In this hour, stories about guts and courage. This episode is hosted by The Moth’s Artistic Director, Catherine Burns. The Moth Radio Hour is produced by The Moth and Jay Allison of Atlantic Public Media.

Hosted by: Catherine Burns

Storytellers:

AJ Jacobs

Aleathia Brown

Kwong Yue Yang

Nisha Coleman

Leonard Lee Smith

France's most famous orangutan delighted zoo visitors with her artistic antics on Thursday (June 13), three days ahead of her 50th birthday. - REUTERS

Trump victory a ‘gut punch’ to US climate action By Benjamin Storrow, Corbin Hiar The president-elect vowed to promote fossil fuels, weaken pollution regulations and reverse Biden climate efforts. President-elect Donald Trump won a second term Wednesday morning after promising to unleash fossil fuel development, slash pollution regulations and dismantle President Joe Biden’s climate agenda. Climate […]

The findings open the door for new microbial-based therapy for anxiety and depression, according to UCC.

Read more: Gut bacteria affects stress response, UCC scientists find

[Vanguard] The United Nations, UN, Secretary-General, António Guterres, has warned about the dire need for climate action and increased funding to support vulnerable nations, stressing that "the era of global warming has ended; the era of global boiling has arrived".

It’s probably best to enjoy your Halloween spoils in moderation.

The "Gutenberg Bible" of Modern Syriac

Kom En Moedig Assyriska FF Aan Op Zaterdag 17 Juli In Gutersloh

Legislation from State Sen. Scott Wiener would introduce standards for product safety testing and liability.

In neonatal mice, the neurotransmitter serotonin mobilizes immune cells that promote tolerance to antigens.

Gut microbiome disruption in male mice increases disease risk in offspring, indicating that preconception paternal health status can affect the next generation.

En este episodio, La Luciérnaga se enciende para hablar con el
candidato a la Presidencia por el Equipo Por Colombia, FICO GUTIÉRREZ. El candidato
habla de sus propuestas y participa en el debate de Roberto Pombo de La
Luciérnaga. 



La Luciérnaga un espacio de humor, análisis y opinión de Caracol
Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este martes10 de octubre. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

En 10AM Hoy por Hoy de Caracol Radio estuvo el alcalde de Medellín, Federico Gutiérrez, para hablar sobre la seguridad y los retos que enfrenta la ciudad.

En este nuevo episodio de El Alargue, debatimos la actitud de Teófilo Gutiérrez y su intención de querer salir del Deportivo Cali. Asimismo, analizamos lo que dejó la tercera jornada de la Liga Colombiana. Como siempre, invitados: nos acompañó Alexis Márquez, extécnico del Pereira.

Andrés Cadavid, jugador antioqueño del Envigado y que en el 2019 fue relacionado con una estructura criminal de parte del exalcalde de Medellín y excandidato a la presidencia del país Federico Gutiérrez, se mostró conforme con la retractación de Fico en las últimas horas; no obstante, aseguró que no se cura todo el daño que le hizo a él y su familia estas acusaciones en su momento.

Gloria Luz Gutiérrez, literata. Hoy en la Feria Internacional del Libro de Bogotá será la premiación de poesía inédita de la tertulia de Gloria Luz Gutiérrez.

En 6AM Hoy por Hoy de Caracol Radio estuvo el alcalde de Medellín, Federico Gutiérrez, para hablar sobre cómo sería la venta que plantea para las acciones de EPM en Tigo-Une y en qué se invertirían los recursos recaudados.

A l'Arxiu Històric de Barcelona acaba d'ingressar tota la documentació del Projecte d'un Ferrocarril Metropolità Circular per a Barcelona, que proposava una xarxa a partir d'anelles que s'entrellacen, amb un abast descomunal. via Pocket

Lara Gut-Behrami has won a shortened World Cup downhill to close in on the injured Sofia Goggia in the discipline standings. She is on a four-race winning streak and overtook the absent Mikaela Shiffrin in the overall standings last weekend.

Gut-wrenching because of how the Broncos (5-5) found themselves on victory’s doorstep.

The Broncos have scored just one offensive touchdown in the second half over the last three games.

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews

Pectins are a major dietary nutrient source for the human gut microbiota. The prominent gut microbe Bacteroides thetaiotaomicron was recently shown to encode the founding member (BT1017) of a new family of pectin methylesterases essential for the metabolism of the complex pectin rhamnogalacturonan-II (RG-II). However, biochemical and structural knowledge of this family is lacking. Here, we showed that BT1017 is critical for the metabolism of an RG-II–derived oligosaccharide ΔBT1017oligoB generated by a BT1017 deletion mutant (ΔBT1017) during growth on carbohydrate extract from apple juice. Structural analyses of ΔBT1017oligoB using a combination of enzymatic, mass spectrometric, and NMR approaches revealed that it is a bimethylated nonaoligosaccharide (GlcA-β1,4-(2-O-Me-Xyl-α1,3)-Fuc-α1,4-(GalA-β1,3)-Rha-α1,3-Api-β1,2-(Araf-α1,3)-(GalA-α1,4)-GalA) containing components of the RG-II backbone and its side chains. We showed that the catalytic module of BT1017 adopts an α/β-hydrolase fold, consisting of a central twisted 10-stranded β-sheet sandwiched by several α-helices. This constitutes a new fold for pectin methylesterases, which are predominantly right-handed β-helical proteins. Bioinformatic analyses revealed that the family is dominated by sequences from prominent genera of the human gut microbiota, including Bacteroides and Prevotella. Our re-sults not only highlight the critical role played by this family of enzymes in pectin metabolism but also provide new insights into the molecular basis of the adaptation of B. thetaiotaomicron to the human gut.

Functions of the gut microbiome have a growing number of implications for host metabolic health, with diet being one of the most significant influences on microbiome composition. Compelling links between diet and the gut microbiome suggest key roles for various macronutrients, including lipids, yet how individual classes of dietary lipids interact with the microbiome remains largely unknown. Sphingolipids are bioactive components of most foods and are also produced by prominent gut microbes. This makes sphingolipids intriguing candidates for shaping diet–microbiome interactions. Here, we used a click chemistry–based approach to track the incorporation of bioorthogonal dietary omega-alkynyl sphinganine (sphinganine alkyne [SAA]) into the murine gut microbial community (Bioorthogonal labeling). We identified microbial and SAA-specific metabolic products through fluorescence-based sorting of SAA-containing microbes (Sort), 16S rRNA gene sequencing to identify the sphingolipid-interacting microbes (Seq), and comparative metabolomics to identify products of SAA assimilation by the microbiome (Spec). Together, this approach, termed Bioorthogonal labeling-Sort-Seq-Spec (BOSSS), revealed that SAA assimilation is nearly exclusively performed by gut Bacteroides, indicating that sphingolipid-producing bacteria play a major role in processing dietary sphinganine. Comparative metabolomics of cecal microbiota from SAA-treated mice revealed conversion of SAA to a suite of dihydroceramides, consistent with metabolic activities of Bacteroides and Bifidobacterium. Additionally, other sphingolipid-interacting microbes were identified with a focus on an uncharacterized ability of Bacteroides and Bifidobacterium to metabolize dietary sphingolipids. We conclude that BOSSS provides a platform to study the flux of virtually any alkyne-labeled metabolite in diet–microbiome interactions.

Bile acids, which are synthesized from cholesterol by the liver, are chemically transformed along the intestinal tract by the gut microbiota, and the products of these transformations signal through host receptors, affecting overall host health. These transformations include bile acid deconjugation, oxidation, and 7α-dehydroxylation. An understanding of the biogeography of bile acid transformations in the gut is critical because deconjugation is a prerequisite for 7α-dehydroxylation and because most gut microorganisms harbor bile acid transformation capacity. Here, we used a coupled metabolomic and metaproteomic approach to probe in vivo activity of the gut microbial community in a gnotobiotic mouse model. Results revealed the involvement of Clostridium scindens in 7α-dehydroxylation, of the genera Muribaculum and Bacteroides in deconjugation, and of six additional organisms in oxidation (the genera Clostridium, Muribaculum, Bacteroides, Bifidobacterium, Acutalibacter, and Akkermansia). Furthermore, the bile acid profile in mice with a more complex microbiota, a dysbiosed microbiota, or no microbiota was considered. For instance, conventional mice harbor a large diversity of bile acids, but treatment with an antibiotic such as clindamycin results in the complete inhibition of 7α-dehydroxylation, underscoring the strong inhibition of organisms that are capable of carrying out this process by this compound. Finally, a comparison of the hepatic bile acid pool size as a function of microbiota revealed that a reduced microbiota affects host signaling but not necessarily bile acid synthesis. In this study, bile acid transformations were mapped to the associated active microorganisms, offering a systematic characterization of the relationship between microbiota and bile acid composition.

While no candy is truly healthy, some options are better for your gut than others. And there are ways you can help wake your gut from its sugar "spell" after holiday indulgence.

Discrimination -- prejudiced actions toward people based on their identity -- may cause stress that impairs gut health and lead to the growth of unhealthy bacteria that promote inflammation, a new study has found.

Bonnie, the subject of a recently published paper, is the Smithsonian National Zoo’s famous whistling orangutan

What makes human and orangutan brains different? Researchers at the National Zoo hope to find out by playing customized computer games with the savvy primates.

At the National Zoo, primates undergo routine checkups to ensure a healthy lifestyle.

The gut microbiome doesn't just regulate digestion and metabolism; it plays a critical role in how we react to stress.

According to Ayurveda and gut health coach Dimple Jangda, smoothies may do more harm than good, especially for your gut health.

The United Nations Secretary General António Guterres congratulated grassroots Japanese organization Nihon Hidankyo on being awarded the 2024 Nobel Peace Prize. “The atomic bomb survivors from Hiroshima and Nagasaki, also known as the hibakusha, are selfless, soul-bearing witnesses of the horrific human cost of nuclear weapons,” he said in a statement. “While their numbers grow smaller each […]

Horses that are bred to race seem to perform better on the course if they had a diverse gut microbiome as foals

The veteran presenter adds authority to Secret Lives of Orangutans, a film about a family of endangered orangutans in Sumatra. File this new entry in his vast oeuvre under lovable but lightweight

Rival tribes of bacteria armed with poison darts are fighting it out in your gut, with armies of traitors often winning the day