Meropenem/vaborbactam resistance in Klebsiella pneumoniae is associated with loss of function mutations in the OmpK35 and OmpK36 porins. Here we identify two previously unknown loss of function mutations that confer cefuroxime resistance in K. pneumoniae. The proteins lost were NlpD and KvrA; the latter is a transcriptional repressor controlling capsule production. We demonstrate that KvrA loss reduces OmpK35 and OmpK36 porin production, which confers reduced susceptibility to meropenem/vaborbactam in a KPC-3 producing K. pneumoniae isolate.

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CONTEXT:

Pneumococcal conjugate vaccines (PCVs) (pneumococcal 13-valent conjugate vaccine [PCV-13] and pneumococcal 10-valent conjugate vaccine [PCV-10]) are available for prevention of pneumococcal infections in children.

It's only a matter of time before your Windows 10 PC begins to run slowly. You can kick the operating system back into high gear with these useful tips. And they won't cost you a penny.

This sequel to Lian Li's original Strimer RGB PC-modding accessory has bolder lighting and more advanced patterns to make your build shine. We built it into a PC to see how it glows.

For a limited time, you can get a Dell Optiplex 9020 Micro computer for as low as $269.99 with a full 1-year warranty as part of an off-lease refurbished sale from the PCMag Shop.

Some are bare-bones kits. Others are ready to go out of the box, complete with an OS, RAM, and memory installed. Whatever the form, these top Windows micro desktops all deliver surprising features, value, and pep for their size.

Dell's SAVE15 coupon is still live, the Dell Vostro 14 3000 is back down to just $299, and Walmart's Overpowered gaming desktop is $800 off right now.

Research firm IHS Markit expects the display panel factories in Wuhan, China, to struggle to resume full production when the Chinese New Year holiday ends on Feb. 2. As a result, supplies for panels for TVs and PCs are expected to be tight in the ensuing months.

Microsoft will probably deliver critical patches after it ends Windows 7 support in January 2020. But it's not guaranteed, so users and organizations should upgrade to Windows 10 now.

Qualcomm-powered 5G PCs will go on sale early next year, likely at very low prices. Intel 5G laptops won't happen until much later, but they could be worth the wait.

Doom Eternal tops its predecessor by featuring larger maps filled with secrets, more ultra-violent weapons, and a huge variety of demons to slay. It is 2020's most extreme, first-person shooter.

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The Big O is two gaming machines in one: either an Xbox One or a PS4, broken down and attached to the same liquid cooling system as a fully customized gaming PC.

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DOVER, Del. – The Delaware Forest Service is looking to increase its wildfire crews for the upcoming season through training for new recruits. During the 2018 wildfire season, Delaware sent two full crews out to Colorado, Idaho, and Montana to be first responders. Interested recruits should be over 18 years old, physically fit, motivated, and […]

Supreme Court overturned HC’s decision of convicting the men on the grounds that the HC had erred in accepting the argument of “passive submission” as there was no fear or apparent threat. Supreme Court further added that since “no marks of injury” were found on Mathura’s body there was “no resistance” on her part and since she did not “raise an alarm” for help she “consented to sex.”The Apex Court acquitted both the accused stating that this alleged intercourse was a “peaceful affair”.

After considering the evidences and conclusions in previous trials, the Court could not establish that the Trial Courts or the High Court were wrong in holding the case against the appellant. Implied consent for the trainer to fly an aircraft do not apply here, as there were telephonic signals sent to the aircraft, to bring it back. Wrongful gain can be mere unlawful acquisition of a property, creating ‘temporary’ loss to the Government. The circumstances conclude both the essential ingredients of theft – absence of consent and unlawfulness of means. From the factual analysis, the Court concludes that the wrongful gain and loss were intentional. However, considering that the appellant has already undergone imprisonment, his sentence was modified to the period already undergone. The appeal was dismissed while maintaining the conviction.

Wilmington --

After statewide Public Hearing Workshops, DART listened to its riders and the public, and as a result, changes were made to the original proposal. The "Bold type" indicates a change from or an addition to the original proposal based on public comments. New schedules will be available online and on buses in early May. [More]

Wilmington. Governor Carney changed upcoming School Board and Municipal Elections in his 6th update to the State of Emergency. The Governor ordered School Board elections scheduled for May 12th delayed until June 16th. He  also ordered municipal elections scheduled before May 15th cancelled and  rescheduled no earlier than May 15, 2020. The Governor further ordered […]

NEW CASTLE (April 8, 2020) – The Department of Health and Social Services (DHSS) is announcing positive cases of coronavirus disease 2019 (COVID-19) at Delaware Psychiatric Center. Five patients and three staff members have tested positive for COVID-19 at DHSS’ public psychiatric hospital on the grounds of the Herman Holloway Sr. Campus near New Castle. […]

Nearly all automakers have been forced to postpone their model launch plans due to the coronavirus lockdown. Here are some cars and SUVs that will be lunched once the dust settles.

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HCL Tech's revenue grew 16.3 per cent to Rs 18,587 crore in the March 2020 quarter, from Rs 15,990 crore in the year-ago period.

Discoms’ over-dues — bills that remained unpaid for more than 60 days — have been rising almost relentlessly over the years, and spiraled 242% on year, to a level of Rs 10,500 crore by FY20 end.

In April, the NR consumption forecast for 2020 to 13.016 million tonne which is down 5.1% from the previous year.

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  Picked up a brand spanking new SSD? or thinking about getting one to improve the performance of your PC or laptop? Well, you’ll need to know how to go about installing or mounting it once you ha...

While four of the MPC members voted in favour of the eventual 75-basis point (bps) cut, external members Chetan Ghate and Pami Dua argued for a 50-bps cut, the minutes, released on Monday, showed.

CPC used a web-based survey to reach out to 1,252 respondents in 31 cities and towns of Maharashtra.

In the world of PC gaming, the bigger the budget, better are the components, which ultimately leads to better gaming experience. We have already created gaming PCs for Rs. 50,000 and Rs. 70,000, so the next step would be to jump to a budget of Rs. 1 lac, and that is exactly what we did. Here are the components you should buy, when building a gaming PC under Rs. 1,00,000.

The Moto G5 Plus launches tomorrow, reskindling the budget wars in India. For budget buyers, there are actually quite a few options coming up soon, including the three new smartphones from Nokia. Here, take a look.

Currently there are a few electric cars on sale in India, however more are confirmed to arrive very soon. Here is a list of seven upcoming electric cars to the Indian market.

Google Duo group video calling for web will arrive in the coming weeks starting as a preview on Chrome.

PCIe has been widely adopted in the electronics industry since its first debut in 2003 (PCIe 1.0 standard release) for wide breach of applications, from Data Center Server, Networking, to Mobile, AI/ML, Automotive, IoT, and many others…. It’s a versatile, high-performance, robust, mature interconnect standard with full “backward compatibility” (e.g., a PCIe 3.0 device can still function well in a PCIe 4.0 system) which enables a solid and strong PCIe eco-system in the industry.  While the market, so as the users,  are enjoying the systems, e.g., desktop/laptop, powered (or to be more specific: “bridged”) by PCIe 3.0 since 2010, the industry is pushing hard for the PCIe 4.0 eco-system enablement. Earlier this year, AMD announced it X570 chipset would support the PCIe 4.0 interface and Phison also introduced the world’s first PCIe 4.0 SSD.

On the standard evolution front, the official PCIe 5.0 came out in May 2019, doubling the data rate to 32GT/s from 16GT/s in PCIe 4.0. The PCIe 6.0 standard will be released in 2021 based on the announcement made by PCI-SIG in June’19 with the goal to further double the data rate to 64GT/s with incorporating the PAM4 coding.

PCIe Protocol Evolution

Having said that, is the latest generation of PCIe always desired?  

My answer would be positive. Just like car maker/enthusiast has kept pursuing faster car in the history, there is no doubt that these speed enhancements/upgrades in the electronic world certainly provide a tremendous benefit for especially those applications craving the most throughput, such as Data center, HPC, Networking, Cloud and AI applications.   

But, does every application have to opt for the fastest speed (bandwidth)? My view would be leaning toward “Not really”. Just like we don’t need a 3-second sport car (meaning 0-60mph acceleration < 3s) for daily commute though it would certainly spice some driving fun on the road, but it may not be "the best fit" for most of commuters.

There are applications still well satisfied with PCIe 3.0 (or even older PCIe 2.0) for its best performance and cost balance.  Those applications include, but not limit to, IoT/consumer, Edge AI, SSD (non-enterprise),…etc. They typically need to make trade-off in between the cost, power consumption (especially battery powered), flexibility on changing product features, and time-to-market (TTM). To address such type of market needs, Cadence also offers an PPA (Performance, Power, Area) optimized PCIe 3.0 solution in addition to its high-performance PCIe 4.0 product line.

Cadence PCIe 3.0 PHY Solution (with Multi-Protocol Multi-Link feature)

With leveraging the multi-protocol SerDes implementation, the same Cadence PHY IP support multi-protocol and multi-link operation. Such a multi-protocol enabled PHY gives the SoC developers the optimum flexibility to integrate multiple commonly used interface protocols (e.g., PCIe 3.0 + USB 3.0) with using only a single PHY design.  This would largely save the product development time (faster TTM), reduce the risk of using multiple different PHY instances (for different protocol needs), and with the configurability to enable different product features/protocols.

Some people might say PCIe 3.0 era has gone. I was not quite yet being convinced as I still see its potential to shine a lot of market use cases. What do you think?

More Information

For more information on Cadence's PCIe IP offerings, see our PCI Express page.

For more information on PCIe in general, and on the various PCI standards, see the PCI-SIG website.

Related Posts

• Blog: PCIe Gen4: It’s Official, We’re Compliant
• Blog: The PCIe 4.0 Era Continues at PCI-SIG Developers Conference 2016
• Blog: Cadence PCIe Solutions: Configurable, Compliant, and Low Power