A UK law allowing gene-edited food has been paused and some British scientists fear being overtaken.

President-elect Donald Trump has chosen the next director of the CIA. Trump tapped former Texas congressman and director of national intelligence John Ratcliffe for the job. According to a statement […]

The post 'Warrior for Truth': Trump Has Chosen His Next CIA Director, Crediting Pick for 'Exposing Russian Collusion' Hoax appeared first on The Western Journal.

Post-transcriptional modifications of pre-mRNAs expand the diversity of proteomes in higher eukaryotes. In the brain, these modifications diversify the functional output of many critical neuronal signal molecules. In this study, we identified a brain-specific A-to-I RNA editing that changed glutamine to arginine (Q/R) at exon 20 and an alternative splicing of exon 4 in Tmem63b, which encodes a ubiquitously expressed osmosensitive cation channel. The channel isoforms lacking exon 4 occurred in ∼80% of Tmem63b mRNAs in the brain but were not detected in other tissues, suggesting a brain-specific splicing. We found that the Q/R editing was catalyzed by Adar2 (Adarb1) and required an editing site complementary sequence located in the proximal 5' end of intron 20. Moreover, the Q/R editing was almost exclusively identified in the splicing isoform lacking exon 4, indicating a coupling between the editing and the splicing. Elimination of the Q/R editing in brain-specific Adar2 knockout mice did not affect the splicing efficiency of exon 4. Furthermore, transfection with the splicing isoform containing exon 4 suppressed the Q/R editing in primary cultured cerebellar granule neurons. Thus, our study revealed a coupling between an RNA editing and a distant alternative splicing in the Tmem63b pre-mRNA, in which the splicing plays a dominant role. Finally, physiological analysis showed that the splicing and the editing coordinately regulate Ca2+ permeability and osmosensitivity of channel proteins, which may contribute to their functions in the brain.

AdvancED, the national accreditation company, has for the last two years operated Wyoming's entire accreditation process but the state will now do the work on its own.

Creating transgenic mosquitoes allows for mechanistic studies of basic mosquito biology and the development of novel vector control strategies. CRISPR–Cas9 gene editing has revolutionized gene editing, including in mosquitoes. This protocol details part of the gene editing process of Aedes aegypti mosquitoes via CRISPR–Cas9, through testing and validating single-guide RNAs (sgRNAs). Gene editing activity varies depending on the sequence of sgRNAs used, so validation of sgRNA activity should be done before large-scale generation of mutants or transgenics. sgRNA is designed using online tools and synthesized in <1 h. Once mutants or transgenics are generated via embryo microinjection, sgRNA activity is validated by quick genotyping polymerase chain reaction (PCR) and DNA sequencing.

CRISPR–Cas9 has revolutionized gene editing for traditional and nontraditional model organisms alike. This tool has opened the door to new mechanistic studies of basic mosquito biology as well as the development of novel vector control strategies based on CRISPR–Cas9, including gene drives that spread genetic elements in the population. Although the promise of the specificity, flexibility, and ease of deployment CRISPR is real, its implementation still requires empirical optimization for each new species of interest, as well as to each genomic target within a given species. Here, we provide an overview of designing and testing single-guide RNAs for the use of CRISPR-based gene editing tools.

Title: Gene 'Editing' in Dog Study Shows Promise for Kids With Muscular Dystrophy
Category: Health News
Created: 8/30/2018 12:00:00 AM
Last Editorial Review: 8/31/2018 12:00:00 AM

Study conducted by researchers from the Perelman School of Medicine at the University of Pennsylvania on genome editing in non-human primates highlights

RNA editing is in its nascent stage, yet there are already at least 11 biotechnology companies worldwide developing RNA editing methods for a range of diseases

Apple had named the Pixelmator Pro as its Mac app of the year in 2018 for its use of AI in editing and colouring

Joined by CRISPR luminaries Feng Zhang and J. Keith Joung, the Harvard chemist raises up to $87 million in funding

Joined by CRISPR luminaries Feng Zhang and J. Keith Joung, the Harvard chemist raises up to $87 million in funding

The OECD Conference on Genome Editing: Applications in Agriculture – Implications for Health, Environment and Regulation will explore the regulatory considerations raised by genome edited products, with the aim to favour a coherent policy approach to facilitate innovation involving genome editing. More information on the programme and the speakers.

Married At First Sight has racked up its fair share of editing fails this season.

The National Academy of Sciences and the National Academy of Medicine are launching a major initiative to guide decision making about controversial new research involving human gene editing.

Scientific advances in molecular biology over the past 50 years have produced remarkable progress in medicine. Some of these advances have also raised important ethical and societal issues – for example, about the use of recombinant DNA technologies or embryonic stem cells.

We thank the organizers of our International Summit on Human Gene Editing for their thoughtful concluding statement and welcome their call for us to continue to lead a global discussion on issues related to human gene editing.

Clinical trials for genome editing of the human germline – adding, removing, or replacing DNA base pairs in gametes or early embryos – could be permitted in the future, but only for serious conditions under stringent oversight, says a new report from the National Academy of Sciences and the National Academy of Medicine.

An international, multidisciplinary organizing committee has been appointed to plan the Second International Summit on Human Genome Editing, which will take place Nov. 27-29 in Hong Kong.

On the eve of the Second International Summit on Human Genome Editing, we were informed of the birth of twins in China whose embryonic genomes had been edited.

Carrie Lam, Hong Kong’s chief executive, welcomed hundreds of participants from around the world to the Second International Summit on Human Genome Editing, which began today.

In December 2015, the U.S. National Academy of Sciences and U.S. National Academy of Medicine, the Royal Society of the United Kingdom, and the Chinese Academy of Sciences hosted an international summit in Washington, D.C., to discuss scientific, ethical, and governance issues associated with human genome editing.

We thank the organizing committee of the Second International Summit on Human Genome Editing, held this week in Hong Kong, for planning an important and timely conference on a rapidly advancing area of science and medicine.

A new publication from the U.S. National Academies of Sciences, Engineering, and Medicine, provides a brief summary of presentations and discussions at the Second International Summit on Human Genome Editing, held in Hong Kong on Nov. 27-29, 2018.

A commentary published in Nature calls for a moratorium on clinical uses of heritable human genome editing and the establishment of an international governance framework.

An international commission has been convened by the U.S. National Academy of Medicine, the U.S. National Academy of Sciences, and the Royal Society of the U.K., with the participation of science and medical academies around the world, to develop a framework for scientists, clinicians, and regulatory authorities to consider when assessing potential clinical applications of human germline genome editing.

Last week, the International Commission on the Clinical Use of Human Germline Genome Editing held its first public meeting at the National Academy of Sciences building in Washington, D.C.

The International Commission on the Clinical Use of Human Germline Genome Editing is tasked with identifying the scientific, medical, and ethical requirements to consider when assessing potential clinical applications of human germline genome editing — if society concludes that heritable human genome editing applications are acceptable.

We recently launched a new website intended to highlight the science underlying questions that our research shows Americans have about current issues.

It has been a little over a year since the Second International Summit on Human Genome Editing in Hong Kong, where scientist He Jiankui (pictured above) announced the birth of twins whose healthy embryonic genomes had been edited to confer resistance to HIV.

Baylis, Françoise, 1961- author

Big money is being poured into a technology that could make it possible to modify your DNA.

Wired's video series, 'Five Levels of Difficulty,' challenges an expert to explain a complicated concept to people at five levels of expertise — and it's cool.

From total beginners to advance creators

"GOM Mix Web", The beginning of the innovative video editing software!

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IN MEDIA KG, a leader in the digital software industry proudly brings their Photo Editing Software for Windows 10, 8 and 7.

Fernanda Schein is the exact definition of what hardworking filmmaking is made of.

High-volume discount on photo editing services amid coronavirus crisis

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On this episode Chris dives into a couple of topics that might as well be at home on The Future of Photography, including Sony’s new layered sensor and lenses that are 1000 times thinner than current ones. Chris also holds a new mini assignment (get your 5 minutes of photography in!), and Daniel wonders about … Continue reading "882 Photo Editing in VR"

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There was a time when there was not a huge demand for video editing software. But over time, video editing software has become one of the highly used tools of modern society. One of the most common examples where video editing software is highly required is for making Vlogs. Apart from the Vlogs, video making...

Whether you’re into photography, there are so many basic skills that you can learn when it comes to photo editing that can make a huge difference in your photos and selfies. Between brightening up a photo, changing the size, or cutting something out, there’s always a small thing you wish you could change. In order to do that, you should learn these basic photo editing tools so that you can adjust your photos in the simplest manner. Adobe photoshop If you were to use only one software for photo editing, then it should be none other than Adobe Photoshop. With

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