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Deep End Kawasaki/Yokohama: A New Challenge for GPs in Deprived Areas in Japan [Innovations in Primary Care]




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Evaluation of the Importance of Capsule Transparency in Dry Powder Inhalation Devices [Research Briefs]

The aim of this work is to test whether the use of a transparent capsule affects the residual capsule weight after inhalation as a surrogate of the inhaled delivered dose for patients with non-reversible chronic airway disease. Researchers conducted an observational cross-sectional study with patients using a single-dose dry powder inhaler. The weight of the capsule was measured with a precision microbalance before and after inhalation. Ninety-one patients were included, of whom 63 (69.2%) used a transparent capsule. Inhalation with a transparent capsule achieved a weight decrease of 30.1% vs 8.6% for devices with an opaque capsule (P <0.001). These data reinforce the need to provide patients with mechanisms that verify the correct inhalation technique.




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Challenges in Receiving Care for Long COVID: A Qualitative Interview Study Among Primary Care Patients About Expectations and Experiences [Original Research]

BACKGROUND

For many patients with post–COVID-19 condition (long COVID), primary care is the first point of interaction with the health care system. In principle, primary care is well situated to manage long COVID. Beyond expressions of disempowerment, however, the patient’s perspective regarding the quality of long COVID care is lacking. Therefore, this study aimed to analyze the expectations and experiences of primary care patients seeking treatment for long COVID.

METHODS

A phenomenological approach guided this analysis. Using purposive sampling, we conducted semistructured interviews with English-speaking, adult primary care patients describing symptoms of long COVID. We deidentified and transcribed the recorded interviews. Transcripts were analyzed using inductive qualitative content analysis.

RESULTS

This article reports results from 19 interviews (53% female, mean age = 54 years). Patients expected their primary care practitioners (PCPs) to be knowledgeable about long COVID, attentive to their individual condition, and to engage in collaborative processes for treatment. Patients described 2 areas of experiences. First, interactions with clinicians were perceived as positive when clinicians were honest and validating, and negative when patients felt dismissed or discouraged. Second, patients described challenges navigating the fragmented US health care system when coordinating care, treatment and testing, and payment.

CONCLUSION

Primary care patients’ experiences seeking care for long COVID are incongruent with their expectations. Patients must overcome barriers at each level of the health care system and are frustrated by the constant challenges. PCPs and other health care professionals might increase congruence with expectations and experiences through listening, validating, and advocating for patients with long COVID.

Annals Early Access article




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DayZ creator reveals a "Kerbal Space Program killer" with kittens and challenges license owners to sue him

Stationeers and Icarus developers RocketWerkz are making a spiritual successor to beloved space sim Kerbal Space Program, which is currently titled "Kitten Space Agency" in a flagrant display of adherence to wholesome internet trends. It's based on an actual Kerbal Space Program 2 pitch the studio threw at Take-Two subsidiary Private Division back in the day. RocketWerkz CEO and original DayZ creator Dean Hall has hired several former KSP and KSP2 developers to work on the game, and is describing it on social media as a "KSP killer".

Read more




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Halo 2's lost E3 2003 demo will finally be playable thanks to modder magic

Halo Infinite recently received a big update in the form of Delta Arena, a playlist that features recreations of Halo 2's most popular maps and a special third-person mode. The true highlight, though, is yet to come. And that's through an entirely different Halo game: The Master Chief Collection. Soon enough, you'll be able to play Halo 2's lost E3 demo on it, thanks to some lovely modders.

Read more




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Offensively good-looking Sims challenger Inzoi hits early access in March 2025

Life simulation game Inzoi will launch on PC via Steam early access on 28th March 2025, publishers Krafton have announced. Billed as a potential Sims 4 usurper, and equipped with syrupy Unreal Engine 5 visuals, it was originally slated for launch this year.

Read more




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Halo's most disgusting enemy was partly inspired by a children's book

It was the 20-year anniversary of Halo 2 at the weekend, which saw the shooter's modern counterparts celebrating with classic multiplayer maps and long-lost levels. But also emerging from the dust of time are insights to the sequel's development back in 2004. Rolling Stone interviewed two key designers of the game and made a fun discovery. The Flood (the sickly pale alien infestation that briefly turns Halo into sci-fi horror) was partly inspired by a colourful and innocent children's book about a nice elephant.

Read more




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‘Shazam for whales’ uses AI to track sounds heard in Mariana Trench

An artificial intelligence model that can identify the calls of eight whale species is helping researchers track the elusive whale behind a perplexing sound in the Pacific




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The Rock Hall Was Cold As Ice to Foreigner

“Somehow, I couldn’t sing a rock song at the Rock Hall of Fame when I’m being inducted? It doesn’t make any sense to me, and it sticks in my craw.”




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Forums, Competitions, Challenges: Inspiring Creativity in Robotics



This is a sponsored article brought to you by Khalifa University of Science and Technology.

A total of eight intense competitions to inspire creativity and innovation along with 13 forums dedicated to diverse segments of robotics and artificial intelligence will be part of the 36th edition of the IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2024) in Abu Dhabi.

These competitions at the Middle East and North Africa (MENA) region’s first-ever global conference and exhibition from 14-18 October 2024 at the Abu Dhabi National Exhibition Center (ADNEC) will highlight some of the key aspects of robotics. These include physical or athletic intelligence of robots, remote robot navigation, robot manipulation, underwater robotics, perception and sensing as well as challenges for wildlife preservation.

This edition of IROS is one of the largest of its kind globally in this category because of active participation across all levels, with 5,740 authors, 16 keynote speakers, 46 workshops, 11 tutorials, as well as 28 exhibitors and 12 startups. The forums at IROS will explore the rapidly evolving role of robotics in many industry sectors as well as policy-making and regulatory areas. Several leading corporate majors, and industry professionals from across the globe are gathering for IROS 2024 which is themed “Robotics for Sustainable Development.”

“The intense robotics competitions will inspire creativity, while the products on display as well as keynotes will pave the way for more community-relevant solutions.” —Jorge Dias, IROS 2024 General Chair

Dr. Jorge Dias, IROS 2024 General Chair, said: “Such a large gathering of scientists, researchers, industry leaders and government stakeholders in Abu Dhabi for IROS 2024 also demonstrates the role of UAE in pioneering new technologies and in providing an international platform for knowledge exchange and sharing of expertise. The intense robotics competitions will inspire creativity, while the products on display as well as keynotes will pave the way for more community-relevant solutions.”

The competitions are:

In addition to these competitions, the Falcon Monitoring Challenge (FMC) will focus on advancing the field of wildlife tracking and conservation through the development of sophisticated, noninvasive monitoring systems.

Khalifa University

IROS 2024 will also include three keynote talks on ‘Robotic Competitions’ that will be moderated by Professor Lakmal Seneviratne, Director, Center for Autonomous Robotic Systems (KU-CARS), Khalifa University. The keynotes will be delivered by Professor Pedro Lima, Institute for Systems and Robotics, Instituto Superior Técnico, University of. Lisbon, Portugal; Dr. Timothy Chung, General Manager, Autonomy and Robotics, Microsoft, US; and Dr. Ubbo Visser, President of the RoboCup Federation, Director of Graduate Studies, and Associate Professor of Computer Science, University of Miami, US.

The forums at IROS 2024 will include:

Other forums include:

One of the largest and most important robotics research conferences in the world, IROS 2024 provides a platform for the international robotics community to exchange knowledge and ideas about the latest advances in intelligent robots and smart machines. A total of 3,344 paper submissions representing 60 countries, have been received from researchers and scientists across the world. China tops the list with more than 1,000 papers, the US with 777, Germany with 302, Japan with 253, and the UK and South Korea with 173 each. The UAE remains top in the Arab region with 68 papers.

One of the largest and most important robotics research conferences in the world, IROS 2024 provides a platform for the international robotics community to exchange knowledge and ideas.

For eight consecutive years since 2017, Abu Dhabi has remained first on the world’s safest cities list, according to online database Numbeo, which assessed 329 global cities for the 2024 listing. This reflects the emirate’s ongoing efforts to ensure a good quality of life for citizens and residents. With a multicultural community, Abu Dhabi is home to people from more than 200 nationalities, and draws a large number of tourists to some of the top art galleries in the city such as Louvre Abu Dhabi and the Guggenheim Abu Dhabi, as well as other destinations such as Ferrari World Abu Dhabi and Warner Bros. World™ Abu Dhabi.

Because of its listing as one of the safest cities, Abu Dhabi continues to host several international conferences and exhibitions. Abu Dhabi is set to host the UNCTAD World Investment Forum, the 13th World Trade Organization (WTO) Ministerial Conference (MC13), the 12th World Environment Education Congress in 2024, and the IUCN World Conservation Congress in 2025.

IROS 2024 is sponsored by IEEE Robotics and Automation Society, Abu Dhabi Convention and Exhibition Bureau, the Robotics Society of Japan (RSJ), the Society of Instrument and Control Engineers (SICE), the New Technology Foundation, and the IEEE Industrial Electronics Society (IES).

More information at https://iros2024-abudhabi.org/




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L.A. Voters Are Fed Up With City Hall Corruption and Scandal




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Whale scientists capture the sights and sounds of a baby sperm whale birth for the first time

Scientists are using machine learning to decode and eventually translate how sperm whales communicate with Morse code-like clicks and pauses.



  • Radio/Quirks & Quarks

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After dismal start, UN hosts 'halftime summit' in bid to save development plan

After a dismal start, the UN is hosting a "halftime summit" about its 15-year plan to meet a series of human-development targets by 2030. Delegates will try to focus on problems like extreme poverty and gender equality while watching for sparks between the representatives of Ukraine and Russia.




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Speaker Johnson could face challenger amid simmering GOP discontent

House Speaker Mike Johnson is seeking a smooth re-election to another term wielding the gavel, but a small group of discontent conservatives are again vying to shake things up at the top.




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Jordan Nobbs Column: England Have Impressed So Far But Must Be Wary of Tough Japan Challenge

Arsenal and England midfielder Jordan Nobbs will be a columnist for 90min & BBC Sport pundit at the Women's World Cup in France this summer, as Phil Neville's Lionesses' look to secure a maiden World Cup triumph. Two wins from our first two games is obviously what we were all hoping for. The first game of a World Cup, or any other major tournament, is never going to be one where you're playing at your absolute best. But the 2-1 win over was Scotland was great given the pre-match hype, the..





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MWC 2024: A wild Journey to the Future in Hall 6

The future and all that is possible was on full display this week at MWC Barcelona 2024 in Hall Six of Gran Via, the site of an innovation zone that featured hands-on and immersive demos of things ranging from devices that enhance the growing of fruit to what has been described as the “world’s first […]

The post MWC 2024: A wild Journey to the Future in Hall 6 first appeared on ITBusiness.ca.





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We will one day be able to slow, halt and even eradicate Alzheimer's

Despite the limitations of Alzheimer's drugs like lecanemab, this new class of treatments and a group of experimental vaccines are paving the way to a world without dementia




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How Did Two Bowhead Whales That Were 60 Miles Apart Sync Their Diving?

Researchers suspect the marine mammals may have been communicating across the vast distance





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Daniel Khalife pleads guilty to escaping Wandsworth prison last year

The former soldier Daniel Khalife has changed his plea to guilty and admitted escaping from Wandsworth prison.




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Rosebank: Legal challenge over Scottish oil field begins

The fight between environmental campaigners and fossil fuel moved to the Scottish courts today.





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My Little Pony, Transformers, Phase 10 join the National Toy Hall of Fame

The three 1980s staples are new National Toy Hall of Fame inductees. Hess Toy Trucks, the Pokémon Trading Card Game, the trampoline, and balloons were among the finalists.




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Meta Quest 3S is a disappointing half-step to Carmack’s low-cost VR vision

Significant visual and comfort compromises make last year's Quest 3 a better VR investment.




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‘I Am Kathalan’ movie review: Fast-paced cyber crime thriller ends up an average fare

Despite being an engaging watch, ‘I Am Kathalan’ hits a little below the mark compared to director Girish A.D’s previous outings




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Shea Weber, Pavel Datsyuk enshrined as part of Hockey Hall of Fame's 2024 class

Shea Weber is member of the Hockey Hall of Fame. The former defenceman headlined the 2024 class inducted Monday, joining Pavel Datsyuk, Jeremy Roenick, Natalie Darwitz and Krissy Wendell in the player category. David Poile and Colin Campbell entered as builders.




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The Best Switch Visual Novels and Adventure Games in 2024 – From Fata Morgana and VA-11 Hall-A to Famicom Detective Club and Gnosia

After tackling the best party games on Switch in 2024, the recent release of Emio – The Smiling Man: Famicom …




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Sukeban Games 2024 Interview: Christopher Ortiz AKA kiririn51 Talks .45 PARABELLUM BLOODHOUND, Inspirations, Fan Reactions, VA-11 Hall-A, The Silver Case, and Much More

Over the years, I’ve been able to interview some of my favorite developers ever including a few I never though …




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Why thousands gathering around rancid 'dead whale' by world's biggest lake...


Why thousands gathering around rancid 'dead whale' by world's biggest lake...


(Third column, 18th story, link)






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This budget Roomba robot vacuum is nearly half off ahead of Black Friday

The blackest of Fridays is nearly upon us and companies have already begun rolling out the deals to separate consumers from their bank accounts. Here’s one for a well-regarded and budget-friendly robovac. The iRobot Roomba Essential Vac is on sale for just $140, which is a discount of 44 percent. The regular price is $250.

The Essential Vac features a similar design to the iRobot Roomba 694, which topped our list of the best budget robot vacuums. This one includes a three-stage cleaning system that works on both carpet and hard floors. It features the same smart navigation system as other iRoomba vacuums, so it’ll avoid stairs and work its way around items of furniture.

Despite being a budget-friendly robovac, there are some modern flourishes. The vacuum will automatically return to the charging station when the battery runs low, which is always nice. It also integrates with the Roomba app for setting cleaning schedules and for building a custom map of the home.

The battery life sits at around two hours, which is a decent metric for the price. That should be more than enough time to thoroughly clean a medium-sized home. The major caveat here is that this is a budget robovac, so it doesn’t mop and it doesn’t ship with a large debris canister. Still, the price is right for those curious about eliminating sweeping from that to-do list.

Check out all of the latest Black Friday and Cyber Monday deals here.

This article originally appeared on Engadget at https://www.engadget.com/deals/this-budget-roomba-robot-vacuum-is-nearly-half-off-ahead-of-black-friday-184426408.html?src=rss




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Drinking water outage hits half of France's Mayotte

Mamoudzou (AFP) Nov 12, 2024
Around half the people in the French Indian Ocean territory of Mayotte were without potable water Tuesday after a "technical incident" at a treatment plant, a local authority said in a statement. The "event of electrical origin" at the Ouroveni plant overnight from Monday to Tuesday "is leading to water cuts mostly located in the centre and south" of Mayotte's main island Grande Terre, the p




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Un modeste conseil au PLQ: laissez les beaux-pères au chalet...

Laissez les beaux-pères au chalet et vos candidats libres de vous étonner. S’ils en sont capables, ils le feront.




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Une ancienne boîte St-Hubert des années 70 retrouvée dans l’entretoit d’un chalet près de Stoneham et remise à la famille Martin en échange d'un don de 1000$

Une ancienne boîte de poulet St-Hubert, retrouvée par hasard dans l’entretoit d’un chalet, a été remise à la famille Martin en échange d'un don.




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Ottawa to reinstate Arctic ambassador as it faces challenges from U.S., Russia and China in region

Ottawa is finalizing its long-awaited Arctic foreign policy with Inuit leaders for release before the end of the year, as Canada braces for a second Trump presidency and increasing threats to its sovereignty from China and Russia.




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Time limits for trials were meant to speed up justice. They've also halted hundreds of criminal cases

Supporters say the Supreme Court of Canada's so-called Jordan ruling in 2016 has sped up proceedings and strengthened Charter rights for prompt justice. But some victims say the time limits for trials work in criminals' favour and cases continue to collapse because those limits are breached. 



  • News/Canada/British Columbia

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Legal challenge to Rosebank oil field begins

Campaigners want to stop the Rosebank oil and Jackdaw gas fields, but oil companies say they are vital.




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The latest trends and challenges in sterilisation

James Hicks, healthcare application development and processing engineer at Syensqo explores the latest trends, challenges and solutions in sterilisation.




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Health boards say around half of pharmacies have expressed interest in providing COVID-19 vaccines

Around half of Wales’ community pharmacies have expressed interest to health boards in providing COVID-19 vaccinations as part of the national programme.




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Chiesi launches postal asthma inhaler recycling scheme

The UK’s first postal inhaler recycling scheme has been launched by pharmaceutical company Chiesi to support a more sustainable way of living for people with respiratory illnesses.




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Half of asthma patients in the UK overusing SABAs, study finds

More than half of patients with asthma in the UK are “potentially overusing” short-acting β2-agonists, according to research.




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Half of US clinical trials are breaking the law on reporting results

New research has shown that the majority of clinical trials which should be following the US law on reporting results aren’t. Less than half (41%) of clinical trial results were reported on time and 1 in 3 trials (36%) remain unreported. The research also found that clinical trials sponsored by companies are the most likely […]




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Half of All Trials Unpublished*

(*For certain possibly nonstandard uses of the word "unpublished")

This is an odd little study. Instead of looking at registered trials and following them through to publication, this study starts with a random sample of phase 3 and 4 drug trials that already had results posted on ClinicalTrials.gov - so in one, very obvious sense, none of the trials in this study went unpublished.

Timing and Completeness of Trial Results Posted at ClinicalTrials.gov and Published in Journals
Carolina Riveros, Agnes Dechartres, Elodie Perrodeau, Romana Haneef, Isabelle Boutron, Philippe Ravaud



But here the authors are concerned with publication in medical journals, and they were only able to locate journal articles covering about half (297/594) of trials with registered results. 

It's hard to know what to make of these results, exactly. Some of the "missing" trials may be published in the future (a possibility the authors acknowledge), some may have been rejected by one or more journals (FDAAA requires posting the results to ClinicalTrials.gov, but it certainly doesn't require journals to accept trial reports), and some may be pre-FDAAA trials that sponsors have retroactively added to ClinicalTrials.gov even though development on the drug has ceased.

It would have been helpful had the authors reported journal publication rates stratified by the year the trials completed - this would have at least given us some hints regarding the above. More than anything I still find it absolutely bizarre that in a study this small, the entire dataset is not published for review.

One potential concern is the search methodology used by the authors to match posted and published trials. If the easy routes (link to article already provided in ClinicalTrials.gov, or NCT number found in a PubMed search) failed, a manual search was performed:
The articles identified through the search had to match the corresponding trial in terms of the information registered at ClinicalTrials.gov (i.e., same objective, same sample size, same primary outcome, same location, same responsible party, same trial phase, and same sponsor) and had to present results for the primary outcome. 
So it appears that a reviewed had to score the journal article as an exact match on 8 criteria in order for the trial to be considered the same. That could easily lead to exclusion of journal articles on the basis of very insubstantial differences. The authors provide no detail on this; and again, that would be easy to verify if the study dataset was published. 

The reason I harp on this, and worry about the matching methodology, is that two of the authors of this study were also involved in a methodologically opaque and flawed study about clinical trial results posted in the JCO. In that study, as well, the authors appeared to use an incorrect methodology to identify published clinical trials. When I pointed the issues out, the corresponding author merely reiterated what was already (insufficiently) in the paper's Methodology section.

I find it strange beyond belief, and more than a little hypocritical, that researchers would use a public, taxpayer-funded database as the basis of their studies, and yet refuse to provide their data for public review. There are no technological or logistical issues preventing this kind of sharing, and there is an obvious ethical point in favor of transparency.

But if the authors are reasonably close to correct in their results, I'm not sure what to make of this study. 

The Nature article covering this study contend that
[T]he [ClinicalTrials.gov] database was never meant to replace journal publications, which often contain longer descriptions of methods and results and are the basis for big reviews of research on a given drug.
I suppose that some journal articles have better methodology sections, although this is far from universally true (and, like this study here, these methods are often quite opaquely described and don't support replication). As for results, I don't believe that's the case. In this study, the opposite was true: ClinicalTrial.gov results were generally more complete than journal results. And I have no idea why the registry wouldn't surpass journals as a more reliable and complete source of information for "big reviews".

Perhaps it is a function of my love of getting my hands dirty digging into the data, but if we are witnessing a turning point where journal articles take a distant back seat to the ClinicalTrials.gov registry, I'm enthused. ClinicalTrials.gov is public, free, and contains structured data; journal articles are expensive, unparsable, and generally written in painfully unclear language. To me, there's really no contest. 

Carolina Riveros, Agnes Dechartres, Elodie Perrodeau, Romana Haneef, Isabelle Boutron, & Philippe Ravaud (2013). Timing and Completeness of Trial Results Posted at ClinicalTrials.gov and Published in Journals PLoS Medicine DOI: 10.1371/journal.pmed.1001566




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AI is Revolutionizing Healthcare, But Are We Ready for the Ethical Challenges? 

Navigating the regulatory and ethical requirements of different medical data providers across many different countries, as well as safeguarding patient privacy, is a mammoth task that requires extra resources and expertise.  

The post AI is Revolutionizing Healthcare, But Are We Ready for the Ethical Challenges?  appeared first on MedCity News.




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State Initiatives Pivot to Address Public Health Challenges During Pandemic

Research has consistently demonstrated strong links between people’s health and societal sectors such as employment, community development, education, housing, and transportation.




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Despite COVID-19 Challenges Dental Therapy Had a Watershed 2020 and Is Poised to Grow

2020 was a difficult year for dental providers as the COVID-19 pandemic swept across the country. When stay-at-home orders went into effect in the spring, dental offices closed their doors to all but emergency patients.




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Create Halloween images and learn SAS basics

Learn how to take simple x/y coordinates, and create map polygons shaped like holiday images, that can be plotted using SAS/Graph's PROC GMAP.




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Singtel's half-year net profit falls 42%

Singapore Telecommunications (SingTel) reported a 42 per cent fall in its half-year profit on Wednesday (Nov 13), as the firm was hurt by the absense of S$1.2 billion it had logged through the divestiture of Telkomsel shares in its prior corresponding period. Last year, Telkomsel, the Indonesian associate of Southeast Asia's largest telecom firm, agreed to merge with its parent's IndiHome broadband arm in an effort to expand into Indonesia's fixed broadband market. SingTel's Australian unit Optus, currently embroiled in a legal battle with the country's competition watchdog, reported operating revenue of A$4.02 billion (S$3.51 billion) during the six months, in line with A$4.02 billion reported a year ago. "Optus and NCS drove the positive momentum, underscoring our focus on execution and operating rigour," the group's Chief Executive Officer Yuen Kuan Moon said. Southeast Asia's largest telecom firm said net profit for the six months ended Sept. 30 was S$1.23 billion, as compared to S$2.14 billion last year and missing a Visible Alpha estimate of S$1.37 billion.