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The Inter-Congolese Dialogue: Political Negotiation or Game of Bluff?




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The Burundi Rebellion and the Ceasefire Negotiations




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Giving the gospel to theatregoers

A performing arts outreach team shares Christ with crowds gathered to watch their street performances every evening during the Avignon Festival.




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Raise and Give for Bosnia-Herzegovina

Mathilde, a French teen, describes her trip to Bosnia-Herzegovina. She and others will raise funds for a youth centre where Bosnian teens can discover God.




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Diego from Chile: skater for Jesus

OM Chile's skateboard ministry in Santiago is bearing fruit. Skater Diego gave his life to Jesus, after becoming friends with OM'er Yerko Clavero.




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Division of the Arts Announces New Focus for Two FY2021 Grant Categories

Grants from community-based organizations and schools that have a trauma-informed focus will receive funding priority Wilmington, Del. (January 24, 2020) – As part of its FY2021 grant application cycle, the Division of the Arts invites grant proposals from community-based organizations and schools that demonstrate the utilization of the arts to address trauma-related issues and challenges […]




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Diego Maradona Autographs Shirt To Help Buenos Aires Poor

The Argentina national team jersey signed by Diego Maradona is being raffled to those who have given donations in an initiative that has collected hygiene products, masks and around 100 kilograms of...




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Delaware remains first in key agricultural categories, Census shows

Delaware farmers are among the most productive and efficient in the nation, with the First State remaining first in the nation in the value of agricultural products sold per acre, according to U.S. Census of Agriculture data released Friday.




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Conor McGregor to monitor UFC 249 'health and safety' as he eyes July return - manager

Conor McGregor will be a keen observer of this weekend's UFC 249 event according to his manager Audie Attar, who says that the Irishman wants to gauge the UFC's health and safety measures before entertaining a return to the cage.
Read Full Article at RT.com




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'I like to face guys that have COUNTRIES behind them': Floyd Mayweather leaves door open to Khabib, McGregor boxing bouts (VIDEO)

While he says he has no interest in facing a top-ranked boxer, Floyd Mayweather is refusing to rule out a fight with the likes of Conor McGregor or Khabib Nurmagomedov, as long as the money is right.
Read Full Article at RT.com




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Suzuki Jimny Sierra made of Lego looks stunning: Fully-functional and off-road capable!

The Suzuki Jimny has developed a huge fan following especially after the introduction of its latest generation iteration. Currently, on sale in select international markets, the demand for this compact off-roader is such that Suzuki dealerships in some countries, recently, had to temporarily suspend new bookings in order to clear the existing backlog.




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Religare to exit AEGON Religare Life Insurance

Religare to exit AEGON Religare Life Insurance Company




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Breezy and 35 F at Fulton, Oswego County Airport, NY


Winds are from the West at 23.0 gusting to 34.5 MPH (20 gusting to 30 KT). The pressure is 1012.4 mb and the humidity is 54%. The wind chill is 23. Last Updated on May 9 2020, 11:54 am EDT.




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Oregon: No large gatherings through September

Large gatherings at sports and other events in Oregon should either be canceled or significantly modified through September because of the coronavirus pandemic, Gov. Kate Brown announced Thursday.




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Virtuosity: Can You Build Lego Masterpieces with All Blocks of One Size?

The way you need blocks of different sizes and styles to build great Lego masterpieces, a complex WSP-based design requires stitching together routing regions with multiple patterns that follow different WSSPDef periods. Let's see how you can achieve this. (read more)





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San Diego Airport installs 2 MW/4 MWh storage system to complement existing PV array

Yesterday, ENGIE Storage announced that San Diego International Airport (SAN) installed a 2 MW/4 MWh GridSynergy energy storage system. Paired with the airport’s existing 5.5 MW of solar capacity, the new energy storage system will reduce energy charges during peak demand, which according to ENGIE equate to approximately 40 percent of the airport’s monthly electricity costs. The system is expected to begin operation in early 2020.




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A-Class vs. CLA-Class, Lego Porsche builds bonds, mobile fast-charging future: What's New @ The Car Connection

2020 Mercedes-Benz A-Class vs 2020 Mercedes-Benz CLA-Class: Compare Cars If you can’t get the lord to buy you a Mercedes-Benz, you have to do it yourself, and that can really stretch the budget. Mercedes answers that issue with its two lowest-priced cars, the A-Class and CLA-Class. IIHS reports that new Jeep Wrangler SUV rolled over on its...



  • Today in Car News

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Crowdfunding Sites That Allow True Investment in Renewable Energy and Sustainability: Alternatives to Kickstarter & Indiegogo

Crowdfunding has become a popular tool for people and organizations to use to test out their new ideas for green products while securing funds to begin operations. The most well-known crowdfunding websites, Kickstarter and Indiegogo, have helped a significant amount of projects in renewable energy and sustainability get off the ground, projects that have been the focus of previous installments in my ongoing articles series about crowdfunding in energy.




ego

San Diego Airport installs 2 MW/4 MWh storage system to complement existing PV array

Yesterday, ENGIE Storage announced that San Diego International Airport (SAN) installed a 2 MW/4 MWh GridSynergy energy storage system. Paired with the airport’s existing 5.5 MW of solar capacity, the new energy storage system will reduce energy charges during peak demand, which according to ENGIE equate to approximately 40 percent of the airport’s monthly electricity costs. The system is expected to begin operation in early 2020.




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Plugging Away: San Diego’s Plan to “Charge” Toward a Cleaner Grid

We love electric vehicles (EVs) in California and we want that love to spread. Why? It isn’t because of the cool factor — though, believe me, EVs like the Tesla are undoubtedly cool. Instead, it’s because these cars can offer significant benefits to the environment, electric grid, and economy.




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Bosnia and Herzegovina Power Market Outlook to 2030 - Market Trends, Regulation and Competitive Landscape

The Report Bosnia and Herzegovina Power Market Outlook to 2030 - Market Trends, Regulation and Competitive Landscape provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz





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Lawbite: No place for the real world in this business rates negotiation

Telereal Trillium v Hewitt (Valuation Officer) [2019] UKSC 23 By a majority 3:2 decision, the Supreme Court has overturned the decision of the Court of Appeal in the case of Telereal Trillium v Hewitt (Valuation Officer) [2018] EWCA Civ 26. The case...




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An introduction to contracts - what to look out for when negotiating

We will look at the legal essentials for contract formation and the meaning of some common clauses found in contracts. ...




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Negotiating isn’t mandatory for Contracting Authorities

As Contracting Authorities will be aware, in circumstances where the Negotiated Procedure is used, they are able to negotiate with tenderers in order that their tenders can be adapted to meet the requirements in the contract notice, the specificatio...




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Germany fears a hard Brexit, as UK moves away from political negotiations

German Foreign Minister Heiko Maas said in a newspaper interview on Saturday there was a growing risk of a hard Brexit in the midst of the coronavirus crisis as negotiations between Britain and the European Union so far on the future trade relationship had yielded hardly any progress.




ego

Scapegoating the WHO as the CHO

Now is not the time to demonize and defund the WHO.




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US-China trade negotiators vow to save phase one deal on first call during pandemic

Top trade negotiators from the United States and China spoke by phone on Friday and vowed to continue to support the phase one trade deal, Chinese state media reported, in their first contact since the agreement was signed in January.On the call, China’s Vice-Premier Liu He, US Treasury Secretary Steven Mnuchin and US Trade Representative Robert Lighthizer “vowed to implement their trade deal and boost cooperation on public health”, the official Xinhua News Agency reported.The officials said…




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Cash payments to category-III beneficiaries begin

Islamabad : Ehsaas Emergency Cash payments to category-III beneficiaries which were identified through district administrations began on Friday.The Ehsaas Emergency Cash disbursements have been ongoing for the last one month and so far, Rs89.143 billion have been distributed cumulatively for...




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Dentons advises CPI Property Group on acquisition of a majority stake in Chałubińskiego 8 office building

Dentons’ Real Estate team advised CPI Property Group (CPI), the largest commercial property owner in the Czech Republic, Berlin and the CEE region, on the acquisition of a 50.3% share in the ownership of Chałubińskiego 8 office building in Warsaw. The divestment was made by First Property Group, an investment company and the manager of real estate funds operating in Great Britain and Central Europe.




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JBL Celebrates 100 Million Headphones Sold while Announcing its entry into the Gaming Category

CES 2020, LAS VEGAS – JANUARY 6, 2020 – HARMAN International Industries, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, is announcing its entry into the gaming...




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Mathematician Eugenia Cheng on the abstract wonder of category theory

Once thought too abstract, category theory has become remarkably pervasive in science, says mathematician and pianist Eugenia Cheng




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Oregon governor plans minimum wage hike

The minimum wage in Portland could increase to $15.52 an hour, and $13.50 an hour in the rest of the state, according to a plan unveiled by Oregon Governor, Kate Brown. Jillian Kitchen reports.




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San Diego opera singer swaps concert stage for front porch

Opera singer Victoria Robertson is accustomed to performing on stages much bigger than the five-foot wide front porch of her San Diego home. But with concert venues closed and work at a standstill due to the coronavirus pandemic, she decided to make the most of it.




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Lego-based robot sanitizer created at refugee camp

Refugees at the Zaatari camp in Jordan have designed a robot prototype made from LEGOs, which automatically dispenses sanitizer to avoid contact with the bottle and help prevent the spread of the coronavirus.




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Lego-based robot sanitizer created at refugee camp

Refugees at the Zaatari camp in Jordan have designed a robot prototype made from LEGOs, which automatically dispenses sanitizer to avoid contact with the bottle and help prevent the spread of the coronavirus.




ego

Christmas crafts: How to make a stegosaurus ornament from a satsuma

Next time you peel yourself a citrus fruit, follow our guide to make your own unique and memorable scientific baubles




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Claims of categorical primacy for musical affect are confounded by using language as a measure [Social Sciences]

Cowen et al. (1) leverage modern gains in data science to describe impressive cross-cultural similarities in the perception of musical affect and do so in unprecedented detail. Their approach is innovative and fundamentally empirical. As such, it should have important applications for prediction in the field of affective computing, which...




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A Mechanistic and Translational Pharmacokinetic-Pharmacodynamic Model of Abicipar Pegol and Vascular Endothelial Growth Factor Inhibition [Drug Discovery and Translational Medicine]

Abicipar pegol (abicipar) is a novel DARPin therapeutic and highly potent vascular endothelial growth factor (VEGF) inhibitor intended for the treatment of neovascular age-related macular degeneration (nAMD). Here we develop a translational pharmacokinetic/pharmacodynamic (PK/PD) model for abicipar to guide dosing regimens in the clinic. The model incorporated abicipar-VEGF binding kinetics, VEGF expression levels, and VEGF turnover rates to describe the ocular and systemic PK data collected from the vitreous, aqueous humor (AH), choroid, retina, and serum of rabbits after a 1-mg abicipar intravitreal (IVT) dose. The model was translated to humans using human-specific mechanistic parameters and refitted to human serum and AH concentrations from patients with diabetic macular edema and nAMD. The model was then used to simulate 8-, 12- (quarterly), and 16-week dosing intervals in the clinic. Simulations of 2 mg abicipar IVT at 8-week or quarterly dosing in humans indicates minimum steady-state vitreal concentrations are maintained above both in vitro IC50 and in vivo human IC50 values. The model predicted virtually complete VEGF inhibition for the 8-week and quarterly dosing schedule during the 52-week treatment period. In the 16-week schedule, clinically significant VEGF inhibition was maintained during the 52-week period. The model quantitatively described abicipar-VEGF target engagement leading to rapid reduction of VEGF and a long duration of VEGF inhibition demonstrating the clinical feasibility of up to a 16-week dosing interval. Abicipar is predicted to reduce IVT dosing compared with other anti-VEGF therapies with the potential to lessen patient treatment burden.

SIGNIFICANCE STATEMENT

Current anti-VEGF treatments for neovascular age-related macular degeneration require frequent (monthly) intravitreal injections and monitoring, which increases patient burden. We developed a mechanistic pharmakinetic/pharmadynamic model to describe the interaction between abicipar (a novel VEGF inhibitor) and VEGF to evaluate the duration of action. The model demonstrates extended abicipar-VEGF target engagement leading to clinical feasibility of up to a 16-week dosing interval. Our model predicted that abicipar 8-week and quarterly dosing schedules maintain virtually complete VEGF inhibition during the 52-week period.




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For Sale The Garden Townhouse Lavila Kien A- Nha Be District- 216.11sqm- The Negotiable Price

FOR SALE THE GARDEN TOWNHOUSE LAVILA KIEN A- NHA BE DISTRICT - Location: is the right facade of the main street, at the corner. - West- North direction - Land area: 8x17.6 m, corner: 136 sqm - Floor area: 216.11 sqm - Structure: a ground floor, 2 floors - Including 4 bedrooms, 5 ...




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Nam Long Villa For Rent in Phu My Hung-Tan Phong Ward-Dist 7- 425 sqm- Negotiable Price

NAM LONG VILLA FOR RENT IN PHU MY HUNG- TAN PHONG WARD- DISTRICT 7 - Including 5 bedrooms, 1 basement, 2 floors, 1 loft - Sauna, swimming pool, karaoke room, gym - Area: 17*25 - The Rental Price : contact Please do not hesitate to contact me via 0907894503 Mr.Le for further infor...




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Selling My Thai Villa In Phu My Hung- Tan Phu Ward -Dist 7- 162 sqm- The Negotiable Price

SELLING MY THAI VILLA IN PHU MY HUNG- DISTRICT 7 - Area : 9 x 18 m - Including a ground floor, 2 floors, a nice house - The house is designed 4 bedrooms, 5 bathrooms, nice furniture - Having the garden with a fish pond inside - Location: facade on 17th street, opposite to the par...




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Selling Chateau Villa In Phu My Hung- Tan Phu Ward- District 7- 612 sqm- The NegotiablePrice

FOR SALE CHATEAU VILLA IN PHU MY HUNG- TAN PHU WARD- DISTRICT 7 - Land area: 612 sqm - Floor area: 1000 sqm - Garden and riverside area: 1000 sqm - The villa is designed a basement, a ground floor, 3 floors, luxury furniture - Having 7 large bedrooms, 8 toilets - Selling price: c...




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Selling Goldview apartment in Van Don Port - Ward 1 - District 4 - 120 sqm - Negotiable

Selling Goldview Apartment In Van Don Port- Ward 1- District 4 - Address: 346 Van Don Port - Area: 120 sqm, on the seventh floor - Having 3 bedrooms, 2 bathrooms, fully furnished - The Selling Price: Contact Please do not hesitate to contact us via 0907894503 Mr Le for consulting...




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The Hotel For Rent In Phu My Hung- Tan Phong Ward- Dist 7- 333 sqm- The Negotiable price

THE HOTEL FOR RENT IN PHU MY HUNG- TAN PHONG WARD - DISTRICT 7 - Area : 18 x 18.5 m - A new house has 36 rooms, a basement, bar club - Including a basement, a ground floor, a mezzanine, 4 floors - The Rental Price: contact Please contact us via 0907894503 Hoa Le Green House for ...




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Townhouse for rent at No.78 Tan My Street Tan Phu Ward District 7 - 100 sqm - Negotiable Price

Townhouse for rent at No.78 Tan My Street Tan Phu Ward District 7 - Area : 5m * 20m - Including a ground floor, 3 floors, a terrace - Deposit is 3 month, paid 2 month The Rental Price: contact Please do not hesitate to contact us via 0907894503 for the best price and exact inform...




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Tips to negotiate asking price like a pro

Negotiating isn’t that dissimilar from playing a game – it involves reading your opponent, strategizing, and then striking.




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How to Negotiate Your Rent

Whether you’re looking for a new place to rent or it’s time to renew your lease, now might be a great time to consider negotiating your rent.




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CNN's David Gregory calls out Donald Trump's 'ego and insecurity' after attack on press at coronavirus briefing

Follow our live coronavirus updates HERE Coronavirus: The symptoms