blocks Categorification via blocks of modular representations for sl(n). (arXiv:1612.06941v3 [math.RT] UPDATED) By arxiv.org Published On :: Bernstein, Frenkel, and Khovanov have constructed a categorification of tensor products of the standard representation of $mathfrak{sl}_2$, where they use singular blocks of category $mathcal{O}$ for $mathfrak{sl}_n$ and translation functors. Here we construct a positive characteristic analogue using blocks of representations of $mathfrak{sl}_n$ over a field $ extbf{k}$ of characteristic $p$ with zero Frobenius character, and singular Harish-Chandra character. We show that the aforementioned categorification admits a Koszul graded lift, which is equivalent to a geometric categorification constructed by Cautis, Kamnitzer, and Licata using coherent sheaves on cotangent bundles to Grassmanians. In particular, the latter admits an abelian refinement. With respect to this abelian refinement, the stratified Mukai flop induces a perverse equivalence on the derived categories for complementary Grassmanians. This is part of a larger project to give a combinatorial approach to Lusztig's conjectures for representations of Lie algebras in positive characteristic. Full Article
blocks Computing with bricks and mortar: Classification of waveforms with a doped concrete blocks. (arXiv:2005.03498v1 [cs.ET]) By arxiv.org Published On :: We present results showing the capability of concrete-based information processing substrate in the signal classification task in accordance with in materio computing paradigm. As the Reservoir Computing is a suitable model for describing embedded in materio computation, we propose that this type of presented basic construction unit can be used as a source for "reservoir of states" necessary for simple tuning of the readout layer. In that perspective, buildings constructed from computing concrete could function as a highly parallel information processor for smart architecture. We present an electrical characterization of the set of samples with different additive concentrations followed by a dynamical analysis of selected specimens showing fingerprints of memfractive properties. Moreover, on the basis of obtained parameters, classification of the signal waveform shapes can be performed in scenarios explicitly tuned for a given device terminal. Full Article
blocks Fast Mapping onto Census Blocks. (arXiv:2005.03156v1 [cs.DC]) By arxiv.org Published On :: Pandemic measures such as social distancing and contact tracing can be enhanced by rapidly integrating dynamic location data and demographic data. Projecting billions of longitude and latitude locations onto hundreds of thousands of highly irregular demographic census block polygons is computationally challenging in both research and deployment contexts. This paper describes two approaches labeled "simple" and "fast". The simple approach can be implemented in any scripting language (Matlab/Octave, Python, Julia, R) and is easily integrated and customized to a variety of research goals. This simple approach uses a novel combination of hierarchy, sparse bounding boxes, polygon crossing-number, vectorization, and parallel processing to achieve 100,000,000+ projections per second on 100 servers. The simple approach is compact, does not increase data storage requirements, and is applicable to any country or region. The fast approach exploits the thread, vector, and memory optimizations that are possible using a low-level language (C++) and achieves similar performance on a single server. This paper details these approaches with the goal of enabling the broader community to quickly integrate location and demographic data. Full Article
blocks Functional fabric based test wrapper for circuit testing of IP blocks By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A Test Wrapper and associated Test Access Mechanism (TAM) architecture for facilitating testing of IP blocks integrated on a System on a Chip (SoC). The TAM architecture includes a Test Controller and one or more Test Wrappers that are integrated on the SoC proximate to IP blocks. Test data and commands corresponding to input from an external tester are packaged by the Test Controller and sent to one or more Test Wrappers via an interconnect fabric. The Test Wrappers interface with one or more IP test ports to provide test data, control, and/or stimulus signals to the IP blocks to facilitate circuit-level testing of the IP blocks. Test results for the circuit-level tests are returned to the Test Controller via the fabric. Test Wrappers may be configured to pass through interconnect signals, enabling functional testing of IP blocks to be facilitated via test packages and test results transmitted between the Test Controller and the IP blocks via the fabric. Test wrappers may also be configured to test multiple IP blocks comprising a test partition. Full Article
blocks Method and apparatus for error-correction in and processing of GFP-T superblocks By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention discloses a method and apparatus for processing and error correction of a GFP-T superblock, where the 64 bytes of payload data of a first superblock are buffered in the first page of a two-page buffer. The flag byte is buffered in a separate buffer, and a CRC operation is performed in a separate logic element. The result of the CRC operation is checked against a single syndrome table which may indicate single- or multi-bit errors. As the payload data of the first superblock is processed and read out of the first page of the two-page buffer, the payload data of a second superblock is written into the second page of the two-page buffer to be processed and corrected. Full Article
blocks Combined branch target and predicate prediction for instruction blocks By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT Embodiments provide methods, apparatus, systems, and computer readable media associated with predicting predicates and branch targets during execution of programs using combined branch target and predicate predictions. The predictions may be made using one or more prediction control flow graphs which represent predicates in instruction blocks and branches between blocks in a program. The prediction control flow graphs may be structured as trees such that each node in the graphs is associated with a predicate instruction, and each leaf associated with a branch target which jumps to another block. During execution of a block, a prediction generator may take a control point history and generate a prediction. Following the path suggested by the prediction through the tree, both predicate values and branch targets may be predicted. Other embodiments may be described and claimed. Full Article
blocks Synthesis of fast squarer functional blocks By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT In one embodiment of the invention, an integrated circuit (IC) design tool is provided for synthesizing logic, including one or more software modules to synthesize a gate-level netlist of a squarer functional block. The software modules include a bitvector generator, a bitvector reducer, and a hybrid multibit adder generator. The bitvector generator multiplies bits of a vector together to generate partial products for a plurality of bitvectors and then optimizes a plurality of least significant bitvectors. The bitvector reducer reduces the partial products in the bitvectors of the squarer functional block down to a pair of final vectors. The hybrid multibit adder generator generates a hybrid multibit adder including a first adder and a second adder coupled together by a carry bit with bit widths being responsive to a dividerbit. The hybrid multibit adder adds the pair of final vectors together to generate a final result for the squarer functional block. Full Article
blocks Adjustment of the number of task control blocks allocated for discard scans By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A controller receives a request to perform a release space operation. A determination is made that a new discard scan has to be performed on a cache, in response to the received request to perform the release space operation. A determination is made as to how many task control blocks are to be allocated to the perform the new discard scan, based on how many task control blocks have already been allocated for performing one or more discard scans that are already in progress. Full Article
blocks Moving blocks of data between main memory and storage class memory By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory. Full Article
blocks Management of multiple software images with shared memory blocks By www.freepatentsonline.com Published On :: Tue, 09 Jun 2015 08:00:00 EDT A data processing entity that includes a mass memory with a plurality of memory locations for storing memory blocks. Each of a plurality of software images includes a plurality of memory blocks with corresponding image addresses within the software image. The memory blocks of software images stored in boot locations of a current software image are relocated. The boot blocks of the current software image are stored into the corresponding boot locations. The data processing entity is booted from the boot blocks of the current software image in the corresponding boot locations, thereby loading the access function. Each request to access a selected memory block of the current software image is served by the access function, with the access function accessing the selected memory block in the associated memory location provided by the control structure. Full Article
blocks Chaining move specification blocks By www.freepatentsonline.com Published On :: Tue, 25 Aug 2015 08:00:00 EDT An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory. Full Article
blocks Chaining move specification blocks By www.freepatentsonline.com Published On :: Tue, 20 Oct 2015 08:00:00 EDT An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory. Full Article
blocks ACK/NACK channelization for resource blocks containing both ACK/NACK and CQI By www.freepatentsonline.com Published On :: Tue, 23 Jun 2015 08:00:00 EDT In one exemplary embodiment, a method includes: transmitting a value from an access node towards an apparatus, where the value is indicative of a size of a first portion of an uplink resource block, where the uplink resource block is shared among a plurality of apparatus, where the first portion is specified for transmission of a first type of signaling to the access node, where a second portion of the uplink resource block is specified for transmission of a second type of signaling to the access node; and receiving at least one transmission using at least one of the first portion and the second portion. Full Article
blocks Building blocks and building block fasteners By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A building block (100) comprises a first mating portion and a second mating portion which are complementary. The first mating portion comprises a mating protrusion (140) which defines an axially extending through bore (144) and the second mating portion comprises an axially extending mating receptacle (180) which is complementary to the mating protrusion (140). The mating protrusion (140) and the mating receptacle (180) are in communication via the through bore (144), and a fastener anchoring device (146) adapted for engaging with an engagement means (920) of a fastener (900) is formed inside the through bore (144). The through bore (144) is adapted to permit axial insertion of the engagement means (920) of the fastener (900) into the mating protrusion (140). The fastener anchoring device (146) is adapted to obstruct axial passage of the engagement means (920) until the engagement means (920) overcomes the obstruction by negotiating rotationally with the fastener anchoring device (146) to thereby gain axial advancement and enter into engagement with the fastener anchoring device (146). Full Article
blocks Collapsible toy blocks By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A collapsible and expandable children's toy building block is described. The toy blocks may be made in various sizes and shapes. The toy block includes an internal frame. A cover is positioned over the internal frame to form the toy block. The toy block converts from a collapsed position to an expanded position, and the toy block converts from the expanded position back to the collapsed position. Full Article
blocks Assembly kit for creating three-dimensional formations, especially toy structures from prefabricated modular building blocks By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT An improved set of toy building or construction blocks, each block having a substantially square cross-section and a generally rectilinear configuration. Incorporated into the structure of the individual toy blocks are transversely oriented slots, grooves and protrusions of predetermined size and location. The slots, grooves and protrusions of pre-determined size and location are of either male or female configuration disposed medially along one or more plane of each block. When the male protrusion of one block is introduced perpendicular to the female slot of one end of another block, a frictional engagement is created resulting in a right angle. When the male protrusion of one block is introduced to the female slot in a linear fashion the result is a line segment. Joining a plurality of said toy building or construction blocks using various perpendicular connections in conjunction with linear connections results in the stable formation of construction or geometric structures without the use of fasteners or other connecting elements. Full Article
blocks Method and apparatus for producing stacks which form book blocks By www.freepatentsonline.com Published On :: Tue, 29 Apr 2014 08:00:00 EDT In order to form stacks, of which each forms a book block, folded sheets are provided with an adhesive application or layer of adhesive before they are placed on one another. Said adhesive application is applied to the sheets adjacent to the folded edge of said sheets and extends in the direction of said folded edge which comes to lie in the spine of the book block. The adhesive can be applied as a continuous track or as a track which is interrupted multiple times, or else in a punctiform manner. The sheets are joined to one another in the stack by means of said adhesive application, with the result that they maintain their position within the stack during further transport of the stack. Full Article
blocks Synthetic rope for powered blocks and methods for production By www.freepatentsonline.com Published On :: Tue, 21 Oct 2014 08:00:00 EDT Disclosed is a method for producing a high strength synthetic strength member (7) containing rope (1) capable of being used with powered blocks where such rope has lighter weight and similar or greater strength than steel wire strength member containing ropes used with powered blocks. Disclosed also is the product resulting from such method. The product includes a synthetic strength member, a first synthetic portion (9) and a second synthetic portion. The first synthetic portion is enclosed within the strength member and the second synthetic portion is situated external the strength member. At least a portion of the second synthetic portion also is situated internal a sheath (8) formed about the strength member. The second synthetic portion has a minimal of 8% at a temperature of between negative 20 and negative 15° C. Full Article
blocks Mold system for forming multilevel blocks By www.freepatentsonline.com Published On :: Tue, 17 Feb 2015 08:00:00 EST A mold system for forming a multilevel block is disclosed which comprises a multilevel mold box insert for forming a multilevel block, a mold box frame adapted for receiving therein the multilevel mold box insert, a multilevel plunger assembly, and a press head plate adapted for receiving thereon the multilevel plunger assembly. Full Article
blocks Process and apparatus for demolding and palletizing cast concrete blocks By www.freepatentsonline.com Published On :: Tue, 03 Mar 2015 08:00:00 EST A method for demolding concrete blocks which are cast in a resilient mold supported in a rigid frame, the mold having a top surface and at least one cavity with an opening on the top surface, which cavity holds a cured cast concrete block. The mold has two opposing edges. The demolded blocks are stacked on a collection surface. A support is positioned over the cavity and the mold, the support and the frame are inverted and positioned in demolding apparatus. After two opposing edges of the mold are engaged by the demolding apparatus, the support is withdrawn to allow the mold to sag. The blocks may release from the mold and fall onto the collection surface. If any blocks remain in the mold, a plunger mechanism is pushed against the sagging mold to release the blocks. Guide members may facilitate positioning the blocks on the collection surface. Full Article
blocks METHOD AND SYSTEM FOR SYNCHRONIZING AN INDEX OF DATA BLOCKS STORED IN A STORAGE SYSTEM USING A SHARED STORAGE MODULE By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A storage system includes a first and second control modules (CMs) connected to a client and a storage module over a communication fabric. In response to a data fragment written to the storage module, the first CM is to create a table of contents (TOC) entry in a TOC page maintained in a first storage partition of the storage module, update its FTL map, determine whether the TOC page contains a predetermined number of TOC entries, and in response to determining that the TOC page contains the predetermined number of TOC entries, send a control signal to the second CM via an inter-processor link. In response to the control signal received from the first CM via the inter-processor link, the second CM is to copy the TOC page from the first storage partition to a memory associated with the second CM to allow the second CM to update its FTL map. Full Article
blocks Process for the manufacture of stone blocks By www.freepatentsonline.com Published On :: Tue, 09 Dec 2014 08:00:00 EST This invention relates to a process which may be automated for the manufacture of stone blocks for use as finished landscape stone blocks from quarry stone. The natural stone is quarried from the quarry and split into rectangular blocks, with squared ends and the top and bottom surfaces are ground with a plurality of grooves and ridges of varying heights. The ridges of varying heights are then removed thereby producing a surface having ridges of uniform height and grooves of uniform depth. The blocks may be used to form an architectural wall. The process is also applicable to pavers, steps and coping stones. Full Article
blocks Method and apparatus for thread-stitching of book blocks, and a book production line equipped with such an apparatus By www.freepatentsonline.com Published On :: Tue, 03 Mar 2015 08:00:00 EST An apparatus for thread-stitching a book block includes a thread tensioning device configured to store and tension a binding thread. A single actuator, including a servo drive, drives the thread tensioning device. The method includes storing a length of binding thread; in a separate step, tensioning the binding thread; and thread-stitching the book block. Full Article
blocks Systems and methods for creating quilt blocks By www.freepatentsonline.com Published On :: Tue, 03 Mar 2015 08:00:00 EST Systems and methods for creating quilt blocks are provided. In one embodiment, a method for creating a quilt block with a computerized embroidery machine includes sewing placement stitching on a backing according to a placement stitching pattern provided by instructions for at least partially creating a quilt block comprised of one or more pieces, providing directions for placing one or more pieces of the quilt block on a corresponding portion of the placement stitching on the backing, and sewing the one or more pieces to the backing in accordance with the instructions. Full Article
blocks Method for manufacturing silicon blocks By www.freepatentsonline.com Published On :: Tue, 20 Jan 2015 08:00:00 EST A device for taking up a silicon melt comprises at least one block of a refractory with a capillary structure. Full Article
blocks Segmental retaining wall corner block and wall corner comprised of corner blocks By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A corner block has spaced-apart front and rear sections interconnected by two spaced-apart side sections that jointly define an internal cavity. Upper protrusions are provided on the top face of the block, and inner protrusions are provided inside the cavity at the bottom of the block. The upper and inner protrusions are configured and arranged relative to one another so that when two corner blocks are stacked one atop another with one block rotated 90° relative to the other, the upper protrusions of the lower block interlock with the inner protrusions of the upper block to interlock the two blocks. The corner blocks are constructed in two variants, a corner block A and a corner block B, which are mirror images of each other. The corner blocks A and B are alternately stacked upon one another to construct a 90° corner of a segmental wall structure. Full Article
blocks Trump ban on fetal tissue research blocks coronavirus treatment effort By www.seattletimes.com Published On :: Wed, 18 Mar 2020 13:28:25 -0700 A senior scientist at a government biomedical research laboratory has been thwarted in his efforts to conduct experiments on possible treatments for the new coronavirus because of the Trump administration’s restrictions on research with human fetal tissue. The scientist, Kim Hasenkrug, an immunologist at the National Institutes of Health’s Rocky Mountain Laboratories in Montana, has […] Full Article Health Nation Nation & World Nation & World Politics Special Reports Travel World
blocks Stock Alert: SG Blocks Jumps 34% On Distribution Deal For COVID-19 Rapid Tests By www.rttnews.com Published On :: Tue, 05 May 2020 13:58:48 GMT Shares of SG Blocks, Inc. (SGBX), a fabricator of container-based structures, are surging almost 34 percent or $1.47 in Tuesday's morning trade at $5.80. The stock has traded in a range of $1.16 to $35.00 in the past 52 weeks. Full Article
blocks Malawi blocks lockdown as experts worry about COVID-19 in Africa By www.abc.net.au Published On :: Wed, 06 May 2020 18:40:00 +1000 Last month, the government of Malawi tried to impose a lockdown, but was knocked back by the courts. Full Article Infectious Diseases (Other)
blocks Dumped gravel and rock blocks environmental water from flowing into Murray-Darling forest By www.abc.net.au Published On :: Mon, 23 Sep 2019 14:24:00 +1000 An irrigation channel used to release water into a forest along the Murray River in NSW is filled with earth and rocks, with an irrigator saying it's a sign of frustration boiling over in the area. Full Article ABC Riverina riverina shepparton Disasters and Accidents:Drought:All Environment:Environmental Management:All Environment:Rivers:Murray-Darling Basin Environment:Water Management:All Law Crime and Justice:Crime:Vandalism Rural:Agricultural Policy:All Rural:Irrigation:All Australia:NSW:Mulwala 2647 Australia:NSW:Wagga Wagga 2650 Australia:VIC:Shepparton 3630
blocks Coronavirus restrictions likely to be removed cautiously in four-week blocks By www.abc.net.au Published On :: Thu, 07 May 2020 15:50:59 +1000 National Cabinet will not be looking to rapidly lift wide-ranging restrictions on movement and business all at once when it meets tomorrow to consider Australia's response to the coronavirus pandemic. Full Article Government and Politics Infectious Diseases (Other) Federal Government Health Respiratory Diseases Federal - State Issues COVID-19 Community and Society
blocks 70m wind turbine blade blocks road after truck rollover near Bothwell in Tasmania By www.abc.net.au Published On :: Thu, 19 Sep 2019 15:54:00 +1000 A 60-tonne truck carrying part of a wind turbine rolls over in Tasmania's central highlands, leaving a 68-metre blade across the road. Full Article ABC Radio Hobart hobart northtas Disasters and Accidents:Accidents:All Disasters and Accidents:Accidents:Road Disasters and Accidents:All:All Environment:Alternative Energy:All Environment:Alternative Energy:Wind Energy Law Crime and Justice:Police:All Australia:TAS:All Australia:TAS:Bothwell 7030 Australia:TAS:Hobart 7000 Australia:TAS:Launceston 7250
blocks Comment on Create With Confidence — and Better Blocks by Ian Stewart By wordpress.com Published On :: Wed, 29 Apr 2020 20:22:21 +0000 In reply to <a href="https://wordpress.com/blog/2020/03/26/block-editor-upgrades/#comment-413515">Roland Little</a>. Hi, Roland! We have some <a href="https://wordpress.com/support/wordpress-editor/" rel="nofollow ugc">videos and help in our WordPress Editor documentation</a> that might help out with that. Full Article
blocks Create With Confidence — and Better Blocks By wordpress.com Published On :: Thu, 26 Mar 2020 19:31:00 +0000 The evolution of the block editor is packed full of features and UI improvements. Start building! Full Article Editing Features New Features Block editor Editor gutenberg wordpress-com
blocks Make Your Business More Accessible with New Blocks By wordpress.com Published On :: Thu, 02 Apr 2020 16:21:18 +0000 From booking and scheduling to events and embeds, these six new blocks for your blog or business website help you to grow your audience, connect with more clients, and reach more customers. Full Article blocks Earn from your site Embeds Features HowTo New Features WordPress.com Block editor business Calendly Eventbrite Google calendar Maps OpenTable Pinterest Small Business
blocks Trump administration blocks public disclosure on coronavirus supplies By www.latimes.com Published On :: Fri, 1 May 2020 16:17:12 -0400 FEMA won't release state-by-state information on where masks, gowns and other protective equipment have been delivered. Full Article
blocks Building blocks of the cell wall: pectin drives reproductive development in rice By www.eurekalert.org Published On :: Thu, 07 May 2020 00:00:00 EDT (University of Tsukuba) Researchers from the University of Tsukuba have revealed that pectin, a carbohydrate found in plant cell walls, plays a vital part in the development of female reproductive tissues of rice plants. It was found that the presence of a gene involved in pectin modification increased plant fertility relative to a modified plant with the gene removed. These findings could have major implications in crop variety development and genetic modification. Full Article
blocks Centrelink blocks 60,000 calls a day, blames smartphone apps By www.smh.com.au Published On :: Fri, 23 Oct 2015 07:05:35 GMT Centrelink blocked 22m phone calls last year, with smartphone apps blamed for inflating the figures. Full Article
blocks Judge blocks Tennessee from implementing voucher program By feedproxy.google.com Published On :: 2020-05-07T22:46:34-04:00 Full Article Education
blocks Judge blocks Tennessee from implementing voucher program By feedproxy.google.com Published On :: Fri, 08 May 2020 00:00:00 +0000 Full Article Tennessee
blocks Judge blocks Tennessee from implementing voucher program By feedproxy.google.com Published On :: 2020-05-08T08:50:39-04:00 Full Article Education
blocks Scottish students design building blocks of Moon base By www.heraldscotland.com Published On :: Wed, 26 Feb 2020 05:10:00 +0000 A GROUP of Glasgow-based students are working on an international project to design the building blocks of a Moon base. Full Article
blocks Novel peptide from commensal Staphylococcus simulans blocks MRSA quorum sensing and protects host skin from damage [Mechanisms of Action] By aac.asm.org Published On :: 2020-04-06T08:49:25-07:00 Recent studies highlight the abundance of commensal coagulase-negative staphylococci (CoNS) on healthy skin. Evidence suggests that CoNS actively shape the skin immunological and microbial milieu to resist colonization or infection by opportunistic pathogens, including methicillin resistant Staphylococcus aureus (MRSA), in a variety of mechanisms collectively termed colonization resistance. One potential colonization resistance mechanism is the application of quorum sensing, also called the Accessory Gene Regulator (agr) system, which is ubiquitous among staphylococci. Common and rare CoNS make autoinducing peptides (AIPs) that function as MRSA agr inhibitors, protecting the host from invasive infection. In a screen of CoNS spent media we found that Staphylococcus simulans, a rare human skin colonizer and frequent livestock colonizer, released potent inhibitors of all classes of MRSA agr signaling. We identified three S. simulans agr classes, and have shown intraspecies cross-talk between non-cognate S. simulans agr types for the first time. The S. simulans AIP-I structure was confirmed, and the novel AIP-II and AIP-III structures were solved via mass spectrometry. Synthetic S. simulans AIPs inhibited MRSA agr signaling with nanomolar potency. S. simulans in competition with MRSA reduced dermonecrotic and epicutaneous skin injury in murine models. Addition of synthetic AIP-I also effectively reduced MRSA dermonecrosis and epicutaneous skin injury in murine models. These results demonstrate potent anti-MRSA quorum sensing inhibition by a rare human skin commensal, and suggest that cross-talk between CoNS and MRSA may be important in maintaining healthy skin homeostasis and preventing MRSA skin damage during colonization or acute infection. Full Article
blocks Nafamostat mesylate blocks activation of SARS-CoV-2: New treatment option for COVID-19 [Letters] By aac.asm.org Published On :: 2020-04-20T08:36:47-07:00 The currently unfolding coronavirus pandemic threatens health systems and economies worldwide.... Full Article
blocks Quercetin blocks Ebola Virus infection by counteracting the VP24 Interferon inhibitory function [Antiviral Agents] By aac.asm.org Published On :: 2020-05-04T08:49:24-07:00 Ebola Virus (EBOV) is among the most devastating pathogens causing fatal hemorrhagic fever in humans. The 2013–2016 epidemics resulted in over 11000 deaths, while another outbreak is currently ongoing. Since there is no FDA-approved drug so far to fight EBOV infection, there is an urgent need to focus on drug discovery. Considering the tight correlation between the high EBOV virulence and its ability to suppress the type-I Interferon (IFN-I) system, identifying molecules targeting viral protein VP24, one of the main virulence determinants blocking IFN response, is a promising novel anti-EBOV therapy approach. Hence, in the effort of finding novel EBOV inhibitors, a screening of a small set of flavonoids was performed, showing that Quercetin and Wogonin can suppress the VP24 effect on IFN-I signaling inhibition. The mechanism of action of the most active compound, Quercetin, showing an IC50 value of 7.4 μM, was characterized to significantly restore the IFN-I signaling cascade, blocked by VP24, by directly interfering with the VP24 binding to karyopherin-α and thus restoring P-STAT1 nuclear transport and IFN genes transcription. Quercetin significantly blocked viral infection, specifically targeting EBOV VP24 anti-IFN-I function. Overall, Quercetin is the first identified inhibitor of the EBOV VP24 anti-IFN function, representing a molecule interacting with a viral binding site that is very promising for further drug development aiming to block EBOV infection at the early steps. Full Article
blocks Grants For Crime Reduction, Community Programs and Projects Available from Neighborhood Building Blocks Fund By news.delaware.gov Published On :: Wed, 25 Oct 2017 16:00:18 +0000 Applications are being accepted from community organizations for $1.3 million in funds to support crime reduction, neighborhood revitalization, and economic development programs statewide, with special emphasis on programs in and around downtown areas and neighborhoods, Attorney General Matt Denn and Delaware Division of Small Business, Development and Tourism Director Cerron Cade announced Tuesday. Applications are […] Full Article Department of Justice Department of Justice Press Releases Small Business Delaware Department of Justice Neighborhood Building Blocks Fund
blocks DPH, United Way and Delaware Division of Libraries to Host Free Books, Balls and Blocks Event for Children By news.delaware.gov Published On :: Thu, 11 Oct 2018 15:41:25 +0000 The Division of Public Health (DPH) invites parents with children from birth to 5 years old to participate in its first Books, Balls and Blocks event, which will take place from 1:00 to 4:00 p.m., Saturday, October 13, at the Route 9 Library and Innovation Center in New Castle, Delaware. Full Article Delaware Health and Social Services Delaware Libraries Division of Public Health News child screening DE Division of Public Health Division of Libraries New Castle New Castle Library
blocks War of words over actual war? US BLOCKS UN resolution on global Covid-19 ceasefire over its support for WHO By www.rt.com Published On :: Sat, 09 May 2020 00:26:00 +0000 A dispute between the US and China scuttled a proposed UN resolution calling for a global ceasefire during the Covid-19 pandemic, after Beijing insisted on support for the World Health Organization and Washington vetoed it. Read Full Article at RT.com Full Article
blocks Library Characterization Tidbits: Exploring Intuitive Means to Characterize Large Mixed-Signal Blocks By feedproxy.google.com Published On :: Fri, 06 Mar 2020 16:41:00 GMT Let’s review a key characteristic feature of Cadence Liberate AMS Mixed-Signal Characterization that offers to you ease of use along with many other benefits like automation of standard Liberty model creation and improvement of up to 20X throughput.(read more) Full Article Liberate AMS video library generation pin capacitance Mixed-Signal library characterization shell libraries Liberate Characterization Portfolio Liberty Virtuoso ADE Explorer Virtuoso ADE Assembler
blocks Virtuosity: Can You Build Lego Masterpieces with All Blocks of One Size? By community.cadence.com Published On :: Thu, 30 Apr 2020 14:41:00 GMT The way you need blocks of different sizes and styles to build great Lego masterpieces, a complex WSP-based design requires stitching together routing regions with multiple patterns that follow different WSSPDef periods. Let's see how you can achieve this. (read more) Full Article ICADVM18.1 cadence WSP Advanced Node Local regions Layout Suite width spacing patterns Layout Virtuoso Virtuosity usability Custom IC ux WSSPDef