The interplay between the genetic makeup of crops and the conditions in which they grow is difficult to untangle. A research team led by an Iowa State University professor aims to help breeders analyze the interactions to make crops more resilient and productive.

Dafoe, L T; Dickie, K; Williams, G L. GAC-MAC-IAH-CNC-CSPG, Halifax 2022; 2022 p. 79
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210585.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210585.jpg" title="GAC-MAC-IAH-CNC-CSPG, Halifax 2022; 2022 p. 79" height="150" border="1" /></a>

We read the stories of the Holy Martyr George (celebrated this Sunday April 23, along with St. Thomas Sunday) in the light of Job, Isaiah and Revelation 12, seeing him as a mirror to our victorious Lord, who cleansed the chaotic waters of all that lurked there, and trampled down death by death.

We argue that employees who perceive that they are provided with a safe climate at work within which to voice their concerns and suggestions about work-related issues or problems will not only be more engaged employees but will also be likely to be more engaged and involved members of their communities. By focusing on the importance of employee voice opportunities, in work organizations, we seek to build our understanding of how to create "positive" organizations that contribute to the building of human potential, both inside the organizational setting and outside in our communities and societies. We also consider how employee voice opportunities in for-profit organizations may be influenced by the law and prevailing attitudes about corporate governance.

The University of Cambridge invites for applications for a Research Associate to work on EU-BON, a major EU-funded research project seeking to improve the use of biodiversity data in public policy.

Applicants should have a PhD in a relevant social science or conservation science. Experience in both qualitative and quantitative analysis is desirable. Applicants should ideally have some first-hand experience of public policy processes and a willingness to travel within the European Union for research. Excellent organisational and communication skills will be essential in working as a successful part of this large, multi-partner and multinational team.

The researcher will carry out research on how biodiversity data is currently used in European policy making and will contribute to analysis of the opportunities to increase its effective provision and use. Research methods are likely to combine qualitative and quantitate analysis and to focus on the use of biodiversity data in public policy contexts. It is expected that some of the research will take place in Brussels. The researcher will have considerable freedom in defining the research project in discussion with Dr Doubleday and Prof Sutherland. In addition to carrying out research on the use of biodiversity data in European policy making, the researcher will support Cambridge's contribution to EU BON as a whole. This will involve contributing to other workpackages as and when required. More information about EU BON can be found here: http://www.eubon.eu

Fixed-term: The funds for this post are available for 36 months in the first instance.

Completed applications consisting of a CHRIS/6 (Parts I & III) (downloadable from http://www.admin.cam.ac.uk/offices/hr/forms/chris6/) a covering letter, and CV, should be sent to Danielle Feger, via email: geogrec@hermes.cam.ac.uk or sent to Research Administrator, Department of Geography, Downing Site, Cambridge, CB2 3EN

Please quote reference LC01355 on your application and in any correspondence about this vacancy.

Any enquiries concerning the position can be made to Dr Robert Doubleday, rob.doubleday@csap.cam.ac.uk

For more information about the position, please visit: http://www.jobs.cam.ac.uk/job/1611/

A second WP4 (Link environment to biodiversity: analyses of patterns, processes and trends) meeting was held on 8 & 9 December 2014 in Brussels, to discuss progress towards objectives and set plans for future development.

Hot topics during the meeting were: GBIF data: who will use them, and how; development and use of methodology; collaboration between WP4 and the relevant WP3 (Improving tools and methods for data analysis and interface) and WP5 (EU BON testing and validation of concepts, tools, and services); as well ways to translate WP4 results for the use of policy and practice.

Image: Participants at the meeting;  Credit: Dirk Schmeller

A new research paper Linking Earth Observation and taxonomic, structural and functional biodiversity: Local to ecosystem perspectives published in the journal Ecological Indicators looks at the ways in which earth observation (EO) techniques may provide a solution to overcome shortcomings in biodiversity monitoring by measuring entities of interest at different spatial and temporal scales. 

Abstract: 

Impacts of human civilization on ecosystems threaten global biodiversity. In a changing environment, traditional in situ approaches to biodiversity monitoring have made significant steps forward to quantify and evaluate BD at many scales but still, these methods are limited to comparatively small areas. Earth observation (EO) techniques may provide a solution to overcome this shortcoming by measuring entities of interest at different spatial and temporal scales.

This paper provides a comprehensive overview of the role of EO to detect, describe, explain, predict and assess biodiversity. Here, we focus on three main aspects related to biodiversity taxonomic diversity, functional diversity and structural diversity, which integrate different levels of organization molecular, genetic, individual, species, populations, communities, biomes, ecosystems and landscapes. In particular, we discuss the recording of taxonomic elements of biodiversity through the identification of animal and plant species. We highlight the importance of the spectral traits (ST) and spectral trait variations (STV) concept for EO-based biodiversity research.

Furthermore we provide examples of spectral traits/spectral trait variations used in EO applications for quantifying taxonomic diversity, functional diversity andstructural diversity. We discuss the use of EO to monitor biodiversity and habitat quality using differ-ent remote-sensing techniques. Finally, we suggest specifically important steps for a better integrationof EO in biodiversity research.EO methods represent an affordable, repeatable and comparable method for measuring, describing,explaining and modelling taxonomic, functional and structural diversity. Upcoming sensor developmentswill provide opportunities to quantify spectral traits, currently not detectable with EO, and will surelyhelp to describe biodiversity in more detail. Therefore, new concepts are needed to tightly integrate EOsensor networks with the identification of biodiversity. This will mean taking completely new directionsin the future to link complex, large data, different approaches and models.

Original reseach:

A. Lausch, L. Bannehr, M. Beckmann, C. Boehm, H. Feilhauer, J.M. Hacker, M. Heurich, A. Jung, R. Klenke, C. Neumann, M. Pause, D. Rocchini, M.E. Schaepman, S. Schmidtlein, K. Schulz, P. Selsam, J. Settele, A.K. Skidmore, A.F. Cord, Linking Earth Observation and taxonomic, structural and functional biodiversity: Local to ecosystem perspectives, Ecological Indicators, Volume 70, November 2016, Pages 317-339, ISSN 1470-160X, http://dx.doi.org/10.1016/j.ecolind.2016.06.022

The post Co-knowledge production linking science, communities and public policy under deep uncertainty in a modern risk society in Japan was curated by information for practice.

Categorization underlies understanding. Conceptualizing solid-state structures of organic molecules with `archetype crystal structures' bridges established categories of disorder, polymorphism and solid solutions and is herein extended to special position and high-Z' structures. The concept was developed in the context of disorder modelling [Dittrich, B. (2021). IUCrJ, 8, 305–318] and relies on adding quantum chemical energy differences between disorder components to other criteria as an explanation as to why disorder – and disappearing disorder – occurs in an average structure. Part of the concept is that disorder, as probed by diffraction, affects entire molecules, rather than just the parts of a molecule with differing conformations, and the finding that an R·T energy difference between disorder archetypes is usually not exceeded. An illustrative example combining disorder and special positions is the crystal structure of oestradiol hemihydrate analysed here, where its space-group/subgroup relationship is required to explain its disorder of hydrogen-bonded hydrogen atoms. In addition, we show how high-Z' structures can also be analysed energetically and understood via archetypes: high-Z' structures occur when an energy gain from combining different rather than overall alike conformations in a crystal significantly exceeds R·T, and this finding is discussed in the context of earlier explanations in the literature. Twinning is not related to archetype structures since it involves macroscopic domains of the same crystal structure. Archetype crystal structures are distinguished from crystal structure prediction trial structures in that an experimental reference structure is required for them. Categorization into archetype structures also has practical relevance, leading to a new practice of disorder modelling in experimental least-squares refinement alluded to in the above-mentioned publication.

Several years ago, biologists discovered a new type of genetic material known as long noncoding RNA. This RNA does not code for proteins and is copied from sections of the genome once believed to be "junk DNA."

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John Galt Solutions has launched Galt Connect, a hub connecting Atlas Planning Platform customers with technology partners and solution extensions to enhance their supply chain planning strategies and elevate operations. 

Courtland Sutton and the Broncos were still celebrating his 32-yard touchdown catch in the second quarter Sunday when the tremor preceding the earthquake rippled.

Construction has started on the undersea component of Google's Umoja fibre-optic cable.

Christian Tagwerker
Apr 1, 2006; 5:737-748
Research

Distinct cell types emerge from embryonic stem cells through a precise and coordinated execution of gene expression programs during lineage commitment. This is established by the action of lineage specific transcription factors along with chromatin complexes. Numerous studies have focused on epigenetic factors that affect embryonic stem cells (ESC) self-renewal and pluripotency. However, the contribution of chromatin to lineage decisions at the exit from pluripotency has not been as extensively studied. Using a pooled epigenetic shRNA screen strategy, we identified chromatin-related factors critical for differentiation toward mesodermal and endodermal lineages. Here we reveal a critical role for the chromatin protein, ARID4B. Arid4b-deficient mESCs are similar to WT mESCs in the expression of pluripotency factors and their self-renewal. However, ARID4B loss results in defects in up-regulation of the meso/endodermal gene expression program. It was previously shown that Arid4b resides in a complex with SIN3A and HDACS 1 and 2. We identified a physical and functional interaction of ARID4B with HDAC1 rather than HDAC2, suggesting functionally distinct Sin3a subcomplexes might regulate cell fate decisions Finally, we observed that ARID4B deficiency leads to increased H3K27me3 and a reduced H3K27Ac level in key developmental gene loci, whereas a subset of genomic regions gain H3K27Ac marks. Our results demonstrate that epigenetic control through ARID4B plays a key role in the execution of lineage-specific gene expression programs at pluripotency exit.

Ion mobility separates molecules in the gas-phase based on their physico-chemical properties, providing information about their size as collisional cross-sections. The timsTOF Pro combines trapped ion mobility with a quadrupole, collision cell and a TOF mass analyzer, to probe ions at high speeds with on-the-fly fragmentation. Here, we show that on this platform ion mobility is beneficial for cross-linking MS (XL-MS). Cross-linking reagents covalently link amino acids in proximity, resulting in peptide pairs after proteolytic digestion. These cross-linked peptides are typically present at low abundance in the background of normal peptides, which can partially be resolved by using enrichable cross-linking reagents. Even with a very efficient enrichable cross-linking reagent, like PhoX, the analysis of cross-linked peptides is still hampered by the co-enrichment of peptides connected to a partially hydrolyzed reagent – termed mono-linked peptides. For experiments aiming to uncover protein-protein interactions these are unwanted byproducts. Here, we demonstrate that gas-phase separation by ion mobility enables the separation of mono-linked peptides from cross-linked peptide pairs. A clear partition between these two classes is observed at a CCS of 500 Ų and a monoisotopic mass of 2 kDa, which can be used for targeted precursor selection. A total of 50-70% of the mono-linked peptides are prevented from sequencing, allowing the analysis to focus on sequencing the relevant cross-linked peptide pairs. In applications to both simple proteins and protein mixtures and a complete highly complex lysate this approach provides a substantial increase in detected cross-linked peptides.

Over 4 decades of research support the link between Alzheimer disease (AD) and somatostatin [somatotropin-releasing inhibitory factor (SRIF)]. SRIF and SRIF-expressing neurons play an essential role in brain function, modulating hippocampal activity and memory formation. Loss of SRIF and SRIF-expressing neurons in the brain rests at the center of a series of interdependent pathological events driven by amyloid-β peptide (Aβ), culminating in cognitive decline and dementia. The connection between the SRIF and AD further extends to the neuropsychiatric symptoms, seizure activity, and inflammation, whereas preclinical AD investigations show SRIF or SRIF receptor agonist administration capable of enhancing cognition. SRIF receptor subtype-4 activation in particular presents unique attributes, with the potential to mitigate learning and memory decline, reduce comorbid symptoms, and enhance enzymatic degradation of Aβ in the brain. Here, we review the links between SRIF and AD along with the therapeutic implications.

Jun 10, 2024

Two and a half decades [after 9/11], Christopher Wray, the director of the FBI, is sounding similar alarms. His discussions within the Biden administration are private, but his testimony to Congress and other public statements could not be more explicit. Testifying in December to members of the Senate Intelligence Committee, Wray said, “When I sat here last year, I walked through how we were already in a heightened threat environment.” Yet after Hamas attacked Israel on October 7, “we’ve seen the threat from foreign terrorists rise to a whole nother level,” he added. In speaking about those threats, Wray has repeatedly drawn attention to security gaps at the United States’ southern border, where thousands of people each week enter the country undetected.

Do the RBI guidelines mandate the linking of PAN with Aadhar as a prerequisite for opening a bank account?

Viswanathan said we had discussions with Ruturaj Gaikwad, MS Dhoni, and coach Stephen Fleming

London ; New York : Routledge, 1994.

Alongside championing jamakalam and Lambadi embroidery on furniture, House of Thinai’s latest initiative links Madras checks and generative art technology

National Bureau of Economic Research

During WordPress theme development you will more then likely need to display some images that are located within your theme directory. The location of the images folder can vary greatly. It really comes down to how you like to set things up. Generally speaking if you were to have an images folder in the root of your theme you can ... Read more

The post Linking to an Image Folder Within a WordPress Theme appeared first on Web Design Weekly.

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

Secretary-General Angel Gurría launched the 2012 Development Co-operation Report “Lessons in linking sustainability and development” at the 48th High Level Meeting of the Development Assistance Committee in London.

This new publication looks at how renewable energy can bring the greatest benefits to host regions.

Secretary-General Angel Gurría launched the 2012 Development Co-operation Report “Lessons in linking sustainability and development” at the 48th High Level Meeting of the Development Assistance Committee in London.

This new publication looks at how renewable energy can bring the greatest benefits to host regions.

This OECD project on Linking indigenous communities with regional development aims to develop policy recommendations for OECD and partner countries to improve economic outcomes for indigenous communities by better linking them with regional development efforts.