As a heating and air conditioning company owner; where do I get leads from today? Where do I put my money today?

A look at how HVAC contractors can manage leads from the phone, website, and social media.

A new survey released by Daikin studied the opinions and habits of more than 1,200 people from 12 cities across the globe when it comes to their a/c systems.

The rule will effectively ban the sale of non-condensing gas furnaces and, according to the American Gas Association (AGA), will affect 55% of U.S. households.

New thermopile sensors save energy and increase safety when applied within the construction and property sectors.

Marketing guru Benjamin Ricciardi gives tips on how to grow your business leads during CAT season…are you ready? This is just a snippet of what Benjamin will share at this year’s Fall Experience and Trade Show! 

Amanda teaches us the importance of understanding the interplay between lead generation and brand recognition.

Washington, D.C. -- NAB Show’s Cine Consortium revealed its new Cine Live program featuring sessions focused on cinematic storytelling experiences in live production. Open to all NAB Show badge holders, Cine Live will take place in the new Create Inspiration Theater in Central Hall. The hour-long sessions kick off daily April 24 – 27 at 10:45 a.m.

Washington, D.C. -- The 2023 NAB Show will lead a collaborative, immersive and interactive exploration of the transformative impact Web3 and other internet advances are having on the media and entertainment industry on April 15-19 at the Last Vegas Convention Center. Educational programming, hands-on demonstrations, special events, networking sessions and dozens of exhibitors on the show floor will explore the next generation of the internet and its potential to unlock new opportunities in the content lifecycle.

After her 2021 breakout in The Worst Person in the World, Renate Reinsve’s 2022 and 2023 seemed fairly quiet for the viewer, but she was working on no shortage of projects that finally saw the light of day this year. Following A Different Man, Handling the Undead, Another End, and Presumed Innocent, she leads Armand, […]

The post Armand Trailer: Renate Reinsve Leads Norway’s Oscar Contender first appeared on The Film Stage.

The Geotab research also shows that only five out of the 27 local authorities that were surveyed have electrified more than 8pc of their fleets.

Read more: Cork City Council leads the EV fleet charge while others lag behind

The aim of the project is to develop and test AI tools to boost the efficiency and sustainability of Europe's energy sector.

Read more: Dublin’s EPRI leads European project to advance AI use in the energy sector

The Insurance Institute of Business & Home Safety conducted a study using hail data to improve the resilience of roofing materials; the aim is to help manufacturers design tougher products.

Nastar Roofing owner William Skaggs and payroll administrator Billie Adkison admitted to a $2.5 million employment tax fraud scheme, paying employees in cash but failing to withhold taxes or report that income to the IRS. 

The New York-based company reportedly last year captioned and subtitled more than 15 million minutes in video on-demand, processed more than 500,000 minutes of content with speech recognition, and live-captioned more than 300,000 minutes of events.

[New Times] If you're among the many people working remotely or travelling as a digital nomad, internet speed and affordability are likely at the top of your list when picking a destination.

Gigi Schumm welcomes Kathleen McInnis, an international security specialist at the Congressional Research Service — where she works to help Congress address national security and defense strategy issues.

The post Novelist, int’l security specialist: Follow your passion wherever it leads first appeared on Federal News Network.

Magyar leads mass protest against Orbán’s rule

MSP Leads. If you’re planning on having any kind of success as a managed services provider, then you need to learn how to acquire those important MSP leads. So do you want to learn how to acquire quality MSP leads so you can expand your client portfolio and build that business of yours? Then carry […]

Source: MSP Leads: Get More Managed Services Clients - Technibble.com

Despite a sliver of good news in the latest monthly climate analyses, global heating continues — and the world is far from taming it.

(The Center Square) – More than 94,000 people are calling Arizona home than they did amid the waning months of the COVID-19 pandemic.

Dozens of beloved Washington restaurants closed this year, more than in 2022, according to the Restaurant Association of Metropolitan Washington.

“I want to increase traffic to my blog or website”- The very same question keeps on haunting all the business owners. It has kept me on my toes for a long while. Now, I thought to jot down all the very best strategies for increasing not only traffic but also qualified leads. Read them, share […]

In evaluating the films released thus far this year, it is hard to think of one that more closely aligns with about everything you would expect than The Lost City…

Employment and training opportunities for local people.

Advice course for sufferers to begin in Erdington.

Police Now officers tackling crime and anti-social behaviour with positive results.

Apple shipped 12.6 million tablets in the third quarter (Q3), with a modest growth of 1.4 per cent year-over-year in the quarter and garnering 31.7 per cent market share, as global tablet shipments grew 20.4 per cent to reach 39.6 million units.

The waterfront town on Maryland’s Eastern Shore provides a timeless getaway for nature seekers and admirers of early American history and architecture.

A Boulder mother on Wednesday admitted she killed her 2-month old son last year, court records show.

Westminster City Council this week retained a law firm that specializes in construction defects to determine what is causing several roads to sag and settle in the northernmost stretches of the city.

The Boogaloo Bois member fired shots at a police station.

He faces a maximum penalty of 10 years in prison.

Ajamu Hollis has pleaded guilty to manslaughter in relation to the death of Daemon Bell. He was initially charged with murdering Mr Bell, an off-duty corrections officer, and pleaded guilty to manslaughter yesterday morning, after his Supreme Court murder trial had been underway. He will be sentenced at a later date. Related Stories Murder Trial […]

Robin-Valana Pearman, a Bermuda women’s youth international football player, was instrumental in assisting her Mount Kelly School teammates win the United Kingdom’s Independent Schools Football Association National Cup on April 25th and the Chelsea Foundation Cup on May 20th. A spokesperson said, “Playing from her center-forward position Robin-Valana stuck the third and dagger goal to […]

Chare Smith and his Uphill Castle Cricket Club teammates defeated Long Sutton Cricket Club Southampton by 4 wickets. Long Sutton won the toss and elected to bat, they were bowled all out for 211, Joseph Martins was the top scorer with 80, while Ashley Allen was the pick of the Uphill Castle bowlers with figures […]

Alyssa De Silva and her Loughborough Team 5 are headed into the EHC England Hockey Cup Final after they defeated the Guernsey Ladies 1st team in their semi-final. De Silva — who is captain of the team — will lead them into the final on May 6th against Lee Valley. The score in the semi-final […]

Camiko Smith leads the Butterfield Bermuda Championship local qualifier after the first round at a rain soaked Port Royal Golf Course. Smith shot a round of 3-under par 68 to lead by four strokes over a three-wat tie for second place between Oliver Betschart, Damian Palanyandi, and Adam Perry who all shot a 1-over par […]

Gavin Dorvil has been held without bond after pleading not guilty to vehicular homicide in the Florida crash that led to the deaths of Lisa Jackson and Geraldine Francis. A South Florida Sun-Sentinel story said, “The teenage driver accused of being behind the wheel of a speeding Tesla that struck an SUV two weeks ago, […]

A man appeared in the Supreme Court in connection with the murder of Daunte Woods, who was fatally stabbed in October 2020 in Sandys. 29-year-old Jahmari Beach pleaded not guilty to the unlawful killing of 27-year-old Daunte Woods, and he also denied a charge of carrying a knife in a public place. The matter was adjourned until […]

34-year-old Melvin Holdipp pleaded guilty to 10 counts of burglary and 4 counts of theft and was remanded into custody. A police spokesperson said, “Between the 30th of August 2022 and the 11th of October 2022, the Bermuda Police Service [BPS] investigated the reported burglaries of several local businesses, namely: Price Rite in Warwick Robin […]

A 38-year-old man appeared in the Supreme Court today [Feb 22], where he pleaded guilty to murder. Anthony Davis admitted to killing 28-year-old Morissa Moniz in November 2021. Puisne Judge Shade Subair-Williams set a sentencing date of March 27th and Davis will remain in custody. The police previously said that Ms Moniz was “found in an unresponsive […]

Providence Friars' Bensley Joseph found Corey Floyd Jr. for a tough alley-oop dunk against the Hampton Pirates.

Hunter Dickson led No. 1 Kansas to an impressive win over Michigan State, while Mark Pope aced his first big test as Kentucky's head coach.

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We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical tumors. Absence of exonic mutations and overexpression at the RNA level suggested a transcriptional and/or posttranscriptional regulation. University of California Santa Cruz genome browser analysis of PACS-1 micro RNAs (miR), revealed two 8-base target sequences at the 3' terminus for hsa-miR-34a and hsa-miR-449a. Quantitative RT-PCR and Northern blotting studies showed reduced or loss of expression of the two microRNAs in cervical cancer cell lines and primary tumors, indicating dysregulation of these two microRNAs in cervical cancer. Loss of PACS-1 with siRNA or exogenous expression of hsa-miR-34a or hsa-miR-449a in HeLa and SiHa cervical cancer cell lines resulted in DNA damage response, S-phase cell cycle arrest, and reduction in cell growth. Furthermore, the siRNA studies showed that loss of PACS-1 expression was accompanied by increased nuclear γH2AX expression, Lys382-p53 acetylation, and genomic instability. PACS-1 re-expression through LNA-hsa-anti-miR-34a or -449a or through PACS-1 cDNA transfection led to the reversal of DNA damage response and restoration of cell growth. Release of cells post 24-h serum starvation showed PACS-1 nuclear localization at G1-S phase of the cell cycle. Our results therefore indicate that the loss of hsa-miR-34a and hsa-miR-449a expression in cervical cancer leads to overexpression of PACS-1 and suppression of DNA damage response, resulting in the development of chemo-resistant tumors.

Sphingolipids have become established participants in the pathogenesis of obesity and its associated maladies. Sphingosine kinase 1 (SPHK1), which generates S1P, has been shown to increase in liver and adipose of obese humans and mice and to regulate inflammation in hepatocytes and adipose tissue, insulin resistance, and systemic inflammation in mouse models of obesity. Previous studies by us and others have demonstrated that global sphingosine kinase 1 KO mice are protected from diet-induced obesity, insulin resistance, systemic inflammation, and NAFLD, suggesting that SPHK1 may mediate pathological outcomes of obesity. As adipose tissue dysfunction has gained recognition as a central instigator of obesity-induced metabolic disease, we hypothesized that SPHK1 intrinsic to adipocytes may contribute to HFD-induced metabolic pathology. To test this, we depleted Sphk1 from adipocytes in mice (SK1^fatKO) and placed them on a HFD. In contrast to our initial hypothesis, SK1^fatKO mice displayed greater weight gain on HFD and exacerbated impairment in glucose clearance. Pro-inflammatory cytokines and neutrophil content of adipose tissue were similar, as were levels of circulating leptin and adiponectin. However, SPHK1-null adipocytes were hypertrophied and had lower basal lipolytic activity. Interestingly, hepatocyte triacylglycerol accumulation and expression of pro-inflammatory cytokines and collagen 1a1 were exacerbated in SK1^fatKO mice on a HFD, implicating a specific role for adipocyte SPHK1 in adipocyte function and inter-organ cross-talk that maintains overall metabolic homeostasis in obesity. Thus, SPHK1 serves a previously unidentified essential homeostatic role in adipocytes that protects from obesity-associated pathology. These findings may have implications for pharmacological targeting of the SPHK1/S1P signaling axis.

Oct. 24, 2024 — The San Diego Supercomputer Center (SDSC), part of the School of Computing, Information and Data Sciences at UC San Diego, has been leading the Open Storage Network (OSN) program for years, and along […]

The post SDSC Leads Expansion of Open Storage Network to More Campus Computing Sites appeared first on HPCwire.