Gomi has revolutionized the electronics industry by tackling the persistent problem of proper disposal at the end of a product's life. Unlike many other speaker companies, Gomi adopts a circular approach that enhances product longevity and significantly reduces pre and post-consumer waste.[...]

When 3D printing first took off, it was difficult to imagine how diverse the field would grow. Nowadays, the realm of additive manufacturing is growing daily. In particular, five sectors are advancing rapidly as a result of developments in additive manufacturing. These are healthcare, food, fashion, motorsports and aerospace. Based on estimates, it is believed that soon these industries will incorporate 3D printing as a key component of their operations.[...]

It all starts with the anything-but-smooth introduction...

An artist's rendering of a black hole

The post Just an Ordinary Girl Filled With Creativity appeared first on English Russia.

Alban Forcione, an internationally renowned scholar of 17th-century literature of “Golden Age” Spain, the Walter S. Carpenter Jr., Professor of Language, Literature and Civilization of Spain, Emeritus, and Princeton alumnus, died Sept. 14 at age 82.

Welcome to an enlightening exploration into the world of macronutrients. These fundamental components of our diet — proteins, carbohydrates, and fats — play integral roles in our body’s physiological functions. While they’re clearly important to our health and well-being, they often remain shrouded in mystery for most of us. By learning more about macronutrients, you’ll understand how ... Read more

The post Macronutrients Unveiled: A Comprehensive Look at Their Roles in a Balanced Diet appeared first on Star Two.

As the country’s civil war decimated elephant populations, the proportion of tuskless females rose dramatically. A new study explains why the tuskless trend continued in peacetime.

The NOVA Universe Revealed Community Outreach Toolkit contains strategies for organizing events around the content of the five-part series as well as examples of hands-on activities and a wide range of multimedia educational resources aligned to the content of each episode.

In the 1700s, an enslaved man named Onesimus shared a novel way to stave off smallpox during the Boston epidemic. Here’s his little-told story, and how the Atlantic slave trade and Indigenous medicine influenced early modern science.

Cameras started rolling for The White Lotus cast on the Thai islands in February

Over a dozen flights cancelled or delayed between Bali and Australia

A court challenge means the government will look again at the cap on the Disabled Facilities Grant.

It was 200 times bigger than the one that wiped out the dinosaurs nearly three billion years later.

I haven’t written for Powdered Wig since October 2020. This once profitable site has now been destroyed by Big Tech, especially Fascistbook, Twitter, and Google. So, at 66 years old, I find myself making a living in the construction field […]

The post Is populism dead? Are We the People now forever under the thumb of unbridled global tyranny? Madame Defarge chimes in appeared first on Powdered Wig Society.

Australian airlines say it is unsafe to fly after Mount Lewotobi Laki-laki spewed ash.

Marine scientist uncovers the story behind Andruha's escape from Russian military training programme.

Nadezhda Buyanova denied making the remarks and called the case absurd.

Antonin Panenka's penalty in the Euro 1976 final birthed a whole new 12-yard tactic. But the risks were higher than anyone could imagine.

According to reports, one of the issues that Donald Trump hopes to address in his second belated term is to institute concealed carry permits reciprocity in every state, allowing a person with a permit in one state to legally carry his firearm in every other state. On Sunday, Donald Trump Jr. posted a video of […]

The post Trump to Work on National Concealed Carry Reciprocity appeared first on The Lid.

United Nations Secretary-General Antonio Guterres told world leaders at the COP29 summit on Tuesday to "pay up" to prevent climate-led humanitarian disasters, and said time was running out to limit a destructive rise in global tempera

Though not common, some Mac users are encountering a strange error message that says “Failed to personalize the software update. Please try again.” when attempting to update their Mac to MacOS Sequoia, and sometimes even with other MacOS software updates too. This is a frustrating error since it prevents the installation of a major system ... Read More

A new children's book transforms a sad, scared and anxious little boy into a superhero. The book is called "Cape," in honor of the bright-red cape the little boy wears and finds comfort in following the death of his father. "Cape" is Kevin Johnson's debut picture book, and it's vividly illustrated by artist Kitt Thomas.

The rental-car giant fell as much as 12% on Tuesday after posting a deeper-than-expected loss.

Lesotho's national assembly has passed a motion to ban the importation of bottled water into the country as part of measures to promote the local industry.

Human Rights Watch (HRW) said Friday that at least 30 people have been killed in Mozambique in almost three weeks of crackdowns on protests over a disputed presidential election.

Update: Surveillance footage of the shooting shown in court

Letcher County Sheriff Shawn "Mickey" Stines shot dead District Judge Kevin Mullins in his chambers, was charged with first-degree murder, and has pleaded not guilty. It soon became apparent that Stines had no intention of resigning, despite the inconvenience of his incarceration, leaving authorities to deal with the long and difficult process of removing him from office. — Read the rest

The post Kentucky Sheriff who killed judge plans to retire; footage of shooting shown in court appeared first on Boing Boing.

When the Baby Boomers retire they are going to be taking their substantial knowledge with them. The younger generation to whom that knowledge should be transferred likes to consume video.  This has some very interesting implications for organizations that want to capture that knowledge, organize it, and make it easy for employees to find it and benefit from it.

Here is a link to a webcast on June 1 where Dan Rasmus, a technology strategist and author of Listening to the Future , will discuss the potential for video to serve as an all important medium for knowledge transfer and organizational learning.

Topics to be Covered:
• Knowledge Acquisition via Video
• Video as a Tool for Knowledge Management
• Use of Video or Operational Efficiency
• Practical Applications of Video for Learning in the Enterprise

Click here to register for the webcast

It was just a couple of weeks ago that the media was bragging about Kamala's HUGE fundraising haul.

The post YIKES: Kamala’s Failed Campaign Finished DEEP In Debt — Here’s The 411 appeared first on Clash Daily.

One of the greatest pass rushers in NFL history appears to be taking a pass himself when it comes to directly addressing a raging controversy. Pro Football Hall of Famer […]

The post NFL Analyst Michael Strahan Speaks Out After Becoming Embroiled in National Anthem Controversy appeared first on The Western Journal.

Presented by the Middle East Forum on Nov. 18, 2022 Panel discussion with Daniel Pipes, Cynthia Farahat, and Jonathan Schanzer:

The main protease (3CL Mpro) from SARS–CoV-2, the etiological agent of COVID-19, is an essential enzyme for viral replication. 3CL Mpro possesses an unusual catalytic dyad composed of Cys145 and His41 residues. A critical question in the field has been what the protonation states of the ionizable residues in the substrate-binding active-site cavity are; resolving this point would help understand the catalytic details of the enzyme and inform rational drug development against this pernicious virus. Here, we present the room-temperature neutron structure of 3CL Mpro, which allowed direct determination of hydrogen atom positions and, hence, protonation states in the protease. We observe that the catalytic site natively adopts a zwitterionic reactive form in which Cys145 is in the negatively charged thiolate state and His41 is doubly protonated and positively charged, instead of the neutral unreactive state usually envisaged. The neutron structure also identified the protonation states, and thus electrical charges, of all other amino acid residues and revealed intricate hydrogen-bonding networks in the active-site cavity and at the dimer interface. The fine atomic details present in this structure were made possible by the unique scattering properties of the neutron, which is an ideal probe for locating hydrogen positions and experimentally determining protonation states at near-physiological temperature. Our observations provide critical information for structure-assisted and computational drug design, allowing precise tailoring of inhibitors to the enzyme's electrostatic environment.

Alfred C. O. Vertegaal
Dec 1, 2006; 5:2298-2310
Research

The aftermath: Navigating a Taliban-led Afghanistan Expert comment NCapeling 20 August 2021

In the coming weeks, governments and international organizations must work through an approach to the Taliban takeover of Afghanistan. It will not be simple.

A failure to acknowledge that the legitimate, elected representatives of Afghanistan are no longer in control of territory or institutions, and to refuse to deal with those that are, will only make for further misery for a population which has already endured decades of violence and poverty.

But to recognize the Taliban risks condemning tens of thousands of Afghan women, children, and men to brutal repression and, for some, potential death, as well as mocking the human rights and rule of law which the US and its allies sought to promote in Afghanistan, and globally, as cornerstones of values-based foreign policies.

The dilemma western governments find themselves in is one they have studiously sought to avoid despite mounting evidence that, without a negotiated deal, a Taliban takeover was only a matter of time. As late as 6 August, the UN Security Council refused to countenance appeals by the UN mission and Afghan civil society activists to press the Taliban and the government to negotiate a ceasefire.

The US reiterated its refrain that it ‘will not accept a military takeover of Afghanistan’ and the UK stressed the Taliban’s only route to power was through meaningful engagement in a peace process. Meanwhile, not until 11 August did Germany and the Netherlands stop deporting Afghan migrants despite the pleas of Afghan authorities and refugee organizations that the country was on the brink of crisis.

Delaying the inevitable

Belief that a military takeover was still some months away may have led diplomats to view dealing with the Taliban as a distant task. The unilateral nature of the US deal with the Taliban and the resistance of the Ghani government to any suggestion of power-sharing arrangements compounded a lack of international coordination and planning on what the conditions for engagement might be.

It cannot be delayed further. The scale of the humanitarian crisis in Afghanistan is daunting, with more than half a million displaced by fighting in 2021 alone, almost 17 million facing crisis levels of food insecurity, and nearly half of all children under five malnourished as a consequence of drought and the COVID-19 pandemic.

With one of the highest global refugee populations and an estimated up 20-30,000 Afghans fleeing the country weekly – even before the government collapsed – Afghanistan evokes still raw memories of the 2015 Syria migrant crisis for Europe. Pakistan and Turkey, home to some of the largest Afghan refugee communities, have already closed their borders to more.

The ongoing chaos at Kabul airport highlights the challenges ahead. But there is a small window – before the UN Security Council is scheduled to review the mandate of the UN mission in Afghanistan by 17 September – for the US and its allies to craft an approach to dealing with the Taliban.

Formal recognition of a Taliban-led government is simply not an option, even for those maintaining a diplomatic presence in Kabul such as China, Iran, Pakistan, and Russia. Technically the Afghan republic has not yet dissolved with vice-president Amrullah Saleh, reportedly in hiding in the Panjshir valley, claiming he is the country’s ‘caretaker’ president.

Conditions for international acceptance

Afghanistan’s ‘enduring partners’ must now focus on building a consensus around five conditions for international acceptance of a Taliban-administered Afghanistan and prevent the Taliban again reaping the benefits of international divisions. The G7 began to articulate some of these conditions but they need to be set out and negotiated with Afghanistan’s neighbours before being formally articulated by the UN Security Council.

1. Adherence to Afghanistan’s human rights obligations. This must specify the rights of women and girls to education and work, the protection of ethnic and religious minorities, and safe passage for all Afghans and internationals leaving the country.
2. Amnesty for all individuals who worked for the Afghan government or international embassies, forces, or aid organizations since 2001.
3. No harbouring of terrorist groups. This has been the central condition for the US deal with the Taliban, and the overriding concern for both China and Russia.
4. Non-lethal public order. The provision of public order to enable supply routes to open, evacuations to continue, and aid to be delivered, is essential and one that Russia has made as a condition for its future relations.
5. Negotiation of inclusive political arrangements with Afghanistan’s political and ethnic factions.

The UN mission in Afghanistan, including its human rights component, and the Al-Qaida Sanctions Committee’s Analytical Support and Sanctions Monitoring Team should be mandated with reporting monthly on the progress toward these five conditions. Their assessments should form the basis for any reconsideration of the Taliban’s status as a terrorist organization. And a negotiated political settlement must be a precondition to the release of the government’s foreign reserves, estimated to be $9.5 billion.

Before this, the humanitarian and development aid on which Afghanistan is almost completely reliant must be recalibrated to flow through international agencies. Models such as Hamas-run Gaza, Assad’s Syria, or Aristide’s Haiti, show that while far from effective, it is possible to provide urgent assistance outside government channels.

This is one of the reasons why the Taliban has sought to retain a strong UN presence across Afghanistan and why the UN must be given a more significant political mandate and resources. The World Bank-administered Afghan Reconstruction Trust Fund should remain the principal channel for international funds.

It is difficult in the short-term to see the US leading this collective effort, given its defensive and domestic-focused position. It could be a moment for the UK and EU to demonstrate their multilateral commitments and forge a coordinated conditions-based approach to a Taliban-administered Afghanistan at the UN.

Going beyond handwringing or gesture politics will be difficult and messy and, ultimately, Afghanistan’s future must be decided by Afghans. Until that day, however, this will save lives.

Expert

The functional mechanisms of multidomain proteins often exploit interdomain interactions, or “cross-talk.” An example is human Pin1, an essential mitotic regulator consisting of a Trp–Trp (WW) domain flexibly tethered to a peptidyl-prolyl isomerase (PPIase) domain, resulting in interdomain interactions important for Pin1 function. Substrate binding to the WW domain alters its transient contacts with the PPIase domain via means that are only partially understood. Accordingly, we have investigated Pin1 interdomain interactions using NMR paramagnetic relaxation enhancement (PRE) and molecular dynamics (MD) simulations. The PREs show that apo-Pin1 samples interdomain contacts beyond the range suggested by previous structural studies. They further show that substrate binding to the WW domain simultaneously alters interdomain separation and the internal conformation of the WW domain. A 4.5-μs all-atom MD simulation of apo-Pin1 suggests that the fluctuations of interdomain distances are correlated with fluctuations of WW domain interresidue contacts involved in substrate binding. Thus, the interdomain/WW domain conformations sampled by apo-Pin1 may already include a range of conformations appropriate for binding Pin1's numerous substrates. The proposed coupling between intra-/interdomain conformational fluctuations is a consequence of the dynamic modular architecture of Pin1. Such modular architecture is common among cell-cycle proteins; thus, the WW–PPIase domain cross-talk mechanisms of Pin1 may be relevant for their mechanisms as well.