King Harv's now has Geisha Coffees from Panama, Colombia, El Salvador, Nicaragua, Papua New Guinea and Peru, complementing other such rarities such as the Galapagos Islands, Malaysia, Bolivia, Vietnam, Congo, Yemen, and the Dominican Republic

Independent developer, Batuhan Akalin, has completed his unique physics based casino series with his latest title, Physics Mini Game Slots. Available for iPad, Physics Mini Game Slots offers a Vegas style entertainment at no cost to download.

Because anyone deserves the chance to become a good tattoo artist, as long as they have something fundamental: attitude. 10MASTERS provides the tools to achieve it.

With a "modern contemporary fine art" style that has helped him develop a successful career, MorEnvyOne's work can be seen in some of the world's most well-known places.

Sip N' Nails Spa is a small business offering a wide range of beauty services beyond nails, including PMU-brow services, lip blushing, lash extensions, make-up application, waxing, electrolysis, chemical peels, skincare, and facials.

The Tarrant Events Center in Haltom City will help you design an event that's right for you

If you're ready to burn some calories and tone those muscles, you can take your workout to a higher level with BungeeONE fitness

Experience the Joy of Ownership with Pestcom's Custom Holiday Lighting Services and Exceptional Customer Care—Brightening Homes and Lives in the Treasure Valley!

Hairs2u51 Offers More Than Just A Haircut

To celebrate the opening, Home2 Suites is offering an Exclusive Government Package, available with the booking code GV7. This package falls under the Alternate Government Rate, offering a rate below the standard government per diem.

With all-inclusive pricing plus flexible food & beverage options, TEC provides the ideal space to have a quinceanera

"As I listened to various genres of music and started expanding my catalog; it was important to me to develop a sound I could call my own. I don't want the world comparing my music to the next artist. I'm unique, and I move different" - 4Seazonz

Best Form of Biometric Identification — J2C's Iris Recognition Devices

Anthony Ventura, an award-winning Canadian artist, is known for his highly detailed and expressive illustrated portraits. A graduate of Sheridan College’s Illustration program, he has worked with major clients like Playboy, Rolling Stone, Time Magazine, Doritos, and ESPN, with standout celebrity pieces featuring Bob Dylan, George Harrison, and Nikki Sixx that showcase his exceptional linework […]

The requirement of safeguarding original presentation designs has never been more crucial as presentations get increasingly interactive, visually appealing, and indispensable in both corporate and creative domains. Your work is valuable, whether you are a tech entrepreneur creating software that changes the way presentations are done or a designer creating fresh slide decks for customers. ...

The post Protecting Your Unique Presentation Designs: IP Strategies for Creators appeared first on noupe.

A troubling report from the Pentagon earlier this year revealed that suicide is the leading cause of death for Army soldiers—a population that is nearly nine times as likely to die by suicide than in combat.  “Suicide in the military continues to be a public health crisis, despite decades of targeted interventions. The rates are persistently higher than in the general population,” says Jayna Moceri-Brooks, an assistant professor at NYU Rory Meyers College of Nursing who studies firearm injury prevention and suicide among service members and veterans.

What makes consumers choose one company over another? Identify your unique value proposition to make more sales at higher prices. Examples & tips.

Want to create more randomized effects in your JavaScript code? The `Math.random()` method alone, with its limitations, won’t cut it for generating unique random numbers. Amejimaobari Ollornwi explains how to generate a series of unique random numbers using the `Set` object, how to use these random numbers as indexes for arrays, and explores some practical applications of randomization.

A troubling report from the Pentagon earlier this year revealed that suicide is the leading cause of death for Army soldiers—a population that is nearly nine times as likely to die by suicide than in combat.  “Suicide in the military continues to be a public health crisis, despite decades of targeted interventions. The rates are persistently higher than in the general population,” says Jayna Moceri-Brooks, an assistant professor at NYU Rory Meyers College of Nursing who studies firearm injury prevention and suicide among service members and veterans.

Here is a Storify round up of the SpotOn London session: ORCID – why do we

Citation Marivoet, Wim; and Hema, Aboubacar. 2024. How did households in Mali cope with covariate shocks between 2018 and 2023? Source: IFPRI Africa Regional Office (AFR)

Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology  Nature.com

TORONTO, ON - Hummingbird metabolism is a marvel of evolutionary engineering. These tiny birds can power all of their energetic hovering flight by burning the sugar contained in the floral nectar of their diet. Now new research from the University of Toronto Scarborough shows they are equally adept at burning both glucose and fructose, which […]

Eclipse Automation is offering employees bicycles to promote environmental impact awareness.

If you publish an RSS feed, you should do a solid for the developers of RSS readers by including a guid in each item. The guid's job is to be a unique identifier that helps software downloading your feed decide whether it has seen that item before. Here's the guid for an item on the arts and technology blog Laughing Squid:

<guid isPermaLink="false">https://laughingsquid.com/?p=914660</guid>

No other item on Laughing Squid will ever have this guid value. It's a URL that loads a blog post with the title Playful Elephant Pretends to Eat Woman's Hat. If you load the guid's URL https://laughingsquid.com/?p=914660, it redirects to the permanent link of the post. Because the guid is not the permanent link, there's an isPermaLink attribute with a value of false.

Most guid values in RSS feeds are the permanent link of the item, as in this example from the world news site Semafor:

<guid>https://www.semafor.com/article/07/07/2023/us-jobs-data-what-experts-make-of-the-new-numbers</guid>

A drawback of using the permalink is that if any part of the URL changes -- such as the title text or the domain name -- the guid changes and RSS readers will think this is a new item to show the feed's subscribers, when it's actually a repeat.

A guid doesn't have to be a URL. It can be any string that the feed publisher has chosen to be unique. Here's the guid from the RSS Advisory Board's feed for this blog post:

<guid isPermaLink="false">tag:rssboard.org,2006:weblog.217</guid>

Our guid follows the TAG URI scheme, a simple way to assure uniqueness by putting these five components together in this order:

1. The text "tag"
2. A domain owned by the feed provider
3. A year the provider owned that domain
4. A short name for the feed different from any other feed on the site
5. The internal ID number of the post

There's different punctuation between each component. The year 2006 was when the board began using the domain rssboard.org. No one else used that domain that year, so any feed reader that stores "tag:rssboard.org,2006:weblog.217" as this item's guid should never encounter that value in any other item on any other feed.

To see how RSS 2.0 feeds are using guid, several thousand feeds were downloaded this evening from an RSS aggregator that publicly shares the OPML subscription lists of its users.

The term guid means "globally unique identifier," but RSS 2.0 does not require global uniqueness in guids. Because the TAG URI scheme does a good job of serving that purpose, Blogger, Flickr, MetaFilter, SoundCloud and The Register are among the sites using it in their feeds.

Leading consumer groups and getting involved in taste tests during the product development phase, Vault49 uncovered what it really means to be ‘Uniquely Bahamian’

The Versatex Printbar leverages the architecture of two print banks, each equipped with six Xaar Nitrox printheads, to achieve up to three different laydown effects in a single pass and with one varnish.

Washington, D.C. -- Media entrepreneur Byron Allen and Gordon Smith, special advisor to the National Association of Broadcasters (NAB), will engage in a candid conversation about their unique careers and roles in the broadcast industry during a fireside chat on the Main Stage of NAB Show on April 27, 2022, at 9:15 a.m. in Las Vegas, Nev.

Bryant Lin has taken his diagnosis of stage IV ‘never-smoker’ lung cancer, which disproportionately affects those of Asian descent, and turned it into a medical school course. He hopes the world takes notes along with the students and Stanford Medicine community.

The post A doctor, his cancer journey and a uniquely teachable moment appeared first on Scope.

The animated series Futurama has a very unique look, so much so that the color supervisor gave the show's color scheme a specific name.

Speech technologies have typically had a hard time understanding jargon, abbreviations, and acronyms, but Israeli startup aiOla is changing all that.

The advantages of 100% voice-controlled picking processes can now be tried out on any Android smartphone with the release of a new, expanded version of the LYDIA Voice Demo App, now available free-of-charge from the Google Play store. 

The new subsidiary of Körber’s Business Area Pharma in Dublin enjoys growing demand for its integrated solutions for pharmaceutical and biotech production in the UK and Ireland.

Vampire bats have complex social relationships.

A sign that read "St. Joseph's Catholic School Gymnasium" used to hang above the front door of a brick building in Spokane's West Central neighborhood, but it's since been replaced by a simple metal sign bearing the surname "Hamilton."…

The first time that pianist Sara Davis Buechner felt what she calls "the real spiritual power" of George Gershwin's music, she was 23 and building a reputation for virtuoso playing on the international concert circuit…

Gift ideas for a canine celebration.

[Written by Stephen Wright] The new Flower Bar on Reid Street, outside the Washington Mall in Hamilton, offers a unique mix of floral-infused cocktails, wine, prosecco and flower arrangements. Steven Faries opened the shop in July with Shane Francis, the director of operations – initially delaying the enterprise because of the Covid-19 pandemic – and […]

How inclusive is NSA in terms of diversity? Recently, two employees answered that question and more. Let’s go straight to the source. Michelle E. Prior to joining the National Security Agency (NSA) as a recruiter, Michelle E., pictured life at the agency like many of us do. “Whenever thinking about NSA, I always thought of […]

The post Diversity in the NSA Workplace: ‘Your Unique Voice and Skillset will be an Asset’ appeared first on DiversityJobs.com.

The pergola is one aspect of ancient architecture that remains relevant today. Pergolas date back to ancient Egypt, but the concept itself might have come much earlier. The evolution of pergolas has witnessed many changes along the way. Today, it is technically impossible to draw a line between a pergola and a gazebo. However, for clarity, we will stick to the traditional idea of a pergola, one that is relatively merged with the house design.[...]

Gardening is one of the most ecologically conscious projects that most people can practice. With concepts such as net-zero gardening taking shape, gardeners go to unimaginable lengths to avoid harming the environment. The one aspect most gardeners never consider is that a garden fence can have negative environmental effects and must be installed with consciousness. Creating a sustainable garden only to install an unsustainable fence negates the entire purpose of your project. Interestingly, installing a sustainable fence is easy and often more affordable than traditional options. [...]

The post The Sad Story of the Unique Monument appeared first on English Russia.

A. Kh. Khachatryan, Kh. A. Khachatryan and A. Zh. Narimanyan
Trans. Moscow Math. Soc. 83 (), 183-200.
Abstract, references and article information

Arabinogalactan proteins (AGPs) are plant proteoglycans with functions in growth and development. However, these functions are largely unexplored, mainly because of the complexity of the sugar moieties. These carbohydrate sequences are generally analyzed with the aid of glycoside hydrolases. The exo-β-1,3-galactanase is a glycoside hydrolase from the basidiomycete Phanerochaete chrysosporium (Pc1,3Gal43A), which specifically cleaves AGPs. However, its structure is not known in relation to its mechanism bypassing side chains. In this study, we solved the apo and liganded structures of Pc1,3Gal43A, which reveal a glycoside hydrolase family 43 subfamily 24 (GH43_sub24) catalytic domain together with a carbohydrate-binding module family 35 (CBM35) binding domain. GH43_sub24 is known to lack the catalytic base Asp conserved among other GH43 subfamilies. Our structure in combination with kinetic analyses reveals that the tautomerized imidic acid group of Gln263 serves as the catalytic base residue instead. Pc1,3Gal43A has three subsites that continue from the bottom of the catalytic pocket to the solvent. Subsite −1 contains a space that can accommodate the C-6 methylol of Gal, enabling the enzyme to bypass the β-1,6–linked galactan side chains of AGPs. Furthermore, the galactan-binding domain in CBM35 has a different ligand interaction mechanism from other sugar-binding CBM35s, including those that bind galactomannan. Specifically, we noted a Gly → Trp substitution, which affects pyranose stacking, and an Asp → Asn substitution in the binding pocket, which recognizes β-linked rather than α-linked Gal residues. These findings should facilitate further structural analysis of AGPs and may also be helpful in engineering designer enzymes for efficient biomass utilization.

Paramphistomosis, caused by the rumen fluke, Calicophoron daubneyi, is a parasitic infection of ruminant livestock which has seen a rapid rise in prevalence throughout Western Europe in recent years. Following ingestion of metacercariae (parasite cysts) by the mammalian host, newly-excysted juveniles (NEJs) emerge and invade the duodenal submucosa which causes significant pathology in heavy infections. The immature larvae then migrate upwards, along the gastrointestinal tract, and enter the rumen where they mature and begin to produce eggs. Despite their emergence, and sporadic outbreaks of acute disease, we know little about the molecular mechanisms used by C. daubneyi to establish infection, acquire nutrients and to avoid the host immune response. Here, transcriptome analysis of four intra-mammalian life-cycle stages, integrated with secretome analysis of the NEJ and adult parasites (responsible for acute and chronic disease respectively), revealed how the expression and secretion of selected families of virulence factors and immunomodulators are regulated in accordance with fluke development and migration. Our data show that whilst a family of cathepsins B with varying S2 sub-site residues (indicating distinct substrate specificities) are differentially secreted by NEJs and adult flukes, cathepsins L and F are secreted in low abundance by NEJs only. We found that C. daubneyi has an expanded family of aspartic peptidases, which is up-regulated in adult worms, although they are underrepresented in the secretome. The most abundant proteins in adult fluke secretions were helminth defence molecules (HDMs) that likely establish an immune environment permissive to fluke survival and/or neutralise pathogen-associated molecular patterns (PAMPs) such as bacterial lipopolysaccharide in the microbiome-rich rumen. The distinct collection of molecules secreted by C. daubneyi allowed the development of the first coproantigen-based ELISA for paramphistomosis which, importantly, did not recognise antigens from other helminths commonly found as co-infections with rumen fluke.

Phillies president Andy MacPhail opened a 28-minute press conference on Friday afternoon at Spectrum Field with facts and figures about investments the organization made the past few seasons as the team wallowed at the bottom of the National League. Then MacPhail talked a lot about Bryce Harper and Manny Machado as well as manager Gabe Kapler.

A Smithsonian curator reflects back on the artistic legend, a "Renaissance man" with 28 Grammys to his name, who died Sunday at 91 years old

Read more at http://www.smithsonianmag.com/arts-culture/Arcimboldos-Feast-for-the-Eyes.html The Hapsburg Dynasty's court painter's unique style of portraiture, using fruits, vegetables and animals to compose his faces -- has fascinated artists and the general public for centuries.

New Tango accelerates like a Porsche, trumps gridlock like a motorcycle