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Assembly of ionic supramolecular polymers using a decacationic pillar[5]arene to noncovalently crosslink hyaluronic acid for short DNA delivery

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00447G, Research Article
Qian Li, Danying Ma, Yue-Yang Liu, Hui Wang, Wei Zhou, Dan-Wei Zhang, Zhan-Ting Li
A multicationic pillar[5]arene noncovalently crosslinks hyaluronic acid to afford ionic supramolecular polymers for intramolecular delivery of short DNA.
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The content of this RSS Feed (c) The Royal Society of Chemistry




luro

5,6-Di­methyl­benzo[d][1,3]oxatellurole

The structure of the title compound, C9H10OTe, at 100 K has ortho­rhom­bic (P21212) symmetry with two independent mol­ecules in the asymmetric unit (Z' = 2). The mol­ecules are folded along their Te⋯O axes, with their Te–C–O planes angled at an average of 25.1° with respect to the remaining non-H atoms, which are almost coplanar (average deviation from planarity = 0.04 Å). A Hirshfeld plot shows weak inter­molecular inter­actions between the two Te atoms located in each asymmetric mol­ecule, with a Te⋯Te distance of 3.7191 (4) Å. The structure is strongly pseudosymmetric to the space group Pccn with Z' = 1. The crystal chosen for data collection was found to be was an inversion twin.




luro

Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology [Glycobiology and Extracellular Matrices]

The extracellular matrix encompasses a reservoir of bioactive macromolecules that modulates a cornucopia of biological functions. A prominent body of work posits matrix constituents as master regulators of autophagy and angiogenesis and provides molecular insight into how these two processes are coordinated. Here, we review current understanding of the molecular mechanisms underlying hyaluronan and HAS2 regulation and the role of soluble proteoglycan in affecting autophagy and angiogenesis. Specifically, we assess the role of proteoglycan-evoked autophagy in regulating angiogenesis via the HAS2-hyaluronan axis and ATG9A, a novel HAS2 binding partner. We discuss extracellular hyaluronan biology and the post-transcriptional and post-translational modifications that regulate its main synthesizer, HAS2. We highlight the emerging group of proteoglycans that utilize outside-in signaling to modulate autophagy and angiogenesis in cancer microenvironments and thoroughly review the most up-to-date understanding of endorepellin signaling in vascular endothelia, providing insight into the temporal complexities involved.




luro

Phenylboronate-salicylate ester cross-linked self-healing hydrogel composed of modified hyaluronan at physiological pH

Soft Matter, 2024, 20,2926-2936
DOI: 10.1039/D3SM01417G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ryotaro Miki, Tsutomu Yamaki, Masaki Uchida, Hideshi Natsume
A self-healing hydrogel can be easily prepared at physiological pH by using phenylboronic acid-modified hyaluronic acid and salicylic acid-modified hyaluronic acid.
The content of this RSS Feed (c) The Royal Society of Chemistry




luro

548: Infinite Canvas, Luro + Figma, and Scraping or Crawling

What's going to happen to homework with AI? Thoughts on infinite canvas which leads into Luro and Sigma integration, and Chris gets nerdsniped and tries to scrap (or should he crawl?) websites for data.




luro

Engineering galactose oxidase for efficient cascade synthesis of L-guluronic acid from D-glucose

Catal. Sci. Technol., 2024, Advance Article
DOI: 10.1039/D4CY00697F, Paper
Qingxiu Wang, Weisong Liu, Lijing Chang, Kuncheng Zhang, Yanbing Shen, Lingling Zhang
A synthetic pathway of L-guluronic acid and rational design of galactose oxidase.
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The content of this RSS Feed (c) The Royal Society of Chemistry




luro

Superstar Ingredient Sodium Hyaluronate More Effective Than Hyaluronic Acid

Sodium Hyaluronate, synthesized salt form of hyaluronic acid. Sodium Hyaluronate is water-soluble and has a smaller molecule structure allowing it to penetrate deeper into the skin. Hyaluronic acid cannot be absorbed by or penetrate the skin.




luro

Dot & Key Water Drench Hydrating Hyaluronic Acid Serum Concentrate

As usual, my dilemma for finding the perfect moisturizer has not yet solved. So, after using the hyaluronic acid serum (Marine Hyaluronics) from The Ordinary, this is my second hyaluronic acid serum and I was and was completely unsure of what to expect. The best part is I am writing the review almost a month […]

The post Dot & Key Water Drench Hydrating Hyaluronic Acid Serum Concentrate appeared first on Perfect Skin Care for you.




luro

Hyaluronic acid based copolymers

Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.




luro

Hyaluronic acid based copolymers

Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.




luro

Injectable dual cross-linked adhesive hyaluronic acid multifunctional hydrogel scaffolds for potential applications in cartilage repair

Polym. Chem., 2020, Advance Article
DOI: 10.1039/D0PY00371A, Paper
Chenxi Yu, Huichang Gao, Qingtao Li, Xiaodong Cao
A double crosslinked hydrogels was designed and prepared by combining the Diels–Alder click reaction and possessed good mechanical strength, injectability and adhesion.
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The content of this RSS Feed (c) The Royal Society of Chemistry




luro

Self-crosslinking smart hydrogels through direct complexation between benzoxaborole derivatives and diols from hyaluronic acid

Polym. Chem., 2020, Advance Article
DOI: 10.1039/D0PY00308E, Paper
Tamiris Figueiredo, Yu Ogawa, Jing Jing, Vanina Cosenza, Isabelle Jeacomine, Johan D. M. Olsson, Thibaud Gerfaud, Jean-Guy Boiteau, Craig Harris, Rachel Auzély-Velty
By tailoring the structure of benzoxaborole (BOR), self-crosslinking hydrogels based on hyaluronic acid (HA) modified with BOR derivatives are obtained for the first time through the direct BOR-HA diol complexation at physiological pH.
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The content of this RSS Feed (c) The Royal Society of Chemistry




luro

Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44

J. Mater. Chem. B, 2020, 8,3880-3885
DOI: 10.1039/D0TB00407C, Paper
Sara Amorim, Iva Pashkuleva, Celso A. Reis, Rui L. Reis, Ricardo A. Pires
We developed hyaluronic acid (HA):poly-L-lysine (PLL) layer-by-layer (LbL) constructs whose viscoelastic properties and bioactivity can be finely tuned by using polyanions of different molecular weight and/or crosslinking.
The content of this RSS Feed (c) The Royal Society of Chemistry




luro

[ASAP] Green Synthetic Approach for Photo-Cross-Linkable Methacryloyl Hyaluronic Acid with a Tailored Substitution Degree

Biomacromolecules
DOI: 10.1021/acs.biomac.0c00196




luro

Correlation of Hierarchical Structure and Rheological Behavior of Polypseudorotaxane Gel Composed of Pluronic and β-cyclodextrin

Soft Matter, 2020, Accepted Manuscript
DOI: 10.1039/D0SM00406E, Paper
kuo-chih Shih, Chien-You Su, Shing-Yun Chang, Grethe V Jensen, Chi-Chung Hua, Mu-Ping Nieh, Hsi-Mei Lai
We have identified the hierarchical (primary, secondary, tertiary and quaternary) structures of a polypseudorotaxane (PPR) gel composed of Pluronic F108 and β-cyclodextrin system to be β-cyclodextrin crystalline, lamellar sheets, lamellar...
The content of this RSS Feed (c) The Royal Society of Chemistry




luro

Multi-praseodymium-and-tungsten bridging octameric tellurotungstate and its 2D honeycomb composite film for detecting estrogen

Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR01901A, Paper
Yan Zhang, Jun JIang, Yifan Liu, Pan Li, Yong Liu, Lijuan Chen, Junwei Zhao
Under coordination driving force of tungsten and rare-earth (RE) bridges, we synthesized a novel giant multi-tungsten-and-RE—bridging octameric tellurotungstate (TT) [H2N(CH3)2]16K8Na6H10[Pr8(H2O)20W16O48][B-α-TeW9O33]8·70H2O (1) in CH3CN-H2O mixed solvent. The cluster anion {[Pr8(H2O)20W16O48][B-α-TeW9O33]8}40– features...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effective atherosclerotic plaque inflammation inhibition with targeted drug delivery by hyaluronan conjugated atorvastatin nanoparticles

Nanoscale, 2020, 12,9541-9556
DOI: 10.1039/D0NR00308E, Paper
Seyedmehdi Hossaini Nasr, Zahra Rashidijahanabad, Sherif Ramadan, Nate Kauffman, Narayanan Parameswaran, Kurt R. Zinn, Chunqi Qian, Ripla Arora, Dalen Agnew, Xuefei Huang
Atherosclerosis is associated with inflammation in the arteries. Hyaluronan atorvastatin nanoparticle conjugate could target CD44 overexpressed in atherosclerotic plaques and significantly reduce plaque associated inflammation.
The content of this RSS Feed (c) The Royal Society of Chemistry




luro

The Top wrap of an Alluro box brand cigar by A. Santaella Cigar Company.




luro

[ASAP] Interaction with Cartilage Increases the Viscosity of Hyaluronic Acid Solutions

ACS Biomaterials Science & Engineering
DOI: 10.1021/acsbiomaterials.0c00100