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Dysfunctional polycomb transcriptional repression contributes to lamin A/C–dependent muscular dystrophy

Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control. Mutations in the lamin A/C gene cause several diseases belonging to the class of laminopathies, including muscular dystrophies. Nevertheless, molecular mechanisms involved in the pathogenesis of lamin A–dependent dystrophies are still largely unknown. The polycomb group (PcG) of proteins are epigenetic repressors and lamin A interactors, primarily involved in the maintenance of cell identity. Using a murine model of Emery-Dreifuss muscular dystrophy (EDMD), we show here that lamin A loss deregulated PcG positioning in muscle satellite stem cells, leading to derepression of non–muscle-specific genes and p16INK4a, a senescence driver encoded in the Cdkn2a locus. This aberrant transcriptional program caused impairment in self-renewal, loss of cell identity, and premature exhaustion of the quiescent satellite cell pool. Genetic ablation of the Cdkn2a locus restored muscle stem cell properties in lamin A/C–null dystrophic mice. Our findings establish a direct link between lamin A and PcG epigenetic silencing and indicate that lamin A–dependent muscular dystrophy can be ascribed to intrinsic epigenetic dysfunctions of muscle stem cells.




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Digging up Positivity - Furry charity and good news - February 2020 (Transcript)

Video from Thabo Meerkat, transcribed

Welcome to another edition of Digging Up Positivity! This episode is dedicated to the many volunteers that make all those amazing conventions and charities possible. But besides them, we are covering some animation news and other (maybe otter?) tidbits!

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'Ego Stripping', by Fleuriel (H.B. Woodrose)

Erowid Exp108047



  • Erowid : Experience :

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Another reason why I will not renew my subscription with Intuit for ProSeries tax software

Are you a taxpreparer who is unsatisfied with the quality of Intuit's ProSeries tax software program? I am not a happy user of ProSeries tax software. Choose your tax software carefully. I will be searching for an alternative tax software vendor for the year 2014. Continue reading




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Jill Stein interviewed by Ralph Nader September 17 2016. Recording and transcript of interview.

This is one of the best interviews on American politics ever to be broadcasted. Ralph Nader and Jill Stein discuss our corrupt government and corrupt media controlled by corporations, and explain how we no longer have a democracy but corporate tyranny. Continue reading




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Chris Hedges argues that corporate commodification of our natural resources and human capital will continue unabated. Transcript and video.

"And you know, we have to stop looking beyond this election cycle and see that this corporate driven ideology, you know, this commodification of the culture, this constant extracting of blood from us as citizens to pay what in essence were private debts of the banks which engaged in casino capitalism, has political consequences. History has taught us that. And Hillary Clinton is only going to further that process." Continue reading




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Glenn Greenwald Asks “Why Did Saudi Regime & Other Gulf Tyrannies Donate Millions to Clinton Foundation?” Transcript and video.

Questions surrounding Hillary Clinton and the Clinton Foundation continue to grow. On Sunday, Democratic National Committee interim chairperson Donna Brazile defended Clinton’s meetings as secretary of state with Clinton Foundation donors, saying, "When Republicans meet with their donors, with their supporters, their activists, they call it a meeting. When Democrats do that, they call it a conflict." Donna Brazile’s comments come in response to an Associated Press investigation revealing that while Hillary Clinton served as secretary of state, more than half of the private citizens she met with during the reporting period had donated to the Clinton Foundation. The AP investigation comes after a three-year battle to gain access to State Department calendars. The analysis shows that at least 85 of 154 people Hillary Clinton had scheduled phone or in-person meetings with were foundation donors. We speak to Pulitzer Prize-winning journalist Glenn Greenwald of The Intercept. His most recent piece is headlined "Why Did the Saudi Regime and Other Gulf Tyrannies Donate Millions to the Clinton Foundation?" Continue reading




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The Brainwashing Of Hillary Voters Is Complete. Transcript of October 20 2016 The Jimmy Dore Show.

The Brainwashing Of Hillary Voters Is Complete. Hillary Clinton voters are either getting paid or have been brainwashed into defending her pro-corporate status quo policies. Jimmy Dore breaks it down on his broadcast, October 20, 2016. Continue reading




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Hillary Clinton and the corporate Democrats lost because Donald Trump ran to their left and outflanked them so don’t blame Jill Stein or sexism or racism. Video and transcript.

There's got to be a reason for the Democrats to suppose to exist. And the reason the Democrats are supposed to exist is to be an opposition party to the Republicans. If you're in bed with the same people, taking money from the same people, you're no longer an opposition party. There's no reason for you to exist. And guess what? Don't be surprised that people don't vote for you. Continue reading




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A co když začne pršet? Restaurace se připravují na otevření zahrádek

Méně stolů a větší rozestupy. Jihomoravské restaurace v pondělí otevřou své zahrádky. Musí dodržet přísná opatření proti šíření koronaviru, přesto nemají alternativu pro špatné počasí.



  • Brno - Brno - Zprávy



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Zombie Strippers Porn Star Dancing

Zombie Strippers has got to be hands down one of the cheesiet, oddest, zombie movies movies I have ever seen




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It’s the trip of a lifetime

In the early hours of July 21st, 1969, shortly after the Apollo Lunar Module landed on its surface, Neil Armstrong and Buzz Aldrin became the first humans to step foot on the Moon. 28 years later, Buzz wrote a letter to Barry Goldman, a professor at the University of Maryland. Transcript follows. (Many thanks to




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'Nancy Pelosi Ripping Paper' Proves The Political Memes Aren't Going Anywhere

While we would love for election season to be over right about now, we've gotta admit that the resulting political memes have been top-notch. The internet has been loving this particular dank meme, which shows Speaker of the House Nancy Pelosi ripping up Donald Trump's State of the Union speech.





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#88: Road Trip






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Pizza-Fueled Lizard Broke The Constipation Record, RIP

By Dan Duddy  Published: May 08th, 2020 




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Twitter Thread: Positive Psychologist Explains Brains Tripping Out

Alexis Hockley hooked it up with a quick and informative thread on what's potentially taking place in our brains right now, as result of the strange shift in external circumstances. Now more than ever is a time to spread that love and kindness. 




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She Shouldn't Have Called Triple Ant

Ma'am, Are you in need of roadside assistance?




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Me: I’m back from my work trip. Do you still need those modifications to your logo...

Me: I’m back from my work trip. Do you still need those modifications to your logo files? 

Client: Hey! I was actually able to talk with my IT guy and he taught me how to use gimp to do all of that. But I will definitely let you know if I need anything else done.

Me: (WRITHING IN SYMPATHETIC PAIN FOR USING GIMP)




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RIP Florian Schneider




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RIP Denise Blakely Fuller, Matte Painter On ‘Toy Story 3,’ ‘The Book Of Life,’ ‘Hotel Transylvania’

Her résumé also includes "Brave," "The Book of Life," "Elf," and an eight-year stint as a layout artist during the Disney Renaissance.

The post RIP Denise Blakely Fuller, Matte Painter On ‘Toy Story 3,’ ‘The Book Of Life,’ ‘Hotel Transylvania’ appeared first on Cartoon Brew.



  • RIP
  • Art Center College of Design
  • Denise Blakely Fuller




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Gibraltar sailing trip

Sailing across the Straits of Gibraltar to North Africa. On a course to get my International Yacht Skipper Licence. Sailing to three countries and two continents in a week. I passed the test so now I'm now an officially licenced Skipper Who's up for a s




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Jaisalmer A trip to the Golden Fort and Desert

Tour to Jaisalmer was the best part of our journey to Rajasthan.Our quest for Golden Fort Sonar Kella We myself and my wife planned for two days at Jaisalmer i.e. from the early morning of day 1 to the midnight of day 2 with night




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Day 03 Dazaifu Shrine Yufuin and Beppu Day Trip Jun 2019

Tuesday 25th June 2019I participated in a Kyushu day tour departing from JR Hakata Station covering Dazaifu as well as the hot spring towns of Yufuin and Beppu. Earlier on I had my breakfast at the popup Hello Kitty Cafe within the station co




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Jordan roadtrip a glimpse of Lebanon

31st May 16th June 2019 This is our first blog post since coming back from a yearlong trip in 2012. Since then we have visited many amazing places but our trip to Jordan is the first one which we decided to blog a




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Oregon Trip 2011 week of July 4th Just me and Mom

Oregon Trip 2011Day 1We left the house at 0600 and ate breakfast at Shoneys before heading to Nashville. After dropping off the car at Alexis Inn and Suites and after Mom was finally able to get up into the shuttle van lol we were off.The fl




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Mexico Trip Oct. 2012 Rob and I

Mexico Trip October 2012 First trip with RobDay 1We headed to Atlanta at 0900 and had a nice drive down. Since we had our dive gear with us upgrading to first class was not too much more so we decided to do that and it was quite fun. We arr




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Trip To Tampa Clearwater

In February 2020 before Coronavirus caused chaos and shut everything down I was able to spend the month in Florida. Most of the month was spent in Amelia Island I'll be writing about that more extensively soon but I had always wanted to see Tampa. The




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Trip to Destin JuneJuly 2013 Rob me Laurel and Mom

Trip to Destin JuneJuly 2013Day 1 June 29thWe left the house at 0730 and drove a very LONG 12 hours to get there due to traffic. We went and checked out our condo which was really nice then did some grocery shopping. When we got back Rob and




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Trip to Oregon May 2013 Rob Me and Mom

Trip to Oregon on May 2013 Honeymoon tripDay 1 May 25thWe left Knoxville at 1240. We had a very long flight to Oregon that included long layovers. But had some awesome chocolates at the Charolotte Airport. We didn't get to the hotel in Medford




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Utah Trip Summer 2014 Rob and I

Utah Trip Summer 2014Day 1 Aug 30thWe woke up at 4am for an early flight. We had a 2 hour delay in Atlanta but still made it to Salt Lake City by 1230pm. We picked up our rental car and Rob took us to see some of his old stomping grounds in SLC




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Trip to Puerto Rico April 2015

Trip to Puerto Rico Me and RobDay 1 April 25thOur flight out of Knoxville was delayed so we had to run to catch our connecting flight in Charolotte. We barely made it. Luckily our luggage made it too. I was concerned about that. We got our re




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Planning a Road Trip to Pai for Our Family Visit in November

I'm so excited to be planning a road trip to Pai this coming November My husband and I are planning a trip for his family when they visit from Australia and I'm so excited to show them around We'll be driving from here in Chiang Mai to




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koh chang and the end of the trip is almost nigh..

Koh chang has been all about the relax and what a beautiful island to have picked. Its very laid back with lots of cute little towns to explore we defo needed a motorbike to do this as the taxi service is very expensive and seen no sign of a local bus ser




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Trip 3 Mehoopany Pa

This trip started out a bummer because they split me and Caitlin up. I headed to Mehoopany Pennsylvania and she headed to Iowa City. We are both at Proctor and Gamble sites but our plants make different products. Our goal for these locations was to learn




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What is Drip and how, precisely, will it help the government ruin your life? | Charlie Brooker

The Data Retention and Investigatory Powers bill is the most tedious outrage ever, right down to the dreary acronym. But oh, the horrors it will bring …

David Cameron cares about your safety. It's all he ever thinks about. It's his passion. He's passionate about it. Every time David Cameron thinks about how safe he'd like to keep you, passion overcomes him and he has to have a lie down. With his eyes shut. A bit like he's having a nap and doesn't care about your safety at all.

Right now he's so committed to keeping you safe, he's rushing something called the Drip bill through the House of Commons. Drip stands for Data Retention and Investigatory Powers and critics are calling it yet another erosion of civil liberties and … see, I've lost you because it's just so bloody boring. Maybe it's just me, but whenever I hear about some fresh internet privacy outrage my brain enters screensaver mode and displays that looped news footage of mumblin' Edward Snowden and I automatically nod off only to be awoken shortly afterwards by the sound of my forehead colliding sharply with the table.

Continue reading...




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Measuring the IPv6 network periphery

Guest Post: IPv6 network periphery is a new term to describe newly measured intricacies of IPv6 CPE and routers at the edge.



  • <a href="https://blog.apnic.net/category/tech-matters/">Tech matters</a>

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Worse than Lehman: Coronavirus Tightens Its Grip on the Economy

It is an unprecedented crisis: The coronavirus pandemic is crippling entire economies, while governments and central banks are deploying all means available to prevent a systemic collapse. How long can we hold out?




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Daryl Austin: If our recent trip to Hogle Zoo is the future, we’re going to be OK




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Orioles stars Cal Ripken and Adam Jones’ former Baltimore County estate back on market

The sprawling Baltimore County home once inhabited by Orioles stars Cal Ripken Jr. and Adam Jones is back on the market after less than six months.




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Coronavirus pandemic rages at NYC’s federal jails — and numbers back lawyers’ and staffers’ claims that management has a poor grip on the problem

Staff at New York City’s two federal jails, defense attorneys and inmates interviewed by the Daily News say the official numbers of COVID-19 cases obscure the magnitude of the crisis behind bars.




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Older NYC high school students working during coronavirus pandemic struggle to keep a grip on classwork

Maira Ramirez feels a pang of guilt when her phone buzzes with class assignments while she’s working double shifts at a kosher market to support her financially-strapped family during the pandemic. “I would be at work and see the notifications pop up on Google Classrooms," said Ramirez, a 20-year-old student at West Brooklyn Community High School — a transfer school for students who have struggled in traditional high schools. “I’d be like ‘Damn, I can’t even do them.'”




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Power trip to Thurles on hold for Premier boss

Declan Whooley chats to Tipperary football manager David Power, who should be preparing for his first Munster SFC game against Clare on Saturday evening.




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New study more than triples estimates of people at risk from rising seas

Researchers used artificial intelligence to reevaluate elevations vulnerable to rising sea levels.