We have been separated from God because of our sin. God created us to be with Him. The plan of salvation is about how to get back into the presence of God.

We have been separated from God because of our sin. God created us to be with Him. The plan of salvation is about how to get back into the presence of God.

When Dave Suter donated the 'innocuous' wartime artefacts he had once used as bookends, he was shocked to learn they were unexploded WWII bombs.

Acoustic & Lighting Systems And Arcadia Tech Are Now Representing The Company’s Products In These Key Territories.

You setup your social media accounts, maybe Facebook, Twitter and Pinterest, but it’s been a few weeks or even years since you’ve touched the accounts. This happens far too often with small businesses. The problem is that even when stores implement decent social strategies it’s tough to improve sales, or at least track whether sales are occurring through social media.
Around 85 percent of social/ecommerce orders come from Facebook.
What does this say? Well, to start, this is talking about ...

The post 9 Unique Tips to Grow Your Store’s Online Presence With Social Media appeared first on RSS Feed Converter.

The Clippers' 120-105 rout of Houston was many things: a sixth consecutive win, a defensive showcase for three quarters and a muscular step toward the postseason.

Anthony Davis didn't know much about Alex Caruso before joining the Lakers, but he said the 6-5 wing player is "surprising me every day with his ability."

Ditte and Nicolaj Reffstrup call their fashion brand's sustainabilty efforts "a moral obligation."

Glial cell line–derived neurotrophic factor (GDNF) is a growth factor that regulates the health and function of neurons and other cells. GDNF binds to GDNF family receptor α1 (GFRa1), and the resulting complex activates the RET receptor tyrosine kinase and subsequent downstream signals. This feature restricts GDNF activity to systems in which GFRa1 and RET are both present, a scenario that may constrain GDNF breadth of action. Furthermore, this co-dependence precludes the use of GDNF as a tool to study a putative functional cross-talk between GFRa1 and RET. Here, using biochemical techniques, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, and immunohistochemistry in murine cells, tissues, or retinal organotypic cultures, we report that a naphthoquinone/quinolinedione family of small molecules (Q compounds) acts as RET agonists. We found that, like GDNF, signaling through the parental compound Q121 is GFRa1-dependent. Structural modifications of Q121 generated analogs that activated RET irrespective of GFRa1 expression. We used these analogs to examine RET–GFRa1 interactions and show that GFRa1 can influence RET-mediated signaling and enhance or diminish AKT Ser/Thr kinase or extracellular signal-regulated kinase signaling in a biased manner. In a genetic mutant model of retinitis pigmentosa, a lead compound, Q525, afforded sustained RET activation and prevented photoreceptor neuron loss in the retina. This work uncovers key components of the dynamic relationships between RET and its GFRa co-receptor and provides RET agonist scaffolds for drug development.

7 May 2020 , Volume 96, Number 3

Glial cell line–derived neurotrophic factor (GDNF) is a growth factor that regulates the health and function of neurons and other cells. GDNF binds to GDNF family receptor α1 (GFRa1), and the resulting complex activates the RET receptor tyrosine kinase and subsequent downstream signals. This feature restricts GDNF activity to systems in which GFRa1 and RET are both present, a scenario that may constrain GDNF breadth of action. Furthermore, this co-dependence precludes the use of GDNF as a tool to study a putative functional cross-talk between GFRa1 and RET. Here, using biochemical techniques, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, and immunohistochemistry in murine cells, tissues, or retinal organotypic cultures, we report that a naphthoquinone/quinolinedione family of small molecules (Q compounds) acts as RET agonists. We found that, like GDNF, signaling through the parental compound Q121 is GFRa1-dependent. Structural modifications of Q121 generated analogs that activated RET irrespective of GFRa1 expression. We used these analogs to examine RET–GFRa1 interactions and show that GFRa1 can influence RET-mediated signaling and enhance or diminish AKT Ser/Thr kinase or extracellular signal-regulated kinase signaling in a biased manner. In a genetic mutant model of retinitis pigmentosa, a lead compound, Q525, afforded sustained RET activation and prevented photoreceptor neuron loss in the retina. This work uncovers key components of the dynamic relationships between RET and its GFRa co-receptor and provides RET agonist scaffolds for drug development.

7 May 2020 , Volume 96, Number 3

Joseph B. Nelson
Aug 1, 2017; 30:171-174
From Research to Practice

18 February 2019

7 May 2020 , Volume 96, Number 3

7 May 2020 , Volume 96, Number 3

The Giants have expressed a desire to add multiple veteran outfielders throughout the offseason, and they made their first notable acquisition earlier this week after signing Gerardo Parra to a Minor League contract.

The reality is setting in for Astros star second baseman Jose Altuve, who's shared a clubhouse with close friend Marwin Gonzalez for the previous seven springs. They became confidants on and off the field, which is what makes this spring so strange.

We consider the problem of learning causal models from observational data generated by linear non-Gaussian acyclic causal models with latent variables. Without considering the effect of latent variables, the inferred causal relationships among the observed variables are often wrong. Under faithfulness assumption, we propose a method to check whether there exists a causal path between any two observed variables. From this information, we can obtain the causal order among the observed variables. The next question is whether the causal effects can be uniquely identified as well. We show that causal effects among observed variables cannot be identified uniquely under mere assumptions of faithfulness and non-Gaussianity of exogenous noises. However, we are able to propose an efficient method that identifies the set of all possible causal effects that are compatible with the observational data. We present additional structural conditions on the causal graph under which causal effects among observed variables can be determined uniquely. Furthermore, we provide necessary and sufficient graphical conditions for unique identification of the number of variables in the system. Experiments on synthetic data and real-world data show the effectiveness of our proposed algorithm for learning causal models.

Given a response $Y$ and a vector $X = (X^1, dots, X^d)$ of $d$ predictors, we investigate the problem of inferring direct causes of $Y$ among the vector $X$. Models for $Y$ that use all of its causal covariates as predictors enjoy the property of being invariant across different environments or interventional settings. Given data from such environments, this property has been exploited for causal discovery. Here, we extend this inference principle to situations in which some (discrete-valued) direct causes of $ Y $ are unobserved. Such cases naturally give rise to switching regression models. We provide sufficient conditions for the existence, consistency and asymptotic normality of the MLE in linear switching regression models with Gaussian noise, and construct a test for the equality of such models. These results allow us to prove that the proposed causal discovery method obtains asymptotic false discovery control under mild conditions. We provide an algorithm, make available code, and test our method on simulated data. It is robust against model violations and outperforms state-of-the-art approaches. We further apply our method to a real data set, where we show that it does not only output causal predictors, but also a process-based clustering of data points, which could be of additional interest to practitioners.

Sophie Achard, Jean-François Coeurjolly

Source: Statist. Surv., Volume 4, 117--147.

Abstract:
This paper gives an overview of the problem of estimating the Hurst parameter of a fractional Brownian motion when the data are observed with outliers and/or with an additive noise by using methods based on discrete variations. We show that the classical estimation procedure based on the log-linearity of the variogram of dilated series is made more robust to outliers and/or an additive noise by considering sample quantiles and trimmed means of the squared series or differences of empirical variances. These different procedures are compared and discussed through a large simulation study and are implemented in the R package dvfBm.

The figures of impact were impressive during a recent medical outreach in the indigenous region of Guamote in Ecuador. But only because He showed up.

Abuse, alcohol, drugs, gangs and poverty are the daily realities for many in the slums. Many arrive at OM MTI looking for food, safety, conversation, advise and help.

In the era of e-commerce, where do direct selling companies with a sparse digital presence stand?

The ongoing Coronavirus crisis across the world and a prolonged lockdown in India has halted MS Dhoni’s planned comeback to competitive cricket. He had joined the training camp with his IPL franchise team Chennai Super Kings but the initial delays in the start of IPL until April 15 and then for an indefinite period stopped him to press on for a place in the Indian squad.

According to the study published in the Indian Journal of Medical Research, there is no evidence or research to claim that these bat coronaviruses can cause disease in humans.

In the lead-up to the Truth Matters conference in October, we will be focusing our attention on the sufficiency, authority, and clarity of Scripture. Of our previous blog series, none better embodies that emphasis than Frequently Abused Verses. The following entry from that series originally appeared on October 2, 2015. -ed.

Truly I say to you, whatever you bind on earth shall have been bound in heaven; and whatever you loose on earth shall have been loosed in heaven. Again I say to you, that if two of you agree on earth about anything that they may ask, it shall be done for them by My Father who is in heaven. For where two or three have gathered together in My name, I am there in their midst. (Matthew 18:18–20)

How often have you heard that passage (or at least part of it) quoted in a church setting?

During my time in the charismatic church, Matthew 18:18–20 was quoted in every prayer meeting and regularly from the pulpit. In fact, I cannot think of any other Scripture passage I heard quoted so frequently without ever hearing a sermon on the passage itself. And yet we would regularly bind demonic forces on earth and loose angelic armies from heaven. And we always reminded ourselves that Jesus was there because at least two or three of us were present.

Our church was far from alone in its dependence on Matthew 18:18–20. In fact, the passage is a favorite of self-appointed experts in spiritual warfare and those who put special emphasis on Christ’s presence. The passage has been chopped up and subdivided all sorts of ways in service to a number of doctrinal positions and practical applications.

For example, notorious faith healer and prosperity preacher Benny Hinn emphasizes Matthew 18:18 as a promise of supernatural power and heavenly authority:

Do you realize that movements on earth govern movements in heaven? Do you realize that a child of God in prayer affects decisions in heaven? The Lord declared: “Whatsoever ye shall bind on earth shall be bound in heaven; and whatsoever ye shall loose on earth shall be loosed in heaven (Matthew 18:18). So awesome is this power that it releases angels to do God’s bidding on the earth and binds demons as it destroys the purpose of the enemy! ^[1]Benny Hinn, https://www.bennyhinn.org/tiyd-video/prayer-that-gets-results-part-1/

Contrast that with the conclusions of Rick Warren, who offers a far less spectacular interpretation and application of the passage, while employing similar hermeneutical technique in his assessment of verses 19–20:

Many people miss out on so much because they only pray by themselves. Yet, when Jesus gave us an outline for prayer, he spoke about praying together. There is power in group prayer. If you’re not praying with other believers, then you’re not getting the support you need. You’re missing out on one of the major benefits of being a Christian. Jesus says “whenever two of you on earth agree about anything you pray for, it will be done for you by my Father in heaven. For where two or three come together in my name, I am there with them” (Matthew 18:19-20 TEV). That’s the power of praying with other people. ^[2]Rick Warren, http://rickwarren.org/devotional/english/a-powerful-key-to-prayer_700

Joyce Meyer comes out of the same Word Faith stream as Benny Hinn and also enjoys a huge television following. But her ministry prefers to traffic in practical advice for day-to-day life. She actually deploys Matthew 18:20 in the realm of marriage counsel:

The Bible says that there is power in agreement. . . .

If you want to have power in your marriage and in your prayer life, then you have to get along. The big question is: How can a disagreeing couple learn to agree? Agreement comes when the people involved stop being selfish. Selfishness is an immature inward focus. The key is to care about what the other person needs, be willing to humble yourself, and do what you can to meet those needs.

When this happens, you can live together in agreement before the Lord, and “wherever two or three are gathered” in His name, God is there with them. So make a choice with your spouse today to pursue agreement and unity before the Lord. ^[3]Joyce Meyer, https://www.bible.com/reading-plans/199-promises-for-your-everyday-life/day/360

How can one passage support such disparate meanings? Are any of those interpretations the true meaning of Matthew 18:18–20? Do they skirt around the edges of the author’s original intent, or are they missing the point of the passage altogether? Bottom line: Does this passage have anything to do with spiritual warfare, group prayer, or marital unity?

As with previous posts in this series, the first thing we should check is the context of our passage. What do the surrounding verses tell us about the meaning of our text? In this case, the preceding verses are likely just as familiar as the passage in question:

If your brother sins, go and show him his fault in private; if he listens to you, you have won your brother. But if he does not listen to you, take one or two more with you, so that by the mouth of two or three witnesses every fact may be confirmed. If he refuses to listen to them, tell it to the church; and if he refuses to listen even to the church, let him be to you as a Gentile and a tax collector. (Matthew 18:15–17)

Just a simple reading of the text makes it clear that the focus is not spiritual warfare, unity in marriage, or empowering your prayer meetings. Instead, verses 15–17 speak exclusively about church discipline.

Therefore, all of Christ’s instructions about binding and loosing, unity, and the promise of His presence come in the context of church discipline. In other words, Matthew 18:18–20 means that when church leaders gather together to deal with unrepentant sinners, they have heavenly backing.

In his commentary on this passage, John MacArthur explains how many of the popular interpretations go wrong when they divorce the verses from their context:

Jesus’ promises in verses 18 and 19 have suffered serious misinterpretation throughout the history of the church. . . . Many charismatics use these promises—along with others, such as those of Matthew 7:7 and 21:22—to claim from God every imaginable blessing and privilege just for the asking.

But in light of the context of what Jesus had just said, in the light of common rabbinical expressions of that day, and in light of the grammatical construction of the text, it is clear that He was not teaching that God’s power can be bent to men’s will. He was not saying that men can force heaven to do things. Quite to the contrary, His promise was that when His people bend their wills to His, He will endorse and empower their act of obedience.

Jesus was here continuing His instruction about church discipline. He was not speaking about petitioning God for special blessings or privileges, and even less was He teaching that the church or any of its leaders has power to absolve the sins of its members. He was declaring that the church has a divine mandate to discipline its members when they refuse to repent. ^[4]John MacArthur, The MacArthur New Testament Commentary: Matthew 16–23 (Chicago: Moody Publishers, 1988) 137.

And what about the power to bind and loose in the spiritual realm? John also carefully debunks that misinterpretation:

The rabbis sometimes spoke of a principle or action as being bound in heaven or loosed in heaven to indicate, respectively, that it was forbidden or permitted in light of God’s revealed Word. . . . Believers have authority to declare that sins are either forgiven or not forgiven when that declaration is based on the teaching of God’s Word. If a person has received Jesus Christ as Savior and Lord, the church can tell him with perfect confidence that his sins are loosed, that is, forgiven, because he has met God’s condition for forgiveness, namely, trust in His Son. If, on the other hand, a person refuses to receive Christ as Savior and acknowledge Him as Lord, the church can tell him with equal confidence that his sins are bound, that is, not forgiven, because he has not met God’s condition for forgiveness. ^[5] The MacArthur New Testament Commentary: Matthew 16–23, 137.

Matthew 18:15–17 is Christ’s explanation of how church discipline is to be practiced. Verses 18–20 expand on His instructions by informing us of the immense heavenly support provided to leaders who maintain the discipline of the church. Here’s how John MacArthur describes it:

Jesus also assures His people that He Himself acts with them when they work to purify the church: “For where two or three have gathered together in My name, there I am in their midst.” Not only does the Father confirm discipline when it is administered according to His Word, but the Son adds His own divine confirmation. . . . To use this statement to claim the Lord’s presence at a small worship service or prayer meeting does not fit the context of church discipline and is superfluous. Christ is always present with His people, even with a lone believer totally separated from fellow Christians by prison walls or by hundreds of miles.

The context demands that the two or three are witnesses in the process of discipline. To ask or to do anything in God’s name is not to utter His name but to ask and to work according to His divine will and character. For the witnesses to have gathered in His name is therefore for them to have faithfully performed their work of verifying the repentance or impenitence of a sinning brother or sister on the Lord’s behalf. When the church gathers in the Lord’s name and for His cause and glory, it must be engaged in self-purifying ministry under His power and authority, and with His heavenly confirmation and partnership. ^[6] The MacArthur New Testament Commentary: Matthew 16–23, 138.

One could make a case that the church’s silence on the issue of biblical discipline (Matthew 18:15-17) has allowed for a cacophony of misinterpretations and misapplications of Matthew 18:18-20. Ripped from their original setting and intent, those verses have been made to serve a variety of false positions and pretexts.

Our interpretation of Scripture has serious practical repercussions. We would all do well to receive Paul’s counsel to Timothy:  “Be diligent to present yourself approved to God as a workman who does not need to be ashamed, accurately handling the word of truth” (2 Timothy 2:15).

This paper presents an analysis of business development programs (BDPs) based on a theoretical framework aimed at understanding the mixed effect of business training on entrepreneurs.

This paper presents an analysis of business development programs (BDPs) based on a theoretical framework aimed at understanding the mixed effect of business training on entrepreneurs.

Glial cell line–derived neurotrophic factor (GDNF) is a growth factor that regulates the health and function of neurons and other cells. GDNF binds to GDNF family receptor α1 (GFRa1), and the resulting complex activates the RET receptor tyrosine kinase and subsequent downstream signals. This feature restricts GDNF activity to systems in which GFRa1 and RET are both present, a scenario that may constrain GDNF breadth of action. Furthermore, this co-dependence precludes the use of GDNF as a tool to study a putative functional cross-talk between GFRa1 and RET. Here, using biochemical techniques, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, and immunohistochemistry in murine cells, tissues, or retinal organotypic cultures, we report that a naphthoquinone/quinolinedione family of small molecules (Q compounds) acts as RET agonists. We found that, like GDNF, signaling through the parental compound Q121 is GFRa1-dependent. Structural modifications of Q121 generated analogs that activated RET irrespective of GFRa1 expression. We used these analogs to examine RET–GFRa1 interactions and show that GFRa1 can influence RET-mediated signaling and enhance or diminish AKT Ser/Thr kinase or extracellular signal-regulated kinase signaling in a biased manner. In a genetic mutant model of retinitis pigmentosa, a lead compound, Q525, afforded sustained RET activation and prevented photoreceptor neuron loss in the retina. This work uncovers key components of the dynamic relationships between RET and its GFRa co-receptor and provides RET agonist scaffolds for drug development.

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Robert J. Bitterman, CEO and President, discusses goals of Cutanea Life Sciences

Robert J. Bitterman, CEO and President, discusses goals of Cutanea Life Sciences

The Ghatkopar plane crash, which killed five, yesterday would have ended up becoming a mammoth disaster, considering it crashed in a densely populated residential area, had it not been for the pilot's presence of mind. Several residents from the area and eyewitnesses said the pilot did a good thing by ensuring the aircraft crashed at an under-construction site, avoiding the residential buildings in the vicinity.

Emergency response
The accident took place when the plane was about to land at Mumbai airport. The four onboard — pilot, co-pilot and maintenance engineers — and a passer-by on whom the wreckage fell have been identified as the deceased. Immediately after the incident, the fire brigade and police reached the spot, and within minutes pictures and videos of the crashed plane and a charred body near the crash site went viral on social media.

Afternoon happenings
mid-day spoke to residents from the area to find out what exactly happened, and most said it all started in the afternoon when they heard a deafening explosion, followed by thick smoke and a tree on fire. Locals said the situation would have been worse had the aircraft crashed on a residential building or the busy LBS Marg, which is adjacent, or the Versova-Andheri Ghatokpar Metro corridor, which, too, is just a few hundred metres away.

A paan shop owner from the area said, "I was sitting in my shop when I heard a loud noise. At first I thought a tyre of some truck busted, but then, a person from the MTNL lane came running to my shop and said a plane had crashed. "We should all be thankful to the pilot, as by crashing it at an under-construction site, he saved hundreds of lives."

Also Read: Mumbai: Chartered plane crashes in Ghatkopar; five killed

Extended Stay America, Inc. (NASDAQ:STAY), the largest mid-priced extended stay hotel brand, today announced the opening of the brand new Extended Stay America® Bluffton - Hilton Head, in Bluffton, S.C. The newly constructed property stands four stories tall and contains 120 rooms, free onsite parking, complimentary WiFi, premium cable, a STAYFIT fitness room, STAYCLEAN laundry room and our signature spacious STAYPLAY lobby to provide guests with a home away from home. The property features fully equipped, in-room kitchens with full-size refrigerators, microwave ovens, stovetops, cookware, utensils and dishes to satisfy all guests' cooking needs. Additional in-room amenities include comfortable platform beds with storage space beneath, recliners, a television with premium cable and device casting capabilities and a spacious workplace with high-speed internet access for business travelers. Pet friendly rooms are also available for guests traveling with their four-legged family members....

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Talks in Seoul broke down after both sides alleged a failure to compromise on the cost of keeping 28,500 troops on the peninsula as a deterrent to North Korea. Pictured: U.S. negotiator James DeHart.

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