solutions containing either TUG891 or LA instead of a control. However, addition of TUG891 to a solution containing LA significantly curtailed fatty acid preference. Our study demonstrates that TUG891 binds to lingual GPR120 receptors, activates the tongue-brain-gut axis, and modulates fat preference. These findings may support the development of new fat taste analogs that can change the approach to obesity prevention and treatment.

Recent studies using mouse models suggest that interaction between the gut microbiome and IL-17/IL-22 producing cells plays a role in the development of metabolic diseases. We investigated this relationship in humans using data from the prediabetes study of the Integrated Human Microbiome Project (iHMP). Specifically, we addressed the hypothesis that early in the onset of metabolic diseases there is a decline in serum levels of IL-17/IL-22, with concomitant changes in the gut microbiome. Clustering iHMP study participants on the basis of longitudinal IL-17/IL-22 profiles identified discrete groups. Individuals distinguished by low levels of IL-17/IL-22 were linked to established markers of metabolic disease, including insulin sensitivity. These individuals also displayed gut microbiome dysbiosis, characterized by decreased diversity, and IL-17/IL-22-related declines in the phylum Firmicutes, class Clostridia, and order Clostridiales. This ancillary analysis of the iHMP data therefore supports a link between the gut microbiome, IL-17/IL-22 and the onset of metabolic diseases. This raises the possibility for novel, microbiome-related therapeutic targets that may effectively alleviate metabolic diseases in humans as they do in animal models.

Patrice D. Cani
Jun 1, 2008; 57:1470-1481
Metabolism

Patrice D. Cani
Jun 1, 2008; 57:1470-1481
Metabolism

Recounting her story of finding opportunity and stability in the US, Elizabeth Camarillo Gutierrez examines the flaws in narratives that simplify and idealize the immigrant experience -- and shares hard-earned wisdom on the best way to help those around us. "Our world is one that flourishes when different voices come together," she says.

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Edinburgh : T. & T. Clark, 1878.

[Paris] : [de l'Imprimerie de Clousier], [between 1780 and 1789]