What would an election cycle be without Massachusetts Sen. Elizabeth Warren making a fool of herself? After President-elect Donald Trump made headlines Tuesday for picking veteran and Fox News host […]

The post Elizabeth Warren Insults All Service Members with Attack on Secretary of Defense Pick Pete Hegseth appeared first on The Western Journal.

A Democratic elected official was arrested in Chicago after allegedly causing a three-car pileup and making inappropriate comments about the arresting officer’s penis.

1. Nurses took to the streets after ‘insulting’ pay offer. Next stop, court  Sydney Morning Herald
2. Hundreds of elective surgeries cancelled as 10,000 nurses and midwives walk off job in NSW  ABC News
3. Who cares? Voters will if NSW nurses start quitting state of origin  Sydney Morning Herald
4. Almost 700 surgeries cancelled as 12,000 NSW nurses strike for better pay  9News
5. As it happened: Donald Trump ally taunts Kevin Rudd; WiseTech shareholders launch class action  The Age

Fr. Theodore Paraskevopoulos reflects on the Gospel reading from the Sunday of the Canaanite woman, and her perseverance to overcome the barriers she faced to reaching Jesus.

La concejala publicó un vídeo que después retiró y asegura sentirse "muy avergonzada y arrepentida" Leer

Las dos jugadoras se conocieron durante su etapa en el baloncesto ruso, cuando militaban en el Dinamo Kursk Leer

En Caracol Radio estuvo Luis Gilberto Murillo, ministro de Relaciones Exteriores.

En Caracol Radio estuvo Luis Gilberto Murillo, ministro de Relaciones Exteriores.

La representante a la Cámara por Arauca, Lina María Garrido, lanzó fuerte crítica al Gobierno nacional por la falta de acciones concretas para atender las emergencias sociales y ambientales que vive el departamento 

En Caracol Radio estuvo Jonathan Bock, director de la Fundación para la Libertad de Prensa, conversando sobre la libertad de prensa y la mirada del Gobierno Nacional

It all starts with the anything-but-smooth introduction...

The following article, Will Black Men Tolerate This Insult from Kamala Harris?, was first published on The Black Sphere.

Who is running the Harris-Walz campaign? Because if I had to guess, I'd say a 13 year-old white girl. Kamala Harris' campaign is watching voters jump ship reminiscent of the Titanic.

Continue reading Will Black Men Tolerate This Insult from Kamala Harris? ...

(Oct. 18) Consider this a plea for forbearance toward your fellow voters. All over the internet, one sees people not just touting the causes of their own presidential candidates, or criticizing […]

The post This election is tough. Don’t insult those who choose differently. appeared first on Quin Hillyer.

They are accused of hate speech as rights groups say the law is being used to restrict freedoms.

Left-wing networks had plenty of bad news for their viewers as former President Donald Trump stormed to victory in the Nov. 5 election. Now, they’re getting plenty of bad news […]

The post Insult to Injury: MSNBC and CNN Suffer Staggering Ratings Plunge Following Trump Victory appeared first on The Western Journal.

A Chicago-area Democrat hurled an insult at police Sunday after being charged with drunken driving, according to local news reports. Samantha Steele represents the Second District on the Cook County […]

The post Democratic Politician Crashes Her Car While Allegedly Drunk, Hurls Vile Insults at Responding Officer: Police Report appeared first on The Western Journal.

Sharon G. Kujawa
Nov 11, 2009; 29:14077-14085
BehavioralSystemsCognitive

Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca²⁺-dependent downstream effects after neuronal cytotoxic edema caused by diverse injuries in mice of both sexes using multiphoton Ca²⁺ imaging in vivo [Postnatal Day (P)12–17] and in acute brain slices (P8–12). After different excitotoxic insults, cytosolic GCaMP6s translocated into the nucleus after a few minutes in a subpopulation of neurons, persisting for hours. We used an automated morphology-detection algorithm to detect neuronal soma and quantified the nuclear translocation of GCaMP6s as the nuclear to cytosolic intensity (N/C ratio). Elevated neuronal N/C ratios occurred concurrently with persistent elevation in Ca²⁺ loads and could also occur independently from neuronal swelling. Electron microscopy revealed that the nuclear translocation was associated with the increased nuclear pore size. The nuclear accumulation of GCaMP6s in neurons led to neocortical circuit dysfunction, mitochondrial pathology, and increased cell death. Inhibiting calpains, a family of Ca²⁺-activated proteases, prevented elevated N/C ratios and neuronal swelling. In summary, in the developing brain, we identified a calpain-dependent alteration of nuclear transport in a subpopulation of neurons after disease-relevant insults leading to long-term circuit dysfunction and cell death. The nuclear translocation of GCaMP6 and other cytosolic proteins after acute excitotoxicity can be an early biomarker of brain injury in the developing brain.

The comments come at a time when more foreign-born black people live in the United States than at any time in history—and many of the residents are children enrolled in the nation's K-12 public schools.

The Kerala High Court has quashed a criminal case against film director Sreekumar Menon who was accused by a prominent Malayalam actress of abusing and defaming her.

Urfi Javed didn't mince her words in questioning Tripti Dimri's dance skills in Mere Mehboob song.

After releasing the BJP’s manifesto for the November 20 Maharashtra Assembly polls, Mr Shah also said his party will not allow religion-based reservation in the country.

'I studied in a government school, whereas all of them came from convent schools, speaking fluent English.''I am one of the most educated girls in my village.'

The money which is distributed by the Centre belongs to the people of India. What did Maharashtra get... Our Chief Minister came back empty-handed: Shiv Sena UBT leader Sanjay Raut

As Elon Musk sues Californian authorities for stopping a Tesla factory from reopening, he has found a somewhat novel way of dealing with his critics – dismissing them with short Russian insults.
Read Full Article at RT.com

Sonny Bill Williams would happily jump in the ring with Mike Tyson, but the former heavyweight champ will only make a sensational ring return to fight “another bona fide boxer.”

Former Union minister and controversial Bharatiya Janata Party MP Anantkumar Hegde has once again stoked a row by calling the freedom struggle led by Mahatma Gandhi a "drama".However, this is not the first time a leader from the ruling party has insulted the Father of the Nation.Here are other instances when BJP leaders took a swipe at Mohandas Karamchand Gandhi.

Margaret Parker, MD, MCCM, speaks with Ericka L. Fink, MD, MS, about the PANGEA study (Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment), published in the April 2017 issue of Pediatric Critical Care Medicine.

Megan Rapinoe considers Sunday to be the final insult. The Women's World Cup final will have to compete with two others men's finals, the Copa America and the CONCACAF Gold Cup. "It's ridiculous, and disappointing, to be honest," Rapinoe said.

This escalated quickly.

Hearing loss caused by the death of sensory hair cells of the inner ear is an unfortunate side effect for many patients treated with aminoglycoside antibiotics or platinum-containing chemotherapy agents. In animal models, induction of heat shock confers substantial otoprotection against aminoglycoside- and cisplatin-induced hair cell death. In this issue of the JCI, Breglio et al. demonstrate that inner ear tissue released exosomes carrying heat shock protein 70 (HSP70) in response to heat stress. HSP70 acted by a paracrine mechanism that engaged the Toll-like receptor 4 (TLR4) on hair cells to protect them from death. Exosomes and the HSP70/TLR4 pathway could thus provide treatment targets for the protection of hair cells from chemically induced death or from other insults, such as noise.

A second-generation surivivor whose grandparents died in the Holocaust blasts a newspaper publisher for comparing coronavirus restrictions to Nazi Germany.

From Ronald Reagan's "evil empire" to Mark Hamill battling Ivanka Trump.

You don't have to be a sports fan to know that something extraordinary happened in the World Cup soccer final last week. Ten minutes from the climactic end -- with his country's hopes, the championship and his place in the history books at stake -- French captain Zinedine Zidane violently...

IT’S strange the different things people took away from Theresa May’s teary goodbye in Downing Street yesterday.

The comments come at a time when more foreign-born black people live in the United States than at any time in history—and many of the residents are children enrolled in the nation's K-12 public schools.

Michael Bay clarified that it wasn’t his decision to lay off Megan Fox

"I felt that they listened to what I was trying to say, and it shows that they do value democracy here in Taiwan."

The U.S. Senate failed on Thursday to override President Donald Trump's veto of a resolution that would have reined in his ability to wage war against Iran by requiring him to obtain congressional authorization for military action.

MIKE GRAHAM furiously lashed out at journalist and author Christopher Snowdon live on-air after the author claimed the country has "never been less free" than it is today under the nationwide lockdown.

This escalated quickly.

This fun AskReddit thread has people describing those insults that sound just like compliments. People might be out there trying to squeeze in a dig on you, through the mask of a smile and lighthearted tone. Who knows? Maybe the next time you hear one of these out in the wild, you'll do away with the passive aggressive antics, and ask the person what they really mean. Or just let it slide. 

Not too many actors from Bollywood or even Television have gone through as many personal ups and downs as Chahatt Khanna. She was unfortunately separated from her husband Farhan Mirza in 2018 and was earlier married to Bharat Narsinghani. And now, there were reports that she was in a relationship with singer Mika Singh. However, she revealed she was staying with him only for their single, Quarantine Love.

And now, speaking about her future and present, she spoke to Zoom and talked about her desire to settle down again and why she feels that the term 'Single Mother' is insulting. Speaking about her wish to settle down again, she said, "Of course, I want to settle down again. I would say that family is my priority and I have done my bit of my work. I have achieved success a few times that I wanted. I am doing well in my life, touchwood."

She added, "Right now, by God's grace, I have everything. After a while, I would like to settle down with a good life partner and not think about anyone or anybody." And as stated above, she also shed light on being a single mother and said, "It is a very insulting term, and I realised this much later. There is a term called Milf which these guys, doggers use for women who are elder to them, married, single parent, single mom, divorced and they think people like them are good to have fun with. This is a hard-hitting fact of our society which I just discovered a few days back and I was shattered when I came to know this. This is what happens when she steps out of her marriage."

Chahatt keeps sharing her pictures and videos on her social media account and the actress is truly beautiful. We wish her all the best for her future and we hope we all can learn from what she said!

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Remote areas are already on the brink of a severe humanitarian crisis caused by contaminated water and low food and fuel supplies with many also cut off from medical help.