A Maryland Lottery player said following a friend's advice led to her winning a $30,000 prize from a Fast Play game.

A North Carolina woman made a stop for orange juice and ended up winning $250,000 from a scratch-off lottery ticket.

A Maryland man found some loose cash in his back pocket and ended up using it to buy a lottery ticket worth more than $45,000.

Nov. 11, 2024 — Forschungszentrum Jülich and its partners in the QSolid project have begun operating Germany’s first prototype quantum computer featuring optimized qubit quality. This prototype lays the groundwork […]

The post Jülich Leads QSolid Quantum Prototype Toward Hybrid HPC Integration for Industry and Research appeared first on HPCwire.

Controversy over an intiative aimed a reducing inequities in Lee's Summit, Mo., schools led the police department to provide security protection for the district's first African-American superintendent. Now the school board has reversed course.

Nothing has changed at the top of the second 2024 College Football Playoff rankings.

JuJu Watkins had 21 points, nine assists and six steals to help No. 3 Southern California trounce Cal State Northridge 124-39 on Tuesday night. The Trojans (3-0) had six players in double figures, including Kiki Iriafen with 15 points and Kayleigh Heckel with 14 points off the bench. All 13 Trojans who played scored.

The University of Regina Rams knock off their provincial rivals, the University of Saskatchewan Huskies to win their second ever Hardy Cup championship. An emotional Rams head coach, Mark McConkey talks about how his team was able to overcome a rough regular season and win the title.

Automation systems provider also streamlines product design and analysis with SolidWorks 3D mechanical design and COSMOS design analysis software

Motion control system provider efficiently competes against larger companies with downloadable 3D CAD models and 2D drawings of its products

A group of people open to the Holy Spirit's leading find an open door for ministry in Nazareth.

A short-termer engages people in spiritual conversation while on tour of Israel.

The impact of coaches' ministry in the lives of nominal Christian and majority-faith background athletes.

During the summer months, OM Ukraine in Odessa facilitated a camp, during which the Lord touched the hearts of many children.

A 17-year-old Utah soccer player accused of killing a referee earlier this year pleaded guilty to third-degree felony homicide by assault.

In 2014, Jane Cook joined the second-ever training class of Penn State Extension Master Watershed Steward volunteers. She was already active in the Monocacy Creek Watershed Association, but since then, she has logged more than 1,000 volunteer hours educating the public and restoring local watersheds.

Liam Geyer, a fifth-year Integrated Undergraduate/Graduate student majoring in cybersecurity analytics and operations, leveraged his involvement in the Competitive Cybersecurity Organization at Penn State to land internships and full-time employment. 

A team of Penn State researchers has been selected to lead a three-year, $8,552,388 multi-institution project funded by the Defense Advanced Research Projects Agency to identify cognitive threats in mixed-reality systems as part of the Intrinsic Cognitive Security program.

The former Chief of the Fenwick Island Police Department has pleaded guilty to Official Misconduct and Falsifying Business Records. Boyden was indicted in August after knowingly submitting, between February of 2014 and March of 2020, false reports to the Delaware Council on Police Training indicating that he had been certified in firearms.  Boyden was charged with, and pleaded guilty to, one count of […]

Following a cold case breakthrough, a Wilmington man has pleaded guilty to a 2014 homicide. Shaquille Briscoe, 26, will be sentenced for Manslaughter and Possession of a Firearm During the Commission of a Felony, both Class B felonies. “Our role is to secure justice for victims of crime, their loved ones, and their communities,” said […]

A New Castle woman has pleaded guilty to Murder by Abuse First Degree, 6 counts of Child Abuse First Degree, and 2 counts of Child Abuse Second Degree. Following an extensive investigation by the Delaware State Police Homicide Unit and the Delaware Department of Justice, a grand jury indicted Dejoynay Ferguson in July for the repeated […]

Defendant banned from law enforcement, required to undergo treatment Attorney General Kathy Jennings announced Tuesday that the Division of Civil Rights & Public Trust (DCRPT) has reached a pre-indictment plea agreement with a former Dover police officer who experienced an opioid overdose in his patrol vehicle and later tested positive for fentanyl and marijuana. “This […]

Prosecutors have secured three convictions against Camden Mayor Justin King over a physical confrontation he began with two victims, as well as his subsequent lack of candor with investigators. King, 41, was until recently the mayor of Camden, Delaware and owns several businesses in the area. On February 25, King confronted two male victims, both […]

The Delaware Forest Service and its new "Tree Stewards" program led more than 50 volunteers and town officials to plant 160 trees in Milton, Sussex County on Saturday, April 24. The trees will enhance the town's hiking and biking trail near West Shore Drive, part of DelDOT's  "Rails to Trails" project in Sussex County. Delaware’s urban and community forestry program funded the cost of the trees and provided technical assistance. 

London LEP and Thames Valley Berkshire LEP hold on to their respective first and second places in the Local Enterprise Partnership rankings, while Oxfordshire LEP jumps up eight places to third. 

London — A British soldier accused of passing sensitive information to Iran's Islamic Revolutionary Guard Corps pleaded guilty Monday to escaping from prison while awaiting trial. Daniel Abed Khalife is on trial at London's Woolwich Crown Court, accused of collecting sensitive information between May 2019 and January 2022. Khalife, who is no longer a member of the British armed forces, also denies leaving a fake bomb on a desk and absconding from his barracks in 2023. Prosecutors had also alleged Khalife escaped from London's Wandsworth prison in September 2023 by tying himself to the bottom of a delivery van, sparking a brief nationwide manhunt. The 23-year-old had originally pleaded not guilty to escaping from lawful custody but changed his plea to guilty Monday after having given evidence for several days earlier this month. Khalife is also charged with gathering information that might be useful to an enemy, namely Iran, obtaining information likely to be useful for terrorism and perpetrating a bomb hoax. He still denies those three charges and his trial continues.

[UNHCR] UNHCR, the UN Refugee Agency has just concluded a three-day event, hosting partners and Governments from the East and Horn of Africa, Great Lakes Region and Yemen, to review strategies for comprehensive solutions to the ongoing displacement crisis in Somalia. The meeting brought together representatives from Uganda, Yemen, Djibouti, Ethiopia and Kenya, as well as the regional body, Intergovernmental Authority on Development (IGAD) and provided a platform for sharing insights and aligning efforts among

King Charles leads Remembrance Sunday ceremony

Rubbish build up after Spanish floods leads to health issues as search for missing people continues

Title: Egg Recall: Trail Leads to Iowa Firm
Category: Health News
Created: 8/24/2010 10:55:00 AM
Last Editorial Review: 8/24/2010 10:55:55 AM

Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic toxin indoxyl sulfate (IDS) levels by intensity (arbitrary unit) of 13.7 ± 7.7 compared with vehicle 0.3 ± 0.1 (P = 0.01) as determined by tissue mass spectrometry imaging analysis. We hypothesized that increased plasma and kidney levels of IDS could be caused by the simultaneous inhibition of both Slc6a19 and a kidney IDS transporter responsible for excretion of IDS into urine. To test this, we first confirmed the formation of IDS through tryptophan metabolism by feeding rats a Trp-free diet. Inhibiting Slc6a19 with RA836 led to increased IDS in these rats. Next, RA836 and its key metabolites were evaluated in vitro for inhibiting kidney transporters such as organic anion transporter (OAT)1, OAT3, and breast cancer resistance protein (BCRP). RA836 inhibits BCRP with an IC₅₀ of 0.045 μM but shows no significant inhibition of OAT1 or OAT3. Finally, RA836 analogs with either potent or no inhibition of SLC6A19 and/or BCRP were synthesized and administered to rats fed a normal diet. Plasma and kidney samples were collected to quantify IDS using liquid chromatography–mass spectrometry. Neither a SLC6A19 inactive but potent BCRP inhibitor nor a SLC6A19 active but weak BCRP inhibitor raised IDS levels, whereas compounds inhibiting both transporters caused IDS accumulation in rat plasma and kidney, supporting the hypothesis that rat Bcrp contributes to the excretion of IDS. In summary, we identified that inhibiting Slc6a19 increases IDS formation, while simultaneously inhibiting Bcrp results in IDS accumulation in the kidney and plasma.

The PlayStation 5 was the best-selling console in the UK in October, according to GfK Entertainment data reported by GamesIndustry. 

The Xbox Series X|S was the second best-selling console for the month, followed by the Nintendo Switch in third. The Xbox Series X|S has also surpassed the Switch in year-to-date sales.

Sales for the PS5 are up 27 percent month-on-month and down 18 percent year-on-year. Sales for the Switch are up 13 percent month-on-month and down 18 percent year-on-year. Sales for the Xbox Series X|S are down seven percent month-on-month and down 17 percent year-on-year. 

Overall, there were just under 144,000 video game consoles sold (NielsenIQ/GfK panel data) in the UK in October 2024. This is down 18 percent year-on-year.

GSD data shows there were 2.9 million games sold in October 2024, which is up 3.2 percent year-on-year. 

Call of Duty: Black Ops 6 debuted in first place on the software charts (digital and physical combined). Sales are 11 percent lower than the launch month of 2023's 2023's Call of Duty: Modern Warfare III, however, this is most likely due to the number of people playing the game via Xbox Game Pass.

Sales of Call of Duty: Black Ops 6 are up 24 percent year-on-year on PlayStation consoles, while sales dropped on Xbox consoles and PC. 75 percent of total sales were on PlayStation consoles, followed by 15 percent on PC, and just under 11 percent on Xbox consoles.

Dragon Ball: Sparking! Zero debuted in third place with the first four week of sales up 80 percent compared to 2020's Dragon Ball Z: Kakarot.

Undisputed debuted in fourth place and had the second biggest launch for a sports title in 2024. Only EA Sports FC 24 had a bigger launch.

The remake of Silent Hill 2 debuted in fifth place. Launch sales are 32 percent lower than the remake of Dead Space and 62 percent lower than the remake of Resident Evil 4.

Super Mario Party Jamboree debuted in ninth place. Sales are 11 percent higher than 2018's Super Mario Party, but are four percent lower than 2021's Mario Party Superstar. It should be noted Nintendo doesn't share digital sales with these charts.

Sonic X Shadows Generations debuted in 10th place. Sales for the game are 150 percent compared to 2023's Sonic Superstars, but are down 21 percent compared to 2022's Sonic Frontiers.

Metaphor: Refantazio debuted in 12th place and the new version of Until Dawn debuted in 30th place.

EA Sports FC 25 came in second place with sales down 14 percent year-on-year.

There were over 681,000 accessories and add-on products sold in the UK in October, which is up nearly 16 percent year-over-year, but is down over eight percent month-on-month.

The White DualSense controller was the best-selling accessory, followed by the Midnight Black DualSense controller. The PlayStation Portal Remote Player is up four spots to take fourth place.

Here are the top 10 best-selling games in the UK (Digital + Physical):

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463042/ps5-best-seller-in-the-uk-in-october-black-ops-6-leads-strong-month-of-new-releases/

A 61-year-old San Antonio man pleaded guilty to two federal charges in the human smuggling incident that led to the deaths of 10 undocumented immigrants this summer.

James Matthew Bradley Jr., who appeared before a U.S. magistrate judge Monday, pleaded guilty to “one count of conspiracy to transport aliens resulting in death and one count of transporting aliens resulting in death,” according to a statement from the U.S. Attorney’s Office for the Western District of Texas.

The office added that Bradley’s “admission of guilt” meant he packed dozens of unauthorized immigrants into a tractor-trailer for financial gain, adding that the suspect confirmed that details from court documents were “factually correct.”

On July 23, San Antonio Police Department officers responded to a call from a Walmart employee shortly past midnight. Once officers arrived, they found 39 immigrants at the scene. Of those carried in the tractor-trailer, eight were found dead in the rear of the trailer, while two died later at nearby hospitals, the statement said.

Survivors of the incident said there was no air conditioning in the overheated trailer and had to take turns to breath through a hole in the back of the truck for air. Bradley also initially told investigators that he was unaware of the immigrants in the trailer until he had stopped at the Walmart in San Antonio for bathroom break.

The attorney’s office also said Bradley faces up to life in prison with the charges and that he is scheduled to be sentenced in January 2018. Immigrants said there were up to 200 people transported on the trailer and that different fees were quoted to them for the ride north from the U.S.-Mexico border, the statement added.

Jason Buch of San Antonio Express-News told the NewsHour earlier this year that Border Patrol agents in Laredo, Texas, reported an uptick of immigrants using tractor-trailers to get pass checkpoints at the border.

“People are usually going on to major metropolitan areas or regions of the country that employ a lot of immigrant laborers, so, areas with large agriculture industries or construction booms,” Buch said.

The NewsHour’s John Yang learned more about the July human smuggling case and immigration politics from Jason Buch of San Antonio Express News.

Shane M. Folden, special agent in charge of homeland security investigations in San Antonio, said in the statement that the proceeding “helps to close the door on one of the conspirators responsible for causing the tragic loss of life and wreaking havoc on those who survived this horrific incident.”

“This case is a glaring reminder that alien smugglers are driven by greed and have little regard for the health and well-being of their human cargo, which can prove to be a deadly combination,” he added.

Bradley’s co-defendant Pedro Silva Segura was also indicted last month with faces two counts of conspiracy and two counts of transporting undocumented immigrants resulting in serious bodily injury and placing lives in jeopardy.

Segura, 47, is an undocumented immigrant who resides in Laredo, Texas.

The post San Antonio truck driver pleads guilty in fatal human smuggling case appeared first on PBS NewsHour.

Ronnie O'Sullivan has agreed to compete in new snooker events.

Who Will Fill the Democratic Vacuum?

The former soldier Daniel Khalife has changed his plea to guilty and admitted escaping from Wandsworth prison.

Wildfires have been raging in New York and New Jersey. People in some areas have been asked to prepare for possible evacuations.

Beyoncé leads the 2025 Grammy Award nominations with 11, bringing her career total to 99 nominations. That makes her the most-nominated artist in Grammy history.

Artificial intelligence tool for detecting skin cancer, which has outperformed existing methods in identifying suspicious lesions has been developed by scientists in the East of England (!--ref1--).

The Indian Medical Association (IMA) announced the formation of a powerful new alliance to tackle the escalating crisis of medlinkAntimicrobial Resistance/medlink (AMR) in India.

Mobile apps are known as the powerful marketing tool in the world of smartphones. According to a research in 2011 research study, professors at Australia’s Murdoch University found that...

India leads Artificial Intelligence (AI) adoption with 30 per cent of companies in the country having maximised AI's value potential -- surpassing the global average of 26 per cent, according to a report.

Ameba takes the unstructured data in a retailer’s supply chain systems, sprinkles in some generative AI, and makes the whole thing more efficient. 

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Like other financial sectors in Latin America, the retail investing space is getting a facelift by local tech startups that are cashing in on the untapped potential for democratizing asset management in the region. One of those startups is Chilean-based Fintual, which today announced a $15 million round led by Kaszek Ventures, the largest fund […]

© 2024 TechCrunch. All rights reserved. For personal use only.

He joined the company as a management graduate and initially spent eight years in sales.

The 47-year-old is one of the most renowned gynaecologists and obstetricians in Hyderabad.