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Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan

Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago




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Farmers demand withdrawal of Tamil Nadu Land Consolidation Act

The Coordination Committee of All Farmers’ Associations of Tamil Nadu says the State government has created a situation where industries can acquire fertile lands




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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand




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Students and agriculture officials grapple with logistical, technical issues during digital crop survey




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AIADMK ready to join hands with like-minded parties to defeat DMK: Palaniswami




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542: Breaking Up with CSS-in-JS, Mastodon, and Stories on the Web

We're talking CSS-in-JS, Token CSS, Matuzo being suspended from Twitter, trying out Mastodon, testing out stable diffusion, stories on the web, and Jake Albaugh's new social network.




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545: Arc Browser with Nate Parrott

Nate Parrott from The Browser Company of New York stops by to talk about Arc - including the history of Arc, how boosts work, building out dev features, how they deciding on what features to build, and feedback from Dave and Chris on Arc.




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547: WordPress and GraphQL with Jason Bahl

Jason Bahl joins the show to talk about the GraphQL and WordPress connection, his work on WP GraphQL plugin, Faust and Atlas from WP Engine, Jamstack and Wordpress, and more.




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550: Sanity with Simen Svale Skogsrud and Espen Hovlandsdal

Simen and Espen from Sanity stop by to talk about the origins of Sanity, how Sanity Studio works, good use cases for Sanity, how Sanity does real time updates, what Groq is, and where to start with Sanity.




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551: PlanetScale with Iheanyi Ekechukwu and Mike Coutermarsh

Iheanyi Ekechukwu and Mike Coutermarsh talk about PlanetScale, what Vitess is, if PlanetScale is for both side and big projects, what read only regions are, what schema changes are, and how PlanetScale compares to other projects.




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553: TypeScript, DX, GripeScript, and Astro v2 with Fred Schott

Fred Schott stops by to talk about TypeScript, what DX means in 2023, a bit of GripeScript, and being transparent about what Astro is good at, and what it's not.




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554: Jamstack Thoughts with Brian Rinaldi

Brian Rinaldi joins us to talk about the state of Jamstack in 2023, acronym confusion, SPA confusion, developing common tools of understanding, why Netlify bought Gatsby, and the state of developer conferences.




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558: Esoteric Weird Content Editable Problems with Kristin Valentine

Kristin Valentine from Vox joins the show to talk about text editor CMS fun across multiple sites, Vox's Chorus, The Verge redesign, sharing Design Systems, theming articles, and a fun new game called "Can Your Text Editor Do This??"




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559: Fidget Apps, Coding with AI, Dialog Element Navs, Getting Rid of CSS

Is there still any value in specializing in front-of-the-frontend dev? Would you ever use the dialog element for a mobile navigation? Why did CodePen decide to use Go for its GraphQL server?




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583: Language Models, AI, and Digital Gardens with Maggie Appleton

Maggie Appleton talks with us about her work at Elicit, working with large and small language models, how humans vet the responses from AI, the discussion around the Soggoth meme in AI, using Discord as UI, what to do if your boss wants AI in your app, and why does she call her blog a digital garden?




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584: Community, Partnerships, Images, and Astro with Fred K. Schott

Fred K. Schott stops by to talk about building community, open source and sponsorship, building on partnerships in the dev community, WordPress + Astro, view transitions, using Discord for support, and leaking secret Astro Studio details.




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586: Micro.blogging with Manton Reece

Manton Reece, creator of Micro.blog, stops by to talk about the history of Micro.blog, what it's written in, how it handles feeds coming in and going out, cross-posting, authentication, and the somewhat hidden features of Micro.blog: bookmarking, bookshelves, and even podcasting.




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591: Cascade Layers, CSS Functions, and more CSS with Miriam Suzanne

Miriam Suzanne stops by to talk about CSS updates and news on container queries, rolling out cascade layers, !important things to remember, custom properties, exit animations, CSS functions, state queries, and more.




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599: Fighting the Algorithm With RSS, Blogging, and the IndieWeb

Dave and Chris discuss indie web culture, the role of social media in today's society, and the challenges and strategies of freelancing. Additionally, they discuss a range of topics from content moderation, coding and refining tech skills, to emerging startups and the future of web technology.




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603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth

Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web.




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606: Web Sustainability with Michelle Barker

Show DescriptionWe're talking with Michelle Barker about the idea of paying to support bloggers (and podcasters!) via services like Patreon, drumming as a fun side gig from CSS, how big of an issue digital sustainability is, trying to understand the environmental impact of our websites and digital life, wondering why YouTube embeds are still so […]




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614: CSS Grid Level 3 aka Masonry with Adam Argyle

Adam Argyle stops by to chat about the conversation that's happening around CSS Grid / Masonry. What do we want? What might Apple's response to Google be? And nitpicking the spec just for fun.




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616: Strum Machine with Luke Abbott

Luke Abbott is the creator of Strum Machine, an app that simulates backing tracks by stitching together individual notes, chords, and strums recorded on guitar, standup bass, and mandolin. We talk about what Strum Machine does, why he decided to build it, how bringing on a professional designer helped, pricing thoughts, and the "fun" of building a version on iOS.




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617: Economic & AI Vibes with Jason Grigsby

We're chatting with Jason Grigsby about what a white-collar recession means, how the sources and methods of consuming news shape our perspectives, whether the current economic conditions represent a market correction and if a rebound is imminent. We explore the critical decision of whether to embrace AI advancements or risk being left behind. We also talk about AI-generated voices, large language models and ethics, and the impact of social media signals in an AI world.




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627: Getting Comfortable with the Struggle and Vibe Driven Development

Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future?




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637: Approachable Open Source with Brian Muenzenmeyer

Brian Muenzenmeyer joins the show to talk about his book, Approachable Open Source, ways we can make open source easier to get in, important conversations around funding and supporting open source, and whether money helps maintainers deal with burnout or not?




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641: Passkey Usage, Writing Code with a Bot, and What’s Up With Java?

We've got a few leftovers from Halloween to process, what's been happening with Passkeys in late 2024, have you tried to write HTML faster than a bot can suggest it to you, CSS anchor positioning and popover polyfills, scroll driven animation thoughts, CSS nesting, and what's the reason for Java?




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How a city deals with water

Water flows through streams and channels and forms a distinct part of the urban landscape of Tehran.




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In harmony with nature

Minimal energy consumption and carbon footprint, use of biogas and solar panels, decentralised water treatment… a look at life in Auroville




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Homes with a ‘conscience’

Around 5,000 homes in the city shun BWSSB water supply and produce enough power of their own. By M.A. Siraj




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Startups join the party with craft mixers

How non-alcoholic mixers, handcrafted by small players, are edging out sugary soft drinks, sodas in cocktail glasses




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Investing with no fear, no greed

Venture capital firm Fundamentum sees growth opportunity in India’s digital transformation




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Investing in companies with ‘indicorn’ potential

Titan Capital backs seed-stage companies with potential to reach ₹100 crore revenue within five years




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Flat organisation believers: Can you imagine a world without managers?

What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important?




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Building digital trust with quantum tech

QNu Labs devises qubit-powered solutions for the ‘trillion-dollar cyber-attack problem’ 




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Navigating the flood of healthcare information, with a little help from AI

A global survey maps how willing, and equipped clinicians are in using artificial intelligence to support their work 




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Devotees throng Delhi ghats, mark Chhath Puja festivity with prayers, songs, selfies

Lakhs of devotees offer ‘Sandhya Arghya’ to the setting sun on the third day of the four-day festival; political leaders make a beeline for ghats with an eye on Purvanchali voters ahead of Assembly poll




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Congress gears up for Delhi poll battle with month-long ‘Nyay Yatra’

Maken, Sukhu flag off foot march; Kharge, Rahul expected to join at different junctures; yatra scheduled to end on Dec. 4; people won’t forget Cong.’s tie-up with AAP in Lok Sabha election: BJP




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One dead, one injured in two firing incidents in Delhi within 10 minutes

The two incidents of firing in northeast Delhi leave one dead and one injured; three suspects apprehended by police




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Living in a world without work

Cohabitation with machines is an inevitable future that awaits us. But is it going to be easy?




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Coming to grips with mega disasters

Rooted in research, the book reveals the existential threats we face and charts the roadmap ahead




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Millennial prophet with a failed vision

A gripping account of WeWork founder Adam Neumann’s meteoric rise and precipitous crash




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Dealing with career dilemmas

Corporate honcho Shiv Shivakumar’s book sheds fresh light




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In love with operations management

The author brings aesthetics into a field obsessed with quantification




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Rushdie’s trysts with truth

Essays in meditation on story, storytelling and storytellers




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For people with aspirations

A book that focuses on an oft neglected aspect — soft skills




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With Alyque on your mind 

The book has some of Alyque’s craziest ideas but it ends up falling between a bunch of stools 




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Paddy varieties with protein, zinc content get thumbs up in Odisha’s tribal pocket

Paddy varieties have high protein (10.1%) and moderately high level of zinc (20 ppm) content




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Centre to provide 15,000 women self help groups with drones that can be rented out for agricultural purposes

The scheme will help in infusing advanced technology in agriculture for improved efficiency, enhance crop yield and reduced cost of operation for the benefit of farmers