What would an election cycle be without Massachusetts Sen. Elizabeth Warren making a fool of herself? After President-elect Donald Trump made headlines Tuesday for picking veteran and Fox News host […]

The post Elizabeth Warren Insults All Service Members with Attack on Secretary of Defense Pick Pete Hegseth appeared first on The Western Journal.

A Democratic elected official was arrested in Chicago after allegedly causing a three-car pileup and making inappropriate comments about the arresting officer’s penis.

A Chicago-area Democrat hurled an insult at police Sunday after being charged with drunken driving, according to local news reports. Samantha Steele represents the Second District on the Cook County […]

The post Democratic Politician Crashes Her Car While Allegedly Drunk, Hurls Vile Insults at Responding Officer: Police Report appeared first on The Western Journal.

Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca²⁺-dependent downstream effects after neuronal cytotoxic edema caused by diverse injuries in mice of both sexes using multiphoton Ca²⁺ imaging in vivo [Postnatal Day (P)12–17] and in acute brain slices (P8–12). After different excitotoxic insults, cytosolic GCaMP6s translocated into the nucleus after a few minutes in a subpopulation of neurons, persisting for hours. We used an automated morphology-detection algorithm to detect neuronal soma and quantified the nuclear translocation of GCaMP6s as the nuclear to cytosolic intensity (N/C ratio). Elevated neuronal N/C ratios occurred concurrently with persistent elevation in Ca²⁺ loads and could also occur independently from neuronal swelling. Electron microscopy revealed that the nuclear translocation was associated with the increased nuclear pore size. The nuclear accumulation of GCaMP6s in neurons led to neocortical circuit dysfunction, mitochondrial pathology, and increased cell death. Inhibiting calpains, a family of Ca²⁺-activated proteases, prevented elevated N/C ratios and neuronal swelling. In summary, in the developing brain, we identified a calpain-dependent alteration of nuclear transport in a subpopulation of neurons after disease-relevant insults leading to long-term circuit dysfunction and cell death. The nuclear translocation of GCaMP6 and other cytosolic proteins after acute excitotoxicity can be an early biomarker of brain injury in the developing brain.

As Elon Musk sues Californian authorities for stopping a Tesla factory from reopening, he has found a somewhat novel way of dealing with his critics – dismissing them with short Russian insults.
Read Full Article at RT.com

Margaret Parker, MD, MCCM, speaks with Ericka L. Fink, MD, MS, about the PANGEA study (Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment), published in the April 2017 issue of Pediatric Critical Care Medicine.

This escalated quickly.

Hearing loss caused by the death of sensory hair cells of the inner ear is an unfortunate side effect for many patients treated with aminoglycoside antibiotics or platinum-containing chemotherapy agents. In animal models, induction of heat shock confers substantial otoprotection against aminoglycoside- and cisplatin-induced hair cell death. In this issue of the JCI, Breglio et al. demonstrate that inner ear tissue released exosomes carrying heat shock protein 70 (HSP70) in response to heat stress. HSP70 acted by a paracrine mechanism that engaged the Toll-like receptor 4 (TLR4) on hair cells to protect them from death. Exosomes and the HSP70/TLR4 pathway could thus provide treatment targets for the protection of hair cells from chemically induced death or from other insults, such as noise.

You don't have to be a sports fan to know that something extraordinary happened in the World Cup soccer final last week. Ten minutes from the climactic end -- with his country's hopes, the championship and his place in the history books at stake -- French captain Zinedine Zidane violently...

This escalated quickly.

This fun AskReddit thread has people describing those insults that sound just like compliments. People might be out there trying to squeeze in a dig on you, through the mask of a smile and lighthearted tone. Who knows? Maybe the next time you hear one of these out in the wild, you'll do away with the passive aggressive antics, and ask the person what they really mean. Or just let it slide. 

Remote areas are already on the brink of a severe humanitarian crisis caused by contaminated water and low food and fuel supplies with many also cut off from medical help.

'Migrants are first of all human persons, and that they are the symbol of all those rejected by today's globalised society,' the pontiff tweeted on Monday.

My Kitchen Rules star Amanda Proud, 29, has unleashed a number of vile insults towards Married At First Sight brides.

Britain's Got Talent auditions are once again underway in London - and judges Simon Cowell and David Walliams are back to their usual catty ways.

'The Mooch' claims Trump is a 'malignant narcissist' who 'needs the spotlight at all times,' and says Australia's PM should keep a low profile around him, like Trudeau, if he wants to be successful.

'Come on folks, we all know that we can't pick them up and ship them back across the border,' Kasich charged. 'It's a silly argument. It's not an adult argument.'

South Africa's parliament is closed and all its meetings are currently held by video conference calls as the country remains under strict lockdown restrictions to combat the spread of the coronavirus.