Phenuiviridae nucleoprotein is the main structural and functional component of the viral cycle, protecting the viral RNA and mediating the essential replication/transcription processes. The nucleoprotein (N) binds the RNA using its globular core and polymerizes through the N-terminus, which is presented as a highly flexible arm, as demonstrated in this article. The nucleoprotein exists in an `open' or a `closed' conformation. In the case of the closed conformation the flexible N-terminal arm folds over the RNA-binding cleft, preventing RNA adsorption. In the open conformation the arm is extended in such a way that both RNA adsorption and N polymerization are possible. In this article, single-crystal X-ray diffraction and small-angle X-ray scattering were used to study the N protein of Toscana virus complexed with a single-chain camelid antibody (VHH) and it is shown that in the presence of the antibody the nucleoprotein is unable to achieve a functional assembly to form a ribonucleoprotein complex.

Every year some of the world’s best young musicians would jet into London to audition for a bursary with the Southbank Sinfonia. Simon Over wanted to cut down on those thousands of air miles and hours in transit. He also didn’t want to miss out on youngsters who couldn’t afford the fare.

SASOL has adopted telepresence for collaboration between far-flung executives in Europe, North America and Africa. Running over the BT IP Connect global network it also enables federation with customers and suppliers. The solution’s earned Alec’s team a special recognition award from the CEO for bringing the company’s One SASOL philosophy and vision vibrantly to life

Eton Solutions, a cloud-based services provider, is establishing a Technology Center in GIFT City, Gandhinagar, supporting their international growth and leveraging GIFT City's regulatory environment. Executive Chairman Satyen Patel emphasized India’s importance, the diaspora’s service potential, and the country's billionaire concentration. The company also launched AtlasFive, an ERP platform, as part of their expansion strategy.

The recall was initiated after it was discovered that wheat-containing product was distributed in packaging that did not reveal the presence of wheat.

Expanding its global distribution presence, Prinova Group LLC has entered into a definitive agreement to acquire industry expert The Ingredient House, LLC.

When I coach leaders, I often hear that the image of wallowing stays with them long after I’m gone - even when they don’t feel like wallowing! Ultimately, the thought of wallowing moves their thoughts to intentions, and then, purposeful actions.

KAILASA's Global Temples Celebrate Ayodhya Ram Prana Pratishtha with Traditional Rituals in the Divine Presence of THE SPH BHAGAVAN SRI NITHYANANDA PARAMASHIVAM

The best rule for a holy life. This version has not been paraphrased. Instead, it has been completely translated into modern English, for today's readers, with questions at the end of each of Brother Lawrence's letters and conversations for you.

Affinity Global Inc, a globally-diversified ad tech firm that provides privacy-friendly advertising solutions and SaaS platforms, has announced its acquisition of Opinary, a Berlin-based consumer engagement focused media tech company.

K&D Landscaping, Inc. Strengthens Presence with New Santa Cruz Office, Offering Superior Landscaping Services to an Expanded Client Base

Crete Mechanical Group, a leading nationwide multi-service building solutions provider, expands its HVAC services by partnering with John's Service and Sales in Oglesby, Illinois.

Crete Mechanical Group, a nationwide multi-service building solutions provider, expands its HVAC services to Stamford, CT by partnering with C&C Service.

Crete Mechanical Group expands its piping and plumbing services in Florida by acquiring majority stake of Blue Works.

Expanding Reach Across Europe with Strategic Office Openings to Enhance Client Support and Service Excellence

Exploring the Dynamic Landscape of the K-12 Game-based Learning Market: A Comprehensive Analysis of Growth Trends, Key Players, and Market Fragmentation from 2022 to 2027

Expanding Reach and Reinforcing Commitment to the Growing Customer Base in the Region

Strategic Insights into the Automotive Aftermarket: Unraveling Market Fragmentation with Industry Giants Aptiv PLC, BorgWarner Inc., and Bridgestone Corp.

When investigating how we frame technology in the design process,... more

Introduction Why Pinterest Deserves Your Attention Now, let’s talk numbers—impressive numbers. With over 450 million active dreamers and doers, Pinterest is not merely thriving; it’s bustling with opportunity. For the astute blogger, these aren’t just stats—they represent a bustling metropolis of potential readers, engaged followers, and eventual customers. Each user is searching, planning, and ready […]

The post Guide to Building a Pinterest Presence for Bloggers appeared first on WPCult.

Jenny Evans has created a Storify summary of her SpotOn London session: Collaborating and building your online

New thermopile sensors save energy and increase safety when applied within the construction and property sectors.

First Onsite, a leading disaster recovery provider in North America, has expanded its New England presence by recruiting a seasoned team of restoration professionals. Led by industry veterans Gary Grout and Jason Green, the team brings decades of experience in water, fire, and mold mitigation, enhancing First Onsite's ability to serve clients across Massachusetts and beyond.

Automation & Modular Components, LLC. (AMC) is a manufacturer of material handling automation systems with integrated controls, as well as conveyors for integration into assembly systems and production lines, headquartered in Davisburg, Michigan, USA.

Acquisition broadens TransPak’s capabilities in custom packaging for military, aerospace and high-value equipment.

Acquisition adds significant capabilities to the Inovar platform, which includes industry-leading pressure sensitive, roll-fed, and RFID label capabilities.

TIRANA, 22 July 2016 – The OSCE Presence in Albania welcomes the Assembly’s adoption today of the set of constitutional amendments aimed at reforming the justice sector. We commend the Assembly for this fundamental achievement, which was supported tangibly by many international experts and diplomats.

It is an important milestone, paving the way for the implementation of a meaningful justice reform. The amendments adopted today must now be cascaded down through the primary and secondary legislation, the procedures and policies of the entire judicial system. Reform is not genuine until it is felt by Albanian citizens in their daily lives, across the country.

The manner in which the reform package is implemented is essential for the sustainability and the success of the reform process. Sustainability and success also depend on a change in attitudes: establishing a culture of responsibility and accountability, countering impunity and consolidating respect for the rule of law at all levels of society. 

The OSCE Presence has been a committed contributor and partner of the reform process so far and stands ready to continue its active support at all levels.

Related Stories

• OSCE Presence launches nationwide ‘Justice without delays’ initiative in Albania
• OSCE Presence, German Embassy launch project to foster public discourse about Communist past in Albania
• OSCE helps Albania dispose of highly toxic chemicals

The United States and the Philippines have announced plans to expand America's military presence in the Southeast Asian nation, with access to four more bases as they seek to deter China’s increasingly aggressive actions toward Taiwan and in the disputed South China Sea. The agreement was reached as Defense Secretary Lloyd Austin was in the country for talks about deploying U.S. forces and weapons in more Philippine military camps. In a joint announcement Thursday by the Philippines and the U.S., the two said they had decided to accelerate the full implementation of their so-called Enhanced Defense Cooperation Agreement, which aims to support combined training, exercises and interoperability.

The post US, Philippines agree to larger American military presence first appeared on Federal News Network.

Backblaze will leverage the new partnership to open its first data region in Canada, which will be based in Toronto, service the whole country, and become available in the first quarter of 2025.

Games organisers moving into new city centre premises.

Marico Limited finalized its acquisition of Just Herbs in September 2024, securing the remaining 40% equity in Apcos Naturals Private Limited, which owns the Just Herbs brand. With this acquisition, Just Herb's expansion momentum is poised to accelerate.

Highlighting the brand’s expansion trajectory in terms of physical retail presence, Sanjay Sharma, Country Head of Shiseido India said that since launching with 15 touchpoints last year, NARS has already doubled its reach to 30 points in India and plans to double again in the next two years.

Abuse, alcohol, drugs, gangs and poverty are the daily realities for many in the slums. Many arrive at OM MTI looking for food, safety, conversation, advise and help.

On view from April 1-29, 2022 Wilmington, Del. (March 30, 2022) – The Delaware Division of the Arts’ Mezzanine Gallery presents artist Mia Muratori’s exhibition, Painting in the Presence of Change, running April 1 through 29, 2022. Her exhibit will also be part of Art Loop Wilmington — the monthly self-guided tour of art in […]

The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC₅₀ and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC₅₀ values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms.

PURPOSE

Currently, 40% of counties in the United States do not have an obstetrician or midwife, and in rural areas the likelihood of childbirth being attended to by a family medicine (FM) physician is increasing. We sought to characterize the effect of the FM presence on unit culture and a key perinatal quality metric in Iowa hospital intrapartum units.

In today’s digital age, your website is more than just a virtual storefront—it’s the heart of your online presence. Whether you’re a small business, a growing startup, or an established brand, a custom-designed website can be the key to standing out in a crowded market. But what does it take to truly transform your digital […]

The post How to Transform Your Online Presence with a Custom Website appeared first on Chart Attack.

Gary Lineker is leaving ‘MOTD’ at the end of this season, after a glittering 25-year tenure as the host of the BBC’s flagship football show. Nick Hilton looks back at the pundit’s highs and lows, from predatory striker to top broadcaster and media mogul

SEDCO Holding Group sees further growth, more global presence by 2025 at the Annual Multaqa

Robert J. Bitterman, CEO and President, discusses goals of Cutanea Life Sciences

With a strategic focus on strengthening its presence in the leisure towns of India, Radisson Hotel Group is proud to announce the opening of Namah Nainital, a member of Radisson Individuals Retreats. This new addition is the Group’s fourth operational hotel in Uttarakhand where its portfolio includes hotels and resorts under multiple brands like Radisson Blu and Radisson Individuals. Nestled in the heart of Nainital Valley, the hotel provides excellent connectivity via road, rail, and air, making it accessible for both international and domestic travelers. Positioned close to Kathgodam Railway Station and Pantnagar Airport, the hotel is also well-connected by road to Almora, Ranikhet, Bhimtal, Mukteshwar, and Ramgarh. Its proximity to Namah Jim Corbett, another member of the Radisson Individuals brand, underscores the Group’s commitment to enhancing the guest experience, offering seamless connections within a four-hour drive of the property. Guests can visit the Mall which is only a s...

IHG Hotels & Resorts (IHG), one of the world’s leading hotel companies, is delighted to announce the signing of the first voco hotel on the Sunshine Coast, partnering again with Sydney-based developer Felix Capital to open voco Maroochydore Sunshine Coast in 2028. Located on bustling Ocean Street, the striking new 153-key upscale hotel will form part of a mixed-use development that is set to transform the city’s accommodation offering, attracting domestic and international patronage. voco Maroochydore will also address the Sunshine Coast’s recent Temporary Local Planning Instrument proposal in response to the need for four- and five-star full-service hotels in the region. With the Brisbane 2032 Olympic and Paralympic Games only eight years away, having the right mix of accommodation options will be crucial to deliver a successful Games and support the region’s economy beyond 2032. Further complementing Maroochydore’s entertainment and dining precinct, guests will enjoy dazzling water ...

After Shahid Kapoor broke up with Kareena Kapoor, he was rumoured to be dating Sania Mirza for a brief period. They were reportedly spotted together on numerous of occasions.

Computer vision applications are getting a huge boost from advances in smartphones combined with AI that helps fill in the gaps of what everyday devices cannot see. Using these tools, a startup out of Munich called Beyond Presence believes it holds the keys to what is coming next: Hyper-realistic avatars that look and sound exactly […]

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Apple is planning on opening four additional retail stores in India. The iPhone maker will also begin production of the iPhone 16 Pro domestically, with the aim to strengthen its position in the world's second-largest smartphone market. The company aims to

Zürich : LIT Verlag, 2020.