scala Tablighi Markaz returnees to Gujarat led to escalation in cases: Vijay Rupani By www.newkerala.com Published On :: Tue, 05 May 2020 08:43:01 +0530 Full Article
scala Converting three-space matrices to equivalent six-space matrices for Delone scalars in S6 By scripts.iucr.org Published On :: 2020-01-01 The transformations from the primitive cells of the centered Bravais lattices to the corresponding centered cells have conventionally been listed as three-by-three matrices that transform three-space lattice vectors. Using those three-by-three matrices when working in the six-dimensional space of lattices represented as Selling scalars as used in Delone (Delaunay) reduction, one could transform to the three-space representation, apply the three-by-three matrices and then back-transform to the six-space representation, but it is much simpler to have the equivalent six-by-six matrices and apply them directly. The general form of the transformation from the three-space matrix to the corresponding matrix operating on Selling scalars (expressed in space S6) is derived, and the particular S6matrices for the centered Delone types are listed. (Note: in his later publications, Boris Delaunay used the Russian version of his surname, Delone.) Full Article text
scala 2019: Cadillac, Escalade ESV, Standard, Standard 4dr SUV By www.woodlandsonline.com Published On :: Full Article
scala 2019: Cadillac, Escalade, Luxury, Luxury 4dr SUV By www.woodlandsonline.com Published On :: Full Article
scala 2019: Cadillac, Escalade, Platinum, 4x4 Platinum 4dr SUV By www.woodlandsonline.com Published On :: Full Article
scala Why you should always stand, not pass others, on the escalator By www.mnn.com Published On :: Sat, 16 Mar 2019 20:45:38 +0000 It's way more efficient, not to mention more polite, for everyone. Full Article Transportation
scala The formation of trapped surfaces in the gravitational collapse of spherically symmetric scalar fields with a positive cosmological constant. (arXiv:2005.03434v1 [gr-qc]) By arxiv.org Published On :: Given spherically symmetric characteristic initial data for the Einstein-scalar field system with a positive cosmological constant, we provide a criterion, in terms of the dimensionless size and dimensionless renormalized mass content of an annular region of the data, for the formation of a future trapped surface. This corresponds to an extension of Christodoulou's classical criterion by the inclusion of the cosmological term. Full Article
scala Semiglobal non-oscillatory big bang singular spacetimes for the Einstein-scalar field system. (arXiv:2005.03395v1 [math-ph]) By arxiv.org Published On :: We construct semiglobal singular spacetimes for the Einstein equations coupled to a massless scalar field. Consistent with the heuristic analysis of Belinskii, Khalatnikov, Lifshitz or BKL for this system, there are no oscillations due to the scalar field. (This is much simpler than the oscillatory BKL heuristics for the Einstein vacuum equations.) Prior results are due to Andersson and Rendall in the real analytic case, and Rodnianski and Speck in the smooth near-spatially-flat-FLRW case. Similar to Andersson and Rendall we give asymptotic data at the singularity, which we refer to as final data, but our construction is not limited to real analytic solutions. This paper is a test application of tools (a graded Lie algebra formulation of the Einstein equations and a filtration) intended for the more subtle vacuum case. We use homological algebra tools to construct a formal series solution, then symmetric hyperbolic energy estimates to construct a true solution well-approximated by truncations of the formal one. We conjecture that the image of the map from final data to initial data is an open set of anisotropic initial data. Full Article
scala Homotopy invariance of the space of metrics with positive scalar curvature on manifolds with singularities. (arXiv:2005.03073v1 [math.AT]) By arxiv.org Published On :: In this paper we study manifolds $M_{Sigma}$ with fibered singularities, more specifically, a relevant space $Riem^{psc}(X_{Sigma})$ of Riemannian metrics with positive scalar curvature. Our main goal is to prove that the space $Riem^{psc}(X_{Sigma})$ is homotopy invariant under certain surgeries on $M_{Sigma}$. Full Article
scala An asynchronous distributed and scalable generalized Nash equilibrium seeking algorithm for strongly monotone games. (arXiv:2005.03507v1 [cs.GT]) By arxiv.org Published On :: In this paper, we present three distributed algorithms to solve a class of generalized Nash equilibrium (GNE) seeking problems in strongly monotone games. The first one (SD-GENO) is based on synchronous updates of the agents, while the second and the third (AD-GEED and AD-GENO) represent asynchronous solutions that are robust to communication delays. AD-GENO can be seen as a refinement of AD-GEED, since it only requires node auxiliary variables, enhancing the scalability of the algorithm. Our main contribution is to prove converge to a variational GNE of the game via an operator-theoretic approach. Finally, we apply the algorithms to network Cournot games and show how different activation sequences and delays affect convergence. We also compare the proposed algorithms to the only other in the literature (ADAGNES), and observe that AD-GENO outperforms the alternative. Full Article
scala Scalable network security with fast response protocol By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT This disclosure provides a network security architecture that permits installation of different software security products as virtual machines (VMs). By relying on a standardized data format and communication structure, a general architecture can be created and used to dynamically build and reconfigure interaction between both similar and dissimilar security products. Use of an integration scheme having defined message types and specified query response framework provides for real-time response and easy adaptation for cross-vendor communication. Examples are provided where an intrusion detection system (IDS) can be used to detect network threats based on distributed threat analytics, passing detected threats to other security products (e.g., products with different capabilities from different vendors) to trigger automatic, dynamically configured communication and reaction. A network security provider using this infrastructure can provide hosted or managed boundary security to a diverse set of clients, each on a customized basis. Full Article
scala Scalable group synthesis By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An illustrative embodiment of a computer-implemented process for scalable group synthesis receives a group definition, applies a sub-set of conditions to the group definition to form a conditioned group definition, receives a set of entities and populates group membership using the received set of entities and the conditioned group definition, wherein each member responds in the affirmative to the sub-set of conditions. Full Article
scala Issue policy control within a multi-threaded in-order superscalar processor By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A multi-threaded in-order superscalar processor 2 includes an issue stage 12 including issue circuitry 22, 24 for selecting instructions to be issued to execution units 14, 16 in dependence upon a currently selected issue policy. A plurality of different issue policies are provided by associated different policy circuitry 28, 30, 32 and a selection between which of these instances of the policy circuitry 28, 30, 32 is active is made by policy selecting circuitry 34 in dependence upon detected dynamic behavior of the processor 2. Full Article
scala Scalable interconnect modules with flexible channel bonding By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present application discloses apparatus and methods for increasing channel utilization for a high-speed serial interface of an integrated circuit (IC). A new circuit architecture is disclosed which provides circuitry that may be programmed flexibly to support a multitude of different channel bonding schemes. In accordance with one aspect of the invention, the new architecture decouples the granularity of control-signal channel bonding from the granularity of data-aggregation channel bonding. This advantageously allows optimization of configurations for both types of channel bonding. In another aspect of the invention, the logical boundaries of bonded user channels are decoupled from the physical boundaries of the PCS modules. This decoupling advantageously eliminates a rigid constraint of previous architectures. Full Article
scala Scalable points-to analysis via multiple slicing By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A method for analyzing software with pointer analysis may include obtaining a software program, and determining a first independent program slice of the software program describing a first code segment of the software program. The method may further include determining, using a first pointer analysis objective, a first result from performing a first pointer analysis on the first independent program slice, and determining, using the first result, a first dependent program slice of the software program. The method may further include determining, using a second pointer analysis objective, a second result from performing a second pointer analysis on the first dependent program slice. The method may further include generating a report, using these results, indicating whether the software program satisfies a predetermined criterion. Full Article
scala Computer System and Method thereof for scalable data processing By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A computer system for processing of data received from a remote device. The computer system includes a master device and at least one slave device. The master device is communicably coupled to the remote device and has a display and a memory. The master device partitions the data into one or more sub data. The at least one slave device is coupled to the master device. The master device delegates processing of the one or more sub data to one or more of the at least one slave device, and the one or more of the at least one slave device correspondingly to the one or more sub data generate processed sub data. The master device stores the processed sub data and outputs the processed sub data to the display. Full Article
scala Plasma sterilization and cleaning treatment device for escalator, and escalator using the same By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT Sterilization and cleaning of an escalator hand rail are performed. A sterilization and cleaning device including a hand rail; a plasma source for irradiating the hand rails with ions or radicals or UV light; an enclosure for housing the plasma source; a power source for generating plasma; a fan for generating relatively negative pressure in the enclosure; filter units for removing removed bacteria, viruses, and organic matters such as hand marks; and filter plates located backward and forward of a moving direction of the hand rail in the enclosure along the hand rail is provided. Full Article
scala Truss device and an escalator or moving walk By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention provides a truss device for an escalator or moving walk comprising an outer panel and an inner panel facing the outer panel, characterized in that, the inner panel is formed from a single integral panel and comprises a body part and a plurality of connection parts extending from the body part toward the outer panel thus forming corresponding through openings in the inner panel, each connection part is connected to the outer panel so that the outer panel and the inner panel are fixed together, wherein the inner panel further comprises a support part formed on the body part of the inner panel and projecting in a direction away from the outer panel. The present invention also provides an escalator or moving walk having the above truss device. Full Article
scala LATERAL DAMPING AND INTERMEDIATE SUPPORT FOR ESCALATORS AND MOVING WALKS IN SEISMIC EVENTS By www.freepatentsonline.com Published On :: Thu, 22 Jun 2017 08:00:00 EDT An intermediate support structure for an escalator or moving walk having a dampening device with slots formed therein allowing a supported escalator truss to be free to move laterally to accommodate lateral displacement caused by story drift during an earthquake or seismic event. Full Article
scala Insurgent Violence Escalates in Iraq By www.washingtonpost.com Published On :: Sun, 8 May 2005 19:03:50 GMT Ambushes and kidnappings targeting Iraqis and foreigners have surged this month while the new government is caught up in power struggles over cabinet positions. Full Article
scala MOZART, W.A.: Entführung aus dem Serail (Die) [Opera] (La Scala, 2017) (NTSC) (752008) By www.naxos.com Published On :: Fri, 01 Nov 2019 00:00:00 GMT Full Article
scala MOZART, W.A.: Entführung aus dem Serail (Die) [Opera] (La Scala, 2017) (Blu-ray, HD) (752104) By www.naxos.com Published On :: Fri, 01 Nov 2019 00:00:00 GMT Full Article
scala Violence against council workers escalates in Victoria, prompting calls for more protection By www.abc.net.au Published On :: Fri, 05 Jul 2019 08:12:00 +1000 A rise in the number of assaults against local government employees prompts Victorian councils to call for a change in sentencing laws to better protect their staff. Full Article ABC Ballarat ballarat melbourne Government and Politics:All:All Government and Politics:Local Government:All Law Crime and Justice:All:All Law Crime and Justice:Traffic Offences:All Australia:VIC:Ballarat 3350 Australia:VIC:Geelong 3220 Australia:VIC:Grovedale 3216 Australia:VIC:Torquay 3228
scala Anxiety 'escalating' in young people as pandemic closes disability supports By www.abc.net.au Published On :: Mon, 27 Apr 2020 06:58:19 +1000 Disability advocates say they are concerned about an increase in anxiety among children whose support services have been stripped back during the coronavirus pandemic. Full Article Disabilities Adolescent Health Autism Spectrum Disorder Anxiety Children Family Mental Health COVID-19 Lockdown Child Health and Behaviour Regional
scala Queensland bushfire threat rises as homes lost in escalating Sunshine Coast emergency situation By www.abc.net.au Published On :: Tue, 10 Sep 2019 09:50:00 +1000 Alarming footage shows high winds driving a large bushfire overnight on the Sunshine Coast, where 10 homes have been lost at Peregian Springs and Peregian Beach. Full Article ABC Gold Coast southqld brisbane goldcoast widebay sunshine Disasters and Accidents:All:All Disasters and Accidents:Emergency Incidents:All Disasters and Accidents:Emergency Planning:All Disasters and Accidents:Fires:All Disasters and Accidents:Fires:Bushfire Australia:All:All Australia:QLD:All Australia:QLD:Applethorpe 4378 Australia:QLD:Ballandean 4382 Australia:QLD:Beechmont 4211 Australia:QLD:Binna Burra 4211 Australia:QLD:Brisbane 4000 Australia:QLD:Bundaberg 4670 Australia:QLD:Canungra 4275 Australia:QLD:Goondiwindi 4390 Australia:QLD:Lamington National Park 4275 Australia:QLD:Lowmead 4676 Australia:QLD:Maroochydore 4558 Australia:QLD:Peregian Beach 4573 Australia:QLD:Stanthorpe 4380 Australia:QLD:The Summit 4377 Australia:QLD:Toowoomba 4350
scala Chris Cornell’s widow fires back at Soundgarden members in escalating legal war, says they’re tying to ‘browbeat’ her into giving up music By www.nydailynews.com Published On :: Fri, 08 May 2020 22:40:30 +0000 Chris Cornell’s widow is firing back at her husband’s Soundgarden bandmates, calling the lawsuit they filed against her Wednesday an attempt to “browbeat” her into giving up “copyrighted works.” Full Article
scala Chris Cornell’s widow fires back at Soundgarden members in escalating legal war, says they’re tying to ‘browbeat’ her into giving up music By www.nydailynews.com Published On :: Fri, 08 May 2020 22:40:30 +0000 Chris Cornell’s widow is firing back at her husband’s Soundgarden bandmates, calling the lawsuit they filed against her Wednesday an attempt to “browbeat” her into giving up “copyrighted works.” Full Article
scala Chris Cornell’s widow fires back at Soundgarden members in escalating legal war, says they’re tying to ‘browbeat’ her into giving up music By www.nydailynews.com Published On :: Fri, 08 May 2020 22:40:30 +0000 Chris Cornell’s widow is firing back at her husband’s Soundgarden bandmates, calling the lawsuit they filed against her Wednesday an attempt to “browbeat” her into giving up “copyrighted works.” Full Article
scala On the Beverly Center escalators, Pae White's art makes for an uplifting ride By www.latimes.com Published On :: Fri, 17 Jan 2020 12:15:16 -0500 Pae White's art installations at the Beverly Center have taken over the walls along the five-story escalators. Full Article
scala strataconf: Building Big Data applications now easier http://t.co/jaATalPL4P Hadoop analytic engines simplify creation of low-cost, scalable apps By twitter.com Published On :: Mon, 10 Jun 2013 10:55:30 +0000 strataconf: Building Big Data applications now easier http://t.co/jaATalPL4P Hadoop analytic engines simplify creation of low-cost, scalable apps Full Article
scala Local Pathways Towards De-escalation of Libya's Conflict By feedproxy.google.com Published On :: Wed, 22 Jan 2020 10:20:01 +0000 Invitation Only Research Event 28 January 2020 - 3:00pm to 4:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Usama Otman Essed, Libya Center for Strategic & Future StudiesChair: Tim Eaton, Middle East and North Africa Programme, Chatham House A shaky truce remains broadly in place among rival Libyan forces fighting for control of Tripoli. However, a durable ceasefire to bring an end to the current bout of conflict, which was initiated by Khalifa Haftar’s Libyan Arab Armed Forces’ (LAAF) offensive on the capital in April 2019, has not been reached. In recent weeks attention has focused on talks hosted in Moscow and Berlin, with the former aimed at agreeing a ceasefire and the latter seeking to reach agreement among international actors to bring an end to external military support for Libyan warring actors, and to craft a way forward for future intra-Libyan talks. Yet, there has been little emphasis on Libyan actors – beyond Haftar and prime minister Fayez al-Serraj – in this process. This roundtable will bring together experts and policymakers to discuss means of de-escalating the conflict and seeking a lasting resolution through the development of interconnected intra-Libyan social and security negotiation tracks. Mr Usama Otman Essed of the Libya Center for Strategic and Future Studies (LCSFS) will present his research group’s ideas on these issues and discuss their ongoing efforts to promote dialogue among social and security actors.Attendance at this event is by invitation only. Event attributes Chatham House Rule Department/project Middle East and North Africa Programme Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
scala NATO Could Play a De-escalating Role in the Russia-Turkey Confrontation By feedproxy.google.com Published On :: Fri, 27 Nov 2015 11:20:45 +0000 27 November 2015 Dr Beyza Unal Senior Research Fellow, International Security Programme @beyzaunal Google Scholar The Alliance must explore its options for negotiating small-scale incidents between member states and partner nations, if it ever hopes to build a coherent coalition to fight ISIS. 20151127RussiaTurkey.jpg Paper planes are seen among debris outside the Turkish embassy in Moscow on 25 November 2015 after an anti-Turkey picket. Photo by Getty Images. In the wake of the Paris attacks and the destruction of a Russian plane by a bomb in Sinai, Russia had been once more calling for a new level of engagement with Western partners over operations in Syria. Even an ‘anti-terrorism coalition’ appeared to gain traction after the terrorist attacks in Paris. But Russian attacks on Western-backed opposition groups in Syria and continuing violation of Turkish airspace narrowed the window of opportunity for engagement between NATO member states and Russia in Syria, and Tuesday’s incident – where Turkey shot down a Russian bomber − fundamentally challenged this option. NATO allies and Secretary General Jens Stoltenberg were quick to call for ‘calm and de-escalation’ of the situation. But they face a problem: in the absence of a strategy, NATO lacks a mechanism—a form of transparent process for crisis resolution—between member states and partner nations when and if a dispute or disagreement arises.NATO has three essential core tasks—collective defence (Article 5), crisis management and cooperative security; it does not prioritize one task over the other. Whereas collective defence applies to member states like Turkey, cooperative security involves engagement with partner nations, such as Russia, to assure Euro-Atlantic security. NATO’s role, in this sense, goes beyond protecting a member’s state’s sovereignty. This aspiration to provide enduring cooperation and cooperative security beyond members lies behind the now-obsolete NATO-Russia Founding Act on Mutual Relations, Cooperation and Security, signed in 1997.NATO’s balance between these tasks and its role vis-à-vis partner states is ill-defined, and among the core issues the Alliance must consider at or before its next summit in Warsaw in July 2016. These discussions must include prioritizing and grouping partner nations—Russia and Sweden, for instance, are clearly not partners in equal terms – and clarifying the role of the NATO-Russia Council (NRC). The NRC is a venue for political dialogue that includes consultation, cooperation and joint action, but does not have a crisis resolution mechanism. From 2014 onwards, the NRC has not functioned, yet it is the only venue where NATO and Russia could have discussions regarding the future of Syria, focusing on ISIS as a major threat both to the Alliance and to the partner nations. Neither Russia nor the Alliance will benefit from escalation; thus, both sides should bear in mind that a troubling partnership is better than an adversarial relationship.This is even more important because NATO member states do not have a cohesive strategy regarding Syria’s future. For some countries, like Germany, the efforts lie on refugee relief policies, while for others, such as France, the focus is the military fight against ISIS. Russia is clearly testing NATO’s response mechanisms through hybrid warfare techniques. Yet, NATO also does not have a coherent policy regarding Russia’s assertiveness in Ukraine, involvement in Syria and its annexation of Crimea. NATO officials are in general agreement that there can be ‘no grand bargain with Russia’ as long as it continues to violate international treaties and norms. Russian aggression and assertiveness is a long-term problem for the Alliance to tackle. So far, though, NATO benefits from ‘avoid[ing] that situations, incidents and accidents spiral out of control’, as the NATO secretary general noted in his speech after the extraordinary North Atlantic Council meeting. Solidarity among allies and protecting Turkish territorial integrity is a clear role for NATO, but the Alliance’s response mechanism in crisis situations should not be exhausted and undermined with small-scale, bilateral disagreements and disputes.NATO could move to incorporate a crisis resolution mechanism, in specified non-escalatory terms and processes, between member states and partner states, where NATO member states and Russia meet together as equals in case of a crisis. This could re-establish a communication channel between NATO and Russia in particular, especially when the NRC is not functioning. If such a mechanism were in existence today, Turkey could have taken the issue to NATO’s crisis management system and pointed out its concerns over airspace violations, rather than shooting down the Russian bomber. This could have enabled the Alliance and Russia to participate in a dialogue that has been silent for more than a year. Instead, this incident demonstrates the delicate strategy of balancing deterrence policies with engagement between a member state and a rather troubling partner nation.When Syria’s future is discussed, as it will be, at the Warsaw summit, Russia will be an unavoidable part of the discussion. But until there is a way to de-escalate these small-scale incidents, it will be increasingly difficult for Russia and NATO to determine whether they do in fact have any scope for cooperation, or at the least collaboration, on shared challenges and threats.To comment on this article, please contact Chatham House Feedback Full Article
scala Fighting escalates in Yemen despite coronavirus 'ceasefire' By feedproxy.google.com Published On :: Wed, 06 May 2020 17:38:30 +0000 Source The Guardian URL https://www.theguardian.com/world/2020/apr/14/fighting-escalates-in-yemen-despit... Release date 14 April 2020 Expert Farea Al-Muslimi In the news type Op-ed Hide date on homepage Full Article
scala Some scalar curvature warped product splitting theorems By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Gregory J. Galloway and Hyun Chul Jang Proc. Amer. Math. Soc. 148 (2020), 2617-2629. Abstract, references and article information Full Article
scala Local Pathways Towards De-escalation of Libya's Conflict By feedproxy.google.com Published On :: Wed, 22 Jan 2020 10:20:01 +0000 Invitation Only Research Event 28 January 2020 - 3:00pm to 4:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Usama Otman Essed, Libya Center for Strategic & Future StudiesChair: Tim Eaton, Middle East and North Africa Programme, Chatham House A shaky truce remains broadly in place among rival Libyan forces fighting for control of Tripoli. However, a durable ceasefire to bring an end to the current bout of conflict, which was initiated by Khalifa Haftar’s Libyan Arab Armed Forces’ (LAAF) offensive on the capital in April 2019, has not been reached. In recent weeks attention has focused on talks hosted in Moscow and Berlin, with the former aimed at agreeing a ceasefire and the latter seeking to reach agreement among international actors to bring an end to external military support for Libyan warring actors, and to craft a way forward for future intra-Libyan talks. Yet, there has been little emphasis on Libyan actors – beyond Haftar and prime minister Fayez al-Serraj – in this process. This roundtable will bring together experts and policymakers to discuss means of de-escalating the conflict and seeking a lasting resolution through the development of interconnected intra-Libyan social and security negotiation tracks. Mr Usama Otman Essed of the Libya Center for Strategic and Future Studies (LCSFS) will present his research group’s ideas on these issues and discuss their ongoing efforts to promote dialogue among social and security actors.Attendance at this event is by invitation only. Event attributes Chatham House Rule Department/project Middle East and North Africa Programme Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
scala 177Lu-EB-PSMA radioligand therapy with escalating doses in patients with metastatic castration-resistant prostate cancer By jnm.snmjournals.org Published On :: 2020-05-01T11:16:57-07:00 Purpose: This study is designed to assess the safety and therapeutic response to 177Lu-EB-PSMA treatment with escalating doses in patients with metastatic castration-resistant prostate cancer (mCRPC). Methods: With institutional review board approval and informed consent, patients were randomly divided into three groups: Group A (n = 10) were treated with 1.18 ± 0.09 GBq/dose of 177Lu-EB-PSMA. Group B (n = 10) were treated with 2.12 ± 0.19 GBq/dose of 177Lu-EB-PSMA. Group C (n = 8) were treated with 3.52 ± 0.58 GBq/dose of 177Lu-EB-PSMA. Eligible patients received up to three cycles of 177Lu-EB-PSMA therapy, at eight-week intervals. Results: Due to disease progression or bone marrow suppression, 4 out of 10, 5 out of 10, and 5 out of 10 patients completed three cycles therapy as planned in Groups A, B, and C, respectively. The prostate-specific antigen (PSA) response was correlated with treatment dose, with PSA disease control rates in Group B (70%) and C (75%) being higher than that in Group A (10%) (P = 0.007), but no correlation between Group B and Group C was found. 68Ga-PSMA PET/CT showed response in all the treatment groups, however, there was no significant difference between the three groups. Hematologic toxicity study found that platelets in Group B and Group C decreased more than those in Group A, and that Grade 4 thrombocytopenia occurred in 2 (25.0%) patients in Group C. No serious nephritic or hepatic side effects were observed. Conclusion: This study demonstrates that 2.12 GBq/dose of 177Lu-EB-PSMA seems to be safe and adequate in tumor treatment. Further investigations with increased number of patients are warranted. Full Article
scala Las puertas abiertas para los migrantes venezolanos y nicaragüenses en América Latina y el Caribe se cierran un poco a medida que aumenta la escala de los flujos y la presión en los servicios públicos By www.migrationpolicy.org Published On :: Mon, 10 Feb 2020 18:22:00 -0500 WASHINGTON – A pesar de que los gobiernos de América Latina y el Caribe han tomado medidas generosas e innovadoras para lidiar con el desplazamiento forzado desde Venezuela y más recientemente desde Nicaragua, la cálida bienvenida se ha enfriado en algunos lugares a medida que el número de entradas, la presión sobre los servicios públicos y la preocupación del público aumenta. Full Article
scala On the consistency of graph-based Bayesian semi-supervised learning and the scalability of sampling algorithms By Published On :: 2020 This paper considers a Bayesian approach to graph-based semi-supervised learning. We show that if the graph parameters are suitably scaled, the graph-posteriors converge to a continuum limit as the size of the unlabeled data set grows. This consistency result has profound algorithmic implications: we prove that when consistency holds, carefully designed Markov chain Monte Carlo algorithms have a uniform spectral gap, independent of the number of unlabeled inputs. Numerical experiments illustrate and complement the theory. Full Article
scala Scalable Approximate MCMC Algorithms for the Horseshoe Prior By Published On :: 2020 The horseshoe prior is frequently employed in Bayesian analysis of high-dimensional models, and has been shown to achieve minimax optimal risk properties when the truth is sparse. While optimization-based algorithms for the extremely popular Lasso and elastic net procedures can scale to dimension in the hundreds of thousands, algorithms for the horseshoe that use Markov chain Monte Carlo (MCMC) for computation are limited to problems an order of magnitude smaller. This is due to high computational cost per step and growth of the variance of time-averaging estimators as a function of dimension. We propose two new MCMC algorithms for computation in these models that have significantly improved performance compared to existing alternatives. One of the algorithms also approximates an expensive matrix product to give orders of magnitude speedup in high-dimensional applications. We prove guarantees for the accuracy of the approximate algorithm, and show that gradually decreasing the approximation error as the chain extends results in an exact algorithm. The scalability of the algorithm is illustrated in simulations with problem size as large as $N=5,000$ observations and $p=50,000$ predictors, and an application to a genome-wide association study with $N=2,267$ and $p=98,385$. The empirical results also show that the new algorithm yields estimates with lower mean squared error, intervals with better coverage, and elucidates features of the posterior that were often missed by previous algorithms in high dimensions, including bimodality of posterior marginals indicating uncertainty about which covariates belong in the model. Full Article
scala Scalar-on-function regression for predicting distal outcomes from intensively gathered longitudinal data: Interpretability for applied scientists By projecteuclid.org Published On :: Tue, 05 Nov 2019 22:03 EST John J. Dziak, Donna L. Coffman, Matthew Reimherr, Justin Petrovich, Runze Li, Saul Shiffman, Mariya P. Shiyko. Source: Statistics Surveys, Volume 13, 150--180.Abstract: Researchers are sometimes interested in predicting a distal or external outcome (such as smoking cessation at follow-up) from the trajectory of an intensively recorded longitudinal variable (such as urge to smoke). This can be done in a semiparametric way via scalar-on-function regression. However, the resulting fitted coefficient regression function requires special care for correct interpretation, as it represents the joint relationship of time points to the outcome, rather than a marginal or cross-sectional relationship. We provide practical guidelines, based on experience with scientific applications, for helping practitioners interpret their results and illustrate these ideas using data from a smoking cessation study. Full Article
scala On a computationally-scalable sparse formulation of the multidimensional and non-stationary maximum entropy principle. (arXiv:2005.03253v1 [stat.CO]) By arxiv.org Published On :: Data-driven modelling and computational predictions based on maximum entropy principle (MaxEnt-principle) aim at finding as-simple-as-possible - but not simpler then necessary - models that allow to avoid the data overfitting problem. We derive a multivariate non-parametric and non-stationary formulation of the MaxEnt-principle and show that its solution can be approximated through a numerical maximisation of the sparse constrained optimization problem with regularization. Application of the resulting algorithm to popular financial benchmarks reveals memoryless models allowing for simple and qualitative descriptions of the major stock market indexes data. We compare the obtained MaxEnt-models to the heteroschedastic models from the computational econometrics (GARCH, GARCH-GJR, MS-GARCH, GARCH-PML4) in terms of the model fit, complexity and prediction quality. We compare the resulting model log-likelihoods, the values of the Bayesian Information Criterion, posterior model probabilities, the quality of the data autocorrelation function fits as well as the Value-at-Risk prediction quality. We show that all of the considered seven major financial benchmark time series (DJI, SPX, FTSE, STOXX, SMI, HSI and N225) are better described by conditionally memoryless MaxEnt-models with nonstationary regime-switching than by the common econometric models with finite memory. This analysis also reveals a sparse network of statistically-significant temporal relations for the positive and negative latent variance changes among different markets. The code is provided for open access. Full Article
scala Sparse high-dimensional regression: Exact scalable algorithms and phase transitions By projecteuclid.org Published On :: Mon, 17 Feb 2020 04:02 EST Dimitris Bertsimas, Bart Van Parys. Source: The Annals of Statistics, Volume 48, Number 1, 300--323.Abstract: We present a novel binary convex reformulation of the sparse regression problem that constitutes a new duality perspective. We devise a new cutting plane method and provide evidence that it can solve to provable optimality the sparse regression problem for sample sizes $n$ and number of regressors $p$ in the 100,000s, that is, two orders of magnitude better than the current state of the art, in seconds. The ability to solve the problem for very high dimensions allows us to observe new phase transition phenomena. Contrary to traditional complexity theory which suggests that the difficulty of a problem increases with problem size, the sparse regression problem has the property that as the number of samples $n$ increases the problem becomes easier in that the solution recovers 100% of the true signal, and our approach solves the problem extremely fast (in fact faster than Lasso), while for small number of samples $n$, our approach takes a larger amount of time to solve the problem, but importantly the optimal solution provides a statistically more relevant regressor. We argue that our exact sparse regression approach presents a superior alternative over heuristic methods available at present. Full Article
scala Scalable high-resolution forecasting of sparse spatiotemporal events with kernel methods: A winning solution to the NIJ “Real-Time Crime Forecasting Challenge” By projecteuclid.org Published On :: Wed, 27 Nov 2019 22:01 EST Seth Flaxman, Michael Chirico, Pau Pereira, Charles Loeffler. Source: The Annals of Applied Statistics, Volume 13, Number 4, 2564--2585.Abstract: We propose a generic spatiotemporal event forecasting method which we developed for the National Institute of Justice’s (NIJ) Real-Time Crime Forecasting Challenge (National Institute of Justice (2017)). Our method is a spatiotemporal forecasting model combining scalable randomized Reproducing Kernel Hilbert Space (RKHS) methods for approximating Gaussian processes with autoregressive smoothing kernels in a regularized supervised learning framework. While the smoothing kernels capture the two main approaches in current use in the field of crime forecasting, kernel density estimation (KDE) and self-exciting point process (SEPP) models, the RKHS component of the model can be understood as an approximation to the popular log-Gaussian Cox Process model. For inference, we discretize the spatiotemporal point pattern and learn a log-intensity function using the Poisson likelihood and highly efficient gradient-based optimization methods. Model hyperparameters including quality of RKHS approximation, spatial and temporal kernel lengthscales, number of autoregressive lags and bandwidths for smoothing kernels as well as cell shape, size and rotation, were learned using cross validation. Resulting predictions significantly exceeded baseline KDE estimates and SEPP models for sparse events. Full Article
scala Scalable Bayesian Inference for the Inverse Temperature of a Hidden Potts Model By projecteuclid.org Published On :: Mon, 13 Jan 2020 04:00 EST Matthew Moores, Geoff Nicholls, Anthony Pettitt, Kerrie Mengersen. Source: Bayesian Analysis, Volume 15, Number 1, 1--27.Abstract: The inverse temperature parameter of the Potts model governs the strength of spatial cohesion and therefore has a major influence over the resulting model fit. A difficulty arises from the dependence of an intractable normalising constant on the value of this parameter and thus there is no closed-form solution for sampling from the posterior distribution directly. There is a variety of computational approaches for sampling from the posterior without evaluating the normalising constant, including the exchange algorithm and approximate Bayesian computation (ABC). A serious drawback of these algorithms is that they do not scale well for models with a large state space, such as images with a million or more pixels. We introduce a parametric surrogate model, which approximates the score function using an integral curve. Our surrogate model incorporates known properties of the likelihood, such as heteroskedasticity and critical temperature. We demonstrate this method using synthetic data as well as remotely-sensed imagery from the Landsat-8 satellite. We achieve up to a hundredfold improvement in the elapsed runtime, compared to the exchange algorithm or ABC. An open-source implementation of our algorithm is available in the R package bayesImageS . Full Article
scala Escalator By www.smithsonianmag.com Published On :: Mon, 24 Feb 2020 05:00:00 +0000 Escalator Full Article
scala Feasibility and Preliminary Outcomes of a Scalable, Community-based Treatment of Childhood Obesity By pediatrics.aappublications.org Published On :: 2012-09-17T00:07:38-07:00 Pediatric obesity is a prevalent public health issue that is associated with medical and physical consequences. Clinic-based interventions for pediatric obesity are effective, but they have limited reach and are costly.This is the first examination of an empirically informed, scalable treatment of pediatric overweight and obesity delivered in YMCAs. The results indicate that a scalable, community-based pediatric obesity intervention can produce clinically meaningful changes in weight and quality of life. (Read the full article) Full Article
scala Elections au Burundi : Prévenir toute escalade de violence By feedproxy.google.com Published On :: Tue, 02 Mar 2010 23:00:00 GMT Full Article
scala Fin24.com | Dis-Chem hiked mask prices before costs escalated, says Commission By www.fin24.com Published On :: Wed, 06 May 2020 14:30:32 +0200 The pharmaceutical retailer says it was forced to increase prices of surgical masks because of suppliers' inflated quotes and to match competitors, while the commission says retailers could have been following Dis-Chem's lead. Full Article
scala Privilege escalation attacks, their impact on enterprises and mitigation By feedproxy.google.com Published On :: 2020-04-23T14:58:00+05:30 Full Article tech
scala USA: New Merit-based Immigration Plan May Escalate Highly-Skilled Workers By www.visareporter.com Published On :: Thu, 25 Apr 2019 00:00:00 GMT A merit-based immigration plan being put together by Jared Kushner, White House senior adviser it could lead to an escalation in US visas for extremely skilled workers, sources revealed on 24 Apr 2019.Merit-based Immigration ProposalKushner is assumed… Full Article