Although the progressive histologic steps leading to endometrial cancer (EndoCA), the most common female reproductive tract malignancy, from endometrial hyperplasia are well-established, the molecular changes accompanying this malignant transformation in a single patient have never been described. We had the unique opportunity to investigate the paired histologic and molecular features associated with the 12-yr development of EndoCA in a postmenopausal female who could not undergo hysterectomy and instead underwent progesterone treatment. Using a specially designed 58-gene next-generation sequencing panel, we analyzed a total of 10 sequential biopsy samples collected over this time frame. A total of eight pathogenic/likely pathogenic mutations in seven genes, APC, ARID1A, CTNNB1, CDKN2A, KRAS, PTEN, and TP53, were identified. A PTEN nonsense mutation p.W111* was present in all samples analyzed except histologically normal endometrium. Apart from this PTEN mutation, the only other recurrent mutation was KRAS G12D, which was present in six biopsy samplings, including histologically normal tissue obtained at the patient's first visit but not detectable in the cancer. The PTEN p.W111* mutant allele fractions were lowest in benign, inactive endometrial glands (0.7%), highest in adenocarcinoma (36.9%), and, notably, were always markedly reduced following progesterone treatment. To our knowledge, this report provides the first molecular characterization of EndoCA development in a single patient. A single PTEN mutation was present throughout the 12 years of cancer development. Importantly, and with potential significance toward medical and nonsurgical management of EndoCA, progesterone treatments were consistently noted to markedly decrease PTEN mutant allele fractions to precancerous levels.

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JUDY WOODRUFF: Longstanding rivalries were re-ignited in Iraq today between vital American allies.

Iraqi military forces and militia moved to push Kurdish forces out of the disputed city of Kirkuk in the country’s north.

Lisa Desjardins begins our coverage.

MAN (through interpreter): The commander in chief of the armed forces, Dr. Haider al-Abadi, gave orders to protect the people of Kirkuk and to impose security in the city.

LISA DESJARDINS: After months of simmering tensions, Iraqi federal troops moved to retake the disputed city of Kirkuk from Kurdish forces.

The effort launched before dawn. By midday, Iraqi soldiers, along with state-backed militias, quickly took control of several massive oil fields north of the city. Iraqis also captured Kirkuk’s military airport and various government buildings. They lowered what had been a symbolic Kurdish flag at the governor’s compound.

Journalist Rebecca Collard in Irbil was in Kirkuk this morning.

REBECCA COLLARD, Journalist: You could hear some clashes, some gunfire in the distance, but for the most part, the city seemed more or less abandoned. Now, the Iraqi army, by the end of today, was essentially in control of the whole city and many of the outskirts of Kirkuk.

LISA DESJARDINS: The spokesman for an Iraqi Shiite militia said they achieved all their goals with little resistance.

AHMED AL-ASSADI,  Spokesman for al-Hashed al-Shaabi (through translator): As the troops approached the area, they were confronted by some rebels, who tried to hinder the progress of the advancing units. Our troops returned fire and silenced its source.

LISA DESJARDINS: This comes three weeks after the Kurds held a nonbinding independence referendum that included the disputed province of Kirkuk.

More than 90 percent of the Kurdish region’s residents voted to split from Iraq. The Iraqi federal government, Turkey, Iran and the U.S. all rejected the independence drive.

The multiethnic region of Kirkuk lies just outside of the autonomous Kurdish region in Iraq’s north. Called the country’s oil capital, Kirkuk produces around 500,000 barrels a day.

In 2014, amid the ISIS onslaught across Northern Iraq, the Kurds took control of Kirkuk, as the Iraqi military fled the city. In the three years since, the Kurds, led by their president, Massoud Barzani, sought to cement their hold, despite tensions with the central government.

Today, Kurdish officials accused Iraq of carrying out a major multipronged attack.

MAJ. GEN. AYOUB YUSUF SAID, Peshmerga Commander (through interpreter): I don’t know what is happening exactly, because we have been in this fight since 4:00 in the morning. We have suffered casualties, including martyrs, and now we have withdrawn to this position. Some of the other Kurdish forces have pulled out. They didn’t fire a single shot.

LISA DESJARDINS: While Kurdish forces withdrew from posts south of the city, some residents vowed to die fighting. Thousands of others fled north.

REBECCA COLLARD: For the last few years, the Iraqi forces, these primarily Shia militia, the Hashed Shaabi, and the Kurdish forces have been focused on fighting ISIS. Now that fight is coming to an end, and what the fear is that now these internal division in Iraq are going to become more apparent and possibly more violent.

LISA DESJARDINS: These clashes pit one substantially American-armed military force against another. Both the Kurdish forces and Iraqi government troops are part of the coalition fighting ISIS. The U.S. sought to downplay the fighting, labeling the exchange of gunfire a misunderstanding.

And, in the Rose Garden, President Trump tried to stay neutral.

PRESIDENT DONALD TRUMP: We don’t like the fact that they’re clashing. We’re not taking sides. But we don’t like the fact that they’re clashing.

LISA DESJARDINS: For the PBS NewsHour, I’m Lisa Desjardins.

JUDY WOODRUFF: For more, I’m joined now by Emma Sky. She served as an adviser to General David Petraeus while he was commander of U.S. forces in Iraq from 2007 to 2010, and by Feisal Istrabadi. He’s a former Iraqi ambassador to the United Nations and he helped write Iraq’s interim constitution.

Welcome to both of you.

Let me start with you, Emma Sky.

This has happened so quickly. What exactly has the Iraqi government done?

EMMA SKY, Yale University: The Iraqi government has deployed its forces back up north into Kirkuk.

And since 2003, the Kurds have made it clear that they want to include Kirkuk within their territory in order to proceed with gaining independence, which has always been their goal. But Kirkuk is important to Iraq itself, and no Iraqi prime minister can afford to lose Kirkuk.

So you can see this reaction that has taken place following the referendum on independence, which happened September the 25th, and also included the disputed territories and the city of Kirkuk.

JUDY WOODRUFF: Feisal Istrabadi, what can you add to why the Iraqi government is so set on taking over the city?

FEISAL ISTRABADI, Former Deputy UN Ambassador, Iraq: Well, a couple of reasons.

First, as Emma just said, it is a part of the disputed territories, which are legally and constitutionally under the jurisdiction of the federal government in Baghdad. The KRG expanded into these disputed territories at the time when ISIL was expanding its territory, and then began to take steps to unilaterally declare that these areas were now incorporated into the Kurdistan region, including when it held the referendum that Emma talked about.

It included holding the referendum in these disputed territories. Now, so long as Iraq — so long as we’re talking about a single country, it matters a little less who controls Kirkuk, but once the referendum was held, this gave rise then to the second reason for Baghdad choosing to act now.

As Emma said, Kirkuk is an important oil-producing zone in Iraq. And it is vital for the economic viability of an independent Kurdish state and an important part of the economic viability of the Iraqi state. So there was never going to be a scenario, I think, in which Baghdad would allow a unilateral exercise of control by Kurds to occur over Kirkuk, so long as independence is on the table.

JUDY WOODRUFF: Emma Sky, we heard President Trump say today the U.S. is not taking sides in this.

Is that accurate, that the U.S. isn’t taking sides? What is the U.S. role here?

EMMA SKY: Well, the U.S. has stipulated over and over again that its policy is to support a united Iraq.

So you can see the U.S. has given support to Iraqi security forces, but also to the Kurdish Peshmerga, to fight against ISIS. The U.S. policy for the last few years has really been focused on ISIS and not on the day after ISIS.

But what we’re witnessing at the moment is that different groups are already moving to the day after, which is the power struggle for control of different territories in Iraq.

And Barzani believed that during the fight against ISIS, he became stronger because he got weapons directly from the international community. And, as Feisal said, he was able to extend his control over the disputed territories.

He’s also facing domestic problems within Kurdistan. There are tensions between the different Kurdish groups, and some believe that Barzani has overstayed his term as president.

JUDY WOODRUFF: Which reminds us just how complicated this is, Feisal Istrabadi.

What does the Iraqi central government want here? They’re not going to get rid of the Kurds. What is it that they want?

FEISAL ISTRABADI: Oh, well, I mean, the Kurds of course are a vital part of Iraq. They’re a vital part of the political process, and they have been represented in Baghdad. The president of Iraq is a Kurd and has been since 2005.

I think what needs to occur and I hope what the government of Iraq wants is a negotiated settlement, in which no party dictates terms to the other, but a negotiated settlement.

Look, Irbil has some legitimate agreements with respect to Baghdad. Baghdad has some legitimate agreements with respect to Irbil. I think we need a mediator perhaps or somebody to convene a roundtable — the United States is who I’m thinking of, of course — to address some of those issues.

Most of the issues are, from the Irbil side, economic issues of payments, and from Baghdad’s side, transparency of how much oil Irbil is producing and exporting, which Irbil has never accounted for to Baghdad.

I think if those issues are resolved, perhaps hopefully some of these other issues can at least be delayed for another day. But at the end of the day, neither government — neither the regional government nor the federal government in Baghdad can really tolerate dictation of terms to it by the other side. My hope is that a negotiated settlement obtains.

JUDY WOODRUFF: Emma Sky, where do you see this going from here? Do you see the peace that different sides have worked to hard to create in Iraq unraveling as a result of this?

EMMA SKY: I think there is an opportunity for a deal, and I think the sort of deal that could be negotiated is one that looks at a special status for the city of Kirkuk and negotiated terms for Kurdistan’s separate, whether that be towards confederation or towards independence.

But there needs to be negotiation. There needs to be a look at where should the border between Iraqi Kurdistan and the rest of Iraq actually be, and that requires mediation district by district through those territories.

JUDY WOODRUFF: Well, we know there are other players who are playing an important role here in Iran and Turkey, and this is all very much playing out as we watch, watch it happen in Iraq.

Emma Sky, Feisal Istrabadi, thank you very much.

FEISAL ISTRABADI: Thank you.

EMMA SKY: Thank you.

The post Why a power struggle has broken out over Kirkuk appeared first on PBS NewsHour.

Kelley makes a Morgen Wonk. Chris loves the smell of Gundam in the morning. Phil plays some Mathfinder while listening to his favorite new band, Creepy Lego Waifus. The cake has arrived.

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Enshrouded has received what developers Keen Games are calling the survival game's "most sizable" update yet, sizable being an appropriate word for mountains. Expect a new playable area, the Alabaneve Summits, with its own enemies, resources, non-threatening wildlife and quests. The maximum character level has risen to 35! There are new townsfolk to find and place in your poorly built houses! You can tame animals, and make them live in poorly built houses too! You can get hypothermia!

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Great God Grove is, in a word, bonkers. I’ve stopped a small community from completing a blood ritual, played the role of matchmaker to a group of lonely hearts that involved organising a date with god, and plastered a statue with paint as part of a revolutionary movement to uplift the power of art. My time with GGG has been a pick n’ mix of colourful escapades, and together with its story of godly woes, striking art style, vacuum-based puzzle-solving, and nightmare-inducing puppet work, I’m now a die-hard LimboLane devotee.

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Google has built a quantum computer that makes fewer errors as it is scaled up, and this may pave the way for machines that could solve useful real-world problems for the first time

Google DeepMind claims its AlphaChip AI method can deliver “superhuman” chip designs that are already used in its data centres – but independent experts say public proof is lacking

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The Competition Bureau has announced that it has expanded its investigation into Google’s online ad practices. This is the first major update to the investigation since it began in 2020, and a year later the competition watchdog obtained a court order from the Federal Courts of Appeal, requiring Google to produce records and written information […]

As traditional web search falters, OpenAI offers an AI-based alternative.

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But the streaming gaming revolution "is not going to happen overnight."

Adjacent angles are one of the earliest and most important concepts to learn in basic geometry, as they have applications in further subjects like trigonometry, physics, and engineering. Effective students of geometry should be able to identify adjacent angles on sight and calculate them to a great degree of accuracy without a protractor.

Two congruent angles are simply pairs of angles with equal measures. You can find congruent angles examples in hundreds of everyday objects.

If you're looking for an excellent midrange smartphone for yourself or a loved one among all the early Black Friday deals, your search may be over. Google's Pixel 8a is on sale. It has dropped by $100 to $399.

That's not quite the lowest price we've seen for the handset. It fell to $380 at one point. But this is still a good deal if you're looking for a great phone that won't break the bank. This price is for a configuration with 128GB of storage, but 256GB models are also $100 off at $459.

The Pixel 8a is our pick for the best midrange smartphone overall. We gave it a score of 90 in our review.

Thanks to Google's inclusion of the Tensor G3 chip, the Pixel 8a supports many of the same AI features that you'll find on flagship Pixel devices. We feel that the cameras are excellent, while that 6.1-inch 120Hz OLED display sure looks pretty.

The Pixel 8a has great battery life too. It lasted for 20 hours and 29 minutes in our video rundown test, actually beating out the Pixel 8 by 13 minutes. On the downside, wireless charging is pretty slow as it maxes out at 7.5W.

The bezels are a little thicker than you might like too, but otherwise the design is fairly slick. Another plus point is that the Pixel 8a is IP67-rated for dust and water resistance, so it should be somewhat durable.

Check out all of the latest Black Friday and Cyber Monday deals here.

If you use Chrome on your iPhone, you’re about to see some features sliding over from the Android version. Google Lens will let you add text to your image searches, and you can save files and pictures directly to Google Drive and Photos. You can get “Shopping Insights” for products you’re browsing.

Chrome for iOS now lets you add words to your Google Lens visual searches, allowing you to add nuance to your query or “perform more complex and specific searches,” as Chrome Product Manager Katia Muradyan wrote in a blog post. After activating Lens by tapping the camera icon in the Chrome search bar, you can ask questions about the object you’re snapping a pic of, and it will produce corresponding results. Google says AI Overviews will also appear for some of these search results.

The feature shares some common ground with an Apple Intelligence feature for iPhone 16 owners in iOS 18.2, which is currently in beta. Visual Intelligence lets you point your camera at something and get info about it, including asking ChatGPT questions about it or searching for it on Google.

Chrome for iPhone now has a feature that lets you save a file directly to Google Drive or Google Photos, sparing you from using your phone’s internal storage. When saving files from Chrome, you’ll see a new option to save the file to Drive. Similarly, when browsing a photo you want to save, long-press on it, and you’ll see a new “Save in Google Photos” option in the context menu. Of course, the feature requires you to be signed into a Google account.

Chrome for iOS also adds a feature that pops up a mini-map when you click on an address. Look for an underlined link to specific addresses; clicking on it will take you to the mini-map without leaving the browser.

Finally, Google is adding Shopping Insights for US users. The company frames it as a way to help you find great prices on items you’re shopping for, but it’s hard to imagine this feature exists strictly from the kindness of Google's heart. Regardless, you’ll soon see a “Good Deal Now” alert in Chrome’s address bar when browsing for products for which it’s available. You’ll see details like price history / tracking and buying options if you tap it.

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The prime minister has announced that a byelection will be held in the federal seat of Cloverdale-Langley City, in B.C.'s Lower Mainland, on Dec. 16.

La vedette colombienne du reggaeton Karol G s’est excusée pour des paroles de son nouveau single «+57» jugées offensantes.

A plan to penalise public hospitals for procedures that resul­t in errors is proving harder than first thought.

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Rob Riggle Stars alongside Brice Williams in the newest Easter Seals Dixon Center PSA, directed by Jim Fabio with support from Judd Apatow

Actor/comedian Rob Riggle announces his next breakfast move as the Holiday Inn Express brand�s Creative Director � BREAKFA-mojis!

With a Keurig� in every room at Holiday Inn Express� hotels, smart travelers � like actor/comedian Rob Riggle � can get a great cup of coffee with just the push of a button.

Think you know who the most accomplished American in history is? I bet you don't. She just passed, and this year for Memorial Day we take a serious moment to remember her.

Check out the latest developer updates for Google Earth and Google Maps Platform, including grounding with Maps.

Here are all the latest updates for Google Maps, Earth, Waze and our developer platforms.

Learn about Google's four-pillar health strategy aimed at improving global health.

Here's how we built adaptive audio in Meet, which transforms multiple laptops in close proximity into a unified audio system so you can create ad-hoc meeting spaces IRL.

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Vivek Ramaswamy: पूर्व रिपब्लिकन राष्ट्रपति पद के उम्मीदवार विवेक रामास्वामी, निर्वाचित राष्ट्रपति डोनाल्ड ट्रंप की एक घोषणा के बाद Google पर सबसे ज्यादा खोजे जाने वाले नामों में से एक बन गए हैं कि विवेक रामास्वामी। अरबपति एलन मस्क के साथ

Google DeepMind has been using its AI watermarking method on Gemini chatbot responses for months – and now it’s making the tool available to any AI developer

Never underestimate what a single gopher can achieve in a day: one of the burrowing mammals helped boost soil fungi in an area blanketed by ash from the explosive eruption of Mount St Helens in Washington state

AI and Google Street View have created 'digital twins' of living trees in North American cities – part of a huge simulation that could help make urban tree planting and trimming decisions

Компания запустила Google новую модель искусственного интеллекта Gemini, которая может помочь сократить разрыв в гонке с OpenAI. .

Теперь история о перемещении пользователя Google Maps будет храниться на локальных устройствах и компания не сможет выдать ее полиции даже после получения ордера. .

Как уже знают те, кто читал «Лёгкий способ бросить курить», ответ на то, как легко бросить Google действительно есть — им надо перестать пользоваться. Сейчас это будет относительно безболезненно. Если вы живёте в России, то проблема может быть даже не в том, что что-то заблокируют из РФ.

Разнообразьте любые переговоры необычными фонами в Zoom для удаленщиков, которые ценят искусство. В артпаке фоны от иллюстраторов, фотографов и дизайнеров, а также инструкция, как установить их себе.

Продолжение поста...

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A new grant from Google’s philanthropic arm will help researchers develop a tool to bolster water security and climate resilience in the Middle East and North Africa.

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