Welcoming remarks by Mr Fernando Restoy, Chairman, Financial Stability Institute, Bank for International Settlements, at the FSI-IADI conference on crisis management, resolution and deposit insurance: what's next and how to prepare, Basel, 4 September 2019.

Giving birth triggers a wide repertoire of physiological and behavioral changes in the mother to enable her to feed and care for her offspring. These changes require coordination and are often orchestrated from the CNS, through as of yet poorly understood mechanisms. A neuronal population with a central role in puerperal changes is the tuberoinfundibular dopamine (TIDA) neurons that control release of the pituitary hormone, prolactin, which triggers key maternal adaptations, including lactation and maternal care. Here, we used Ca²⁺ imaging on mice from both sexes and whole-cell recordings on female mouse TIDA neurons in vitro to examine whether they adapt their cellular and network activity according to reproductive state. In the high-prolactin state of lactation, TIDA neurons shift to faster membrane potential oscillations, a reconfiguration that reverses upon weaning. During the estrous cycle, however, which includes a brief, but pronounced, prolactin peak, oscillation frequency remains stable. An increase in the hyperpolarization-activated mixed cation current, I_h, possibly through unmasking as dopamine release drops during nursing, may partially explain the reconfiguration of TIDA rhythms. These findings identify a reversible plasticity in hypothalamic network activity that can serve to adapt the dam for motherhood.

SIGNIFICANCE STATEMENT Motherhood requires profound behavioral and physiological adaptations to enable caring for offspring, but the underlying CNS changes are poorly understood. Here, we show that, during lactation, neuroendocrine dopamine neurons, the "TIDA" cells that control prolactin secretion, reorganize their trademark oscillations to discharge in faster frequencies. Unlike previous studies, which typically have focused on structural and transcriptional changes during pregnancy and lactation, we demonstrate a functional switch in activity and one that, distinct from previously described puerperal modifications, reverses fully on weaning. We further provide evidence that a specific conductance (I_h) contributes to the altered network rhythm. These findings identify a new facet of maternal brain plasticity at the level of membrane properties and consequent ensemble activity.

Times like this have led us to rethink our daily lives, from our basic everyday habits to the way we usually get information. FAO is working to guarantee continued [...]

Together, the paintings—including one by Anthony van Dyck—could be worth around £10 million if sold on the open market

Hundreds of museums are participating in an online attempt to spread joy as COVID-19 keeps their galleries empty

The Getty Museum hopes its social media challenge will spark inspiration amid the COVID-19 pandemic

Doctors and nurses are attaching smiling photos of themselves to the outside of their protective gear to maintain connections with patients

These paintings, sculptures and illustrations honor the bonds of motherhood

Man working on a new building

The Kent State shootings further widened the chasm among a citizenry divided over the Vietnam War

Schools were closed March 13 to reduce the risk of spread of the coronavirus, and there is no plan to reopen them by the end of the current school year in June.

​

A former miner who was forced to breathe in a fine aluminum dust before each shift says he’s not surprised a new report links that dust and a higher risk of Parkinson’s disease.

Press release about the Basel Committee publishing consultation paper on revisions to the credit valuation adjustment risk framework, 28 November 2019.

Press release about the Basel Committee launching the consolidated Basel Framework, 16 December 2019.

Press release about Basel Committee assesses members' implementation of the Net Stable Funding Ratio and large exposures framework, 19 March 2020

It works like a very fine "molecular knob" able to modulate the electrical activity of the neurons of our cerebral cortex, crucial to the functioning of our brain.

For those working in CHSLDs — the province's long-term care homes which are the site of the most serious outbreaks — the bonus will amount to as much as $1,000 per month.

Kristy-Lyn Kemp can't believe how close she came to potentially starting a COVID-19 outbreak at her new job.

Baseball Hall of Famer Andre Dawson spoke to CBC's John Northcott about the realities of running a funeral home during the pandemic.

The Cleveland Indians held a video conference with players and other team officials to lay out the provisional plan for returning to organized workouts with designs on being ready for a potential 2020 opening day of July 1, according to The Athletic.

The University of Manitoba is laying off dozens of employees as it tries to find savings at a time when post-secondary schools have largely been closed since COVID-19 emerged on the Prairies, a union says.

The union that represents thousands of Manitoba workers is asking what safety protocols were in place when a construction worker was killed after a trench wall collapsed on him earlier this week.

With Mother's Day only a few days away, businesses are coming up with creative ways to help your family celebrate. Everything from brunch in a box to colourful bouquets and home delivered chocolate.

Salesforce has announced a new version of Work.com designed to help businesses function safely during the COVID-19 pandemic. "Work.com is a completely new initiative using an existing domain name that we previously owned," said Salesforce spokesperson Joel Steinfeld. "Our focus is on speed and moving as quickly as possible to help our customers, and Work.com is an optimal way to do that.

Some Prince Edward Islanders are raising concerns about returning to work under the province's plan to ease back COVID-19 restrictions, but if they choose to stay home they could lose financial support from the federal government.

Women on P.E.I. are having a harder time holding onto their jobs than men in the COVID-19 pandemic, which runs contrary to the national trend.

As the nation unifies, divisiveness falls flat.

Robbyn Plumb tried to balance a career in the public service with looking after two kids, one with special needs. When the pandemic hit she finally hit a wall and decided to stop working. She writes about how hard it is for parents trying to do it all during COVID-19.

Despite having no ice on which to perform, more than 40 figure skaters from nine countries will take part in a fundraiser Friday to help health care workers on the front lines battling the new coronavirus.

The Canadian four-time world champion figure skater took part in the Americares Blades for the Brave fundraiser for front-line workers battling the COVID-19 pandemic.

Former Canadian figure skater and Olympic medallist Joannie Rochette will be working at Quebec's long-term care homes hit hard by COVID-19.

Vincent Novara, Head of the Music Division's Acquisitions & Processing Section, describes his section's new teleworking practices during a global pandemic.

The Chicago Bulls announced Marc Eversley as their new general manager on Friday, making him the first Canadian GM in NBA history.

'Creative Music Making' Documentary to Air on Nine Network - MPress  Maryville University News

Major League Soccer is easing its training restrictions, allowing clubs to use their practice fields but only for individual workouts and under strict rules.

The COVID-19 pandemic won’t slow down road construction in Saskatoon. The city says it re-evaluated all planned projects for the year and determined it can move forward with the majority of the projects.

Laurent Duvernay-Tardif and the Kansas City Chiefs have agreed to a restructured deal for the Canadian offensive lineman.

Leonard Rodriquez's grieving loved ones say he was a man who would drop everything to help those in need. But they say his death could have been prevented if he'd had the personal protective gear he needed to do his job.

Ontario reported its lowest new COVID-19 case count of the week on Saturday with 346 new confirmed cases of the virus. Meanwhile, the government has issued an emergency order allowing school board employees to be voluntarily redeployed to hospitals, long-term care homes, retirement homes and women's shelters.

As automakers look to restart the industry, union representatives are looking to ensure safety is the number one priority for workers.

Nearly a quarter-million more Albertans lost work in April as the economic shutdown due to COVID-19 continued, with young workers — particularly young women — being disproportionately affected.

Employees in Alberta continuing care homes and seniors’ residences are the most likely recipients of a federal wage top-up intended for essential workers.

A normal draft year would see NHL scouts and executives spend the spring crisscrossing Europe and North America collecting information. The circumstances surrounding a 2020 draft and the COVID-19 pandemic, however, aren't anything resembling normal.

The post SOLIDWORKS Apps for Kids How-To: Create a Collage in Capture It appeared first on SOLIDWORKS Education Blog.

The post SOLIDWORKS Apps for Kids How-To: Trim an Image appeared first on SOLIDWORKS Education Blog.