Samantha-Su Z. Taylor, Nicole L. Jacobsen, Tasha K. Pontifex, Paul Langlais, and Janis M. Burt

Connexin 37 (Cx37) expression profoundly suppresses proliferation of rat insulinoma (Rin) cells in a manner dependent on gap junction channel (GJCh) functionality and the presence and phosphorylation status of its carboxyl-terminus (CT). In Rin cells growth arrested by induced Cx37 expression, serine 319 (S319) is frequently phosphorylated. Preventing phosphorylation at this site (alanine substitution; S319A) relieved Cx37 of its growth suppressive effect whereas mimicking phosphorylation at this site (aspartate substitution; S319D) enhanced Cx37's growth suppressive properties. Like Cx37-WT, -S319D GJChs and hemichannels (HChs) preferred the closed state, rarely opening fully, and gated slowly. In contrast, Cx37-S319A channels preferred open states, opened fully, and gated rapidly. These data indicate that phosphorylation-dependent conformational differences in Cx37 protein and channel function underlie Cx37-induced growth arrest vs. growth permissive phenotypes. That the closed state of -WT and Cx37-S319D GJChs and HChs favors growth arrest suggests that rather than specific permeants mediating cell cycle arrest, the closed conformation instead supports interaction of Cx37 with growth regulatory proteins that result in growth arrest.

Monday, April 30 marks planetary geologist Dr. Ellen Stofan’s first day as the new John and Adrienne Mars Director of the National Air and Space […]

The post Ellen Stofan leads Air and Space Museum appeared first on Smithsonian Insider.

UK-based banks have received around 100,000 applications in a single day after The Bounce Back Loans scheme for small businesses was released.

Coronavirus deaths in the U.K. have passed those in Italy. Workers in the intensive care unit at the Royal Papworth Hospital in Cambridge are shown gearing up to care for COVID-19 patients.; Credit: Neil Hall/AP

Over 32,000 people have died from the new coronavirus in the United Kingdom, according to the Office for National Statistics, marking the first time in the pandemic that it has led Europe in the number of deaths.

The country has surpassed Italy in COVID-19 deaths. The U.S. still leads the world in the highest number of coronavirus deaths; over 70,270 had died from the disease as of Tuesday.

The number of total deaths recorded in the U.K. is "higher than we would wish, I think is all I can say," Angela McLean, chief scientific adviser of Ministry of Defence said during the country's press briefing Tuesday.

McLean also emphasized that deaths in U.K. care homes have been steadily rising and said the trend was something the country "need[s] to get to grips with."

"I don't think we'll get a real verdict on how well countries have done until the pandemic is over," British Foreign Secretary Dominic Raab said Tuesday. "And particularly until we have comprehensive international data on all causes of mortality."

Since different countries collect and report coronavirus data using different methods, the comparisons between regions are not perfect. As more time passes and more tests are conducted and more data comes in, coronavirus death rates will become more precise.

The peak in deaths comes as other European countries, including Italy and Spain, are easing shelter-in-place restrictions, while U.K. Prime Minister Boris Johnson is expected to modify Britain's orders in the next week.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Floods are devastating natural hazards, which can cause loss of life and substantial damage to buildings and other infrastructure. Assessing future flood risk is complicated by the influence of climate change, land-use change and economic development in an area. A study on an Alpine valley suggests that land- use change and urbanisation will affect future flood risk by 2030 more than climate change, but risks can be reduced by adopting low-cost adaptation strategies, such as building restrictions in flood-prone areas and residents taking their own precautions against flooding.

Whatever form it takes, urban growth leads to reduced groundwater availability, according to a new study. The paper highlights the fact that urbanisation is not always sustainable and recommends that planners consider no-growth scenarios for economic development.

Researchers have analysed the policy response to the 2013–2014 flooding of the Somerset Levels and Moors in the UK. Analysis of media coverage and interviews with stakeholders revealed how local pressure promoted dredging — a policy that had fallen out of favour with the national Environment Agency (EA). Although dredging was eventually readopted by the EA, there remain uncertainties over its long-term viability due to funding constraints and debates over its effectiveness.

This study paves the way for better projections of the impact of climate change on plants, including agricultural crops and carbon drawdown. The research shows how an equation used in climate models to represent soil moisture levels is responsible for major variations in estimates of the carbon cycle.

Eradication of invasive mammal species is a strategy used to help conserve biodiversity on islands and restore populations of native species. Researchers have now assessed the success of this strategy globally, highlighting the importance of controlling invasive species to protect biodiversity on islands and achieve global conservation targets.

Results from a long-term study of fish communities in the Bay of Somme in the English Channel show that numbers of cold-water fish, such as dab and plaice, have been dropping since 1998, as sea temperatures have risen. The researchers say this is evidence of ‘tropicalisation’ in an English-Channel ecosystem. The findings may have implications for conservation policies in the Bay, which is a Marine Protected Area1 designated under the Natura 2000 programme, as well as other marine sites affected by warming.

Time can be rough on a dam: as it ages, repairs are more costly and it risks catastrophic breakage. But removing one can also be a major eco-hazard.

The city fleet will have 425 Leafs, Volts and Energis on the road by early next year.

How search engine optimization and page optimization, can lead to higher conversion rates.

All customers want and expect superior customer service, and it is all too important that we give it to them. Otherwise, our competition will.

If you are a loan officer or mortgage broker on the market for internet mortgage leads. Sometimes it may be better to go after quality leads, as opposed to buying your leads in quantity.

If you are a loan officer or mortgage broker, and you are on the market for mortgage leads, you may want to consider buying them in "real time."

A junk lead is classified as a lead that is old or recycled by many loan officers and many lead companies. It may come cheap, but chances are, it won't be worth the two dollars you spent on it.

If you are a loan officer or mortgage broker on the market for internet mortgage leads, than many things will be of importance to you, including the cost of the lead.

If you are a loan officer or mortgage broker on the market for exclusive mortgage leads, how do you know if that lead is really exclusive or not?

If you are a loan officer or mortgage broker, either working with, or considering working with leads from a mortgage lead company. Here are a few tips on how to close more deals.

There have been hundreds to thousands of entrepreneurs interested in growing their business in the online world. To stay on top of the competition, you should employ a sound marketing strategy that can help build your company’s online presence. Thus, the need for a marketing agency that would improve your blog pages and generate more […]

BlogPress.

Examples Include Pepsi, Wells Fargo, Target, Starbucks, Samsung, Volkswagen and more. Foreword by Best-selling Author Marshall Goldsmith

Aims to shake up B2B lead gen with bold new ideas to drive revenue

Carlsbad and Eddy County Continue to Grow

Fernanda Schein is the exact definition of what hardworking filmmaking is made of.

New high-visibility uniform line provides safety for employees and new product offering for customers

Tammy Erickson, author of "What's Next, Gen X?: Keeping Up, Moving Ahead, and Getting the Career You Want."

Bharat Anand, author of The Content Trap and professor at Harvard Business School, talks about the strategic challenges facing digital businesses, and explains how he and his colleagues wrestled with them when designing HBX, the school's online learning platform.

In 1915, polar explorer Ernest Shackleton’s ship became trapped in ice, north of Antarctica. For the next two years, he kept his crew of 27 men alive on a drifting ice cap, then led them in their escape. How Shackleton did that has become one of the most famous leadership case studies. In the first episode of a four-part special series on leadership, HBR Editor in Chief Adi Ignatius and Harvard Business School professor and historian Nancy Koehn analyze Shackleton’s leadership during the struggle to survive. They discover lessons in building a team, learning from bad bosses, and cultivating empathy.

The Situation Cheree Berry Paper (CBP), one of the nation’s premier custom stationery and graphic design firms, has designed wedding invitations for first families and delivered paper possibilities to Hollywood’s most sought-after stars. They have expanded from a one-person shop to a team of more than 20 women in just over a decade so they are...

The post Strategic Guidance Leads to Growth for Cheree Berry appeared first on Anders CPA.

Graeme MacLaren, MD, FCCM, is the lead author on an article published in the March Pediatric Critical Care Medicine.

An Allentown, Pennsylvania, attorney pleaded guilty today for his role in a $2.7 million investment fraud scheme that victimized his law clients.

The owner and Chief Executive Officer of a Republic of Korea–based company, DK Marine, that provided ship husbanding services to the U.S. Navy pleaded guilty today for his role in a bribery conspiracy.

Fredrick Brown, 38, of Las Vegas, Nevada, a former civilian medical records administrator for the U.S. Army at the 65th Medical Brigade, Yongsan Garrison, South Korea, admitted yesterday to his role in an identity-theft and fraud scheme that victimized thousands of U.S. servicemembers and veterans.

Gregg Ramsdell, 61, of Columbus, entered a guilty plea to one count of false statements and one count of violation of the Stolen Valor Act.

A Hoover, Alabama, salesman and tax defier pleaded guilty Friday to tax evasion, announced Principal Deputy Assistant Attorney General Richard E. Zuckerman of the Justice Department’s Tax Division and U.S. Attorney Jay E. Town for the Northern District of Alabama.

A man who did not file tax returns for several years in a row pleaded guilty Friday, March 13, 2020, to evading his income taxes, announced Principal Deputy Assistant Attorney General Richard E. Zuckerman of the Justice Department’s Tax Division.

A Lake Worth, Florida, businessman pleaded guilty today to tax evasion and willful failure to file a Report of Foreign Bank or Financial Account, announced Principal Deputy Assistant Attorney General Richard E. Zuckerman of the Justice Department’s Tax Division and U.S. Attorney Ariana Fajardo Orshan for the Southern District of Florida.

A North Carolina man has admitted taking part in a conspiracy to steal design information from aircraft companies to speed up approval of competing airplane technology.

TULSA, Okla. – Hongjin Tan, a 35 year old Chinese national and U.S. legal permanent resident, pleaded guilty Tuesday in federal court to committing theft of trade secrets from his employer, a U.S. petroleum company.

Seattle – A 21-year-old Palmdale, California, man pleaded guilty today in U.S. District Court in Seattle to federal crimes related to his computer hacking scheme and his possession of child pornography found on his digital devices, announced U.S. Attorney Brian T. Moran.