ine Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00660G, Review ArticleShutang Li, Jinfei YangAs research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3395-3417DOI: 10.1039/D4MD00334A, Research ArticleVu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh ThanhD-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3469-3476DOI: 10.1039/D4MD00422A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim NenckaSARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3477-3484DOI: 10.1039/D4MD00266K, Research ArticleRaitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps JaudzemsThe aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024) By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3371-3394DOI: 10.1039/D4MD00384E, Review ArticleDebasis Das, Lingzhi Xie, Jian HongProspects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00471J, Research ArticlePoorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar ShrivastavaScreening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00608A, Research ArticleSunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo MathewA total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00594E, Research ArticleNagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza ElrayessOne benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00562G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. StevensFlow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00632A, Review ArticleAshish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder KumarThe present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00619D, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00555D, Research ArticleShenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong LiuThe continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00670D, Research ArticleYuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen ZhouIn the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00614C, Research ArticleVijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip BanerjiThe development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00663A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin KrátkýLinking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00553H, Research ArticleStefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro CosconatiNon-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ine Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:25:49 +0530 Full Article Tiruchirapalli
ine Art and literary contests lined up for District Central Library’s National Library Week By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:07:57 +0530 Full Article Tiruchirapalli
ine Nagapattinam MP presses for new express trains, railway line extensions By www.thehindu.com Published On :: Sat, 09 Nov 2024 20:34:19 +0530 Full Article Tiruchirapalli
ine 558: Esoteric Weird Content Editable Problems with Kristin Valentine By shoptalkshow.com Published On :: Mon, 27 Mar 2023 07:34:54 +0000 Kristin Valentine from Vox joins the show to talk about text editor CMS fun across multiple sites, Vox's Chorus, The Verge redesign, sharing Design Systems, theming articles, and a fun new game called "Can Your Text Editor Do This??" Full Article All Episodes CMS editor vox
ine 576: Blocks, Components, Linting Images, Engines, and “Web Integrity” By shoptalkshow.com Published On :: Tue, 01 Aug 2023 16:59:09 +0000 We're talking how we stay online - or not - on vacation, is create-guten-block the future for us WP developers? Can we get a state of the web component address from the President of web components? Have we seen the last new browser engine? And deciding whether to add features or remove them from your app. Full Article All Episodes Luro Web Components web integrity api
ine 589: CSS Functions, Read It Later, Making Money in Business, and More By shoptalkshow.com Published On :: Mon, 30 Oct 2023 07:28:10 +0000 A quick bit of union news follow up, CSS function round up, Read It Later inside Feedbin, fun uses for a Stream Deck+, how to turn up the money dial in your own business, and having the audacity to call yourself a publisher. Full Article All Episodes CSS Feedbin Making Money Read It Later
ine 605: Jim Nielsen on Subversive URLs, Blogging + AI, and Design Engineers By shoptalkshow.com Published On :: Mon, 04 Mar 2024 08:53:29 +0000 Jim Nielsen joins us to about URLs and linking as the new subversive way to maintain the web, paying for news in Canada, should content creators be worried about AI, the case for design engineers, RSS in HTML, and the state of state and UI. Full Article All Episodes AI Blogging linking rss
ine 616: Strum Machine with Luke Abbott By shoptalkshow.com Published On :: Mon, 20 May 2024 08:09:58 +0000 Luke Abbott is the creator of Strum Machine, an app that simulates backing tracks by stitching together individual notes, chords, and strums recorded on guitar, standup bass, and mandolin. We talk about what Strum Machine does, why he decided to build it, how bringing on a professional designer helped, pricing thoughts, and the "fun" of building a version on iOS. Full Article All Episodes app banjo music
ine 628: Tending to RSS Feeds, Code Hike’s Fine Markdown, and Cloudflare R2 By shoptalkshow.com Published On :: Mon, 12 Aug 2024 07:04:48 +0000 Doc told me to travel but there's COVID on the planes, Dave's got a 2x life update, how often do you manage or prune your RSS feed subscriptions, checking in on Code Hike and their fine grained Markdown approach, JavaScript decorators use case, and using Cloudflare R2 for image storage. Full Article All Episodes Cloudflare covid-19 dogs markdown R2 rss
ine 633: Thomas Steiner on AI in Chrome and the Web By shoptalkshow.com Published On :: Mon, 16 Sep 2024 09:30:53 +0000 Thomas Steiner from Project Fugu talks with us about AI in Chrome, the small large language model in use, how features like this are rolled out, the ethics and concerns around sending and sharing data, on device vs web APIs, and ideas for use cases and ways to explore AI on the web. Full Article All Episodes AI Chrome Fugu
ine 636: W Hot Drama Week (WordPress, WP Engine, and Web Components – Oh My!) By shoptalkshow.com Published On :: Mon, 07 Oct 2024 07:55:29 +0000 We're getting some feelings out about WordPress and Matt Mullenweg vs WP Engine drama, as well as the Web Components conversation that happened this past week. Full Article All Episodes HotDrama Matt Mullenweg Web Components Wordpress
ine Sunshine cities By www.thehindu.com Published On :: Fri, 26 Dec 2014 17:19:51 +0530 Kochi and Thiruvananthapuram are among the 60 cities that have received in principle approval from the Union Ministry of New and Renewable Energy to be developed as Solar Cities, writes K.A. Martin Full Article Green Living
ine Guidelines for green urbanisation By www.thehindu.com Published On :: Fri, 02 Oct 2015 21:12:45 +0530 The Ministry of Urban Development has proposed environmental guidelines for construction projects in urban areas. Nidhi Adlakha reports Full Article Property Plus
ine Why we need lane discipline By www.thehindu.com Published On :: Fri, 18 Dec 2015 12:49:08 +0530 Stick to the left lane when making a turn, even in smaller lanes Full Article Property Plus
ine A premium for cleanliness By www.thehindu.com Published On :: Fri, 26 Feb 2016 15:16:24 +0530 If you’re looking at buying a home, take a pick from one of India’s cleanest cities. Full Article Property Plus
ine Ferrari's Leclerc fined for swearing By www.rediff.com Published On :: Stewards at the Brazilian race summoned Leclerc on Friday, acting on a report from the governing FIA's media delegate and after reviewing a written transcript. Full Article
ine The last thing business founders need is a wasteful public spat By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 As entrepreneurship explodes in India, we need more iconic founders who not only build sustainable firms but also retain their humility Full Article Emerging Entrepreneurs
ine Flat organisation believers: Can you imagine a world without managers? By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:24:36 +0530 What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important? Full Article Corporate File
ine Cargo companies upsize for new business By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 19:43:00 +0530 Booming demand for ecommerce delivery spurs freight handlers to open more centres, digitise for efficiency Full Article Logistics
ine Senior feline resident: Defib stays at his ambulance station By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 21:19:43 +0530 Online petition halts re-homing of 16-year-old cat in London Full Article Pulse
ine Making medicines at the point of patient care By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 18:52:12 +0530 UK readies law allowing preparation of medicines near hospital setting to reach patients safely, quickly Full Article Pulse
ine Planned meals, personal trainer, and a tea for every reason By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 19:20:49 +0530 Personal fitness diary Full Article Pulse
ine Delhi election: AAP to hold nine-day convention for party workers By www.thehindu.com Published On :: Thu, 07 Nov 2024 01:05:04 +0530 Full Article Delhi
ine Delhi cop Nidhin Valsan’s inspiring journey from arresting cancer to Ironman finish line By www.thehindu.com Published On :: Fri, 08 Nov 2024 02:05:22 +0530 Diagnosed with stage 4 non-Hodgkin’s lymphoma in 2021, IPS officer Nidhin Valsan resurrected himself by competing the Ironman triathlon and writing his memoir because he hopes to be a good influence on other cancer patients Full Article Delhi
ine Delhi HC imposes ₹10,000 fine on advocate for casting aspersions on judge By www.thehindu.com Published On :: Sun, 10 Nov 2024 00:37:52 +0530 Full Article Delhi
ine Delhi Cabinet passes proposal for reinstatement of bus marshals By www.thehindu.com Published On :: Mon, 11 Nov 2024 01:37:48 +0530 Full Article Delhi
ine ARRL Members Raise $47,000 for STEM Education in Online Auction By www.arrl.org Published On :: Fri, 01 Nov 2024 15:23:00 -0500 ARRL® The National Association for Amateur Radio® is pleased to announce that the 19th annual ARRL Online Auction, sponsored by RT Systems Inc, raised $47,000 for amateur radio STEM education. The event was held from October 18- 24, 2024. In addition to hundreds of views, the auction saw 329 individual bidders vying for equipment, vintage books, “mystery junk boxes” from the ARRL Lab, and more.... Full Article
ine Amazon is designed to spin like a flywheel: Brian Dumaine By www.thehindubusinessline.com Published On :: Mon, 06 Jul 2020 08:01:00 +0530 In Bezonomics, the Fortune jounralist explains how Jeff Bezos has shrewdly changed the way business is done in today’s world Full Article Books
ine Can India arrest income inequality? By www.thehindubusinessline.com Published On :: Sun, 26 Jul 2020 20:12:21 +0530 Thomas Piketty’s prescriptions are too radical. Dattopant Thengadi’s vision is more useful for us Full Article Books
ine Values that make a business tick By www.thehindubusinessline.com Published On :: Sun, 27 Sep 2020 20:34:27 +0530 The authors use their experience to show that business should be about ethics, dharma and more Full Article Books
ine Cashing out of a business, smartly By www.thehindubusinessline.com Published On :: Sun, 09 May 2021 20:04:10 +0530 The book draws upon diverse experiences of entrepreneurs to highlight the need for an exit strategy Full Article Books
ine The inevitability of uncertainty By www.thehindubusinessline.com Published On :: Sun, 16 May 2021 20:07:22 +0530 The book tells us quite convincingly that the future is unknown. But it does not offer an alternative Full Article Books
ine International conference to recommend policies to address gender inequality at farms By www.thehindu.com Published On :: Sat, 07 Oct 2023 03:43:00 +0530 “The conference aims to promote the sharing of cutting-edge knowledge on gender and inclusion in agri-food systems.” Full Article India