Questions remain about the safety and effectiveness of alternative solvents

Combining vibrational circular dichroism and infrared spectroscopy yields real-time probe of asymmetric catalytic reactions

U.S. natural gas production loses 2.3% of methane to leaks

Large and small suppliers vow to help a resource-intensive, cost-sensitive industry change with the times

Technology is a step on the path to on-demand manufacturing of biologics

Smooth engine, plush interiors, great suspension that handle dodgy roads with ease, futuristic design elements that have little by way of competition in the market -- it's all there, says Pavan Lall.

Radio and TV producer who revitalised The Archers during his tenure as editor

Despite being a soft-spoken Lancastrian of mild-mannered appearance, the writer and producer William Smethurst, who has died aged 71, was known to his detractors in radio and television as “Butcher Bill”. But the ruthless skills combined with mischievous flair that he displayed as editor of The Archers for eight years from 1978 were widely credited with saving Radio 4’s flagging rural soap opera and making it the cult show it later became. Smethurst was the man who licensed writers to scandalise sleepy Ambridge and once persuaded Princess Margaret to make a guest appearance.

He was less successful when Central TV lured him from BBC Pebble Mill in Birmingham to pull off the same trick with Crossroads, its Midlands motel saga, which had run out of steam. Smethurst ditched Tony Hatch’s theme tune, killed off characters (much as he had Dan and Doris Archer), and made the plots (and scenery) more credible and the cast much more glamorous, with the help of the motel swimming pool he installed. Some critics preferred its previous awfulness and the show folded in 1988.

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Hayden Library - TA418.9.N35 F87 2018

What's the problem?

Edwin Cabrera, a father of two, was unlocking his e-bike after dropping off a pizza on Fort George Hill near Fairview Ave. on May 3 when two suspects jumped out of the shadows and attacked him around 9 p.m.

Filed under: Food and Drink, North America, United States

Traveling "home" this holiday season? Don't fall into your old routine. Your high school hangout may be an easy go-to, but if you don't live there anymore there's a good chance you're missing out on some great new local spots. (Plus, be honest: you already know what all your classmates are up to from Facebook.)

We turned to local writers to help you rediscover your hometown over Thanksgiving and the winter holidays. Each city guide features a great new restaurant to try while you're in town, a cool neighborhood that wasn't on the radar last year or a store where you can pick up a keepsake to bring your old home back to your new home. We'll also catch you up to speed on the hot topics of conversation in each city, so you'll come back savvy enough to join the local sports banter or eat your holiday weight in Cronuts.

Click your city below to learn what's new since the last time you went home:

Continue reading Discover Something New at Home this Holiday Season

Discover Something New at Home this Holiday Season originally appeared on Gadling on Mon, 25 Nov 2013 12:15:00 EST. Please see our terms for use of feeds.

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Filed under: Food and Drink, North America, United States

Traveling "home" this holiday season? Don't fall into your old routine. Your high school hangout may be an easy go-to, but if you don't live there anymore there's a good chance you're missing out on some great new local spots. (Plus, be honest: you already know what all your classmates are up to from Facebook.)

AOL Travel turned to local writers to help you rediscover your hometown over the winter holidays. Each city guide features a great new restaurant to try while you're in town, a cool neighborhood that wasn't on the radar last year or a store where you can pick up a keepsake to bring your old home back to your new home. AOL Travel also will catch you up to speed on the hot topics of conversation in each city, so you'll come back savvy enough to join the local sports banter or eat your holiday weight in Cronuts.

Click your city below to learn what's new since the last time you went home:

Continue reading Discover Something New at Home this Holiday Season

Discover Something New at Home this Holiday Season originally appeared on Gadling on Wed, 18 Dec 2013 11:04:00 EST. Please see our terms for use of feeds.

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β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

The enactment of President Clinton’s Limited English Proficiency (LEP) Executive Order, issued in 2000, triggered a proliferation of efforts to provide services to individuals who cannot speak, understand, read, or write English fluently. With increased service provision, state and local government agencies have expressed a strong and growing interest in assuring the quality and cost-effectiveness of language access services. This paper attempts to catalog and describe some of those tools and practices.

Researchers at MIT have developed a new method of electrically stimulating deep brain tissues without opening the skull

Since 1997, more than 100,000 Parkinson’s Disease patients have been treated with deep brain stimulation (DBS), a surgical technique that involves the implantation of ultra-thin wire electrodes. The implanted device, sometimes referred to as a ‘brain pacemaker’, delivers electrical pulses to a structure called the subthalamic nucleus, located near the centre of the brain, and effectively alleviates many of the physical symptoms of the disease, such as tremor, muscle rigidity, and slowed movements.

DBS is generally safe but, like any surgical procedure, comes with some risks. First and foremost, it is highly invasive, requiring small holes to be drilled in the patient’s skull, through which the electrodes are inserted. Potential complications of this include infection, stroke, and bleeding on the brain. The electrodes, which are implanted for long periods of time, sometimes move out of place; they can also cause swelling at the implantation site; and the wire connecting them to the battery, typically placed under the skin of the chest, can erode, all of which require additional surgical procedures.

Related: Blowing up the brain to reveal its finer details

Related: Traces of memory in a dish | Mo Costandi

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Testimony of MPI President Demetrios G. Papademetriou before the House Judiciary’s Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law.

The singer-composer, who has collaborated with quite a few international names in music, has his plans firmly in place.

A MDT trainee puts what she has learned into practice as she teaches German to an Egyptian immigrant in Switzerland.

To help ensure the safety of fish passing through the new turbines at 912-MW Priest Rapids, Public Utility District No. 2 of Grant County is employing the BioPA method to analyze the biological performance of proposed designs - and to choose an improved one for this facility.

The FCA has issued its long awaited consultation on extension of the Senior Managers and Certification Regime (also known as “Accountability II”). Consultation Paper (CP17/25), which sets out the “what” and the “why&rdq...

With the new advances, fertility doctors will be able to hand-select the healthiest and quality sperm for artificial insemination, in effect increasing a woman's chance of becoming pregnant.

How cool is that?

       The office worker is general will see much of a scene, at new of the year split a head, you nearby of person or many or little all someone drive the inner part...

Few things in life are as difficult as acknowledging mistakes, in particular those that we have made out of conviction. Choosing an unsuitable profession or...

While there has been a recent revival of interest in industrial policy around the world, systematic evidence of efficacy is relatively scarce. This report considers recent evidence from the evaluation of industrial policy. It focuses on three specific policy areas: support for R&D, capital market interventions (with a focus on risk capital), and public procurement for innovation.

When economic shocks occur, economic agents are expected to react to reduce the negative impact or amplify the positive effects. The ability of a country to contain economic losses can be defined as the resilience to economic shocks. Using the OECD Inter-Country Input-Output tables, this paper investigates the relationship between changes in final demand and production structures for 61 economies.

The OECD has adopted a new basket methodology for benchmarking wireless broadband prices. It adds to the existing baskets for voice, leased lines and fixed broadband services and reflects the increasing importance of wireless broadband for laptops, tablets and smartphones.

This report takes an initial look at methodologies to measure and estimate the monetary value of personal data, which is creating economic and social value at an increasing pace. But measuring and estimating its value is difficult. This is because not only a huge amount of personal data is being generated, but also as it is used in many different situations and for numerous purposes.

This paper details a methodology for calculating the extent of terrestrial and marine protected areas recorded in the World Database on Protected Areas by country, type and IUCN management categories. The method allows the data on protected areas to be summarised in a harmonised and more detailed way than is currently available, without requiring any additional reporting by countries.

Every traveler makes a bucket list of the places they want to explore the beauty of, and places in Rajasthan is something no one would want to let slip from their list.

This OECD Regulatory Policy Working Paper presents the methodology, key results and statistical analysis of the 2015 Indicators of Regulatory Policy and Governance (iREG) to complement the OECD Regulatory Policy Outlook 2015.

A detailed explanation of the methodology used to build the OECD PMR indicators