Zoning technology has experienced success in both residential and commercial applications of hot water and hydronic systems.

Breaking the DNC blackout on Gaza, Codepink's Jodie Evans joined other activists working to keep Palestinians on the Democratic Party’s radar.

Understanding the difference between technologies that disrupt and technologies that sustain innovation, and acting on that knowledge.

The past as a bridge to the future: the increasing importance of service orientation in cloud-based, highly mobile world.

Rolling with the changes: think big, start small, and learn fast in order to turn trends into professional evolution.

[Capital FM] Nairobi -- The Communications Authority of Kenya (CA) is in the spotlight over insufficient measures to protect consumers from data bundle expirations and frequent internet disruptions by major Internet Service Providers (ISPs) like Safaricom, Airtel, and Telkom.

[Leadership] In addition to the Consumer Protection Portal (CPP), recently unveiled to address issues and agitations arising from flight delays and cancellations, the Nigeria Civil Aviation Authority (NCAA), has again, introduced another layer of protection for air travel consumers.

A severe geomagnetic storm could disrupt communications and bring northern lights to parts of California, according to a warning from the National Oceanic and Atmospheric Administration.

Dysfunctional neurons in the cerebellum, a brain region that controls motor functions, reduced REM sleep in mice.

As mysterious displays of fireworks continue to be set off across the country – in Chicago, Philadelphia, Boston, Los Angeles – residents in New York City say the nightly cacophony is driving them nuts. "It's kind of been a bit all-consuming to be honest," said Brooklyn resident Eric Anderson, 33. "I go to bed hearing it. I get woken up hearing it, and then on my Twitter feed all anybody is doing is talking about it." In New York City, the police department said there were 54 fireworks complaints in the first half of last year. In the same period this year, there have been more than 11,000. It's illegal to set off your own fireworks in New York, and Mayor Bill de Blasio has said the city is going to crack down on suppliers. "We're going to start a huge sting operation to go and get these illegal fireworks at the base," he said. Last week he appointed a task force made up of officers from the New York City Police Department, fire marshals and members of the Sheriff's Bureau of Criminal

As you may know or not know, Google is not providing keywords data when users are logged in to their accounts. This has been an on-going topic throughout the SEO world for sometime now. Link Worx Seo wrote about this topic on 10/23/2011 and 11/03/2011 and the effects it is having on SEO analysis. As […]

German law enforcement authorities have announced the disruption of a criminal service called dstat[.]cc that made it possible for other threat actors to easily mount distributed denial-of-service (DDoS) attacks. "The platform made such DDoS attacks accessible to a wide range of users, even those without any in-depth technical skills of their own," the Federal Criminal Police Office (aka

INTERPOL on Tuesday said it took down more than 22,000 malicious servers linked to various cyber threats as part of a global operation. Dubbed Operation Synergia II, the coordinated effort ran from April 1 to August 31, 2024, targeting phishing, ransomware, and information stealer infrastructure. "Of the approximately 30,000 suspicious IP addresses identified, 76 per cent were taken down and 59

Dilated cardiomyopathy (DCM) is associated with mutations in cardiomyocyte sarcomeric proteins, including α-tropomyosin. In conjunction with troponin, tropomyosin shifts to regulate actomyosin interactions. Tropomyosin molecules overlap via tropomyosin–tropomyosin head-to-tail associations, forming a continuous strand along the thin filament. These associations are critical for propagation of tropomyosin's reconfiguration along the thin filament and key for the cooperative switching between heart muscle contraction and relaxation. Here, we tested perturbations in tropomyosin structure, biochemistry, and function caused by the DCM-linked mutation, M8R, which is located at the overlap junction. Localized and nonlocalized structural effects of the mutation were found in tropomyosin that ultimately perturb its thin filament regulatory function. Comparison of mutant and WT α-tropomyosin was carried out using in vitro motility assays, CD, actin co-sedimentation, and molecular dynamics simulations. Regulated thin filament velocity measurements showed that the presence of M8R tropomyosin decreased calcium sensitivity and thin filament cooperativity. The co-sedimentation of actin and tropomyosin showed weakening of actin-mutant tropomyosin binding. The binding of troponin T's N terminus to the actin-mutant tropomyosin complex was also weakened. CD and molecular dynamics indicate that the M8R mutation disrupts the four-helix bundle at the head-to-tail junction, leading to weaker tropomyosin–tropomyosin binding and weaker tropomyosin–actin binding. Molecular dynamics revealed that altered end-to-end bond formation has effects extending toward the central region of the tropomyosin molecule, which alter the azimuthal position of tropomyosin, likely disrupting the mutant thin filament response to calcium. These results demonstrate that mutation-induced alterations in tropomyosin–thin filament interactions underlie the altered regulatory phenotype and ultimately the pathogenesis of DCM.

Nica M. Borradaile
Dec 1, 2006; 47:2726-2737
Research Articles

Infiltration of peripheral immune cells after blood-brain barrier dysfunction causes severe inflammation after a stroke. Although the endothelial glycocalyx, a network of membrane-bound glycoproteins and proteoglycans that covers the lumen of endothelial cells, functions as a barrier to circulating cells, the relationship between stroke severity and glycocalyx dysfunction remains unclear. In this study, glycosaminoglycans, a component of the endothelial glycocalyx, were studied in the context of ischemic stroke using a photochemically induced thrombosis mouse model. Decreased levels of heparan sulfate and chondroitin sulfate and increased activity of hyaluronidase 1 and heparanase (HPSE) were observed in ischemic brain tissues. HPSE expression in cerebral vessels increased after stroke onset and infarct volume greatly decreased after co-administration of N-acetylcysteine + glycosaminoglycan oligosaccharides as compared with N-acetylcysteine administration alone. These results suggest that the endothelial glycocalyx was injured after the onset of stroke. Interestingly, scission activity of proHPSE produced by immortalized endothelial cells and HEK293 cells transfected with hHPSE1 cDNA were activated by acrolein (ACR) exposure. We identified the ACR-modified amino acid residues of proHPSE using nano LC–MS/MS, suggesting that ACR modification of Lys139 (6-kDa linker), Lys107, and Lys161, located in the immediate vicinity of the 6-kDa linker, at least in part is attributed to the activation of proHPSE. Because proHPSE, but not HPSE, localizes outside cells by binding with heparan sulfate proteoglycans, ACR-modified proHPSE represents a promising target to protect the endothelial glycocalyx.

Disruptive technologies by nation states and malign cyber actors – the US response 16 February 2023 — 1:00PM TO 2:00PM Anonymous (not verified) 2 February 2023 Chatham House and Online

Lisa Monaco, the US deputy attorney general, discusses how autocratic governments and malign cyber actors use disruptive technologies to project power and engage in illicit activity.

Weaponizing data, ransomware attacks and other illicit cyber activity represent significant threats to national security. 

Governments and malicious cyber actors around the world exploit disruptive technology to engage in criminal activity, track citizens and coerce other countries thereby weakening the rules-based order and fundamental principles of democracy. 

Lisa Monaco discusses how the world is at an inflection point when it comes to meeting this challenge and describes how the US and partner nations are responding to protect their citizens and the broader international community.

Key questions to discuss include:

• What steps does the US government need to take to properly address this threat?
• How are countries coordinating policies to confront the problem?
• To what extent does this challenge go beyond US-China competition?

As with all member events, questions from the audience drive the conversation.

Read the transcript.

In the latest episode of Invent Penn State’s "Dare to Disrupt" podcast, host Ryan Newman interviews Peter Cocoziello, chairman, founder and CEO of Advance Realty Investors, a company specializing in real estate development, construction and property management.

Join Invent Penn State’s "Dare to Disrupt" for a live podcast recording in the newly renovated Nittany Lion Inn’s 1855 Lounge at 11 a.m. Friday, Nov. 22, featuring Scholar Hotels Founder and CEO Gary Brandeis.

Citing widespread delays in mail deliveries, President Trump’s intent to use the Postal Service to suppress the vote, and reports of deliberate disruptions in daily postal operations amid a global pandemic, Attorney General Kathy Jennings announced Tuesday that Delaware and other states are suing the United States Postal Service to stop their practices. “Every American depends on […]

Commercially available quantum technology could let stock traders coordinate decisions to buy or sell nearly instantaneously using a technique called “quantum telepathy”

A link between volcanic activity and rising bubbles of low pressure in the ionosphere has now been proven, which may be why the colossal Tonga volcano eruption in 2022 disrupted satellite communications

Title: Chronic Drinking Linked to Circadian Disruptions
Category: Health News
Created: 8/25/2010 12:00:00 AM
Last Editorial Review: 8/26/2010 12:00:00 AM

https://maps.google.co.in/url?q=https://yukselenakademi.com/kurs/detay/emlakcilik-belgesi-seviye-5

Ulmart�s stunning growth continues unabated as sales for the first six months of 2014 were up 31% in a year-on-year comparison. Sequential quarterly growth increased by 47%.

Disruptions to the body's internal clock can speed up the development of colorectal cancer. By influencing the gut microbiome and intestinal barrier,

People who work night shifts or irregular hours and eat at inconsistent times are more susceptible to weight gain and diabetes, likely because their eating

A survey of low-income adults in Arkansas, Kentucky, Louisiana, and Texas revealed that one in eight respondents who had enrolled in Medicaid at some

The tech world took a major double take this year when a security startup called Wiz founded out of Israel just four years earlier became the subject of a record-breaking, $23 billion acquisition attempt by Google — an offer the startup boldly proceeded … to refuse. Really? Yes, really. We will be talking to Assaf Rappaport, […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Creator of the iPod, Nest Labs founder, and investor Tony Fadell took a shot at OpenAI CEO Sam Altman on Tuesday during a spirited interview at TechCrunch Disrupt 2024 in San Francisco. Speaking about his understanding of the longer history of AI development before the large language model (LLM) craze and the serious issues with […]

© 2024 TechCrunch. All rights reserved. For personal use only.

At TechCrunch Disrupt, our team sits front and center, furiously typing away at our laptops to publish real-time news from impressive speakers like NFL quarterback-turned-founder Colin Kaepernick, Perplexity AI founder Aravind Srinivas, and Ashton Kutcher. We are a well-oiled machine. Some writers have been covering Disrupt since the old days, before Meta was Meta and […]

© 2024 TechCrunch. All rights reserved. For personal use only.

It’s been a tumultuous year for OnlyFans, the popular subscription-based social media platform best known for hosting explicit content and offering an online safe haven to the sex workers who create it. In August 2021, the company launched OFTV, a streaming platform featuring safe-for-work content, a move widely seen as an attempt to attract investors […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Disrupt is turning 12 years old. If it were a human, it would be addicted to technology (which it is) and starting to get an attitude (again, yes). But after a couple of years coming to you virtually, the world’s most impactful tech startup conference is coming back to real life. The Moscone Center will […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Disrupt is just a few short weeks away. Alongside our return to a live, in-person show, we’ve beefed up the Battlefield program. Two hundred companies have been hand selected by the TechCrunch editorial staff to grace the expo hall, 20 of which will launch their company for the first time live on our stage. The […]

© 2024 TechCrunch. All rights reserved. For personal use only.

The time has finally come to announce the five finalists of the Startup Battlefield. It all started earlier this year when the TechCrunch editorial team selected 200 companies from thousands that applied. From there, the team then chose the 20 finalists who pitched this week onstage at TechCrunch Disrupt 2024 to investor judges and packed […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Over the last three days, 20 startups participated in the incredibly competitive Startup Battlefield at TechCrunch Disrupt. These 20 companies were selected as the best of the Startup Battlefield 200 and competed for a chance to take home the Startup Battlefield Cup and $100,000. After three days of intense pitching, we have a winner. The […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Frugal founders and savvy shoppers take heed. TechCrunch Disrupt, which takes place in person on October 18–20 — and online October 21 — can be a serious boon to your business. But our early-bird pricing disappears in a cloud of ruffled feathers on Friday, July 29 at 11:59 p.m. PT. You have just 48 hours […]

© 2024 TechCrunch. All rights reserved. For personal use only.

We’re T-minus 24 hours until the TechCrunch Disrupt early bird flies south and takes up to $1,300 in savings with it. If you’re serious about realizing your startup dreams, you need to be kind to your bottom line. Disrupt is packed with many long-tail opportunities, but this one ends in just 24 hours. Buy your […]

© 2024 TechCrunch. All rights reserved. For personal use only.

It takes a veritable army to make TechCrunch Disrupt — which takes place October 18–20 in San Francisco — the well-oiled experience that savvy startuppers have come to know and love. And we couldn’t do it nearly as well without our incredible volunteers. If you’re looking for a no-budget way to experience Disrupt up close […]

© 2024 TechCrunch. All rights reserved. For personal use only.

We see how hard early startup community members work to build their dreams. You’re all wicked busy, and that’s why we’re extending our early-bird pricing on passes to TechCrunch Disrupt, taking place on October 18–20 in San Francisco. You get one extra week to save up to $1,300, so shake your tail feathers and buy […]

© 2024 TechCrunch. All rights reserved. For personal use only.

We’re coming down to the wire, folks. Your chance to save early-bird pricing on passes to TechCrunch Disrupt ends this Friday. Our three-day flagship tech startup conference offers superior ROI at full price, but why spend more when you don’t have to? To-do today: Buy your early-bird pass to TechCrunch Disrupt by Friday, August 5 […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Time is running out on one of the biggest opportunities in Disrupt history. We stop accepting applications to the Startup Battlefield 200 tonight, August 5, at precisely 11:59 p.m. PDT. No more deadline extensions, no last-minute exceptions. Nada. Zip. Zilch. Lollygagger alert: Drop what you’re doing and go apply to the Startup Battlefield 200 right […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Team TechCrunch wants you! Forget the village, people. It takes a battalion of smart, eager people to produce a world-class tech conference as epic as TechCrunch Disrupt. That’s where you come in. We’re looking for volunteers interested in work exchange. You give us 10 hours of your time, and we’ll give you a three-day pass […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Australia lags behind the world's best corporate performers in all ten indicators of digital intelligence needed to drive financial performance.

Airlines scrapped more than 3,000 U.S. flights and delayed more than 5,000 on Monday. The new wave of cancellations and delays comes as the surge in Covid-19 infections in the U.S. has left the airline industry stretched thin. Photo: Chandan Khanna/AFP/Getty Images

Many are calling decentralized finance, or DeFi, the “Wild West of finance.” This fast-growing industry aims to provide automated banking services for cryptocurrencies to everyone, with no middle men. But DeFi is still in its early stages, which means there are risks. WSJ explains. Photo illustration: Tammy Lian/WSJ