Location: Electronic Resource- 

There's starting off on the right foot, and then there's whatever happened Monday night inside Spokane Arena. The Gonzaga men's basketball team loudly announced itself as a national title contender late on college basketball's opening night with a dominating 101-63 win against Baylor…

How Election Day results on the federal, state, and local level impact the labor, arts, and LGBTQ+ communities. Finally, comedian W. Kamau Bell performs at the Mondavi Center at UC Davis.

Tuesday's election offered a wide range of results to digest, both in Colorado and nationally -- at times going in different directions. Here are major takeaways from voters' decisions.

Rarely does something get developed which is a real game changer in space exploration. One example is the Skylon reusable single-stage-to-orbit spaceplane. Powered by the hypersonic SABRE engine it operates like a jet engine at low altitude and more like a conventional rocket at high altitude. Sadly, ‘Reaction Engines’ the company that designs the engines …

Continue reading "Reaction Engines Goes Into Bankruptcy, Taking the Hypersonic SABRE Engine With it"

The post Reaction Engines Goes Into Bankruptcy, Taking the Hypersonic SABRE Engine With it appeared first on Universe Today.

1. All-time reaction to coaching ‘disaster’; Steph’s stunning clutch moment: NBA Wrap  Fox Sports
2. Bike rides and Balkan music: Klay Thompson is embracing a fresh start with the Mavericks  ESPN Australia
3. 10 unforgettable Klay Thompson moments with Warriors ahead of return  NBA.com
4. Dub Hub: Warriors players share ‘welcome back’ messages for Klay Thompson’s return  Golden State of Mind

Why do politics always make for the best meme material? We'll just let the politicians speak for themselves. 

In case you missed last night's democratic presidential debate, then we'll give you a little run down: Cory Booker accused Joe Biden of being high, Amy Klobuchar claimed she raised a crap-load of money from her ex-boyfriends, and Biden made an, uh, brain-dead comment about domestic violence. 

Scroll down to watch some of the highlights and view some of the internet's reactions!

Last night the 2020 Iowa Democratic Caucus stirred up quite the controversy when it was announced that the results would be delayed due to "inconsistencies" in a new app meant to speed up the reporting results of the caucus. Ironic, to say the least. 

But hang tight, because they're set to be released at 5 pm Eastern Time.

Ahead of the results being released, Pete Buttigieg gave what appeared to be a victory speech last night to the confusion of many. The bizarre move has lead many to believe that the system may have been rigged in Mayor Pete's favor.

As always, we have to give the disclaimer that we're not picking sides; we're merely reporting on what the internet has been saying, so scroll down to see some of our favorite reaction memes and tweets while we all wait impatiently for the results.

The internet went crazy today when a rumor seemed to break through about the always-destined Harry Potter television show — specifically that while no series is actually in the works, WB is now officially shopping for writers and pitches for an HBO Max event. We did a quick-and-dirty reaction pod with our three hosts and our good friend Proma Khosla, a longtime LeakyCon staffer and Mashable entertainment reporter, to break down the news, what it means for the franchise, and what the fandom does now. 

Basically, we decided the fandom just needs to get a trillion dollars together and buy the franchise from JKR. 

You can follow Proma on Twitter at @promawhatup  and read her Mashable articles here!

~*~

Don't forget to follow us on @pottercast on Twitter and @pottercastpod on Instagram!

Join our patreon! patreon.com/pottercast - Now, you can also join our Discord community there!

You can also buy PotterCast-related merch at mischiefmerch.com!

If Trump's proposed 60% tariff against China is enacted and the country responds aggressively, it could pressure some of America's largest companies.

Instant Reaction: CPI, August 14, 2024

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Amelia C. Peterson
Nov 1, 2012; 11:1475-1488
Technological Innovation and Resources

Leigh Anderson
Apr 1, 2006; 5:573-588
Research

G Lepage
Jan 1, 1986; 27:114-120
Articles

John A. Glomset
Mar 1, 1968; 9:155-167
Reviews

A. Kh. Khachatryan, Kh. A. Khachatryan and A. Zh. Narimanyan
Trans. Moscow Math. Soc. 83 (), 183-200.
Abstract, references and article information

Intrinsically disordered protein domains often have multiple binding partners. It is plausible that the strength of pairing with specific partners evolves from an initial low affinity to a higher affinity. However, little is known about the molecular changes in the binding mechanism that would facilitate such a transition. We previously showed that the interaction between two intrinsically disordered domains, NCBD and CID, likely emerged in an ancestral deuterostome organism as a low-affinity interaction that subsequently evolved into a higher-affinity interaction before the radiation of modern vertebrate groups. Here we map native contacts in the transition states of the low-affinity ancestral and high-affinity human NCBD/CID interactions. We show that the coupled binding and folding mechanism is overall similar but with a higher degree of native hydrophobic contact formation in the transition state of the ancestral complex and more heterogeneous transient interactions, including electrostatic pairings, and an increased disorder for the human complex. Adaptation to new binding partners may be facilitated by this ability to exploit multiple alternative transient interactions while retaining the overall binding and folding pathway.

War in Ukraine: The world reaction - Brazil and Africa Audio NCapeling 9 June 2022

The ninth episode of our podcast mini-series examines perspectives from Brazil and the Africa region and the impact on their relations with Russia.

How have Brazil and Africa reacted to the war in Ukraine? With impending elections in Brazil, how is President Bolsonaro’s relationship with Putin received by the public? How will food insecurity affect African nations’ response to the war?

This episode was produced by David Dargahi and Anouk Millet of Earshot Strategies on behalf of Chatham House.

Daphne E.C. Boer
Dec 23, 2020; 0:jlr.RA120001043v1-jlr.RA120001043
Research Articles

Deficiency of glucocerebrosidase (GBA), a lysosomal β-glucosidase, causes Gaucher disease. The enzyme hydrolyzes β-glucosidic substrates and transglucosylates cholesterol to cholesterol-β-glucoside. Here we show that recombinant human GBA also cleaves β-xylosides and transxylosylates cholesterol. The xylosyl-cholesterol formed acts as acceptor for subsequent formation of di-xylosyl-cholesterol. Common mutant forms of GBA from patients with Gaucher disease with reduced β-glucosidase activity were similarly impaired in β-xylosidase, transglucosidase and transxylosidase activities, except for a slightly reduced xylosidase/glucosidase activity ratio of N370S GBA and a slightly reduced transglucosylation/glucosidase activity ratio of D409H GBA. XylChol was found to be reduced in spleen from Gaucher disease patients. The origin of newly identified XylChol in mouse and human tissues was investigated. Cultured human cells exposed to exogenous β-xylosides generated XylChol in a manner dependent on active lysosomal GBA but not the cytosol-facing β-glucosidase GBA2. We later sought an endogenous β-xyloside acting as donor in transxylosylation reactions, identifying xylosylated ceramide (XylCer) in cells and tissues that serve as donor in the formation of XylChol. UDP-glucosylceramide synthase (GCS) was unable to synthesize XylChol but could catalyse formation of XylCer. Thus, food-derived β-D-xyloside and XylCer are potential donors for the GBA-mediated formation of XylChol in cells. The enzyme GCS produces XylCer at a low rate. Our findings point to further catalytic versatility of GBA and prompt a systematic exploration of the distribution and role of xylosylated lipids.

Protein tyrosine kinases (PTKs) play key roles in cellular signal transduction, cell cycle regulation, cell division, and cell differentiation. Dysregulation of PTK-activated pathways, often by receptor overexpression, gene amplification, or genetic mutation, is a causal factor underlying numerous cancers. In this study, we have developed a parallel reaction monitoring (PRM)-based assay for quantitative profiling of 83 PTKs. The assay detects 308 proteotypic peptides from 54 receptor tyrosine kinases and 29 nonreceptor tyrosine kinases in a single run. Quantitative comparisons were based on the labeled reference peptide method. We implemented the assay in four cell models: 1) a comparison of proliferating versus epidermal growth factor (EGF)-stimulated A431 cells, 2) a comparison of SW480Null (mutant APC) and SW480APC (APC restored) colon tumor cell lines, and 3) a comparison of 10 colorectal cancer cell lines with different genomic abnormalities, and 4) lung cancer cell lines with either susceptibility (11-18) or acquired resistance (11-18R) to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib. We observed distinct PTK expression changes that were induced by stimuli, genomic features or drug resistance, which were consistent with previous reports. However, most of the measured expression differences were novel observations. For example, acquired resistance to erlotinib in the 11-18 cell model was associated not only with previously reported upregulation of MET, but also with upregulation of FLK2 and downregulation of LYN and PTK7. Immunoblot analyses and shotgun proteomics data were highly consistent with PRM data. Multiplexed PRM assays provide a targeted, systems-level profiling approach to evaluate cancer-related proteotypes and adaptations. Data are available through Proteome eXchange Accession PXD002706.

Voice assistants (VAs) like Alexa and Siri continue to gain popularity in households and on personal devices. According to digital trends research company Emarketer, the number of VA users will surpass 150 million in 2025. Despite the ubiquity, companies haven’t been able to work around users’ strong negative reactions to advertising on these applications. A research team, including scholars from Penn State, may have a solution.

Signal has been updated with Call Links, a feature that enables users to initiate a group call with multiple participants without the need to form a separate group chat. Additional updates include a "raise hand" button, emoji reactions, and a dedicated calls tab on Signal.

The Great Indian Kapil Show episode featuring Navjot Singh Sidhu will premiere on Netflix on Saturday, November 16 

Shraddha dropped a string of sweaty face and head slamming emojis

Shilpa Shetty's unapologetic foodie side shines through in her latest Instagram reel. "My food is my food, and none of your food!" she declared.

The situation of local fruit vendors has gone from bad to worse after the Thai Pesticide Alert Network (Thai-PAN) released its finding two weeks ago, revealing chemical contamination in popular Shine Muscat grapes.

to write a reaction paper book

Title: Serious Reactions to Vaccines Rarely Recur: Review
Category: Health News
Created: 8/28/2017 12:00:00 AM
Last Editorial Review: 8/28/2017 12:00:00 AM

End-to-end RNA-sequencing methods that capture 5'-sequence content without cumbersome library manipulations are of great interest, particularly for analysis of long RNAs. While template-switching methods have been developed for RNA sequencing by distributive short-read RTs, such as the MMLV RTs used in SMART-Seq methods, they have not been adapted to leverage the power of ultraprocessive RTs, such as those derived from group II introns. To facilitate this transition, we dissected the individual processes that guide the enzymatic specificity and efficiency of the multistep template-switching reaction carried out by RTs, in this case, by MarathonRT. Remarkably, this is the first study of its kind, for any RT. First, we characterized the nucleotide specificity of nontemplated addition (NTA) reaction that occurs when the RT extends past the RNA 5'-terminus. We then evaluated the binding specificity of specialized template-switching oligonucleotides, optimizing their sequences and chemical properties to guide efficient template-switching reaction. Having dissected and optimized these individual steps, we then unified them into a procedure for performing RNA sequencing with MarathonRT enzymes, using a well-characterized RNA reference set. The resulting reads span a six-log range in transcript concentration and accurately represent the input RNA identities in both length and composition. We also performed RNA-seq from total human RNA and poly(A)-enriched RNA, with short- and long-read sequencing demonstrating that MarathonRT enhances the discovery of unseen RNA molecules by conventional RT. Altogether, we have generated a new pipeline for rapid, accurate sequencing of complex RNA libraries containing mixtures of long RNA transcripts.

The comedian is more than ready to reprise her Emmy-nominated 'SNL' guest role.

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Over the years, I’ve been able to interview some of my favorite developers ever including a few I never though …

Continue reading "Sukeban Games 2024 Interview: Christopher Ortiz AKA kiririn51 Talks .45 PARABELLUM BLOODHOUND, Inspirations, Fan Reactions, VA-11 Hall-A, The Silver Case, and Much More"

Jardiance is a popular drug used to treat type 2 diabetes and help reduce cardiovascular risk. DTC campaigns […]

Pagans from across the community react to the US 2024 Presidential Election.

Continue reading Pagan Voices: Reactions to the 2024 US Presidential Election at The Wild Hunt.

Commonly prescribed medlinkantibiotics/medlink, sulfonamides and cephalosporins, pose the highest risk for severe, potentially fatal skin reactions (!--ref1--).

Layered with metaphors and allegories that give varied meanings to the narration, on the surface, the film is the adventure of a young boy named Jake (Asa Butterfield), who shuttles in time.

Directed by Nag Ashwin, Mahanati has Keerthy Suresh and Dulquer Salmaan in the lead roles. Dulquer Salmaan has done a great job in this film, and it marked his debut in Telugu cinema.