era Harvard dental student recipient of health literacy essay contest By www.ada.org Published On :: Thu, 02 Apr 2020 10:49:00 -0500 An essay on community water fluoridation yielded a Harvard University dental student a first-place win in the annual American Dental Association’s Health Literacy in Dentistry essay contest. Full Article
era Office of Federal Student Aid has an FAQ for student loan questions By www.ada.org Published On :: Thu, 02 Apr 2020 15:42:00 -0500 The U.S. Department of Education’s Office of Federal Student Aid has published an extensive FAQ addressing student loans, including answered questions that cover several new provisions from the Coronavirus Aid, Relief and Economic Security Act. Full Article
era North Carolina interactive map launches to help public find emergency dental treatment during pandemic By www.ada.org Published On :: Wed, 15 Apr 2020 14:07:00 -0500 A North Carolina oral health coalition, in collaboration with multiple state partners, has developed an interactive map to help guide the public to sites where emergency dental services are available throughout the Tar Heel State both during and after the COVID-19 outbreak. Full Article
era ADA urges HHS to federally recognize licensed dentists to administer point of service COVID-19 tests By www.ada.org Published On :: Fri, 17 Apr 2020 10:14:00 -0500 The ADA sent a letter to the U.S. Department of Health and Human Services April 17 asking the agency to “issue federal recognition that licensed dentists may administer point of service tests authorized by the Food and Drug Administration” during the COVID-19 pandemic. Full Article
era Dental groups seek federal approval to administer COVID-19 tests By www.ada.org Published On :: Wed, 22 Apr 2020 15:14:00 -0500 The Organized Dentistry Coalition is asking the U.S. Department of Health and Human Services to “extend federal authorization for licensed dentists to conduct Food and Drug Administration-authorized, point-of-care testing” during the COVID-19 pandemic. Full Article
era Find COVID-19 dental regulations by state with ADA interactive map By www.ada.org Published On :: Thu, 30 Apr 2020 10:23:00 -0500 Dentists can find regulations, recommendations and mandates regarding the practice of dentistry in their state during the COVID-19 pandemic on the ADA Center for Professional Success. Full Article
era EIA sees fuel prices below 2018 average for the next two years By www.upi.com Published On :: Thu, 17 Jan 2019 08:11:18 -0500 U.S. retail fuel prices will drop this year and in 2020 from 2018, but in both cases higher than January levels due to mandated lower sulfur in marine fuel. Full Article
era Study: Opioid overdose 14 times more likely in general public than cancer survivors By www.upi.com Published On :: Thu, 07 May 2020 13:25:09 -0400 Cancer survivors have a lower risk for a fatal opioid overdose -- from prescription pain medications or illegal drugs -- than those without the disease, an analysis published Thursday by JAMA Oncology shows. Full Article
era Poverty, poorer health make some in the Bronx more vulnerable to COVID-19 By www.upi.com Published On :: Fri, 08 May 2020 16:40:25 -0400 New York City has been the epicenter of the COVID-19 outbreak in the United States, with immigrant populations in areas such as the Bronx "disproportionately" affected, a commentary in JAMA Internal Medicine says. Full Article
era Exploring the Potential of Two-Generation Strategies in Refugee Integration By www.migrationpolicy.org Published On :: Fri, 14 Dec 2018 11:45:21 -0500 On this webinar, MPI researchers and Utah and Colorado refugee coordinators explore promising practices to better serve refugee families, including education services for refugee youth, innovative efforts to secure better jobs for adult refugees, and other services designed to aid integration over time. They also discuss the potential for implementing and supporting two-generation approaches to refugee integration at a time when the system’s funding and capacity are in peril. Full Article
era Incidence of Type 2 Diabetes in Patients With Chronic Hepatitis C Receiving Interferon-Based therapy By care.diabetesjournals.org Published On :: 2020-03-24T15:44:44-07:00 Full Article
era Combination Therapy With Canagliflozin Plus Liraglutide Exerts Additive Effect on Weight Loss, but Not on HbA1c, in Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-03-27T15:11:48-07:00 OBJECTIVETo examine the effect of combination therapy with canagliflozin plus liraglutide on HbA1c, endogenous glucose production (EGP), and body weight versus each therapy alone.RESEARCH DESIGN AND METHODSForty-five patients with poorly controlled (HbA1c 7–11%) type 2 diabetes mellitus (T2DM) on metformin with or without sulfonylurea received a 9-h measurement of EGP with [3-3H]glucose infusion, after which they were randomized to receive 1) liraglutide 1.2 mg/day (LIRA); 2) canagliflozin 100 mg/day (CANA); or 3) liraglutide 1.2 mg plus canagliflozin 100 mg (CANA/LIRA) for 16 weeks. At 16 weeks, the EGP measurement was repeated.RESULTSThe mean decrease from baseline to 16 weeks in HbA1c was –1.67 ± 0.29% (P = 0.0001), –0.89 ± 0.24% (P = 0.002), and –1.44 ± 0.39% (P = 0.004) in patients receiving CANA/LIRA, CANA, and LIRA, respectively. The decrease in body weight was –6.0 ± 0.8 kg (P < 0.0001), –3.5 ± 0.5 kg (P < 0.0001), and –1.9 ± 0.8 kg (P = 0.03), respectively. CANA monotherapy caused a 9% increase in basal rate of EGP (P < 0.05), which was accompanied by a 50% increase (P < 0.05) in plasma glucagon-to-insulin ratio. LIRA monotherapy reduced plasma glucagon concentration and inhibited EGP. In CANA/LIRA-treated patients, EGP increased by 15% (P < 0.05), even though the plasma insulin response was maintained at baseline and the CANA-induced rise in plasma glucagon concentration was blocked.CONCLUSIONSThese results demonstrate that liraglutide failed to block the increase in EGP caused by canagliflozin despite blocking the rise in plasma glucagon and preventing the decrease in plasma insulin concentration caused by canagliflozin. The failure of liraglutide to prevent the increase in EGP caused by canagliflozin explains the lack of additive effect of these two agents on HbA1c. Full Article
era Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and All-Cause Mortality for Widely Used Antihyperglycemic Dual and Triple Therapies for Type 2 Diabetes Management: A Cohort Study of All Danish Users By care.diabetesjournals.org Published On :: 2020-04-01T06:54:34-07:00 OBJECTIVEThe vast number of antihyperglycemic medications and growing amount of evidence make clinical decision making difficult. The aim of this study was to investigate the safety of antihyperglycemic dual and triple therapies for type 2 diabetes management with respect to major adverse cardiovascular events, severe hypoglycemia, and all-cause mortality in a real-life clinical setting.RESEARCH DESIGN AND METHODSCox regression models were constructed to analyze 20 years of data from the Danish National Patient Registry with respect to effect of the antihyperglycemic therapies on the three end points.RESULTSA total of 66,807 people with type 2 diabetes were treated with metformin (MET) including a combination of second- and third-line therapies. People on MET plus sulfonylurea (SU) had the highest risk of all end points, except for severe hypoglycemia, for which people on MET plus basal insulin (BASAL) had a higher risk. The lowest risk of major adverse cardiovascular events was seen for people on a regimen including a glucagon-like peptide 1 (GLP-1) receptor agonist. People treated with MET, GLP-1, and BASAL had a lower risk of all three end points than people treated with MET and BASAL, especially for severe hypoglycemia. The lowest risk of all three end points was, in general, seen for people treated with MET, sodium–glucose cotransporter 2 inhibitor, and GLP-1.CONCLUSIONSFindings from this study do not support SU as the second-line treatment choice for patients with type 2 diabetes. Moreover, the results indicate that adding a GLP-1 for people treated with MET and BASAL could be considered, especially if those people suffer from severe hypoglycemia. Full Article
era Effect of Cost and Formulation on Persistence and Adherence to Initial Metformin Therapy for Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-04-06T09:03:16-07:00 Full Article
era Novel Use of GLP-1 Receptor Agonist Therapy in HNF4A-MODY By care.diabetesjournals.org Published On :: 2020-04-07T07:46:27-07:00 Full Article
era Acrylamide Exposure and Oxidative DNA Damage, Lipid Peroxidation, and Fasting Plasma Glucose Alteration: Association and Mediation Analyses in Chinese Urban Adults By care.diabetesjournals.org Published On :: 2020-04-28T14:58:19-07:00 OBJECTIVEAcrylamide exposure from daily-consumed food has raised global concern. We aimed to assess the exposure-response relationships of internal acrylamide exposure with oxidative DNA damage, lipid peroxidation, and fasting plasma glucose (FPG) alteration and investigate the mediating role of oxidative DNA damage and lipid peroxidation in the association of internal acrylamide exposure with FPG.RESEARCH DESIGN AND METHODSFPG and urinary biomarkers of oxidative DNA damage (8-hydroxy-deoxyguanosine [8-OHdG]), lipid peroxidation (8-iso-prostaglandin-F2α [8-iso-PGF2α]), and acrylamide exposure (N-acetyl-S-[2-carbamoylethyl]-l-cysteine [AAMA], N-acetyl-S-[2-carbamoyl-2-hydroxyethyl]-l-cysteine [GAMA]) were measured for 3,270 general adults from the Wuhan-Zhuhai cohort. The associations of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α, and FPG were assessed by linear mixed models. The mediating roles of 8-OHdG and 8-iso-PGF2α were evaluated by mediation analysis.RESULTSWe found significant linear positive dose-response relationships of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α, and FPG (except GAMA with FPG) and 8-iso-PGF2α with FPG. Each 1-unit increase in log-transformed level of AAMA, AAMA + GAMA (UAAM), or 8-iso-PGF2α was associated with a 0.17, 0.15, or 0.23 mmol/L increase in FPG, respectively (P and/or P trend < 0.05). Each 1% increase in AAMA, GAMA, or UAAM was associated with a 0.19%, 0.27%, or 0.22% increase in 8-OHdG, respectively, and a 0.40%, 0.48%, or 0.44% increase in 8-iso-PGF2α, respectively (P and P trend < 0.05). Increased 8-iso-PGF2α rather than 8-OHdG significantly mediated 64.29% and 76.92% of the AAMA- and UAAM-associated FPG increases, respectively.CONCLUSIONSExposure of the general adult population to acrylamide was associated with FPG elevation, oxidative DNA damage, and lipid peroxidation, which in turn partly mediated acrylamide-associated FPG elevation. Full Article
era Strict Preanalytical Oral Glucose Tolerance Test Blood Sample Handling Is Essential for Diagnosing Gestational Diabetes Mellitus By care.diabetesjournals.org Published On :: 2020-04-29T13:46:01-07:00 OBJECTIVEPreanalytical processing of blood samples can affect plasma glucose measurement because on-going glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to an early centrifugation protocol. The effect of this change on the rate of gestational diabetes mellitus (GDM) diagnosis was determined.RESEARCH DESIGN AND METHODSAll pregnant women in the Australian Capital Territory (ACT) are recommended for GDM testing with a 75-g OGTT using the World Health Organization diagnostic criteria. From January 2015 to May 2017, OGTT samples were collected into sodium fluoride (NaF) tubes and kept at room temperature until completion of the test (delayed centrifugation). From June 2017 to October 2018, OGTT samples in NaF tubes were centrifuged within 10 min (early centrifugation).RESULTSA total of 7,509 women were tested with the delayed centrifugation protocol and 4,808 with the early centrifugation protocol. The mean glucose concentrations for the fasting, 1-h and 2-h OGTT samples were, respectively, 0.24 mmol/L (5.4%), 0.34 mmol/L (4.9%), and 0.16 mmol/L (2.3%) higher using the early centrifugation protocol (P < 0.0001 for all), increasing the GDM diagnosis rate from 11.6% (n = 869/7,509) to 20.6% (n = 1,007/4,887).CONCLUSIONSThe findings of this study highlight the critical importance of the preanalytical processing protocol of OGTT blood samples used for diagnosing GDM. Delay in centrifuging of blood collected into NaF tubes will result in substantially lower rates of diagnosis than if blood is centrifuged early. Full Article
era Is U.S.-Mexico Cooperation on Migration Possible? By www.migrationpolicy.org Published On :: Mon, 08 Apr 2019 09:48:29 -0400 As the numbers of Central American migrants crossing into Mexico and the United States rises—putting migration front and center in the U.S.-Mexico relationship again—this event examines the opportunities for cooperation between the two countries, along with ways to improve U.S. and Mexican asylum systems, create new approaches to labor migration, address smuggling networks, and modernize border management. Full Article
era Federal judge declines to block COVID-19 abortion ban in Arkansas By www.upi.com Published On :: Thu, 07 May 2020 23:41:21 -0400 A federal court on Thursday denied a motion to block an Arkansas directive preventing patients from receiving abortion care. Full Article
era Electrolyte disorders in a young female following short-term omeprazole therapy By resources.medipacademy.com Published On :: 23 September 2018 08:07:02 A 29 years old female presented to us in the metabolic clinic of the University of Port Harcourt Teaching Hospital (UPTH) on account of a week history of easy fatigability, weakness, and lower extremity muscle cramps associated with numbness and tingling sensation in the peri-oral area, fingers and toes. Two weeks prior to the onset of her presenting symptoms, she had visited a local pharmaceutical shop on account of a distressing epigastric discomfort and was subsequently placed on daily oral omeprazole 20mg daily for a month by a pharmacist. She had been on the omeprazole medication for two weeks before her present symptoms manifested. Her past medical history was not suggestive of hypoparathyroidism nor pancreatitis. She was married with three children and has an uneventful family, social and obstetric histories. On examination, she was a healthy well-oriented young female with positive Trousseau’s, Chvostek’s and epigastric tenderness signs. Further Laboratory evaluation revealed she had low plasma magnesium, low plasma albumin-corrected calcium, and low serum parathyroid hormone levels, while other laboratory parameters were essentially normal. A diagnosis of omeprazole-induced electrolyte disorders (hypomagnesaemia and hypocalcaemia) associated with hypoparathyroidism was made following the review of her clinical examination and laboratory findings. She was subsequently managed with oral magnesium supplements following the withdrawal of the omeprazole medication (replaced with oral ranitidine), monitored weekly, and full recovery was achieved after three weeks. Full Article
era Amino acid swap may help wheat tolerate rising heat, scientists say By www.upi.com Published On :: Mon, 04 May 2020 17:18:55 -0400 British scientists said Monday that an amino acid swap can help protect wheat crops from rising heat due to global warming. Full Article
era Shifting Gears, Trump Administration Launches High-Profile Worksite Enforcement Operations By www.migrationpolicy.org Published On :: Wed, 24 Jan 2018 10:52:22 -0500 An unannounced sweep of 98 convenience stores by U.S. immigration authorities—resulting in the arrest of 21 unauthorized workers—may signal a new approach to worksite enforcement under the Trump administration, moving away from a strategy of paper-based audits that resulted in higher employer fines and fewer worker arrests. This article explores worksite enforcement over recent decades. Full Article
era How Can Parents Help Teach Generation Z Teens about Living in Uncertain Times? By psychcentral.com Published On :: Wed, 06 May 2020 10:30:09 +0000 The prolonged health and safety stressors of COVID-19 has many parents reaching out to mental health professionals with concern over their teenagers’ increased levels of anxiety. In the United States,... Full Article Children and Teens Parenting Child Development Coping Skills coronavirus COVID-19 Emotional Development pandemic Uncertainty
era [ Cell Phones & Plans ] Open Question : What is the closest android equivalent to the 1st generation iPhone SE? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:15:19 +0000 I am torn, I know it is time to upgrade my phone, but I don't know whether to upgrade to just accept the larger phone size and go with the 2nd gen SE or go with an android. I'd be interested to know what the closest equivalent android device there is to the 1st gen SE. I am open to a bigger screen size, but not a bigger phone. So, if there was an andriod that was all screen on the front, but was similar size to the original SE, I would be open to that. Full Article
era [ Politics ] Open Question : Trump supporters: Do you watch Disney and Pixar movies even though they carry hidden liberal agendas? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:23:37 +0000 Do you let your kids watch Disney and Pixar movies? They're all created by liberals. Full Article
era In Search of a New Equilibrium: Immigration Policymaking in the Newest Era of Nativist Populism By www.migrationpolicy.org Published On :: Wed, 07 Nov 2018 10:15:48 -0500 In many recent European and U.S. elections, candidates touting nativist populist and anti-immigrant platforms have enjoyed rising support. As populism moves from the fringes into the mainstream, this report takes stock of the economic and social forces driving its rise, the diverse ways populists are influencing immigration policymaking, and what it will take to build a new center around immigration and integration issues. Full Article
era Vulnerable to COVID-19 and in Frontline Jobs, Immigrants Are Mostly Shut Out of U.S. Relief By www.migrationpolicy.org Published On :: Fri, 24 Apr 2020 12:55:07 -0400 On the frontlines of responding to the COVID-19 pandemic yet also more disproportionately affected by the virus and with reduced health care access, immigrants in the United States have largely found themselves blocked from federal economic relief. As states and philanthropic groups seek to plug the gap, this article examines conditions and changing policies around immigration and the coronavirus response. Full Article
era The Future of Medicine: A New Era for Alzheimer's By rss.sciam.com Published On :: Tue, 14 Apr 2020 13:00:00 GMT It is time for a fresh approach to the illness -- Read more on ScientificAmerican.com Full Article Features Health Mind Neurological Health
era A New Era for Alzheimer's By rss.sciam.com Published On :: Wed, 15 Apr 2020 15:00:00 GMT Fresh approaches and hopeful clues in the search for novel therapies -- Read more on ScientificAmerican.com Full Article Mind Neurological Health
era Effective Psychological Therapy May Slow Cellular Aging By rss.sciam.com Published On :: Mon, 20 Apr 2020 10:45:00 GMT Cognitive-behavioral therapy improved both symptoms and markers of senescence in people with anxiety -- Read more on ScientificAmerican.com Full Article Advances Health The Body Mind Behavior & Society Cognition Mental Health The Sciences Biology
era Wars Ultimately Measure Tolerance of Pain By www.washingtonpost.com Published On :: Mon, 08 Jan 2007 00:00:00 EST Here's a question with three different answers. The first answer is derived from arithmetic. The second comes from common sense. The third is based on psychology. Full Article Opinions Wars Ultimately Measure Tolerance of Pain
era Investing in the Neighborhood: Changing Mexico-U.S. Migration Patterns and Opportunities for Sustainable Cooperation By www.migrationpolicy.org Published On :: Thu, 19 Sep 2019 16:25:58 -0400 Migration between Mexico and the United States has changed dramatically in recent years, but policies and political rhetoric in both countries have not always kept up. This report, which draws from discussions of a high-level Mexico-U.S. study group convened by MPI and El Colegio de México, explores this new migration reality and how the two governments could work more closely together to address shared policy challenges. Full Article
era Invertir en el vecindario: Cambios en los patrones de migración entre México y Estados Unidos y oportunidades para una cooperación sostenible By www.migrationpolicy.org Published On :: Fri, 20 Sep 2019 11:03:45 -0400 La migración entre México y Estados Unidos ha cambiado dramáticamente en los últimos años, pero las políticas y la retórica política en ambos países no se han actualizado a este contexto a la misma velocidad. Este reporte explora esta nueva realidad migratoria y cómo los dos gobiernos podrían trabajar juntos para abordar los desafíos de políticas públicas que tienen en común. Full Article
era Chasing Efficiency: Can Operational Changes Fix European Asylum Systems? By www.migrationpolicy.org Published On :: Wed, 04 Mar 2020 10:08:27 -0500 Brussels is searching for bright ideas on how to fix the Common European Asylum System. While recent EU-level legal reforms have stalled, this report examines the many innovative, operations-focused approaches Member States have used since the 2015-16 migration crisis to improve registration and reception systems, asylum case processing, and options for returning failed asylum seekers. Full Article
era Immigrant Workers: Vital to the U.S. COVID-19 Response, Disproportionately Vulnerable By www.migrationpolicy.org Published On :: Thu, 26 Mar 2020 19:23:35 -0400 Six million immigrant workers are at the frontlines of keeping U.S. residents healthy and fed during the COVID-19 pandemic, representing disproportionate shares of physicians, home health aides, and retail-store pharmacists, for example. They also are over-represented in sectors most immediately devastated by mass layoffs, yet many will have limited access to safety-net systems and to federal relief, as this fact sheet details. Full Article
era Immigrants and the New Brain Gain: Ways to Leverage Rising Educational Attainment By www.migrationpolicy.org Published On :: Fri, 09 Jun 2017 13:24:43 -0400 A recent MPI study reveals that 48 percent of recent immigrants to the United States were college graduates, a sharp increase over earlier periods. How can the United States better leverage this brain gain? This commentary outlines some policies that could allow the United States to more fully utilize the professional and academic credentials that highly skilled immigrants have, for their benefit and that of the U.S. economy. Full Article
era Promoting Refugee Integration in Challenging Times: The Potential of Two-Generation Strategies By www.migrationpolicy.org Published On :: Wed, 12 Dec 2018 10:02:13 -0500 At a time when the U.S. refugee resettlement system is facing unprecedented challenges, innovative and cost-effective tools for supporting refugee integration are in demand. This report explores how a two-generation approach to service provision could help all members of refugee families—from young children to working-age adults and the elderly—find their footing. Full Article
era The Green Knowe Books & Multiculturalism in Children's Literature By brooklynbooktalk.blogspot.com Published On :: Sun, 30 Jun 2013 18:47:00 +0000 Recently while listening to WNYC, I heard a segment about the lack of diversity in children's literature. While the US's population is becoming more diverse, it is apparently not reflected in children's books. Lucy Maria Boston was a head of the curve since four of the Green Knowe books could be regarded as multicultural since they contain not only Asian and African main characters but also a physically disabled character and deal with the issues of slavery and exile due to war.Ping, a young refugee from Burma, is the main human character in A Stranger at Greene Knowe and a supporting character in The River at Green Knowe and An Enemy at Green Knowe. Ping has spent most of his life in a hostel for displaced children and goes to stay at Green Knowe during his summer holiday. He is eventually asked by Mrs. Oldknow to live with her and Tolly at Green Knowe. His experiences as a homeless child trapped in the grey world of the London home cause him to appreciate not only the natural world around the house but also to empathize with the escaped gorilla, Hanno. Boston wanted to dedicate Stranger to a gorilla keeper that she knew but was forbidden to do so by the zoo since it portrayed captivity for animals as cruel and harmful to the animal. When Green Knowe is under siege from evil in Enemy, Ping calls back Hanno with a traditional prayer to help save the house.Jacob, in Treasure at Green Knowe, is bought as a child in a slave auction by Captain Oldknowe as a companion for the Captain's blind daughter, Susan. Susan's mother is uninterested in Susan since she views her as an unmarriageable burden. Susan's blindness puts her outside of the normal constraints for an upper-class girl so she can spend her time climbing trees with Jacob and learning how to write with him and their tutor Jonathan. Susan's brother Sefton views Jacob as less than human, buying him clothes patterned on those of an organ-grinder's monkey. Both Jacob and Susan rely on each other to navigate the rules of a society that views them as worthless because of their respective race and disability. They work together to educate themselves and lead successful adult lives despite their differences in race, sex, and station.Despite the fifty or so years since they were written, the books still hold up due to the quality of the writing, the strong characterizations, and the universal themes. They are well-worth being placed on any reading list, multicultural or not. Good children's books should be read whether or not they are written by US authors. Full Article An Enemy at Green Knowe. children's literature Lucy Maria Boston multiculturalism River of Greeen Knowe Stranger at Green Knowe Treasure of Green Knowe
era Elementary Guide to Literary Criticism, by Franklin Newton Painter By brooklynbooktalk.blogspot.com Published On :: Thu, 02 Jan 2014 16:53:00 +0000 “As a rule,” urges Franklin Newton Painter in his critically acclaimed classic, Elementary Guide to Literary Criticism, “we should read only books of recognized excellence, and read them with sympathetic intelligence. Trashy books, whatever pleasure they may give, add but little to knowledge or culture; and immoral books often leave an ineradicable stain upon the soul.” The ideas of “recognized excellence,” “sympathetic intelligence” and “ineradicable stain upon the soul” make one wonder about the criteria by which Painter determines and advocates such notions. Although the criteria for evaluating literature are as old as Homer, they have undergone massive expansion in the 20th century. Besides, in view of new trends in literary theory and criticism, it is also worth pausing for a moment to reconsider the meaning of "theory" itself. According to the Norton Anthology of Theory and Criticism, today the term "theory" entails a mode of questioning and analysis that goes beyond the earlier criteria of "literariness" of literature. To an earlier generation, it seems that theory is more of an advocacy rather than a disinterested, objective inquiry into poetics of literature. Because of the effects new social movements, especially the women's and civil rights movements, theory now entails skepticism towards previously taken for granted systems, institutions, and norms. Now theory shows a readiness to take critical stands and to engage in resistance, an interest in blind spots, contradictions, and distortions, and a habit of linking local and personal practices to the larger economic, political, historical, and ethical forces of culture. How and why did that happen in the world of literature? Please join us at Brooklyn Book Talk, as we compare Painter’s classical criteria from the beginnings of the 20th century to newer perspectives such as formalism, Marxism, psychoanalysis, structuralism, post-structuralism, reader-response , feminism, deconstruction, queer theory, cultural studies, new historicism, post-colonial, race, and ethnicity studies, etcetera. The electronic version of Painter's Elementary Guide to Literary Criticism is in the public domain and can be accessed from Project Gutenberg online at: http://www.gutenberg.org/files/24326/24326-h/24326-h.htm Full Article
era Latinos & Immigrants in Kansas City Metro Area Face Higher Health Insurance Coverage Gaps, Even as They Represent Fast-Growing Share of Workforce By www.migrationpolicy.org Published On :: Tue, 19 Nov 2019 09:31:19 -0500 WASHINGTON — Latinos and immigrants are at least twice as likely to lack health insurance coverage as the overall population in three central Kansas City metro counties, a new Migration Policy Institute (MPI) study reveals. In fact, they are four times as likely to be uninsured in Johnson County, Kansas. Full Article
era What Should Successful Integration Look Like for Vulnerable Newcomers? By www.migrationpolicy.org Published On :: Wed, 08 Jan 2020 09:26:09 -0500 WASHINGTON — As host countries in Europe, North America and beyond prioritize getting refugees and other newly arrived migrants into work, another challenge has received less attention: Helping those who may never find jobs participate meaningfully in their new communities. Newcomers who are not in the workplace (particularly refugee women, migrants who are unskilled or illiterate and the elderly) are at high risk for social isolation. Full Article
era Get Top Statistics on Immigrants in the U.S and Changing Immigration Trends; MPI Updates its Interactive Data Tools, Maps & One-Stop Resource for Key Stats By www.migrationpolicy.org Published On :: Fri, 14 Feb 2020 14:36:44 -0500 WASHINGTON — The Migration Policy Institute (MPI) today published the annual update to its data-rich article, Frequently Requested Statistics on Immigrants and Immigration in the United States, offering readers a wealth of information that can help inform understanding about an issue that is the subject of much conversation. Full Article
era Immigrant Workers Are Vital to the U.S. Coronavirus Pandemic Response, But Disproportionately Vulnerable By www.migrationpolicy.org Published On :: Fri, 27 Mar 2020 15:29:22 -0400 WASHINGTON — Six million immigrant workers are at the frontlines of keeping U.S. residents healthy, safe and fed during the COVID-19 pandemic, according to a Migration Policy Institute (MPI) analysis of U.S. Census Bureau data issued today. While the foreign born represented 17 percent of the 156 million civilians working in 2018, they account for larger shares in pandemic-response frontline occupations: 29 percent of all physicians in the United States, 38 percent of home health aides and 23 percent of retail-store pharmacists, for example. Full Article
era As Millions Are Pushed from Jobs amid Pandemic, the Loss of Employer Health Coverage & Limited Access to Public Coverage for Many Immigrants Hold Major Implications for Them – and U.S. Overall By www.migrationpolicy.org Published On :: Thu, 07 May 2020 10:44:32 -0400 WASHINGTON – As more than 33 million U.S. workers have lost their jobs since March amid the pandemic-induced economic crisis, immigrants are among the most vulnerable: They are more likely than the U.S. born to be laid off and to live in communities with high COVID-19 infection rates, and less likely to have health insurance coverage and access to a doctor or other usual source of health care. Full Article
era Employment Services for Refugees: Leveraging Mainstream U.S. Systems and Funding By www.migrationpolicy.org Published On :: Wed, 08 Jan 2020 13:22:28 -0500 On this webinar, experts and state refugee resettlement program leaders discuss two activities that can be key parts of a broader strategy for sustaining and improving employment services for refugees: Partnerships with experts in workforce development strategies, and access to federal workforce development funding. Full Article
era COVID-19 in Latin America: Tackling Health Care & Other Impacts for Vulnerable Migrant Populations By www.migrationpolicy.org Published On :: Fri, 27 Mar 2020 10:58:29 -0400 This MPI webinar brought together public health and migration experts to analyze the impact that COVID-19 preventative measures will have on vulnerable immigrants and refugees in Latin America, with a particular look at Colombia as a case study. Speakers also discussed how policymakers and international organizations can include migrant populations in their emergency response plans. Full Article
era Reduction in Global Myocardial Glucose Metabolism in Subjects With 1-Hour Postload Hyperglycemia and Impaired Glucose Tolerance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study. RESEARCH DESIGN AND METHODS The myocardial metabolic rate of glucose (MRGlu) was measured by using dynamic 18F-fluorodeoxyglucose positron emission tomography combined with a euglycemic-hyperinsulinemic clamp in 30 volunteers without coronary artery disease. Three groups were studied: 1) those with 1-h postload glucose <155 mg/dL (NGT 1-h low) (n = 10), 2) those with NGT 1-h high (n = 10), 3) and those with IGT (n = 10). RESULTS After adjusting for age, sex, and BMI, both subjects with NGT 1-h high (23.7 ± 6.4 mmol/min/100 mg; P = 0.024) and those with IGT (16.4 ± 6.0 mmol/min/100 mg; P < 0.0001) exhibited a significant reduction in global myocardial MRGlu; this value was 32.8 ± 9.7 mmol/min/100 mg in subjects with NGT 1-h low. Univariate correlations showed that MRGlu was positively correlated with insulin-stimulated whole-body glucose disposal (r = 0.441; P = 0.019) and negatively correlated with 1-h (r = –0.422; P = 0.025) and 2-h (r = –0.374; P = 0.05) postload glucose levels, but not with fasting glucose. CONCLUSIONS This study shows that myocardial insulin resistance is an early defect that is already detectable in individuals with dysglycemic conditions associated with an increased risk of type 2 diabetes, such as IGT and NGT 1-h high. Full Article
era Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate whether high glucose levels in the normoglycemic range and higher have a causal genetic effect on risk of retinopathy, neuropathy, nephropathy, chronic kidney disease (CKD), peripheral arterial disease (PAD), and myocardial infarction (MI; positive control) in the general population. RESEARCH DESIGN AND METHODS This study applied observational and one-sample Mendelian randomization (MR) analyses to individual-level data from 117,193 Danish individuals, and validation by two-sample MR analyses on summary-level data from 133,010 individuals from the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), 117,165 from the CKDGen Consortium, and 452,264 from the UK Biobank. RESULTS Observationally, glucose levels in the normoglycemic range and higher were associated with high risks of retinopathy, neuropathy, diabetic nephropathy, PAD, and MI (all P for trend <0.001). In genetic causal analyses, the risk ratio for a 1 mmol/L higher glucose level was 2.01 (95% CI 1.18–3.41) for retinopathy, 2.15 (1.38–3.35) for neuropathy, 1.58 (1.04–2.40) for diabetic nephropathy, 0.97 (0.84–1.12) for estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, 1.19 (0.90–1.58) for PAD, and 1.49 (1.02–2.17) for MI. Summary-level data from the MAGIC, the CKDGen Consortium, and the UK Biobank gave a genetic risk ratio of 4.55 (95% CI 2.26–9.15) for retinopathy, 1.48 (0.83–2.66) for peripheral neuropathy, 0.98 (0.94–1.01) for eGFR <60 mL/min/1.73 m2, and 1.23 (0.57–2.67) for PAD per 1 mmol/L higher glucose level. CONCLUSIONS Glucose levels in the normoglycemic range and higher were prospectively associated with a high risk of retinopathy, neuropathy, diabetic nephropathy, eGFR <60 mL/min/1.73 m2, PAD, and MI. These associations were confirmed in genetic causal analyses for retinopathy, neuropathy, diabetic nephropathy, and MI, but they could not be confirmed for PAD and seemed to be refuted for eGFR <60 mL/min/1.73 m2. Full Article
era Epigenetic Link Between Statin Therapy and Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To investigate the role of epigenetics in statins’ diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers in an epigenome-wide association study in blood. RESEARCH DESIGN AND METHODS Five cohort studies’ participants (n = 8,270) were classified as statin users when they were on statin therapy at the time of DNAm assessment with Illumina 450K or EPIC array or noncurrent users otherwise. Associations of DNAm with various outcomes like incident type 2 diabetes, plasma glucose, insulin, and insulin resistance (HOMA of insulin resistance [HOMA-IR]) as well as with gene expression were investigated. RESULTS Discovery (n = 6,820) and replication (n = 1,450) phases associated five DNAm sites with statin use: cg17901584 (1.12 x 10–25 [DHCR24]), cg10177197 (3.94 x 10–08 [DHCR24]), cg06500161 (2.67 x 10–23 [ABCG1]), cg27243685 (6.01 x 10–09 [ABCG1]), and cg05119988 (7.26 x 10–12 [SC4MOL]). Two sites were associated with at least one glycemic trait or type 2 diabetes. Higher cg06500161 methylation was associated with higher fasting glucose, insulin, HOMA-IR, and type 2 diabetes (odds ratio 1.34 [95% CI 1.22, 1.47]). Mediation analyses suggested that ABCG1 methylation partially mediates the effect of statins on high insulin and HOMA-IR. Gene expression analyses showed that statin exposure and ABCG1 methylation were associated with ABCG1 downregulation, suggesting epigenetic regulation of ABCG1 expression. Further, outcomes insulin and HOMA-IR were significantly associated with ABCG1 expression. CONCLUSIONS This study sheds light on potential mechanisms linking statins with type 2 diabetes risk, providing evidence on DNAm partially mediating statins’ effects on insulin traits. Further efforts shall disentangle the molecular mechanisms through which statins may induce DNAm changes, potentially leading to ABCG1 epigenetic regulation. Full Article
era Employment Services for Refugees: Leveraging Mainstream U.S. Systems and Funding By www.migrationpolicy.org Published On :: Mon, 27 Jan 2020 16:53:00 -0500 On this webinar, experts and state refugee resettlement program leaders discuss activities that can be key parts of a broader strategy for sustaining and improving employment services for refugees, including partnerships with experts in workforce development strategies, access to federal workforce development funding, and other policies and resources. Full Article