More than 127,000 acres of Delaware farmland are now permanently preserved for future generations, with the purchase of the development rights of 41 farms totaling 3,534 acres. This is the 22nd consecutive year of easement selections by the Delaware Agricultural Lands Preservation Foundation.

The Delaware Department of Insurance today released a list of consumer-friendly automobile insurer actions that are being implemented due to reduced vehicle use throughout the COVID-19 pandemic. As filed with the department, these actions represent millions of dollars being returned to or saved by policyholders throughout the state. The following list may not be inclusive […]

HDFC Bank, ICICI Bank and SBI leads in mobile banking transactions

London LEP and Thames Valley Berkshire LEP hold on to their respective first and second places in the Local Enterprise Partnership rankings, while Oxfordshire LEP jumps up eight places to third. 

The nation’s energy sector employed 6.5 million Americans in 2017, up 133,000 jobs from the year prior, according to a comprehensive report released today from the Energy Futures Initiative (EFI) and the National Association of State Energy Officials (NASEO). This two percent growth rate exceeded the national average of 1.7 percent.

India is modifying its 2020 National Cybersecurity Policy to take into account the shift to teleworking as a result of the COVID-19 pandemic, says Lt. Gen. (Retd) Rajesh Pant, national cybersecurity coordinator.

India is modifying its 2020 National Cybersecurity Policy to take into account the shift to teleworking as a result of the COVID-19 pandemic, says Lt. Gen. (Retd) Rajesh Pant, national cybersecurity coordinator.

India is modifying its 2020 National Cybersecurity Policy to take into account the shift to teleworking as a result of the COVID-19 pandemic, says Lt. Gen. (Retd) Rajesh Pant, national cybersecurity coordinator.

India is modifying its 2020 National Cybersecurity Policy to take into account the shift to teleworking as a result of the COVID-19 pandemic, says Lt. Gen. (Retd) Rajesh Pant, national cybersecurity coordinator.

India is modifying its 2020 National Cybersecurity Policy to take into account the shift to teleworking as a result of the COVID-19 pandemic, says Lt. Gen. (Retd) Rajesh Pant, national cybersecurity coordinator.

India is modifying its 2020 National Cybersecurity Policy to take into account the shift to teleworking as a result of the COVID-19 pandemic, says Lt. Gen. (Retd) Rajesh Pant, national cybersecurity coordinator.

India is modifying its 2020 National Cybersecurity Policy to take into account the shift to teleworking as a result of the COVID-19 pandemic, says Lt. Gen. (Retd) Rajesh Pant, national cybersecurity coordinator.

India is modifying its 2020 National Cybersecurity Policy to take into account the shift to teleworking as a result of the COVID-19 pandemic, says Lt. Gen. (Retd) Rajesh Pant, national cybersecurity coordinator.

In Woods Building Services v Milton Keynes Council [2015] EWHC 2011 (TCC), the High Court upheld a challenge by an unsuccessful bidder (“Woods”) of a tender process undertaken by Milton Keynes Council (the “Council”) on the g...

PEBBLE BEACH: Gary Woodland took a two-shot lead over two-time defending champion Brooks Koepka and Justin Rose into the back nine at Pebble Beach on Sunday in the final round of the US Open Golf Championship.

President Vladimir Putin marked Victory Day calling for unity and a dignified honoring of those killed during World War II, even as the coronavirus pandemic curtailed the pomp the Kremlin had planned for Russia’s most important secular holiday. 

Eversheds Sutherland has advised Energetický a prumyslový holding, a.s. (EPH), on the acquisition, by its subsidiary EP UK Investments Ltd. (EPUKI), of Humbly Grove Energy Limited from PETRONAS, Malaysia's integrated petroleum corporat...

[Nation] Eliud Kipchoge, the legend, is leading from the front in distributing relief food to vulnerable athletes in the Rift Valley.

[U.S. House] Washington, DC -Rep. Ilhan Omar (D-MN) led a letter to General Stephen J. Townsend today calling for increased transparency and public accountability of civilian causalities from the United States Defense Department's Africa Command (AFRICOM). The letter was signed by Rep. Adam Smith, Chair, House Committee on Armed Services; Rep. Adam Schiff, Chair, House Permanent Select Committee on Intelligence; Rep. Eliot Engel, Chair, House Committee on Foreign Affairs; Rep. André Carson, Chair, Subcommittee on Counterterrori

In the lead-up to the Truth Matters conference in October, we will be focusing our attention on the sufficiency, authority, and clarity of Scripture. Of our previous blog series, none better embodies that emphasis than Frequently Abused Verses. The following entry from that series originally appeared on September 30, 2015. -ed.

We live in an age that demands short bursts of rapid-fire information. The day is fast approaching—perhaps it’s already here—when the number of Twitter followers will hold the preeminent place on a pastor’s resume. Sermon lengths are going the way of our shrinking attention spans. Modern pastors are tempted to replace exegesis and exposition with sound bite sermons and slogan theology.

But Bible verses are not slogans or sound bites. They are eternal truths that find their meaning within the overall story God is telling. Uprooting a verse, or even a biblical phrase, from its native habitat can lead to all kinds of mayhem. That is especially the case when, independent of their proper context, verses are enlisted as the supporting cast for someone’s opinion or agenda. Romans 2:4 is one verse that is regularly misused that way—carelessly sprinkled into sermons, interviews, and social media.

For example, in January 2013, Rick Warren explained to his legions of Facebook followers how the verse factored in his evangelistic methods:

In that particular case, Warren was quoting Romans 2:4 (actually only about half of it) as justification for downplaying sin and soft-peddling the threat of judgment. But is that what Romans 2:4 is really all about? Was Paul telling his Roman readers to jettison the parts of gospel preaching that lack curb appeal?

Joel Osteen is even more explicit in his use of Romans 2:4 to defend his feel-good messages:

Listen, don’t dangle people over the fires of hell. . . . Listen, that doesn’t draw people to God. They know what kind of life they live. They know how bad they’ve lived. What you’ve got to do is talk about the goodness of God. Listen, it's the goodness of God that brings people to repentance. ^[1] Joel Osteen, "What the Resurrection Means to Us as Believers" (Sermon) cited in Philip Sinitiere, Salvation with a Smile: Joel Osteen, Lakewood Church, and American Christianity (New York: New York University Press, 2015) 223.

Joel Osteen may think that people know they are sinners and that we therefore don’t need to warn them or preach about it, but does Romans 2:4 really back up his point?

Moreover, is his point biblical at all? Just as prisons are full of convicts who will proclaim their innocence, Scripture is clear that sinners reject the guilt of their sin. As Solomon explained, “Every man’s way is right in his own eyes” (Proverbs 21:2). And even those who do acknowledge their sin have little grasp of the depth of their wretchedness, or the eternal cost of their transgressions.

In fact, it’s ironic that Osteen and Warren would use Romans 2:4 to excuse themselves from discussing sin and the need for repentance, since that verse is plucked from Scripture’s most profound discourse on man’s depravity.

Romans 1–3 is undeniable proof that Paul began his exposition of the gospel by first addressing the universality of sin and the justness of God’s wrath against sin. John MacArthur points this out:

The biblical order in any gospel presentation is always first the warning of danger and then the way of escape, first the judgment on sin and then the means of pardon, first the message of condemnation and then the offer of forgiveness, first the bad news of guilt and then the good news of grace. The whole message and purpose of the loving, redeeming grace of God offering eternal life through Jesus Christ rests upon the reality of man’s universal guilt of abandoning God and thereby being under His sentence of eternal condemnation and death. Consistent with that approach, the main body of Romans begins with 1:18, a clear affirmation of God’s wrath “against all ungodliness and unrighteousness of men.” ^[2] John MacArthur, The MacArthur New Testament Commentary: Romans 1-8 (Chicago: Moody Press, 1991) 74.

It is actually our guilt and the justness of God’s wrath that provide the all-important context for Romans 2:4:

And we know that the judgment of God rightly falls upon those who practice such things. But do you suppose this, O man, when you pass judgment on those who practice such things and do the same yourself, that you will escape the judgment of God? Or do you think lightly of the riches of His kindness and tolerance and patience, not knowing that the kindness of God leads you to repentance? But because of your stubbornness and unrepentant heart you are storing up wrath for yourself in the day of wrath and revelation of the righteous judgment of God. (Romans 2:2-5)

Now you can see why Romans 2:4 is so frequently divorced from its context, and why it’s usually paraphrased instead of quoted. In the full context of Paul’s writing we see clearly what he means by God’s goodness—it is “the riches of His kindness and tolerance and patience.” And Romans 2:2-3 explains how God demonstrates that tolerance and patience—by withholding the wrath we deserve. God’s goodness is the reality that we have not yet experienced His judgment. MacArthur adds:

Forbearance [tolerance] comes from anochē, which means “to hold back,” as of judgment. It was sometimes used to designate a truce, which involves cessation of hostilities between warring parties. God’s forbearance with mankind is a kind of temporary divine truce He has graciously proclaimed. Patience translates makrothumia, which was sometimes used of a powerful ruler who voluntarily withheld vengeance on an enemy or punishment of a criminal. Until the inevitable moment of judgment, God’s kindness and forbearance and patience are extended to all mankind. ^[3] The MacArthur New Testament Commentary: Romans 1-8, 119.

It is impossible to preach the goodness of God without talking about sin and judgment because its very meaning is bound up in those terms. When we see our sinfulness and rebellion against God, and when we see our hypocrisy in condemning others for committing the same wrath-deserving sins, then we can also marvel at God’s goodness in patiently and tolerantly withholding the wrath that we deserve.

That is what leads us to repentance. And it is entirely consistent with what Paul taught elsewhere in Scripture:

I now rejoice, not that you were made sorrowful, but that you were made sorrowful to the point of repentance; for you were made sorrowful according to the will of God, so that you might not suffer loss in anything through us. For the sorrow that is according to the will of God produces a repentance without regret, leading to salvation, but the sorrow of the world produces death. (2 Corinthians 7:9-10)

A Hong Kong man has admitted in court to raping his nine-year-old daughter and telling his younger son that it was none of his business when the child caught him in the act.The High Court heard the sexual attacks spanned nearly six years, since 2011, when the casual vegetable seller, who could not be identified for legal reasons, first attempted to rape his daughter after school.At the time she was only six, while he was 40.Acting deputy director of public prosecutions Catherine Ko said the…

Dozens of people have died in Indonesia and Mozambique as a result of storms and flooding, possibly driven by climate change

Title: Better Diabetes Blood Sugar Management Leads to Fewer Eye Surgeries
Category: Health News
Created: 4/29/2015 12:00:00 AM
Last Editorial Review: 4/30/2015 12:00:00 AM

Title: Measles Case Leads to Quarantine of Cruise Ship in St. Lucia
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM

The nuclear factor kappa B (NF-B) is a potent transcription factor, activation of which typically results in robust proinflammatory signaling and triggering of fast negative feedback modulators to avoid excessive inflammatory responses. Here, we report that infection of epithelial cells, including primary porcine respiratory epithelial cells, with the porcine alphaherpesvirus pseudorabies virus (PRV) results in the gradual and persistent activation of NF-B, illustrated by proteasome-dependent degradation of the inhibitory NF-B regulator IB and nuclear translocation and phosphorylation of the NF-B subunit p65. PRV-induced persistent activation of NF-B does not result in expression of negative feedback loop genes, like the gene for IBα or A20, and does not trigger expression of prototypical proinflammatory genes, like the gene for tumor necrosis factor alpha (TNF-α) or interleukin-6 (IL-6). In addition, PRV infection inhibits TNF-α-induced canonical NF-B activation. Hence, PRV infection triggers persistent NF-B activation in an unorthodox way and dramatically modulates the NF-B signaling axis, preventing typical proinflammatory gene expression and the responsiveness of cells to canonical NF-B signaling, which may aid the virus in modulating early proinflammatory responses in the infected host.

IMPORTANCE The NF-B transcription factor is activated via different key inflammatory pathways and typically results in the fast expression of several proinflammatory genes as well as negative feedback loop genes to prevent excessive inflammation. In the current report, we describe that infection of cells with the porcine alphaherpesvirus pseudorabies virus (PRV) triggers a gradual and persistent aberrant activation of NF-B, which does not result in expression of hallmark proinflammatory or negative feedback loop genes. In addition, although PRV-induced NF-B activation shares some mechanistic features with canonical NF-B activation, it also shows remarkable differences; e.g., it is largely independent of the canonical IB kinase (IKK) and even renders infected cells resistant to canonical NF-B activation by the inflammatory cytokine TNF-α. Aberrant PRV-induced NF-B activation may therefore paradoxically serve as a viral immune evasion strategy and may represent an important tool to unravel currently unknown mechanisms and consequences of NF-B activation.

A ubiquitous structural feature in biological systems is texture in extracellular matrix that gains functions when hardened, for example, cell walls, insect scales, and diatom tests. Here, we develop patterned liquid crystal elastomer (LCE) particles by recapitulating the biophysical patterning mechanism that forms pollen grain surfaces. In pollen grains, a...

Transcription of a chromatin template involves the concerted interaction of many different proteins and protein complexes. Analyses of specific factors showed that these interactions change during stress and upon developmental switches. However, how the binding of multiple factors at any given locus is coordinated has been technically challenging to investigate. Here we used Epi-Decoder in yeast to systematically decode, at one transcribed locus, the chromatin binding changes of hundreds of proteins in parallel upon perturbation of transcription. By taking advantage of improved Epi-Decoder libraries, we observed broad rewiring of local chromatin proteomes following chemical inhibition of RNA polymerase. Rapid reduction of RNA polymerase II binding was accompanied by reduced binding of many other core transcription proteins and gain of chromatin remodelers. In quiescent cells, where strong transcriptional repression is induced by physiological signals, eviction of the core transcriptional machinery was accompanied by the appearance of quiescent cell–specific repressors and rewiring of the interactions of protein-folding factors and metabolic enzymes. These results show that Epi-Decoder provides a powerful strategy for capturing the temporal binding dynamics of multiple chromatin proteins under varying conditions and cell states. The systematic and comprehensive delineation of dynamic local chromatin proteomes will greatly aid in uncovering protein–protein relationships and protein functions at the chromatin template.

Approximately 40% of patients with diabetic macular edema (DME) are resistant to anti–vascular endothelial growth factor (VEGF) therapy (rDME). Here, we demonstrate that significant correlations between inflammatory cytokines and VEGF, as observed in naive DME, are lost in patients with rDME. VEGF overexpression in the mouse retina caused delayed inflammatory cytokine upregulation, monocyte/macrophage infiltration (CD11b⁺ Ly6C⁺ CCR2⁺ cells), macrophage/microglia activation (CD11b⁺ CD80⁺ cells), and blood-retinal barrier disruption due to claudin-5 redistribution, which did not recover with VEGF blockade alone. Phosphorylated protein analysis of VEGF-overexpressed retinas revealed rho-associated coiled-coil–containing protein kinase (ROCK) activation. Administration of ripasudil, a selective ROCK inhibitor, attenuated retinal inflammation and claudin-5 redistribution. Ripasudil also contributed to the stability of claudin-5 expression by both transcriptional enhancement and degradation suppression in inflammatory cytokine–stimulated endothelium. Notably, the anti-VEGF agent and the ROCK inhibitor were synergic in suppressing cytokine upregulation, monocyte/macrophage infiltration, macrophage/microglia activation, and claudin-5 redistribution. Furthermore, in vitro analysis confirmed that claudin-5 redistribution depends on ROCK2 but not on ROCK1. This synergistic effect was also confirmed in human rDME cases. Our results suggest that ROCK-mediated claudin-5 redistribution by inflammation is a key mechanism in the anti-VEGF resistance of DME.

A fosfomycin-resistant and carbapenemase (OXA-48)-producing Klebsiella pneumoniae isolate was recovered, and whole-genome sequencing revealed ISEcp1-bla_CTX-M-14b tandemly inserted upstream of the chromosomally encoded lysR-fosA locus. Quantitative evaluation of the expression of lysR and fosA genes showed that this insertion brought a strong hybrid promoter leading to overexpression of the fosA gene, resulting in fosfomycin resistance. This work showed the concomitant acquisition of resistance to broad-spectrum cephalosporins and fosfomycin due to a single genetic event.

According to Batdongsan.com.vn’s real estate market Q3-2019, Ho Chi Minh City’s District 1 saw the highest housing listing prices in the third quarter due to limited supply.

Two Windsor men face multiple drug, property and weapon charges after police pulled over a vehicle for a traffic violation Thursday night. At around 8 p.m., officers from the Windsor police property crimes unit in the area of Tecumseh Road East and Mercer Road saw a black Chrysler 300 commit a traffic violation, police said […]

Jodian Self is hanging out with some of the biggest names in pro sports these days — all from the comfort of her south Winnipeg home. The 52-year-old former physical education ...

Lorry driver Maurice Robinson has admitted the manslaughter of 39 people who were found dead in a refrigerated trailer in Essex.

Follow our live coronavirus updates HERE Coronavirus: The symptoms

Boris Johnson has hailed Captain Tom Moore a "point of light" in the lives of the nation as he led tributes to the war veteran on his 100th birthday.

Brits across the country have erupted in applause in tribute to healthcare workers during the seventh week of the Clap for our Carers initiative.

Prime Minister Boris Johnson led the sixth national applause for frontline workers as his fiancee Carrie Symonds tweeted she had "another wonderful reason to thank the NHS this week too".

Cometh the hour, cometh the eggs.

Cometh the hour, cometh the eggs.

Chelsea and Australia striker Sam Kerr believes the coronavirus pandemic has put paid to any plans her national team-mates have to get pregnant in the next five years.

Arsenal loanee Henrikh Mkhitaryan has pleaded with the club to allow him join AS Roma on a permanent basis.

Jacob Fuller, the son of NSW's top cop Mick Fuller, pleads guilty to drink driving while on a suspended license. The P-plater blew 0.031 when he was tested on the Prince's Highway last month.

A group of cyber sleuths from Adelaide takes out the national missing persons "hackathon", finding nearly 100 new pieces of information for police to investigate.