At every level of America's food system, mandated closures and outbreaks of COVID-19 have interrupted the finely tuned network that normally gets food from farmers and food processors to restaurants, grocery stores and food banks.…

A precision coaxial water jet disruption explosive device system that holds a blasting cap precisely to the surface of a cylindrically cut positioned plastic explosive that couples a detonation shock wave into water surrounding a hollow forming cavity. A pressure relief vent enables the water filled system to be assembled without deforming the thin walled hollow jet forming cavity, enabling forming repeatable supersonic jets on centerline axis. This system is positioned with two triangular pivot legs and aligned with two fan light beams or a line sight to define a projected jet route to deliver a water jet that can cut through over 1 inch of steel and disrupt target objects more than 9 feet away. This system is used to disable improvised explosive devices, and other dangerous objects, without detonating the targeted explosives and electronic devices such that the contents are destroyed without explosion sequences occurring.

A system that may be used as an initiation disruption system (IDS) according to one embodiment includes an explosive charge; a plurality of particles in a layer at least partially surrounding the explosive charge; and a fire suppressant adjacent the plurality of particles. A method for disabling an object according to one embodiment includes placing the system as recited above near an object; and causing the explosive charge to initiate, thereby applying mechanical loading to the object such that the object becomes disabled. Additional systems and methods are also presented. A device according to another embodiment includes a plurality of particles bound by a binder thereby defining a sidewall having an interior for receiving an explosive; and a fire suppressant adjacent the plurality of particles and binder. Additional systems and methods are also presented.

Aspects of the present disclosure include a navigation system and computer-implemented methods for detecting traffic disruption events based on an analysis of input component data obtained from navigation-enabled devices of vehicles near a particular location. Traffic disruption events are events such as accidents, construction road closures, police and speed traps, or road hazards that cause a decrease in the flow of traffic along a particular route and thus, added time delays for occupants of vehicles traveling along those routes. The navigation system scores the input component data associated with each vehicle and aggregates the scored input component data to obtain a frustration score associated with the vehicle. The navigation system may detect traffic disruption events based on a number of vehicles near a particular area having associated frustration scores above a certain threshold.

Coming on the heels of the AB5 trauma, the coronavirus lockdown poses an extra economic threat. The COVID-19 pandemic has affected all facets of life in California and the world.…

HAMPSHIRE rail users can expect a week of disruptions.

“There are supply issues for several brands. There is no clarity when the situation will normalise,” said Nilesh Gupta, director at Vijay Sales, a leading electronics retailer in Mumbai and New Delhi. “If it doesn’t get corrected fast, we may move into a stock-out situation from next month.”

World's gold demand during the first quarter of 2019 stood at 1070.8 tonne, according to WGC's Q1 Gold Demand Trends report.

Macy's, like many retailers, has had to close its stores, furlough employees, suspend dividend and tap into credit facilities to survive the financial hit caused by the lockdowns.

"The consumer goods industry... is in turmoil," new Beiersdorf CEO Stefan De Loecker, who took over on Jan. 1, told a presentation to analysts. "I need to act now."

The Mayors of DeKalb and Rockford responded to the statewide minimum wage hike that was signed into law last week. The measure will raise the state's minimum wage to $15 per hour by 2025. DeKalb Mayor Jerry Smith worries about the effect this may have on small businesses. Smith says he would have preferred that the increase be done more incrementally. "I would have liked to have seen something that was written into law that mandated perhaps a one or two year step, and then let's take a look at it," he said. "You know, economies change." But he says the law taking effect means businesses know what to expect. "If you know that you're going to be paying nine and a quarter next year and ten the following year, or whatever the case may be, the smart businesses -- small or large -- are going to make those adjustments that are necessary so the bottom line is still black," he said. Smith says the City of DeKalb already pays its employees at a level where the wage hike's effect on city

Food production has been seriously disrupted to the coronavirus pandemic. It has forced producers, including dairy farmers, to dispose of more of their supplies, which has led to more food waste. Joe Diglio, president/CEO of the Michigan Milk Producers Association, has a conversation with WEMU's David Fair about how the problems are being addressed in this week's "Issues of the Environment."

Food production has been seriously disrupted to the coronavirus pandemic. It has forced producers, including dairy farmers, to dispose of more of their supplies, which has led to more food waste. Joe Diglio, president/CEO of the Michigan Milk Producers Association, has a conversation with WEMU's David Fair about how the problems are being addressed in this week's "Issues of the Environment."

QBE's chief executive says the eventual recovery from COVID-19 will hasten the trend of digital disruption that was underway before the pandemic began.

With plant-based burgers, bean-free coffee and the proliferation of insect farms, experts say alternative foods are on the verge of upending the traditional agriculture and livestock industries.

Life has changed dramatically for many Canadians because of the COVID-19 pandemic. On a special Saturday edition of Checkup, our expert panel will answer your questions about money, medical concerns, relationships and parenting in this period of social distancing and quarantine.

The federal government this week passed its $107-billion aid package to help Canadians struggling during the COVID-19 pandemic. But will it be enough to make April rent?

Digital disruption has changed the craft of writing, and crime writing in particular, according to those in the industry, but has not caused the death of print books.

The sizzle of a steak on a barbecue may soon sound a little different as Australia's $16.8 billion beef industry prepares to adapt to demands from 'locavores' and technological change.

#architektura #architekt #dom #design

IBM Security today released a global study examining consumer perspectives around digital identity and authentication, which found that people now prioritize security over convenience when logging into applications and devices. Generational differences also emerged showing that younger adults are putting less care into traditional password hygiene, yet are more likely to use biometrics, multifactor authentication and password managers to improve their personal security.

While marketing and sales professionals increasingly find themselves drowning in data, a new IBM study finds that nearly two thirds—64 percent--of surveyed CMOs and sales leaders believe their industries will be ready to adopt cognitive technologies in the next three years. However despite this stated readiness, the study finds that only 24 percent of those surveyed believe they have strategy in place to implement these technologies today.

Etude IBM : les directions Marketing doivent adopter la « disruption créative » pour fidéliser leurs clients La nouvelle étude IBM révèle les principaux axes de priorités des directions Marketing pour 2016

The latest episode of the "She Roars" podcast features Wendy Kopp, Class of 1989, reflecting on her experience as a groundbreaking social entrepreneur — which she has been since long before the term was invented.

The outbreak of the coronavirus has dealt a shock to the global economy with unprecedented speed as it continues to spread across the world. Here is a look at some of the latest developments Wednesday related to the global economy, particular economic sectors, and the workplace.

First-year UCLA gymnastics coach Chris Waller knew the Bruins would face challenges, but he's pleased with what the team accomplished.

CSU Chancellor Timothy P. White and the presidents of the Northridge and East Bay campuses say they will stay on through fall 2020.

A lawsuit announced Tuesday seeks refunds for students who, as a result of the coronavirus closures, lost out on in-person instruction, housing, meals and other elements of campus life and were not paid back tuition and fees.

Fire crews attended around 160 weather related incidents in a 12 hour period.

The San Francisco-based website is auctioning collectible cars online in real time — 50-plus a day, five days a week.

The plan for the Premier League to return next month may hit a roadblock with six clubs not so keen on the idea of giving up their remaining home games.

Home color kits and Zoom crystal readings fill the void. But underground services break the lockdown.

Research Event

Event participants

Research Event

Event participants

Nica M. Borradaile
Dec 1, 2006; 47:2726-2737
Research Articles

Research Event

Event participants

Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric pH indicator (2',7'-bis-(2-carboxyethyl)-5-(and-6-)-carboxyfluorescein and acrylodated intestinal FA-binding protein-based dual fluorescence assays, we investigated the effects of nine inhibitors of the putative FA transporter protein CD36 on the binding and transmembrane movement of LCFAs. We particularly focused on sulfosuccinimidyl oleate (SSO), reported to be a competitive inhibitor of CD36-mediated LCFA transport. Using these assays in adipocytes and inhibitor-treated protein-free lipid vesicles, we demonstrate that rapid LCFA transport across model and biological membranes remains unchanged in the presence of these purported inhibitors. We have previously shown in live cells that CD36 does not accelerate the transport of unesterified LCFAs across the PM. Our present experiments indicated disruption of LCFA metabolism inside the cell within minutes upon treatment with many of the "inhibitors" previously assumed to inhibit LCFA transport across the PM. Furthermore, using confocal microscopy and a specific anti-SSO antibody, we found that numerous intracellular and PM-bound proteins are SSO-modified in addition to CD36. Our results support the hypothesis that LCFAs diffuse rapidly across biological membranes and do not require an active protein transporter for their transmembrane movement.

The coach and rail journey app has launched a new AI voice app for automated disruption alerts

(Kudos Innovations Ltd) Kudos helps researchers maximize reach and visibility of research by opening up Kudos Pro. The platform helps showcase work to a range of target audiences, supporting researchers in fields where conferences have been cancelled -- and those with COVID-19-relevant work that needs rapid communication. Over 2,000 researchers have already signed up.

Research Event

Event participants

Henry J. Pownall
May 1, 2020; 61:595-597
Commentary

Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric pH indicator (2',7'-bis-(2-carboxyethyl)-5-(and-6-)-carboxyfluorescein and acrylodated intestinal FA-binding protein-based dual fluorescence assays, we investigated the effects of nine inhibitors of the putative FA transporter protein CD36 on the binding and transmembrane movement of LCFAs. We particularly focused on sulfosuccinimidyl oleate (SSO), reported to be a competitive inhibitor of CD36-mediated LCFA transport. Using these assays in adipocytes and inhibitor-treated protein-free lipid vesicles, we demonstrate that rapid LCFA transport across model and biological membranes remains unchanged in the presence of these purported inhibitors. We have previously shown in live cells that CD36 does not accelerate the transport of unesterified LCFAs across the PM. Our present experiments indicated disruption of LCFA metabolism inside the cell within minutes upon treatment with many of the "inhibitors" previously assumed to inhibit LCFA transport across the PM. Furthermore, using confocal microscopy and a specific anti-SSO antibody, we found that numerous intracellular and PM-bound proteins are SSO-modified in addition to CD36. Our results support the hypothesis that LCFAs diffuse rapidly across biological membranes and do not require an active protein transporter for their transmembrane movement.

A new scientific study published Monday found that global warming is fueling a destructive algal bloom that is disrupting fisheries in the Arabian sea.

A Smarter Balanced testing vendor has released completion rates in three states that had serious challenges giving the common-core aligned exam.

Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET receptor. HGF stimulates cell proliferation, cell dispersion, neuronal survival, and wound healing. In the inner ear, levels of HGF must be fine-tuned for normal hearing. In mice, a deficiency of HGF expression limited to the auditory system, or an overexpression of HGF, causes neurosensory deafness. In humans, noncoding variants in HGF are associated with nonsyndromic deafness DFNB39. However, the mechanism by which these noncoding variants causes deafness was unknown. Here, we reveal the cause of this deafness using a mouse model engineered with a noncoding intronic 10 bp deletion (del10) in Hgf. Male and female mice homozygous for del10 exhibit moderate-to-profound hearing loss at 4 weeks of age as measured by tone burst auditory brainstem responses. The wild type (WT) 80 mV endocochlear potential was significantly reduced in homozygous del10 mice compared with WT littermates. In normal cochlea, endocochlear potentials are dependent on ion homeostasis mediated by the stria vascularis (SV). Previous studies showed that developmental incorporation of neural crest cells into the SV depends on signaling from HGF/MET. We show by immunohistochemistry that, in del10 homozygotes, neural crest cells fail to infiltrate the developing SV intermediate layer. Phenotyping and RNAseq analyses reveal no other significant abnormalities in other tissues. We conclude that, in the inner ear, the noncoding del10 mutation in Hgf leads to developmental defects of the SV and consequently dysfunctional ion homeostasis and a reduction in the EP, recapitulating human DFNB39 nonsyndromic deafness.

SIGNIFICANCE STATEMENT Hereditary deafness is a common, clinically and genetically heterogeneous neurosensory disorder. Previously, we reported that human deafness DFNB39 is associated with noncoding variants in the 3'UTR of a short isoform of HGF encoding hepatocyte growth factor. For normal hearing, HGF levels must be fine-tuned as an excess or deficiency of HGF cause deafness in mouse. Using a Hgf mutant mouse with a small 10 bp deletion recapitulating a human DFNB39 noncoding variant, we demonstrate that neural crest cells fail to migrate into the stria vascularis intermediate layer, resulting in a significantly reduced endocochlear potential, the driving force for sound transduction by inner ear hair cells. HGF-associated deafness is a neurocristopathy but, unlike many other neurocristopathies, it is not syndromic.