Two rovers are active right now on the surface of Mars: Opportunity, which landed in January 2004, and Curiosity, which started exploration in August 2012. […]

The post Sol Man: John Grant is on a road trip across Mars appeared first on Smithsonian Insider.

One of the primary features that distinguish hominids such as chimpanzees, gorillas and humans from the rest of the animal kingdom are uniquely dexterous hands. […]

The post Did ripening fruit help hominids develop complex hands? appeared first on Smithsonian Insider.

The 11 farthest known stars in our galaxy are located about 300,000 light-years from Earth, well outside the Milky Way’s spiral disk. New research by […]

The post Farthest Milky Way stars might be ripped from another galaxy appeared first on Smithsonian Insider.

Recent underwater photographs and video from the National Marine Park of the southern Caribbean island of Bonaire has led to the discovery of a new species […]

The post Meet the candy striped hermit crab, a new Caribbean species appeared first on Smithsonian Insider.

When it comes to the birds of South Asia, Pamela Rasmussen wrote the book on it. Literally. Twice.

The post New Book: “Birds of South Asia: The Ripley Guide” appeared first on Smithsonian Insider.

Scott J. Neal, Qingxiang Zhou, and Francesca Pignoni

The specification of organs, tissues and cell types results from cell fate restrictions enacted by nuclear transcription factors under the control of conserved signaling pathways. The progenitor epithelium of the Drosophila compound eye, the eye imaginal disc, is a premier model for the study of such processes. Early in development, apposing cells of the eye disc are established as either retinal progenitors or support cells of the peripodial epithelium (PE), in a process whose genetic and mechanistic determinants are poorly understood. We have identified Protein Phosphatase 2A (PP2A), and specifically a STRIPAK-PP2A complex that includes the scaffolding and substrate-specificity components Cka, Strip and SLMAP, as a critical player in the retina-PE fate choice. We show that these factors suppress ectopic retina formation in the presumptive PE and do so via the Hippo signaling axis. STRIPAK-PP2A negatively regulates Hpo kinase, and consequently its substrate Wts, to release the transcriptional co-activator Yki into the nucleus. Thus, a modular higher-order PP2A complex refines the activity of this general phosphatase to act in a precise specification of cell fate.

David Guerit, Pauline Marie, Anne Morel, Justine Maurin, Christel Verollet, Brigitte Raynaud-Messina, Serge Urbach, and Anne Blangy

Among hematopoietic cells, osteoclasts (Oc) and immature dendritic cells (Dc) are closely related myeloid cells with distinct functions; Oc participate skeleton maintenance while Dc sample the environment for foreign antigens. Such specificities rely on profound modifications of gene and protein expression during Oc and Dc differentiation. We provide global proteomic and transcriptomic analyses of primary mouse Oc and Dc, based on original SILAC and RNAseq data. We established specific signatures for Oc and Dc including genes and proteins of unknown functions. In particular, we showed that Oc and Dc have the same α and β tubulin isotypes repertoire but that Oc express much more β tubulin isotype Tubb6. In both mouse and human Oc, we demonstrate that elevated expression of Tubb6 in Oc is necessary for correct podosomes organization and thus for the structure of the sealing zone, which sustains the bone resorption apparatus. Hence, lowering Tubb6 expression hindered Oc resorption activity. Overall, we highlight here potential new regulators of Oc and Dc biology and illustrate the functional importance of the tubulin isotype repertoire in the biology of differentiated cells.

Mei Wang, Luping Yu, Shu Wang, Fan Yang, Min Wang, Lufan Li, and Xin Wu

RNA-binding protein LIN28A is required for maintaining tissue homeostasis, including the reproductive system, but the underlying mechanisms on how LIN28A regulates germline progenitors remain unclear. Here, we dissected LIN28A-binding targets using high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) in the mouse testes. LIN28A preferentially binds to CDS or 3'UTR regions through these sites with GGAG(A) sequences enriched within mRNAs. Further investigation of Lin28a null mouse testes indicated that meiosis-associated mRNAs mediated by LIN28A were differentially expressed. Next, ribosome profiling revealed that the mRNA levels of these targets were significantly reduced in polysome fractions, and their protein expression levels decreased in the Lin28a null mouse testes, even when meiotic arrest in null mouse testes was not apparent. Collectively, these findings provide a set of binding targets that are regulated by LIN28A, which may potentially be the mechanism for the prominent role of LIN28A in regulating mammalian undifferentiated spermatogonia fates and male fertility.

Stephen Kershaw, David J. Morgan, James Boyd, David G. Spiller, Gareth Kitchen, Egor Zindy, Mudassar Iqbal, Magnus Rattray, Chris M. Sanderson, Andrew Brass, Claus Jorgensen, Tracy Hussell, Laura C. Matthews, and David W. Ray

Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) to regulate immunity, energy metabolism, and tissue repair. Upon ligand binding, activated GR mediates cellular effects by regulating gene expression, but some GR effects can occur rapidly without new transcription. We show GCs rapidly inhibit cell migration, in response to both GR agonist and antagonist ligand binding. The inhibitory effect on migration is prevented by GR knockdown with siRNA, confirming GR specificity, but not by actinomycin D treatment, suggesting a non-transcriptional mechanism. We identified a rapid onset increase in microtubule polymerisation following glucocorticoid treatment, identifying cytoskeletal stabilisation as the likely mechanism of action. HDAC6 overexpression, but not knockdown of αTAT1, rescued the GC effect, implicating HDAC6 as the GR effector. Consistent with this hypothesis, ligand-dependent cytoplasmic interaction between GR and HDAC6 was demonstrated by quantitative imaging. Taken together, we propose that activated GR inhibits HDAC6 function and thereby increases the stability of the microtubule network to reduce cell motility. We therefore report a novel, non-transcriptional mechanism whereby GCs impair cell motility through inhibition of HDAC6 and rapid reorganization of the cell architecture.

The post How a giant T. Rex packs for a road trip appeared first on Smithsonian Insider.

What might lure someone away from the sunny beaches and lush forests of Brazil to the concrete jungle of Washington, D.C.? For wood anatomist Marcelo […]

The post Rigid yet flexible: Anatomy of woody vines has its grip on botanist Marcelo Pace appeared first on Smithsonian Insider.

The crystal structure of vanthoffite, Na6Mg(SO4)4, was redetermined and refined with anisotropic displacement parameters for all atoms. Here, for the first time, we give its detailed description.

The crystal structure of vanthoffite {hexasodium magnesium tetrakis[sulfate(VI)]}, Na6Mg(SO4)4, was solved in the year 1964 on a synthetic sample [Fischer & Hellner (1964). Acta Cryst. 17, 1613]. Here we report a redetermination of its crystal structure on a mineral sample with improved precision. It was refined in the space group P21/c from a crystal originating from Surtsey, Iceland. The unique Mg (site symmetry overline{1}) and the two S atoms are in usual, only slightly distorted octahedral and tetrahedral coordinations, respectively. The three independent Na atoms are in a distorted octahedral coordination (1×) and distorted 7-coordinations intermediate between a `split octahedron' and a pentagonal bipyramid (2×). [MgO6] coordination polyhedra interchange with one half of the sulfate tetrahedra in <011> chains forming a (100) meshed layer, with dimers formed by edge-sharing [NaO7] polyhedra filling the interchain spaces. The other [NaO7] polyhedra are organized in a parallel layer formed by [010] and [001] chains united through edge sharing and bonds to the remaining half of sulfate groups and to [NaO6] octahedra. The two types of layers interconnect through tight bonding, which explains the lack of morphological characteristics typical of layered structures.

The application of groupoids to modular crystal structures is presented.

President Trump walks to the White House on Sunday, after returning from Camp David in Maryland.; Credit: Andrew Caballero-Reynolds/AFP via Getty Images

Tamara Keith and Don Gonyea | NPR

As President Trump attempts to project an image of America rising out of quarantine and beginning to reopen, he's set to travel to an Arizona factory that's expanded into production of N95 face masks to respond to the coronavirus pandemic.

And while the trip is in part meant to tell a positive story about the Trump administration's response, it also highlights the challenges of the current moment.

Arizona remains under a modified stay-at-home order until May 15, though Republican Gov. Doug Ducey allowed some retail establishments to begin to open voluntarily Monday. The state hasn't yet notched the two consecutive weeks of reduced COVID-19 cases called for as a first step in the White House guidelines for reopening. In fact, the number of confirmed cases in the state is on the rise.

And Trump's trip itself will be anything but normal. Those traveling with the president or coming in close proximity to him in Arizona are being tested for the coronavirus. Social distancing measures are expected.

"The President takes the health and safety of everyone traveling in support of himself and all White House operations very seriously," White House spokesman Judd Deere said in a statement provided to NPR. "When preparing for and carrying out any travel, the White House's operational teams work together to ensure plans to incorporate current CDC guidance and best practices for limiting COVID-19 exposure are followed to the greatest extent possible."

Asked last week if he would wear a mask on the trip, Trump was noncommittal.

"I'm going to have to look at the climate. I'd have no problem wearing a mask. I don't know," Trump said at the White House. "I'm supposed to make a speech. I just don't know: Should I speak in a mask? You're going to have to tell me if that's politically correct. I don't know. If it is, I'll speak in a mask."

Vice President Mike Pence faced criticism for not wearing a mask while visiting the Mayo Clinic in Minnesota last week, in apparent violation of the center's policy. Sitting next to Trump at a televised town hall Sunday night, Pence said he "should have worn a mask at the Mayo Clinic."

Pence has left Washington, D.C., a few times recently — a series of trips the White House used in part as test runs for Trump to get back on the road.

Different than the big rallies

Tuesday's travel is a far cry from Trump's last trip to Arizona, for a campaign rally on Feb. 19. He didn't mention the coronavirus in his speech that night, and when asked about it in an interview with a local TV reporter, he downplayed the risk.

"I think it's going to work out fine," Trump told Fox 10 Phoenix. "I think when we get into April, in the warmer weather, that has a very negative effect on that and that type of a virus. So let's see what happens, but I think it's going to work out fine."

As of Monday morning, more than 350 deaths had been attributed to COVID-19 in Arizona, according to researchers at Johns Hopkins University, with about 68,000 deaths nationwide.

Trump still yearns for those big rallies of the not-so-distant past, musing about the day when he can pack arenas again and not have to have people spaced 6 feet apart. But for now, he's relishing the idea of escaping the confines of the White House. Aside from a trip to the presidential retreat at Camp David last weekend, this will be Trump's first trip away from the White House since March 28, when he sent off the Navy hospital ship USNS Comfort in Norfolk, Va. While it's been a little more than a month, Trump has described himself as stuck at the White House "for many months."

In Phoenix, Trump will tour a Honeywell aerospace manufacturing facility that freed up space to start making N95 respirator masks. According to a company spokesman, the first masks rolled off the line on April 30, ahead of schedule. Once up to full capacity, it will make 10 million of the masks per month. The company said it would be adding 500 employees to make the masks. Another Honeywell factory in Rhode Island also started making masks last month. Most of them are headed to the federal government, which is distributing the protective equipment. Mask shortages have been a major concern for health care workers treating patients with the highly contagious coronavirus.

Battleground state

Although there isn't officially a political component to the trip, Arizona is a state Trump won in 2016, but that Democrats expect to be competitive in 2020.

Trump's visit clearly underscores how he isn't taking anything for granted in the state in 2020. His goal is to remind voters how the Arizona economy was booming before the pandemic.

"Arizona is a state where President Trump's campaign will be aggressive, where we have had a presence since 2015," said Erin Perrine, principal deputy communications director for the reelection campaign. "We will reach voters where ever they are — sharing the message that only President Trump can bring back the booming Trump economy and highlighting his strong leadership during the coronavirus."

For several election cycles, Democrats have been eyeing Arizona as a state they might put in the presidential win column. Analysts say Democrats challenge will will be to win in the suburbs and get a solid turnout from Hispanics, even as the pandemic's effect on campaigning and on the actual process of voting is yet to be known. No Democratic nominee had carried the state since Bill Clinton in 1996. In 2016, there was talk of a late play for the state by Hillary Clinton's campaign, but that was seen more as overconfidence than her actually have a real shot at winning there. Then, when the votes were counted, Trump won the presidency, including a victory in Arizona, but his margin in the state was only 3.5%.

Four years earlier, GOP nominee Mitt Romney carried the state over President Obama by more than 9 percentage points. Democrats took Trump winning so narrowly in the state as a sign that maybe the future was closer than people realized. Longtime GOP strategist Chuck Coughlin says Democrats kept the story line going two years later by winning four statewide offices, including an open U.S. Senate seat and secretary of state. Now strategist Coughlin says, "There is a trend line going on, Republicans have had to acknowledge that, and the swing voters have become more important — independents and Republican suburban women." He says those are the keys to a Democratic victory in the state.

An average of recent polls shows former Vice President Joe Biden, the presumptive Democratic presidential nominee, leading in head-to-head matchups. Although horse race polling this far out, and especially in the middle of an unprecedented crisis, isn't necessarily predictive, it's one of a few causes for alarm for Republicans.

In 2018, Democrat Kyrsten Sinema won an open U.S. Senate seat in Arizona. Another Senate seat is up in 2020, and the latest campaign finance reports show Democratic challenger Mark Kelly with nearly twice as much cash on hand as incumbent Republican Sen. Martha McSally. Kelly has also led in recent polls.

McSally portrays herself as a strong ally of Trump's, even echoing his style of negative campaigning. Here's how she began her remarks when Trump called her up to speak at that big rally in February, "I just want to say I have a message for the liberal hack media in the back," she told the noisy crowd, "Arizona is going to vote in November to keep America great and send President Trump back to the White House.

In April McSally tweeted that she was able to secure ventilators for her state after talking to Trump.

"Huge news for Arizona!" McSally tweeted. "I spoke with @realDonaldTrump on Wednesday afternoon to request additional ventilators from the Strategic National Stockpile. Today, POTUS delivers with 100 ventilators headed to AZ. Thank you to President Trump and @VP for hearing our call."

Copyright 2020 NPR. To see more, visit https://www.npr.org.

This content is from Southern California Public Radio. View the original story at SCPR.org.

People sit on a hill overlooking Dodger Stadium on what was supposed to be Major League Baseball's opening day, now postponed due to the coronavirus, on March 26, 2020 in Los Angeles, California. ; Credit: Mario Tama/Getty Images

AirTalk®

Had the 2020 MLB season started at the end of March like it was scheduled to, at this point we’d be starting to see divisions shape up, star pitchers and position players separating themselves from the rest of the league and a first look at who this year’s contenders and pretenders really would be. Sadly, the COVID-19 outbreak forced the league to postpone the start of the season, and now the question has become if there will be a season, not when. 

Not to be dragged down by the idea of no baseball, Wall Street Journal sports writer Jared Diamond took a recent proposal the league floated for an abbreviated 2020 campaign and gamed out how that might look in real life. The league’s idea would do away with the National and American Leagues and divide all 30 MLB teams into three divisions of 10 teams separated by region, and those teams would play in empty stadiums and only against other teams in their geographic division in the interests of reducing travel. But how viable is this, really? And what other considerations would the league and players union have to take with regards to testing and protocol for what happens if someone were to contract COVID-19? Is there a world where baseball still happens this year?

Today on AirTalk, Jared Diamond joins the Triple Play of Larry Mantle, Nick Roman and A Martinez to talk about what a shortened 2020 MLB season might look like, which teams stand to win and lose the most from the realignment and what other precautions the league would have to take against the spread of COVID-19.

Guests:

Jared Diamond, national baseball writer for the Wall Street Journal; his new book is "Swing Kings: The Inside Story of Baseball's Home Run Revolution” (William Morrow, March 2020); he tweets @jareddiamond

Nick Roman, host of KPCC’s “All Things Considered”; he tweets @RomanOnTheRadio

A. Martinez, host of KPCC’s “Take Two”; he tweets @amartinezLA

This content is from Southern California Public Radio. View the original story at SCPR.org.

Santa Monica Beach, a very wide, artificially built, and regularly maintained beach. Photographed on September 9, 2019 in Santa Monica, California.; Credit: James Bernal for KPCC

Jacob Margolis

You may not know this, but oftentimes in newsrooms we write obituaries ahead of time so that they're ready to publish when the person passes away. But what if the obit wasn't for a person, but for a place that's been the home of magical memories for generations?

Sea levels could rise by more than three feet by the end of the century, and that's going to mean many things you love about our coast are not going to be around much longer.

As part of our Covering Climate Now collaboration, we thought it was appropriate to start preparing an obit for one of Southern California's most prized areas of Pacific Coast Highway: Santa Monica to Malibu. 

It's slated to run in 80 years or so - the year 2100. 

This content is from Southern California Public Radio. View the original story at SCPR.org.

President Trump has said he wants to see the country begin to reopen. The pandemic crashed the economy by keeping people at home, leading to millions of job losses.; Credit: Pool/Getty Images

Franco Ordoñez and Alana Wise | NPR

The White House coronavirus task force rejected detailed guidance drafted by the Centers for Disease Control and Prevention on how workplaces ranging from schools to bars to churches should resume operations to prevent the spread of the virus because it was viewed as "overly prescriptive."

President Trump has said he wants to see the country begin to reopen. The pandemic crashed the economy by keeping people at home, leading to millions of job losses. The White House task force issued guidelines on how to gradually and safely reopen but left decisions up to governors based on conditions in their states.

Experts have warned that a rush to reopen could have disastrous implications for containing COVID-19. Many businesses have said they want more details about how to do things safely.

The draft detailed guidance was provided to the task force in late April, a couple of weeks after it released its April 16 guidance to states for reopening.

The task force sought "certain revisions" to the CDC's detailed guidance, two administration officials told NPR. But revised recommendations were never returned to the task force.

The Associated Press first reported on the task force decision to shelve the detailed guidance. Copies obtained and published by the AP, The New York Times and The Washington Post revealed detailed, staged directions for child care centers, schools, camps, restaurants and bars, churches and mass transit providers about how to safely resume operations.

"I think many people would argue that it is not the role of the federal government to tell specific entities — whether they be schools or churches or businesses — how they should go about doing things because the nation is so diverse," one of the administration officials said.

The task force said that some of the points may be helpful, but they needed to "zoom out a little bit and not be so prescriptive," according to the official. The task force said they would welcome a new set of recommendations, but that never happened, the official said.

"Issuing overly specific instructions — that CDC leadership never cleared — for how various types of businesses open up would be overly prescriptive and broad for the various circumstances states are experiencing throughout the country," the second administration official said. "Guidance in rural Tennessee shouldn't be the same guidance for urban New York City."

The United States last month reached 1 million known coronavirus cases, representing one-third of all coronavirus cases worldwide. Nearly 74,000 Americans have been felled by the disease as of Thursday, according to data compiled by the Johns Hopkins Coronavirus Resource Center.

Copyright 2020 NPR. To see more, visit https://www.npr.org.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Alex Wolff in Human Capital.; Credit: Vertical Entertainment/Human Capital (2019)

FilmWeek®

Larry Mantle and KPCC film critics Lael Loewenstein, Claudia Puig and Tim Cogshell review this weekend’s new (streaming and VOD) movie releases.

• "Human Capital" on DirecTV

• "Crip Camp" on Netflix

• "The Platform" on Netflix

• "Blow The Man Down" on Amazon Prime Video

• "Phoenix, Oregon" on film's website

• "The Dog Doc" on Amazon Prime Video

• "Hooking Up" on Xfinity OnDemand

​CORRECTION: The film Human Capital is available on all on-demand platforms as of March 20th.

Guests:

Claudia Puig, film critic for KPCC and president of the Los Angeles Film Critics Association (LAFCA); she tweets @ClaudiaPuig

Lael Loewenstein, KPCC film critic and film columnist for the Santa Monica Daily Press; she tweets @LAELLO

Tim Cogshell, film critic for KPCC, Alt-Film Guide and CineGods.com; he tweets @CinemaInMind

 

This content is from Southern California Public Radio. View the original story at SCPR.org.

Researchers from the University of Oxford's Bodleian Libraries and from universities in the Netherlands have used high-tech imaging to uncover the details of a rare Mexican codex dating from before the colonization of the Americas. The newly revealed codex, or book, has been hidden from view for almost 500 years, concealed beneath a layer of plaster and chalk on the back of a later manuscript known as the Codex Selden, which is housed at the Bodleian Libraries. Scientists have used hyperspectral imaging to reveal pictographic scenes from this remarkable document and have published their findings in the Journal of Archaeological Science: Reports.

read more

5G will cover more than 20 percent of the global population six years from now, according to the latest Ericsson Mobility Report

A mobile-centric approach and the emergence of new digital platforms fuelling greater adoption of e-commerce has driven reach and growth of MakeMyTrip, the online travel company said in a presentation to investors.

Rippon, Gina, author

DDoS attacks during the first three months of this year have seen a significant spike in attacks on educational websites.

DDoS attacks during the first three months of this year have seen a significant spike in attacks on educational websites.

Researchers have recommended new, improved ways of increasing the ecological value of European grasslands. Plant diversity ??? or species richness ??? can be increased by a factor of three through sowing grass and wildflower seed mixtures, together with a carefully controlled plan for animal grazing.

The post Mirror finding ripples in time appeared first on The Lead SA.

FAIRFAX, Va. – Rolling lane closures are planned to occur in both directions on I-66 between Route 29 in Gainesville and Sudley Road (Route 234...

To provide complete care for its residents, Chaseley Trust, offers amenities such as a movie theater, a gymnasium and a pool table. And strippers.

A federal judge has ordered the Food and Drug Administration to make the morning-after pill available to teens without a prescription.

MNN family blogger's attempt to live without oil while embarking on a family vacation.

A mere change of governments will not make Arab countries’ economic problems go away. Indeed, the converging effects of population growth, climate change, and

Antarctica ice loss was only contributing 0.2 millimeters per year to sea level rise, but that number has jumped to 0.6 millimeters since 2012.

What is gripe water and what does malaria have to do with colic? (Besides making babies and everyone around them miserable, that is.)

An ancient, two-sided amulet uncovered in Cyprus contains a 59-letter inscription that reads the same backward as it does forward.

Urban development is set to triple in the first three decades of this century, the largest cityscape expansion in human history, according to a new study that f

Reuters investigates the growing trend of builders keeping hush about the severing of mineral rights attached to newly built homes.

I liked this small battery SUV fine, though it exhibited a mysterious slowdown. If charge times are speeded up and the price kept within reason, it should sell.

New network will enable coast-to-coast electric rides and 20-minute charges. CEO Elon Musk is ramping up the timetable.

Oil sands, international relations and energy policy make for a touchy visit in Ottawa.

New Horizons is the subject of "Mission Pluto," a special that will premiere July 15 on National Geographic Channel.

By keeping things compact, Matt Kirkpatrick and Katherine Bovee were able to splurge and have some fun when designing their boxy, prefab abode.