Selection for bigger tomatoes has made the fruits less sweet, but now it has been shown that gene editing can make them sweeter without decreasing yields

Edimakor provides an AI subtitle generator to support multiple languages and enables accurate subtitling with hardly any human involvement.

Move over, Lightroom! This portrait photo editor brings serious competition to Adobe's game.

Joey Logano responded to critics of his NASCAR Cup Series Championship win with, "It's a bunch of bull----" and discussed the NASCAR playoff structure.

My career started with HTML, and then Flash. Flash had a great run, but mobile devices with limited battery life and Flash movies which required complicated computation were not a good match. People mostly don’t make Flash content anymore, though some actual cartoon animation has had Flash in their workflows. As for my own personal...

NotePage, Inc. today announced the release of RecordForAll, audio recording and editing software designed specifically for podcasters. With RecordForAll, podcasters have the ability to record new audio files from scratch, or edit and enhance existing audio files.

RecordForAll was designed from the ground up, with ease of use in mind. RecordForAll has an intuitive look, and built in tutorials to walk users through the process of recording and editing their first audio file.

One click audio recording easily records voices, music and other sounds. RecordForAll has reduced the learning curve, making audio recording easy even for beginners. RecordForAll allows podcasters to layer, synchronize and transition multiple audio tracks. Podcasters can now easily create transitional effects between show segments or insert advertisements into their podcasts. Existing audio files can also be imported into RecordForAll for editing. RecordForAll even has built-in filtering that helps eliminate extraneous background noises and distortions.

Simply put, RecordForAll is an all-in-one recording studio that assists users in recording, editing and mixing their podcasts, resulting in a professional podcast, even for beginners.

I've always liked the iPad Mini form factor more than other tablets, but that preference goes beyond hand-feel and comfort.

Dr. Albert Rossi interviews Dr. Gayle Woloschak on the topic of bioethics. Dr. Woloschak is a professor of Radiation Oncology at Northwestern University in Chicago and an adjunct professor of Religion and Science at Lutheran School of Theology Chicago, and at Pittsburgh Theological Seminary, as well as Professor of Bioethics at St. Vladimir's Orthodox Theological Seminary in Yonkers, NY.

Adobe Firefly Video Model, the artificial intelligence tool will be released in beta version for AI generated videos

The guidance describes how firms can voluntarily engage with the FDA before marketing food from genome-edited plants.

Patrick Doherty volunteered for a new medical intervention of gene-editor infusions for the treatment of genetically-based diseases.; Credit: /Patrick Doherty

Patrick Doherty had always been very active. He trekked the Himalayas and hiked trails in Spain.

But about a year and a half ago, he noticed pins and needles in his fingers and toes. His feet got cold. And then he started getting out of breath any time he walked his dog up the hills of County Donegal in Ireland where he lives.

"I noticed on some of the larger hill climbs I was getting a bit breathless," says Doherty, 65. "So I realized something was wrong."

Doherty found out he had a rare, but devastating inherited disease — known as transthyretin amyloidosis — that had killed his father. A misshapen protein was building up in his body, destroying important tissues, such as nerves in his hands and feet and his heart.

Doherty had watched others get crippled and die difficult deaths from amyloidosis.

"It's terrible prognosis," Doherty says. "This is a condition that deteriorates very rapidly. It's just dreadful."

So Doherty was thrilled when he found out that doctors were testing a new way to try to treat amyloidosis. The approach used a revolutionary gene-editing technique called CRISPR, which allows scientists to make very precise changes in DNA.

"I thought: Fantastic. I jumped at the opportunity," Doherty says.

On Saturday, researchers reported the first data indicating that the experimental treatment worked, causing levels of the destructive protein to plummet in Doherty's body and the bodies of five other patients treated with the approach.

"I feel fantastic," Doherty says. "It's just phenomenal."

The advance is being hailed not just for amyloidosis patients but also as a proof-of-concept that CRISPR could be used to treat many other, much more common diseases. It's a new way of using the innovative technology.

"This is a major milestone for patients," says Jennifer Doudna of the University of California, Berkeley, who shared a Nobel Prize for her work helping develop CRISPR.

"While these are early data, they show us that we can overcome one of the biggest challenges with applying CRISPR clinically so far, which is being able to deliver it systemically and get it to the right place," Doudna says.

CRISPR has already been shown to help patients suffering from the devastating blood disorders sickle cell disease and beta thalassemia. And doctors are trying to use it to treat cancer and to restore vision to people blinded by a rare genetic disorder.

But those experiments involve taking cells out of the body, editing them in the lab, and infusing them back in or injecting CRISPR directly into cells that need fixing.

The study Doherty volunteered for is the first in which doctors are simply infusing the gene-editor directly into patients and letting it find its own way to the right gene in the right cells. In this case, it's cells in the liver making the destructive protein.

"This is the first example in which CRISPR-Cas9 is injected directly into the bloodstream — in other words systemic administration — where we use it as a way to reach a tissue that's far away from the site of injection and very specifically use it to edit disease-causing genes," says John Leonard, the CEO of Intellia Therapeutics, which is sponsoring the study.

Doctors infused billions of microscopic structures known as nanoparticles carrying genetic instructions for the CRISPR gene-editor into four patients in London and two in New Zealand. The nanoparticles were absorbed by their livers, where they unleashed armies of CRISPR gene-editors. The CRISPR editor honed in on the target gene in the liver and sliced it, disabling production of the destructive protein.

Within weeks, the levels of protein causing the disease plummeted. Researchers reported at the Peripheral Nerve Society Annual Meeting and in a paper published in The New England Journal of Medicine.

"It really is exciting," says Dr. Julian Gillmore, who is leading the study at the University College London, Royal Free Hospital.

"This has the potential to completely revolutionize the outcome for these patients who have lived with this disease in their family for many generations. It's decimated some families that I've been looking after. So this is amazing," Gillmore says.

The patients will have to be followed longer, and more patients will have to be treated, to make sure the treatment's safe, and determine how much it's helping, Gillmore stresses. But the approach could help those struck by amyloidosis that isn't inherited, which is a far more common version of the disease, he says.

Moreover, the promising results potentially open the door for using the same approach to treatment of many other, more common diseases for which taking cells out of the body or directly injecting CRISPR isn't realistic, including heart disease, muscular dystrophy and brain diseases such as Alzheimer's.

"This is really opening a new era as we think about gene-editing where we can begin to think about accessing all kinds of different tissue in the body via systemic administration," Leonard says.

Other scientists who are not involved in the research agree.

"This is a wonderful day for the future of gene-editing as a medicine,"
agree Fyodor Urnov, a professor of genetics at the University of California, Berkeley. "We as a species are watching this remarkable new show called: our gene-edited future."

Doherty says he started feeling better within weeks of the treatment and has continued to improve in the weeks since then.

"I definitely feel better," he told NPR. "I'm speaking to you from upstairs in our house. I climbed stairs to get up here. I would have been feeling breathless. I'm thrilled."

This content is from Southern California Public Radio. View the original story at SCPR.org.

The National Academy of Sciences and the National Academy of Medicine are launching a major initiative to guide decision making about controversial new research involving human gene editing.

Scientific advances in molecular biology over the past 50 years have produced remarkable progress in medicine. Some of these advances have also raised important ethical and societal issues – for example, about the use of recombinant DNA technologies or embryonic stem cells.

We thank the organizers of our International Summit on Human Gene Editing for their thoughtful concluding statement and welcome their call for us to continue to lead a global discussion on issues related to human gene editing.

Clinical trials for genome editing of the human germline – adding, removing, or replacing DNA base pairs in gametes or early embryos – could be permitted in the future, but only for serious conditions under stringent oversight, says a new report from the National Academy of Sciences and the National Academy of Medicine.

An international, multidisciplinary organizing committee has been appointed to plan the Second International Summit on Human Genome Editing, which will take place Nov. 27-29 in Hong Kong.

On the eve of the Second International Summit on Human Genome Editing, we were informed of the birth of twins in China whose embryonic genomes had been edited.

Carrie Lam, Hong Kong’s chief executive, welcomed hundreds of participants from around the world to the Second International Summit on Human Genome Editing, which began today.

In December 2015, the U.S. National Academy of Sciences and U.S. National Academy of Medicine, the Royal Society of the United Kingdom, and the Chinese Academy of Sciences hosted an international summit in Washington, D.C., to discuss scientific, ethical, and governance issues associated with human genome editing.

We thank the organizing committee of the Second International Summit on Human Genome Editing, held this week in Hong Kong, for planning an important and timely conference on a rapidly advancing area of science and medicine.

A new publication from the U.S. National Academies of Sciences, Engineering, and Medicine, provides a brief summary of presentations and discussions at the Second International Summit on Human Genome Editing, held in Hong Kong on Nov. 27-29, 2018.

A commentary published in Nature calls for a moratorium on clinical uses of heritable human genome editing and the establishment of an international governance framework.

An international commission has been convened by the U.S. National Academy of Medicine, the U.S. National Academy of Sciences, and the Royal Society of the U.K., with the participation of science and medical academies around the world, to develop a framework for scientists, clinicians, and regulatory authorities to consider when assessing potential clinical applications of human germline genome editing.

Last week, the International Commission on the Clinical Use of Human Germline Genome Editing held its first public meeting at the National Academy of Sciences building in Washington, D.C.

The International Commission on the Clinical Use of Human Germline Genome Editing is tasked with identifying the scientific, medical, and ethical requirements to consider when assessing potential clinical applications of human germline genome editing — if society concludes that heritable human genome editing applications are acceptable.

We recently launched a new website intended to highlight the science underlying questions that our research shows Americans have about current issues.

It has been a little over a year since the Second International Summit on Human Genome Editing in Hong Kong, where scientist He Jiankui (pictured above) announced the birth of twins whose healthy embryonic genomes had been edited to confer resistance to HIV.

Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably without introducing undesired changes — a criterion that has not yet been met by any genome editing technology, says a new report by an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.’s Royal Society.

Two new companion reports from a World Health Organization expert panel provide recommendations to the scientific community on the use of human genome editing. The panel’s work was informed by a 2020 report written by an international commission under the auspices of NAS, NAM, and the U.K.’s Royal Society.

A multidisciplinary committee representing 11 nations will plan the Third International Summit on Human Genome Editing, to be held in London March 7-9, 2022. The NAS and NAM join other international partners in organizing the summit, which will build upon previous events held in Washington, D.C. and Hong Kong.

Registration is now open for the Third International Summit on Human Genome Editing, to be held March 6-8, 2023, in London. The three-day summit is being organized by the Royal Society and U.K. Academy of Medical Sciences, the U.S. National Academy of Sciences and National Academy of Medicine, and the World Academy of Sciences.

The final agenda is now available for the Third International Summit on Human Genome Editing, to be held March 6-8 in London and virtually. The National Academy of Sciences and National Academy of Medicine are among the international partners hosting the summit.

Get a lifetime license with endless features for 70% down price of 15.99$ valid only in August!

Eye Candy, Inc. adds Digital Vision's 2013 rev2 grading and mastering suite, including ACES (ST 2065-1-2012)

Alice Heiserman Commands the Helm at WriteBooksRight

Emmanuel Lee's award-winning documentary showcases a little-known or understood phenomenon whose victims may number into the millions across the nation and the globe.

Chris’ main workstation is still out, but a replacement is getting closer, in form of a fan-less compact laptop that will outperform the previous iMac Pro by a decent margin. This is mainly possible thanks to your support! Topics: [PHOTO] Flat Lenses Are Here : Flat lenses are finally becoming a reality. Just not in … Continue reading "921 Video Editing Game Changer"

The post 921 Video Editing Game Changer appeared first on PHOTOGRAPHY TIPS FROM THE TOP FLOOR.

CapCut is a multifaceted one of the best free video editing mobile application that offers many features and tools to elevate the quality of your influencer ...

Hey there, fellow design enthusiasts! I've got something super cool to share with you today. You know those grungy, vintage-looking textures that make your ...

Here is a Storify collecting the online conversations from the Wikipedia editing workshop at this year’s

AI knowledge combined with gene-editing precision opens the way to dial-a-protein.

For the past decade, scientists have relied almost exclusively on CRISPR-Cas systems for genome editing. Now, a smaller but equally efficient nuclease is here to compete. 

In the second episode of his series learning Logic Pro X for Mac, Ming introduces two main sections. In the first part, Ming explains why the Interface and Microphone are important in professional recording and music editing, and how the Interface works. Ming uses logic to demonstrate how to slice and dice regions, efficiently move regions to neighboring regions, and export and merge projects into different audio formats. These shortcuts include:

Command + B: Bounce your project

Option + [ ] "Align the current region to the left or right of other regions.

Pause or play: Space bar.

See also: Learning Logic Pro X: Episode 1 - Creating a New Project

Note: Logic Pro X is a professional grade digital audio workstation (DAW) and MIDI sequencer. It is suggested to have some familiarity with Digital Audio Workstations to get the most from this series.

Zencastr makes it easy to get high-quality, multi-ender audio and video podcast recordings with your guests and cohosts. Now, they've added multiple features to help you edit and monetize your podcast!

The post Zencastr Adds Hosting, Editing, and Monetization for Podcasters first appeared on The Audacity to Podcast.

Whether you're just starting your podcast or you've been podcasting for a while, you might find some things easier by using better tools. Here are the audio-editing apps I recommend most for podcasting in 2023.

The post Best Audio-Editing Apps for Podcasting in 2023 first appeared on The Audacity to Podcast.

This is me, preparing for an evening of copyediting articles for The Pomegranate: The International Journal of Pagan Studies. There is in fact a small shrine within arm’s length of my desktop computer, but I usually don’t have so many … Continue reading →

Now in Feeds Box you can change feeds title, add tags to your feeds, and, most remarkable, you can edit feeds' settings. We have also fine-tuned feeds search in your Feeds Box.

The post Feeds Editing And Better Search appeared first on RSSground.com.